A

Aguiar, Carla J, Rocha-Franco, Joao A, Souza, Pedro A, Santos, Anderson K, Ladeira, Marina, Rocha-Resende, Cibele, Ladeira, Luis O, Resende, Rodrigo R, Botoni, Fernando A, Barrouin Melo, Marcos, Lima, Cristiano X, Carballido, Jose, Cunha, Thiago M, Menezes, Gustavo B, Guatimosim, Silvia and Leite, M Fatima (2014) SUCCINATE CAUSES CARDIOMYOCYTE HYPERTROPHY THROUGH GPR91 ACTIVATION. Cell Communication and Signaling.

Ahene, A, Calonder, C, Davis, S, Kowalchick, J, Nakamura, T, Nouri, P, Vostiar, I, Wang, Y and Wang, J (2014) Automation practices in large molecule bioanalysis: Recommendations from group l5 of the global bioanalytical consortium. AAPS journal. pp. 164-171.

Akkus, Funda, Terbeck, Sylvia, Ametamey, Simon/M, Rufer, Michael, Treyer, Valerie, Burger, Cyrill, Johayem, Annas, Gomez-Mancilla, Baltazar, Sovago, Judit, Buck, Alfred and Hasler, Gregor (2014) Metabotropic Glutamate Receptor 5 Binding in Patients with Obsessive-Compulsive Disorder. International Journal of Neuropsychopharmacology.

Alper, Phillip and Epple, Robert (2014) Discovery of structurally novel, potent and orally efficacious GPR119 agonists. Bioorganic and Medicinal Chemistry Letters, 24 (10). pp. 2383-2387. ISSN 1464-3405

Amato, Anthony A, Sivakumar, Kumaraswamy, Goyal, Namita, David, William S, Salajegheh, Mohammad, Praestgaard, Jens, Trifilieff, Estelle, Trendelenburg, Anne-Ulrike, Laurent, Didier, Glass, David, Roubenoff, Ronenn, Tseng, Brian and Greenberg, Steven A (2014) Treatment of sporadic inclusion body myositis with bimagrumab. Neurology, 83 (24). pp. 2239-2246. ISSN 1526-632X

Ando, Yuichi, Inada-inoue, Megumi, Mitsuma, Ayako, Yoshino, Takayuki, Ohtsu, Atsushi, Noumi, Naoko, Sato, Masahiko, Kakizume, Tomoyuki, Robson, Matthew, Quadt, Cornelia and Doi, Toshihiko (2014) A Phase I dose-escalation study of buparlisib (BKM120), an oral pan-class I PI3K inhibitor, in Japanese patients with advanced solid tumors. Cancer Science, 105 (3). pp. 347-353.

Antczak, Christophe, Somalinga, Balajee and Djaballah, Hakim (2014) Heat shock proteins: A high content assay opportunity to measure cellular stress response. European Drug Target Review.

Arias, Hugo R, Feuerbach, Dominik, Targowska-Duda, Katarzyna M, Kaczor, Agnieszka A, Poso, Antti and Jozwiak, Krzysztof (2014) Pharmacological and molecular studies on the interaction of varenicline with different nicotinic acetylcholine receptor subtypes. Potential mechanism underlying partial agonism at human 42 and 34 subtypes. Biochimica et Biophysica Acta.

Arm, Jonathan, Bottoli, Ivan, Skerjanec, Andrej, Groenewegen, Andrea, Maahs, Suzanne, Owen, Charles, Jones, Ieuan and Lowe, Phil (2014) Efficacy and safety of QGE031, a novel anti-IgE antibody, in atopic subjects. Clinical and Experimental Allergy, 44 (11). pp. 1371-1385.

Arnold, Nicola, Beattie, David, Bradley, Michelle, Brearley, Andrew, Brown, Lyndon, Charlton, Steven, Farr, David Colin, Fozard, John R., Fullerton, Joe, Gosling, Martin, Hatto, Julia, Janus, Diana, Jones, Darryl, Jordan, Lynne, Lewis, Christine, Maas, Janet, Mercer, Mark, Oakman, Helen, Press, Neil, Profit, Rachael, Schuerch, Friedrich, Sykes, David, Taylor, Roger, Trifilieff, Alexandre, Tuffnell, Andrew and Mccarthy, Clive (2014) The identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone as an inhaled long-acting beta2-adrenoceptor agonist. Bioorganic and Medicinal Chemistry Letters, 24. pp. 4341-4347.

Aronchik, Ida, Appleton, Brent, Basham, Stephen, Crawford, Kenneth, Del Rosario, Merci, Doyle, Laura, Estacio, William, Lindvall, Mika, Luu, Catherine, Venetsanakos, Eleni, Shafer, Cynthia and Jefferson, A.B. (2014) Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancers. Molecular Cancer Research, 12 (5). pp. 803-812. ISSN 1557-3125

Aronchik, Ida, Appleton, Brent, Basham, Stephen, Crawford, Kenneth, Del Rosario, Merci, Doyle, Laura, Estacio, William, Lindvall, Mika, Luu, Catherine, Venetsanakos, Eleni, Shafer, Cynthia and Jefferson, A.B. (2014) Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancers. Molecular Cancer Research, 12 (5). pp. 803-812. ISSN 1557-3125

Auberson, Yves, Troxler, Thomas J., Zhang, Xuechun, Yang, Charles, Fendt, Markus, Feuerbach, Dominik, Liu, Yu-Chih, Lagu, Bharat, Lerchner, Andreas, Perrone, Mark, Lei, Lijun, Zhang, Chao, Wang, Chunxiu, Wang, Tie-Lin and Bock, Mark (2014) Ergoline-derived Inverse Agonists of the Human H3-Receptor for the Treatment of Narcolepsy. ChemMedChem. ISSN 18607179

Auberson, Yves, Troxler, Thomas J., Zhang, Xuechun, Yang, Charles, Feuerbach, Dominik, Liu, Yu-Chih, Lagu, Bharat, Perrone, Mark, Lei, Lijun, Shen, Xiaoxia, Zhang, Dushan, Wang, Chunxiu, Wang, Tie-Lin and Bock, Mark (2014) From Ergolines to Indoles: Improved Inhibitors of the Human H3-Receptor for the Treatment of Narcolepsy. ChemMedChem, 10 (2). pp. 266-275. ISSN 18607179

Auld, Douglas (2014) October Literature Search and Review. Assay and Drug Development Technologies. ASSAY and Drug Development Technologies.

Auld, Douglas (2014) September Literature Search and Review. Assay and Drug Development Technologies. Assays and Drug Development Technologies.

Auld, Douglas, Hill, William and Orme, Jonathon (2014) Examining Ligand-based Stabilization of Proteins in Cells with MEK1 Kinase Inhibitors. Assay Drug Development Technologies, 13 (5). pp. 266-276. ISSN 1540-658X1557-8127

Auld, Douglas, Hill, William, Smith, Thomas, Zhang, Ji, Kang, Zhao Bin, Ho, Pei-I, Ardayfio, Ophelia and Bowes, Scott (2014) Applications of quantitative HTS (qHTS) to facilitate assay pilot testing. Journal of Biomolecular Screening, 19 (5). pp. 651-660. ISSN 1087-05711552-454X

Austin, Steven, Dunstan, David, Reilly, John, Wall, Daniel, Ek, Jared and Mckinnon, Michael (2014) The Implementation of Spotfire to Analyze Open-Access Instrumentation Metrics. Chromatography Today, Aug-Se. pp. 2-4.

Avchalumov, Yosef, Sander, Svenja, Porath, Katrin, Hamann, Melanie, Richter, Franziska, Kirschstein, Timo, Köhling, Rüdiger and Richter, Angelika (2014) Role of striatal NMDA receptor subunits in a model of paroxysmal dystonia. Experimental Neurology, 261. pp. 677-684. ISSN 00144886

Azimioara, Mihai, Epple, Robert, Alper, Phillip, Cow, Christopher, Mutnick, Daniel, Nikulin, Victor, Lelais, Gerald, Mcneill, Matthew, Michellys, Pierre, Wang, Zhiliang, Li, Jing, Bao, Dingjiu, Zoll, Jocelyn, Kim, Young, Zimmerman, Matthew, Groessl, Todd, Tuntland, Tove, Mcnamara, Peter, Seidel, Martin, Joseph, Sean, Mecom, John, Reding, Esther and Paliotti, Michael (2014) Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists. Bioorganic and Medicinal Chemistry Letters, 24 (23). pp. 5478-5483. ISSN 1464-3405

B

Bachelier, Richard, Confavreux, Cyrille, Goehring, Delphine, van der Pluijm, Gabri, Clezardin, Philippe and Carmeli, Yael (2014) Combination of Antiangiogenic Therapies Reduces Osteolysis and Tumor Burden in Experimental Breast Cancer Bone Metastasis. International journal of cancer, 135 (6). pp. 1319-1329. ISSN 1097-0215

Baertschi, Stefan, Baur, Nina, Lueders-Lefevre, Valerie, Voshol, Johannes and Keller, Hansjoerg (2014) Class I and IIa Histone Deacetylases Have Opposite Effects on Sclerostin Gene Regulation. Journal of Biological Chemistry.

Barnes, David, Boiselle, Carri, Chopra, Rajiv, Hoffmaster, Keith, Kato, Mitsunori, Lin, Kai, Pan, Guoyu, Zheng, Rui, Shu, Lei, Ma, Sue, Wang, Jianling, Whiteman, Leah, Xu, Mei and Fu, Jiping (2014) Design and synthesis of lactam-thiophene carboxylic acids as potent hepatitis C virus polymerase inhibitors. Bioorganic & Medicinal Chemistry Letters, 24 (16). pp. 3979-3985. ISSN 0960894X

Barone, Eugenio, Mosser, Sebastien and Frearing, Patrick C (2014) Cofilin-1 activity is modulated by age, Alzheimer's disease pathology and gamma secretase. Biochim Biophys Acta, 1842 (12 Pt ). pp. 2500-2509.

Baskin, KK, Rodriguez, MR, Kansara, S, Chen, W, Carranza, S, Frazier, OH, Glass, DJ and Taegtmeyer, H (2014) MAFbx/Atrogin-1 is required for atrophic remodeling of the unloaded heart. Journal of Molecular and Cellular Cardiology. pp. 168-176.

Bassilana, Frederic, Carlson, Adam, Dasilva, Jennifer, Grosshans, Bianka, Vidal, Solange, Beck, Valerie, Wilmering Wetter, Barbara, Llamas, Luis, Bourret, Aaron, Wu, Xu, Harbinski, Fred, Ruffner, Heinz, Grandi, Paola, Schirle, Markus, Jenkins, Jeremy, Bouwmeester, Antonius, Porter, Jeffrey, Myer, Vic, Finan, Peter, Tallarico, John, Kelleher Iii, Joseph, Seuwen, Klaus, Jain, Rishi and Luchansky, Sarah (2014) Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39. Nature Chemical Biology, 10 (5). pp. 343-349. ISSN 1552-4469

Bauer, Daniel, Averett, Lacey A, De Smedt, Ann, Kleinman, Mark H, Muster, Wolfgang, Pettersen, Betty A and Robles, Catherine (2014) Standardized UV-vis spectra as the foundation for a threshold-based, integrated photosafety evaluation. Regulatory Toxicology and Pharmacology, 68 (1). pp. 70-75. ISSN 02732300

Beale, J, Jayaraman, A, Jackson, DJ, Macintyre, JD, Edwards, MR, Walton, RP, Zhu, J, Ching, YM, Shamji, B, Edwards, M, Westwick, J, Cousins, DJ, Hwang, YY, McKenzie, A, Johnston, SL and Bartlett, NW (2014) Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation. Science Translational Medicine. 256ra134-.

Beck, Jeremy and Springer, Clayton (2014) Quantitative structure-activity relationship models of chemical transformations from matched pairs analyses. Journal of chemical information and modeling, 54 (4). pp. 1226-1234. ISSN 1549-960X

Becker, Dieter, Zhang, Jin, Heimbach, Tycho, Kulmatycki, Kenneth, Shimizu, Jeff, Dole, Kiran, He, Handan and Wanke, Christoph (2014) Novel orally swallowable IntelliCap(®) device to quantify regional drug absorption in human GI tract using diltiazem as model drug. AAPS PharmSciTech, 15 (6). pp. 1490-1497. ISSN 1530-9932

Bell, RE, Khaled, M, Netanely, D, Schubert, S, Golan, T, Buxbaum, A, Janas, MM, Postolsky, B, Goldberg, MS, Shamir, R and Levy, C (2014) Transcription factor/microRNA axis blocks melanoma invasion program by miR-211 targeting NUAK1. Journal of Investigative Dermatology. pp. 441-451.

Berghausen, Joerg and Faller, Bernard (2014) Diagnosing solubility limitations – the example of hydrate formation (revised). ADMET & DMPK.

Bernat, Viachaslau, Brox, Regine, Heinrich, Markus, Auberson, Yves and Tschammer, Nuska (2014) Ligand biased and probe-dependent modulation of the chemokine receptor CXCR3 signaling by negative allosteric modulators. ChemMedChem, 10 (3). pp. 566-574. ISSN 18607179

Bhinder, B, Antczak, C, Shum, D, Radu, C, Mahida, JP, Liu-Sullivan, N, Ibanez, G, Raja, BS, Calder, PA and Djaballah, H (2014) Chemical & RNAi screening at MSKCC: A collaborative platform to discover & repurpose drugs to fight disease. Combinatorial Chemistry and High Throughput Screening. pp. 298-318.

Bhinder, Bhavneet, Antczak, Christophe, Shum, David, Radu, Constantin, Mahida, Jeni, Liu-Sullivan, Nancy, Ibanez, Glorymar, Somalinga Raja, Balajee, Calder, Paul and Djaballah, Hakim (2014) Chemical & RNAi Screening at MSKCC: A Collaborative Platform to Discover & Repurpose Drugs to Fight Disease. Combinatorial Chemistry & High Throughput Screening, 17 (4). pp. 298-318. ISSN 1875-5402

Bialek, P, Parkington, J, Li, X, Gavin, D, Wallace, C, Zhang, J, Root, A, Yan, G, Warner, L, Seeherman, HJ and Yaworsky, PJ (2014) A myostatin and activin decoy receptor enhances bone formation in mice. Bone. pp. 162-171.

Bigaud, Marc, Guerini, Danilo, Billich, Andreas, Bassilana, Frederic and Brinkmann, Volker (2014) Second generation S1P receptor modulators: Research strategies and clinical developments. Biochimica et Biophysica Acta - Molecular and cell Biology of lipids, 1841 (5). pp. 754-758. ISSN 1388-1981

Bill, A, Popa, MO, van Diepen, MT, Gutierrez, A, Lilley, S, Velkova, M, Acheson, K, Choudhury, H, Renaud, NA, Auld, DS, Gosling, M, Groot-Kormelink, PJ and Gaither, LA (2014) Variomics screen identifies the reentrant loop of the calcium-activated chloride channel ANO1 that facilitates channel activation. Journal of Biological Chemistry .

Bin, Huang, Tanja, Lucas, Claudia, Küppers, Xiaomin, Dong, Maike, Krause, Alexander, Bepperling, Johannes, Buchner, Voshol, Johannes, Andreas, Weiss, Gerrits, Bertran and Stefan, Kochanek (2014) Scalable production of full-length normal and mutant huntingtin in human cells and its biochemical characterization. PLOS ONE.

Blackford, J, Brimacombe, KR, Dougherty, EJ, Pradhan, M, Shen, M, Li, Z, Auld, DS, Chow, CC, Austin, CP and Stoney, S (2014) Research resource: Modulators of glucocorticoid receptor activity identified by a new high-throughput screening assay. Molecular Endocrinology. pp. 1194-1206.

Blasco, Francesca, Fu, Yilong, Chen, Yen Liang, Herve, Maxime Marcel, Gu, Feng and Shi, Pei-Yong (2014) Development of a FACS-based assay for evaluating antiviral potency of compound in dengue infected peripheral blood mononuclear cells. Journal of Virological Methods, 196. pp. 18-24. ISSN 1879-0984

Boettcher, Andreas, Gradoux, Nathalie, Lorthiois, Edwige, Brandl, Trixi, Orain, David, Schiering, Nikolaus, Cumin, Frederic, Woelcke, Julian and Hassiepen, Ulrich (2014) Fluorescence Lifetime-based Competitive Binding Assays for Measuring the Binding Potency of Protease Inhibitors In Vitro. Journal of Biochemical Screening, 19 (6). pp. 870-877. ISSN 1087-05711552-454X

Bonapace, Laura, coissieux, marie-may, wyckoff, jeffrey, Mertz, Kirsten D., Varga, Zsuzsanna, Junt, Tobias and Bentires-Alj, Mohamed (2014) Discontinuation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis. Nature, 515 (7525). pp. 130-133.

Bonapace, Laura, wyckoff, Jeffrey, Mertz, Kirsten D., Varga, Zsuzsanna, coissieux, marie-may, Junt, Tobias and Bentires-Alj, Mohamed (2014) Cessation of CCL2 Inhibition Precipitates Breast Cancer Metastases and Death. Nature.

Bots, M, Verbrugge, I, Martin, BP, Salmon, JM, Ghisi, M, Baker, A, Stanley, K, Shortt, J, Ossenkoppele, GJ, Zuber, J, Rappaport, AR, Atadja, P, Lowe, SW and Johnstone, RW (2014) Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors. Blood. pp. 1341-1352.

Boudon, Stephanie Marie, Morandi, Gregory, Prideaux, Brendan , Staab, Dieter, Junker Walker, Ursula, Odermatt, Alex, Stoeckli, Markus and Bauer, Daniel (2014) EVALUATION OF SPARFLOXACIN PHOTOTOXICITY USING MASS SPECTROMETRY IMAGING. Journal of the American Society for Mass Spectrometry, 25 (10). pp. 1803-1809. ISSN 1879-1123

Boudon, Stephanie Marie, Plappert Helbig, Ulla, Odermatt, Alex and Bauer, Daniel (2014) CHARACTERIZATION OF VEMURAFENIB PHOTOTOXICITY IN A MOUSE MODEL. Toxicological Sciences, 137 (1). pp. 259-267. ISSN 1096-60801096-0929

Boudreaux, Ramon D , Perticone, Jacqueline I , Ellman, Rachel , Lenfest, Scott E , Bloomfield, Susan A and Hogan, Harry A (2014) Sequential High-Impact Loading and Zoledronic Acid Before Hindlimb Unloading Protects Against Decrements in Bone Microarchitecture and Strength. Published Thesis: http://oaktrust.library.tamu.edu/handle/1969.1/152600.

Bourgailh, Julien, Garnier, Maxime, Nufer, Robert, Pirard, Hans, Walles, Markus and Swart, Pieter Jacob (2014) ViewLux Microplate Imager for Metabolite Profiling: Validation and Applications in Drug Development. J Anal Bioanal Tech.

Boutouyrie-Dumont, B (2014) How to link biomarkers using physiologically based pharmacokinetic models. Biomarkers in Medicine. p. 74.

Boutouyrie-Dumont, B (2014) An IL-17-mediated paracrine network promotes tumor resistance to antiangiogenic therapy. Biomarkers in Medicine. p. 73.

Boutouyrie-Dumont, B (2014) A new biomarker to identify high-risk renal transplant patients. Biomarkers in Medicine. p. 75.

Boutouyrie-Dumont, Bruno (2014) How to link biomarkers using physiologically based pharmacokinetic models. Biomarkers in Medicine, 8 (1). pp. 73-75. ISSN 1752-0363

Boutouyrie-Dumont, Bruno (2014) An IL-17-mediated paracrine network promotes tumor resistance to antiangiogenic therapy. Biomarkers in Medicine, 8 (1). pp. 73-75. ISSN 1752-0363

Boutouyrie-Dumont, Bruno (2014) A new biomarker to identify high-risk renal transplant patients. Biomarkers in Medicine, 8 (1). pp. 73-75. ISSN 1752-0363

Boyce, SE, Tirunagari, N, Niedziela-Majka, A, Perry, J, Wong, M, Kan, E, Lagpacan, L, Barauskas, O, Hung, M, Fenaux, M, Appleby, T, Watkins, WJ, Schmitz, U and Sakowicz, R (2014) Structural and regulatory elements of HCV NS5B polymerase - beta-loop and C-terminal tail - Are required for activity of allosteric thumb site II inhibitors. PLoS ONE.

Breitschaft, A, Hu, K, Darstein, C, Ligueros-Saylan, M, Jordaan, P, Song, D, Hudson, M and Shah, R (2014) Effects of Subcutaneous Pasireotide on Cardiac Repolarization in Healthy Volunteers: A Single-Center, Phase I, Randomized, Four-Way Crossover Study. JOURNAL OF CLINICAL PHARMACOLOGY. pp. 75-86.

Brennan, MA, Gleeson, JP, O'Brien, FJ and McNamara, LM (2014) Effects of Ageing, Prolonged Estrogen Deficiency and Zoledronate on Bone Tissue Mineral Distribution. Journal of the Mechanical Behavior of Biomedical Materials, 29. pp. 161-170.

Briegel, A, Wong, ML, Hodges, HL, Oikonomou, CM, Piasta, KN, Harris, MJ, Fowler, DJ, Thompson, LK, Falke, JJ, Kiessling, LL and Jensen, GJ (2014) New insights into bacterial chemoreceptor array structure and assembly from electron cryotomography. Biochemistry. pp. 1575-1585.

Briggs, Katharine, Barber, Chris, Cases, Montse, Marc, Philippe and Steger-Hartmann, Thomas (2014) Value of shared preclinical safety studies – the eTOX database. Toxicology Reports.

Brigida, I, Sauer, AV, Ferrua, F, Giannelli, S, Scaramuzza, S, Pistoia, V, Castiello, MC, Barendregt, BH, Cicalese, MP, Casiraghi, M, Brombin, C, Puck, J, Muller, K, Notarangelo, LD, Montin, D, Van Montfrans, JM, Roncarolo, MG, Traggiai, E, Van Dongen, JJM, Van Der Burg, M and Aiuti, A (2014) B-cell development and functions and therapeutic options in adenosine deaminase-deficient patients. Journal of Allergy and Clinical Immunology. pp. 799-806.

Bulliard, Yannick, Zhang, Jimin, Jolicoeur, Rose, Brogdon, Jennifer, Dranoff, Glenn and Wilson, Nicholas (2014) OX86 mediates depletion of OX40-expressing intratumoral regulatory T cells through Fc receptor co-engagement, leading to potent anti-tumor efficacy. OX40 engagement depletes intratumoral Tregs via activating FcγRs, leading to antitumor efficacy. pp. 1-6.

Bunzendahl, Sina, Basler, Anne, Kneuer, Rainer and Babu, Suresh (2014) Characterization of Small Immunoconjugates (< 40 kDa) Using Capillary Electrophoresis–Mass Spectrometry. Agilent Application Note .

Bush, CO, Pokrovskii, MV, Saito, R, Morganelli, P, Canales, E, Clarke, MO, Lazerwith, SE, Golde, J, Reid, BG, Babaoglu, K, Pagratis, N, Zhong, W, Delaney, WE, Paulson, MS and Beran, RKF (2014) A small-Molecule inhibitor of hepatitis C virus infectivity. Antimicrobial Agents and Chemotherapy. pp. 386-396.

Bushee, JL, Dunne, CE and Argikar, UA (2014) An in vitro approach to investigate ocular metabolism of a topical, selective beta1-adrenergic blocking agent, betaxolol. Xenobiotica. pp. 1-10.

Bushee, Jennifer, Liang, Guiqing, Dunne, Christine, Harriman, Shawn and Argikar, Upendra (2014) Identification of saturated and unsaturated fatty acids as microsomal degradation by-products by direct high resolution -ESI-MS/MS. Xenobiotica.

Butcher, Joshua, Stanley, Shyla, Brooks, Steven, Chantler, Paul, Wu, Fan and Frisbee, Jefferson (2014) IMPACT OF INCREASED INTRAMUSCULAR PERFUSION HETEROGENEITY ON SKELETAL MUSCLE MICROVASCULAR HEMATOCRIT IN THE METABOLIC SYNDROME. Microcirculation, 21 (8). pp. 677-687.

C

Cahill, JF, Darlington, TK, Wang, X, Mayer, J, Spencer, MT, Holecek, JC, Reed, BE and Prather, KA (2014) Development of a High-Pressure Aerodynamic Lens for Focusing Large Particles (4-10 mu m) into the Aerosol Time-of-Flight Mass Spectrometer. Aerosol Science and Technology. pp. 948-956.

Cai, Xinming, Xu, Yongyao, Kim, You-Me, Loureiro, Joe and Huang, Qian (2014) PIKfyve, a class III lipid kinase, is required for TLR-induced Type i IFN production via modulation of ATF3. Journal of Immunology, 192 (7). pp. 3383-3389. ISSN 1550-6606

Cao, F, Townsend, EC, Karatas, H, Xu, J, Li, L, Lee, S, Liu, L, Chen, Y, Ouillette, P, Zhu, J, Hess, JL, Atadja, P, Lei, M, Qin, ZS, Malek, S, Wang, S and Dou, Y (2014) Targeting MLL1 H3K4 Methyltransferase Activity in Mixed-Lineage Leukemia. MOLECULAR CELL. pp. 247-261.

Cao, James, Ying, Xiaoyou, Beyer, Bruce K. and Delise, Anthony (2014) The use of optical imaging to assess the potential for embryo-fetal exposure to an exogenous material after intravaginal administration. Reproductive Toxicology, 48. pp. 138-147.

Carnemolla, A, Labbadia, JP, Lazell, H, Neueder, A, Moussaoui, S and Bates, GP (2014) Contesting the dogma of an age-related heat shock response impairment: implications for cardiac-specific age-related disorders. Hum Mol Genet . pp. 3641-3656.

Carter, Edward, Miron-Buchacra, G., Goldoni, Silvia, Danahay, Henry, Westwick , John, Watson, M.L., Tosh, David and Ward, Stephen (2014) Phosphoinositide 3-kinase alpha-dependent regulation of branching morphogenesis in murine embryonic lung: evidence for a role in determining morphogenic properties of FGF7. PLOS ONE.

Casas, J, Brzostek, J, Zarnitsyna, V, Hong, JS, Hoerter, J, Ampudia, J, Zamoyska, R, Zhu, C and Gascoigne, N (2014) Ligand engaged TCR is triggered by active Lck not associated with coreceptor. Nature Communications.

Cases, Montse, Briggs, Katharine, Steger-Hartmann, Thomas, Pognan, Francois, Marc, Philippe, Kleinöder, Thomas, Schwab, Christof H., Pastor, Manuel, Wichard, Joerg and Sanz, Ferran (2014) The eTOX data-sharing project to advance in silico drug-induced toxicity prediction. International Journal of Molecular Sciences, 15 (11). pp. 21136-21154.

Cavadini, Simone, Fischer, Eric, Goldie, Kenneth, Bohm, Kerstin, Lingaraju Gondichatnahalli, Manjappa, Jones, Matthew, Bunker, Richard, Faty, Mahamadou, Tichkule, Ritesh, Patelic, Radosav, Mohamed, Weaam, Hassiepen, Ulrich, Beckwith, Rohan, Stahlberg, Henning and Thomae, Nicolas (2014) Specificity, plasticity and regulation of cullin-RING ubiquitin E3 ligases by the COP9 signalosome. Nature.

Ceribelli, M, Kelly, PN, Shaffer, AL, Wright, GW, Xiao, W, Yang, Y, Griner, LAM, Guha, R, Shinn, P, Keller, JM, Liu, D, Patel, PR, Ferrer, M, Joshi, S, Nerle, S, Sandy, P, Normant, E, Thomas, CJ and Staudt, LM (2014) Blockade of oncogenic IB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors. Proceedings of the National Academy of Sciences of the United States of America. pp. 11365-11370.

Chan, JG, Tyne, AS, Pang, A, McLachlan, AJ, Perera, V, Chan, JC, Britton, WJ, Chan, HK, Duke, CC, Young, PM and Traini, D (2014) Murine pharmacokinetics of rifapentine delivered as an inhalable dry powder. International Journal of Antimicrobial Agents.

Chan, Stephen, Woollam, Grahame, Trixie, Wagner, Martin U., Schmidt and Lewis, Richard (2014) Can picolinamide be a promising cocrystal former? CrystEngComm, 16. pp. 4365-4368. ISSN 1466-8033

Chandriani, S, DePianto, DJ, N'Diaye, EN, Abbas, AR, Jackman, J, Bevers, IJ, Ramirez-Carrozzi, V, Pappu, R, Kauder, SE, Toy, K, Ha, C, Modrusan, Z, Wu, LC, Collard, HR, Wolters, PJ, Egen, JG and Arron, JR (2014) Endogenously expressed IL-13Ralpha2 attenuates IL-13- mediated responses but does not activate signaling in human lung fibroblasts. Journal of Immunology. pp. 111-119.

Chapman, Kathryn, Chivers, Simon, Gliddon, Dan, Mitchell, David, Robinson, Sally, Sangster, Tim, Sparrow, Susan, Spooner, Neil and Wilson, Amanda (2014) Overcoming the barriers to the uptake of nonclinical microsampling in regulatory safety studies. Drug Discovery Today, 19 (5). pp. 528-532. ISSN 1878-5832

Chapman, Victoria L, Zollinger, Tulipan, Terranova, Remi, Moggs, Jonathan, Kimber, Ian and Dearman, Rebecca (2014) Chemical allergen induced perturbations of the mouse lymph node DNA methylome. Toxicological Sciences, 139 (2). pp. 350-361. ISSN 1096-0929

Chen, G, Chakravarti, N, Aardalen, K, Lazar, AJ, Tetzlaff, MT, Wubbenhorst, B, Kim, SB, Kopetz, S, Ledoux, AA, Gopal, YN, Pereira, CG, Deng, W, Lee, JS, Nathanson, KL, Aldape, KD, Prieto, VG, Stuart, D and Davies, MA (2014) Molecular Profiling of Patient-Matched Brain and Extracranial Melanoma Metastases Implicates the PI3K Pathway as a Therapeutic Target. Clin Cancer Res . pp. 5537-5546.

Chen, Yen Liang, Abdul Ghafar, Nahdiyah, Karuna, Ratnaningrum, Fu, Yilong, Lim, Siew Pheng, Schul, Wouter, Gu, Feng, Yokokawa, Fumiaki, Wang, Gang, Cerny, Daniela, Fink, Katja, Blasco, Francesca and Shi, Pei-Yong (2014) Activation of PBMC by dengue virus infection depotentiates Balapiravir in dengue patients. Journal of Virology, 88 (3). pp. 1740-1747.

Cheng, Hailing, Liu, Pixu, Zhang, Fan, Xu, Erbo, Symonds, Lynn, Bronson, Roderick, Maira, Sauveur-Michel, Di Tomaso, Emmanuelle, Myers, Andrea, Cantley, Lewis, Mills, Gordon and Zhao, Jean (2014) A genetic mouse model of invasive endometrial cancer driven by concurrent loss of pten and Lkb1 is highly responsive to mTOR inhibition. Cancer Research, 74 (1). pp. 15-23. ISSN 0008-5472

Chew, SK, Lu, D, Campos, LS, Scott, KL, Saci, A, Wang, J, Collinson, A, Raine, K, Hinton, J, Teague, JW, Jones, D, Menzies, A, Butler, AP, Gamble, J, O'Meara, S, McLaren, S, Chin, L, Liu, P and Futreal, PA (2014) Polygenic in vivo validation of cancer mutations using transposons - art. no. 455. Genome Biology. 455-.

Chia, J, Tham, KM, Gill, DJ, Bard-Chapeau, EA and Bard, FA (2014) ERK8 is a negative regulator of O-GalNAc glycosylation and cell migration. eLife.

Cho, Hyunhee, Alderman, Ed, Kreder, Natasha, Garcia Caro, Roxana, Leong, Kristen, Hill, William and Pandey, Pramod (2014) Immunometric AMMP assay for rapid analysis of expression constructs for protein production. Competitive, immunometric assay for fusion protein quantification: Protein production prioritization.

Choi, Paul (2014) Quantitative analysis of resistance to NK attacks reveals stepwise killing kinetics. Integrative biology, 6 (12). pp. 1153-1161. ISSN 1757-9708

Choi, Paul, Mitchison, Timothy, Clark, John and Huang, Lino (2014) Screening chemical libraries for modulators of natural killer mediated cytotoxicity. Quantitative analysis of resistance to natural killer attacks reveals stepwise killing kinetics.

Cobos-Correa, Amanda and Kaufmann, Markus (2014) The Impact of Cyclopropane Configuration on the Biological Activity of Cyclopropyl-Epothilones. ChemMedChem, 9 (10). pp. 2227-2232. ISSN 18607179

Collins, LM, Lazic, SE and Barker, RA (2014) A retrospective analysis of hand tapping as a longitudinal marker of disease progression in Huntington's disease. BMC Neurology, 14. p. 35. ISSN 1471-2377

Costa, C, Ebi, H, Martini, M, Beausoleil, SA, Faber, AC, Jakubik, CT, Huang, A, Wang, Y, Nishtala, M, Hall, B, Rikova, K, Zhao, J, Hirsch, E, Benes, CH and Engelman, JA (2014) Measurement of PIP Levels Reveals an Unexpected Role for p110beta in Early Adaptive Responses to p110alpha-Specific Inhibitors in Luminal Breast Cancer. Cancer Cell.

Costales, Abran, Mathur, Michelle, Ramurthy, Savithri, Lan, Jiong, Subramanian, Sharadha, Jain, Rama, Atallah, Gordana, Setti, Lina, Lindvall, Mika, Appleton, Brent, Ornelas, Elizabeth, Feucht, Paul, Warne, Robert, Doyle, Laura, Basham, Stephen, Aronchik, Ida, Jefferson, A.B. and Shafer, Cynthia (2014) 2-Amino-7-Substitued Benzoxazole Analogs as Potent RSK2 Inhibitors. Bioorganic and Medicinal Chemistry Letters, 24 (6). pp. 1592-1596. ISSN 0960894X

Crouse, J, Bedenikovic, G, Wiesel, M, Ibberson, M, Xenarios, I, VonLaer, D, Kalinke, U, Vivier, E, Jonjic, S and Oxenius, A (2014) Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1. Immunity. pp. 961-973.

Cumberbatch, M, Tang, X, Beran, G, Eckersley, S, Wang, X, Ellston, RPA, Dearden, S, Cosulich, S, Smith, PD, Behrens, C, Kim, ES, Su, X, Fan, S, Gray, N, Blowers, DP, Wistuba, II and Womack, C (2014) Identification of a subset of human non-small cell lung cancer patients with high PI3Kbeta and low PTEN expression, more prevalent in squamous cell carcinoma. Clinical Cancer Research. pp. 595-603.

D

D'Arcy, Allan, Bergfors, Terese, Marsh, May and Jacob, Sandra (2014) Microseed matrix screening for optimization in protein crystallization: what have we learned? Acta Crystallogr F Struct Biol Commun., 70 (Pt 9). pp. 1117-1126. ISSN 2053-230X

DaRosa, PA, Wang, Z, Jiang, X, Pruneda, JN, Cong, F, Klevit, RE and Xu, W (2014) Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal. Nature.

Dales, Natalie, Hubbard, Brian, Winther, Michael, Zhang, Zaihui, Sun, Shaoyi, Leung, Po-Yee and Tran, Jennifer (2014) Systematic evaluation of amide bioisosteres leading to the discovery of novel and potent thiazolylimidazolidinone inhibitors of SCD1 for the treatment of metabolic diseases. Bioorganic and Medicinal Chemistry Letters, 24 (2). pp. 520-525. ISSN 0960-894X

Dales, Natalie, Sun, Shaoyi, Zhang, Zaihui, Hubbard, Brian, Ferreira, Suzie and Winther, Michael (2014) Discovery of thiazolylpyridinone SCD1 inhibitors with preferential liver distribution and reduced mechanism-based adverse effects. Bioorganic and Medicinal Chemistry Letters, 24 (2). pp. 526-531. ISSN 0960-894X

Dales, Natalie, Zhang, Zaihui and Winther, Michael (2014) Opportunities and challenges in developing stearoyl-coenzyme A desaturase-1 inhibitors as novel therapeutics for human disease. Journal of Medicinal Chemistry, 57 (12). pp. 5039-5056. ISSN 1520-4804

Dalvit, Claudio, Invernizzi, Christian and Vulpetti, Anna (2014) Fluorine as hydrogen bond acceptor: Experimental Evidence and Computational Calculations. Chemistry A European Journal.

Darpo, B, Sarapa, N, Garnett, C, Benson, C, Dota, C, Ferber, G, Jarugula, V, Johannesen, L, Keirns, J, Krudys, K, Ortemann-Renon, C, Riley, S, Rogers-Subramaniam, D and Stockbridge, N (2014) The IQ-CSRC Prospective Clinical Phase 1 Study: 'Can Early QT Assessment Using Exposure Response Analysis Replace the Thorough QT Study?'. ANNALS OF NONINVASIVE ELECTROCARDIOLOGY. pp. 70-81.

Das Thakur, M and Stuart, DD (2014) Molecular Pathways: Response and Resistance to BRAF and MEK Inhibitors in BRAF(V600E) Tumors. CLINICAL CANCER RESEARCH. pp. 1074-1080.

Daugvilaite, Viktorija, Arfelt, Kristine, Benned-Jensen, Tau, Sailer, Andreas and Rosenkilde, Mette (2014) Oxysterol-EBI2 signaling in immune regulation and viral infection. European Journal of Immunology, 44. pp. 1904-1912.

Davis, MI, Gross, S, Shen, M, Straley, KS, Pragani, R, Lea, WA, Popovici-Muller, J, DeLaBarre, B, Artin, E, Thorne, N, Auld, DS, Li, Z, Dang, L, Boxer, MB and Simeonov, A (2014) Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1. Journal of Biological Chemistry, 289 (20). pp. 13717-13725. ISSN 0021-92581083-351X

Davis, MI, Simeonov, A, Lea, W and Auld, D (2014) A Kaleidoscope of Colored Beads to Investigate Serine Hydrolases. Assay and Drug Development Technologies. pp. 497-505.

De Buck, Stefan, Jakab, Annamaria, Boehm, Markus, Bootle, Douglas, Quadt, Cornelia, Goggin, Timothy Kieran and Juric, Dejan (2014) Population pharmacokinetics and pharmacodynamics of BYL719, a phosphoinositide 3-kinase antagonist, in adult patients with advanced solid malignancies. British Journal of Clinical Pharmacology.

DePianto, DJ, Chandriani, S, Abbas, AR, Jia, G, N'Diaye, EN, Caplazi, P, Kauder, SE, Biswas, S, Karnik, SK, Ha, C, Modrusan, Z, Matthay, MA, Kukreja, J, Collard, HR, Egen, JG, Wolters, PJ and Arron, JR (2014) Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis. Thorax.

Deng, Y, Shipps, J, Zhao, L, Siddiqui, MA, Popovici-Muller, J, Curran, PJ, Duca, JS, Hruza, AW, Fischmann, TO, Madison, VS, Zhang, R, McNemar, CW, Mayhood, TW, Syto, R, Annis, A, Kirschmeier, P, Lees, EM, Parry, DA and Windsor, WT (2014) Modulating the interaction between CDK2 and cyclin A with a quinoline-based inhibitor. Bioorganic and Medicinal Chemistry Letters. pp. 199-203.

Diagana, Thierry Tidiane, Mcnamara, Case, Roland, Jason, Nagle, Advait, Yeung, Bryan King Sing, Zeeman, Anne-Marie, Winzeler, Elizabeth, Plouffe, David and Kocken, Clemens (2014) KAI407, a potent non 8-aminoquinoline compound that kills Plasmodium cynomolgi dormant liver stage parasites in vitro. Antimicrobial Agents and Chemotherapy.

Diagana, Thierry Tidiane, Yeung, Bryan King Sing, Manjunatha, Ujjini Havaldar, Shi, Pei-Yong, Bodenreider, Christophe and Jones, Catherine (2014) Ten years of drug discovery for the developing world at the Novartis Institute for Tropical Diseases. Nature Reviews Drug Discovery, 14 (6). pp. 442-444. ISSN 1474-1784

Dixon, Darlene, Alison, Roger, Bach, Ute, Colman, Karyn, Foley, George L, Harleman, Johannes, Haworth, Richard, Herbert, Ronald, Heuser, Anke, Long, Greald, Mirsky, Michael, Regan, Karen, van Esch, Eric, Westwood, F Russell , Vidal, Justin and Yoshida, Midori (2014) INHAND: Nonproliferative and Proliferative Lesions of the Rat and Mouse Female Reproductive Tract. Journal of Toxicologic Pathology, 27 (3 & 4 ). 1S-107S. ISSN 0914-9198

Djidja, M, Chang, J, Hadjiprocopis, A, Schmich, F, Sinclair, J, Mrsnik, M, Schoof, EM, Barker, HE, Linding, R, Jorgensen, C and Erler, JT (2014) Identification of hypoxia-regulated proteins using MALDI-mass spectrometry imaging combined with quantitative proteomics. Journal of Proteome Research. pp. 2297-2313.

Doi, Toshihiko, Onozawa, Yusuke, Yoshino, Takayuki, Yamazaki, Kentaro, Junichiro, Watanabe, Akimov, Mikhail, Robson, Matthew, Boku, Narikazu and Ohtsu, Atsushi (2014) Phase I Dose-Escalation Study of the HSP90 Inhibitor AUY922 in Japanese Patients with Advanced Solid Tumors. Cancer Chemotherapy Pharmacology .

Dong, Hongping, Fink, Katja Fink, Roland , Zuest, Lim, Siew Pheng, Cheng-Feng , Qin and Shi, Pei-Yong (2014) Flavivirus RNA methylation. Journal of General Virology, 95 (PART 4). pp. 763-778. ISSN 1465-2099

Dressler, H, Economides, K, Favara, S, Wu, NN, Pang, Z and Polites, HG (2014) The CRE luc Bioluminescence Transgenic Mouse Model for Detecting Ligand Activation of GPCRs. JOURNAL OF BIOMOLECULAR SCREENING. pp. 232-241.

Duan, QL, Lasky-Su, J, Himes, BE, Qiu, W, Litonjua, AA, Damask, A, Lazarus, R, Klanderman, B, Irvin, CG, Peters, SP, Hanrahan, JP, Lima, JJ, Martinez, FD, Mauger, D, Chinchilli, VM, Soto-Quiros, M, Avila, L, Celedon, JC, Lange, C, Weiss, ST and Tantisira, KG (2014) A genome-wide association study of bronchodilator response in asthmatics. Pharmacogenomics Journal. pp. 41-47.

Duca, Jose and Cross, Jason (2014) Quantum Mechanics Approaches to Structurally Informed Design. International Journal of Quantum Chemistry, 114. pp. 305-313. ISSN 1097-461X

Dudal, S, Baltrukonis, D, Crisino, R, Goyal, MJ, Joyce, A, Osterlund, K, Smeraglia, J, Taniguchi, Y and Yang, J (2014) Assay formats: recommendation for best practices and harmonization from the global bioanalysis consortium harmonization team. AAPS Journal. pp. 194-205.

Dumotier, Berengere (2014) A Straightforward Guide to the Basic Science Behind Arrhythmogenesis. Heart , Epub a. ISSN 1355-6037

Dutta, P, O'Connell, KE, Ozkan, SB, Sailer, AW and Dev, KK (2014) The protein interacting with C-kinase (PICK1) interacts with and attenuates parkin-associated endothelial-like (PAEL) receptor-mediated cell death. Journal of Neurochemistry. pp. 360-373.

Dutta, Priyanka, O'Connell, Kara, Ozkan, S. Banu, Sailer, Andreas and Dev, Kumlesh K. (2014) PICK1 interacts with and attenuates PAEL receptor-mediated cell death. Journal of Neurochemistry, 130. pp. 360-373.

da Silva, A, Kronthaler, U, Koppenburg, V, Fink, M, Meyer, I, Papandrikopoulou, A, Hofmann, M, Stangler, T and Visser, J (2014) Target-directed development and preclinical characterization of the proposed biosimilar rituximab GP2013. LEUKEMIA & LYMPHOMA. pp. 1609-1617.

di Paolo, Therese, Gregoire, Laurent, Feuerbach, Dominik, Elbast, Walid, Weiss, Markus and Gomez-Mancilla, Baltazar (2014) AQW051, a novel, and selective nicotinic acetylcholine receptor α7 partial agonist, reduces L-Dopa-induced dyskinesias and extends the duration of L-Dopa effects in parkinsonian monkeys. Parkinsonism Relat Disord.

E

Eder, Joerg, Sedrani, Richard and Wiesmann, Christian (2014) The discovery of first-in-class drugs: origins and evolution. Nature Reviews Drug Discovery, 13 (8). pp. 577-587. ISSN 1474-17761474-1784

Ehara, Takeru, Kosaka, Takatoshi, Kanazawa, Takanori, Grosche, Philipp, Ostermann, Nils, Cumin, Frederic, Schiering, Nikolaus, Rigel, Dean, Webb, Randy, Maibaum, Juergen Klaus, Yokokawa, Fumiaki, Irie, Osamu Irie, Breitenstein, Werner , Suzuki, Masaki , Kawakami, Shimpei , Konishi, Kazuhide , Hitomi, Yuko , Toyao, Atsushi and Gunji, Hiroki (2014) Structure-based Design of 4-Hydroxy-3,5-Substituted Piperidines as a New Class of Highly Efficacious Oral Direct Renin Inhibitors. ACS Medicinal Chemistry Letters, 5 (7). pp. 787-792.

Eibel, H, Kraus, H, Sic, H, Kienzler, A and Rizzi, M (2014) B cell biology: An overview topical collection on basic and applied science. Current Allergy and Asthma Reports.

Einolf, Heidi (2014) Using Calibration Curve-based Approaches of RIS, R3, Cmax/EC50, and AUC/F2, from mRNA and Activity Induction Data in Human Hepatocytes to Predict Clinical Inducers and Non-inducers of CYP3A4. Drug Metabolism and Disposition, 42 (9). pp. 1379-1391. ISSN 1521-009X

Ekuadzi, E., Dickson , R.A., Fleischer, T.C., Amponsah, I.K., Pistorius, Dominik and Oberer, Lukas (2014) Chemical Constituents from Gouania longipetala and Glyphaea brevis. Natural Product Research, 28 (15). pp. 1210-1213.

Ekuadzi, Edmund, Dickson, Rita, Fleischer, Theophilus, Annan, Kofi, Pistorius, Dominik, Oberer, Lukas and Gibbons, Simon (2014) Flavonoid glycosides from the stem bark of Margaritaria discoidea demonstrate antibacterial and free radical scavenging activities. Phytotherapy Research, 28 (5). pp. 784-787.

Elbast, Walid, White, Stephen, Adcock, Neil, Hiller, Jim, Knutsson, Magnus, Lausecker, Berthold, Long, Jeff, McDougall, Stuart, Salavert, Fabrice, Sangster, Timothy, Verhaeghe, Tom and van Amsterdam, Peter (2014) European Bioanalysis Forum ‐ Recommendation on Dealing with Internal Standard Variability. Bioanalysis.

Ellinger-Ziegelbauer, H, Toft, DB, Braeuning, A, Couttet, P, DaCosta, A, Dhalluin, S, Eichner, J, Elcombe, CR, Grenet, O, Henderson, C, Kossler, N, Meehan, RR, Ostenfeld, N, Templin, M, Terranova, R, Thompson, JP, Unterberger, EB, Wrodzek, C, Wolf, CR and Moggs, JG (2014) Early microRNA and other non-coding RNA biomarkers for rodent non-genotoxic carcinogens. Toxicology Letters. S23-S23.

Elliott, Luke D, Knowles , Jonathan P, Maskill, Kate G, Ralph, Michael J, Lejeune, Guillaume, Hook, Ben D A, Edwards, Lee, Robinson, Richard, Clemens, Ian, Cox, Brian, Pascoe, David, Koch, Guido, Eberle, Martin, Berry, Malcolm B and Booker-Milburn, Kevin I (2014) Batch vs. Flow Photochemistry: A Thorough Analysis of Yields and Productivities. Chemistry - a European journal, 20 (46). pp. 15226-15232. ISSN 09476539

Eltom, S, Dale, N, Raemdonck, KR, Stevenson, CS, Snelgrove, RJ, Sacitharan, PK, Recchi, C, Wavre-Shapton, S, McAuley, DF, O'Kane, C, Belvisi, MG and Birrell, MA (2014) Respiratory Infections Cause the Release of Extracellular Vesicles: Implications in Exacerbation of Asthma/COPD. PLoS ONE [Electronic Resource]. e101087, 2014-.

Epple, Robert, Azimioara, Mihai, Alper, Phillip, Cow, Christopher, Mutnick, Daniel, Nikulin, Victor, Lelais, Gerald, Mcneill, Matthew, Michellys, Pierre, Wang, Zhiliang, Li, Jing, Bao, Dingjiu, Zoll, Jocelyn, Kim, Young, Zimmerman, Matthew, Groessl, Todd, Tuntland, Tove, Mcnamara, Peter and Seidel, Martin (2014) Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists. Bioorganic and Medicinal Chemistry Letters, 24 (23). pp. 5478-5483. ISSN 1464-3405

Erdemli, Gul and Priest, Birgit (2014) Phenotypic Screening in the 21st Century. Frontiers in Pharmacology , 5. p. 264. ISSN 1663-9812

Ertl, P (2014) Intuitive ordering of scaffolds and scaffold similarity searching using scaffold keys. Journal of Chemical Information & Modeling. pp. 1617-1622.

Ertl, P (2014) Visualization of chemical space for medicinal chemists. J Cheminform . O4-.

Ertl, Peter (2014) Intuitive Ordering of Scaffolds and Scaffold Similarity Searching Using Scaffold Keys. J. Chem. Inf. Comp. Sci., 54 (6). pp. 1617-1622. ISSN 1549-95961549-960X

Ewart, Lorna, Aylott, Mike, Deurinck, Mark, Ju, Haisong and Suter, Willi (2014) AN ANALYSIS OF THE CONSCIOUS DOG TELEMETRY MODEL AND ITS ABILITY TO DETECT AND PREDICT CARDIOVASCULAR CHANGE IN PHASE I. Toxicological sciences, 142 (2). pp. 427-435. ISSN 1096-0929; 1096-6080

F

Faller, Bernard, Artursson, Per, Avdeef, Alex, Li, Di, Ecker, Gerhard, Houston, Brian, Kansy, Manfred, Kerns, Ed, Kraemer, Stefanie, Lennernaes, Hans, van de Waterbeemd, Han, Sugano, Kiyohiko and Testa, Bernard (2014) Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition. Molecular Pharmacology, 11 (-). pp. 1727-1738. ISSN -

Feng, JY, Cheng, G, Perry, J, Barauskas, O, Xu, Y, Fenaux, M, Eng, S, Tirunagari, N, Peng, B, Yu, M, Tian, Y, Lee, Y, Stepan, G, Lagpacan, LL, Jin, D, Hung, M, Ku, KS, Han, B, Kitrinos, K, Perron, M, Birkus, G, Wong, KA, Zhong, W, Kim, CU, Carey, A, Cho, A and Ray, AS (2014) Inhibition of Hepatitis C Virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug. Antimicrobial Agents and Chemotherapy. pp. 1930-1942.

Fernández-Golbano, Isabel Maria, Giblin, Jonathan, Idrissi, Fatima-Zahra, Grötsch, Helga, del Mar Borrás , Maria and Geli, Maria Isabel (2014) A cross-talk between PI(4,5)P2 and CK2´ modulates actin polymerization during endocytic uptake. Developmental Cell.

Ferreira, Maria Carolina, Whibley, Natasha, Mamo, Anna J, Siebenlist, Ulrich, Chan, Yvonne and Gaffen, Sarah L (2014) The IL-17-induced gene Lipocalin 2 is dispensable for immunity to oral candidiasis. Infection and immunity, 82 (3). pp. 1030-1035. ISSN 1098-5522; 0019-9567

Feuerbach, Dominik, Pezous, Nicole, Weiss, Markus, Shakeri-Nejad, Kasra, Lingenhoehl, Kurt, Hoyer, Daniel, Hurth, Konstanze, Bilbe, Graeme, Pryce, Christopher R, Mcallister, Kevin, Chaperon, Frederique, Kucher, Klaus, Johns, Donald, Blaettler, Thomas and Lopez Lopez, Cristina (2014) AQW051, a novel, potent and selective nicotinic acetylcholine receptor α7 partial agonist: Pharmacological characterisation and Phase I evaluation in healthy subjects. Journal pharmacology and experimental therapeutics.

Finco, Deborah, Grimaldi, Christine, Narayanan, Padman, Walker, M, Kiessling, Andrea, Wolf, Babette, Salcedo, Theodora, Faggioni, R, Schneider, A, Ibrahimov, A, Scesney, S, Serna, D, Prell, R and Stebbings, R (2014) Cytokine release assays: Current practices and future directions. Cytokine, 66 (2). pp. 143-155. ISSN 1043-4666

Fischer, Eric, Boehm, Kerstin, Lydeard, John R., Lingaraju Gondichatnahalli, Manjappa, Cavadini, Simone, Acker, Vincent, Ottl, Johannes, Harper, Wade J., Thomae, Nicolas, Stadler, Michael, Yang, Haidi, Nagel, Jane, Hassiepen, Ulrich, Hild, Marc, Forrester, William, Beckwith, Rohan, Schirle, Markus, Jenkins, Jeremy, Serluca-Aegerter, Fabrizio, Tichkule, Ritesh and Schebesta, Michael (2014) The Structure of DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature, 512 (7512). pp. 49-53. ISSN 0028-08361476-4687

Fluhler, Eric , Vazvaei, Faye , Singhal, Puran, Vinck, Petra , Li, Wenkui, Bhatt, Jignesh , de Boer, Theo, Chaudhary, Ajai , Tangiuchi, Masahiro, Rezende, Vinicius and Zhong, Dafang (2014) Repeat Analysis and Incurred Sample Reanalysis: Recommendation for Best Practices and Harmonization from the Global Bioanalysis Consortium Harmonization Team. AAPS Journal, 16 (6). pp. 1167-1174.

Fredenhagen, Andreas and Kuehnoel, Juergen (2014) Evaluation of the optimization space for atmospheric pressure photoionization (APPI) in comparison to APCI. Journal of mass spectrometry, 49 (8). pp. 727-736.

Frisbee, Jefferson C., Goodwill, Adam G., Frisbee, Stephanie J., Butcher, Joshua T., Wu, Fan and Chantler, Paul D. (2014) Skeletal muscle microvasculopathy in the metabolic syndrome: What is the fundamental problem contributing to increased muscle fatigue. Journal of Physiology.

Fu, B, Kuang, E, Li, W, Avey, D, Li, X, Turpin, Z, Valdes, A, Brulois, K, Myoung, J and Zhu, F (2014) Activation of p90 Ribosomal S6 Kinases (RSKs) by ORF45 of Kaposi Sarcoma-Associated Herpesvirus is Critical for Optimal Production of Infectious Viruses. Journal of Virology .

Fu, D, Zhou, J, Zhu, WS, Manley, PW, Wang, YK, Hood, T, Wylie, A and Xie, XS (2014) Imaging the intracellular distribution of tyrosine kinase inhibitors in living cells with quantitative hyperspectral stimulated Raman scattering. Nature Chemistry . pp. 614-622.

Fu, Dan, Zhou, Jing, Zhu, Wenjing, Manley, Paul W., Wang, Yingqi, Wylie, Andrew, Hood, Tami and Xie, Xiaoliang Sunney (2014) Quantitative Hyperspectral Stimulated Raman Scattering (SRS) Imaging of Intracellular Tyrosine Kinase Inhibitor Drug Distribution in Living cells. Imaging the intracellular distribution of tyrosine kinase inhibitors in living cells with quantitative hyperspectral stimulated Raman scattering.

Full, F, Jungnickl, D, Reuter, N, Bogner, E, Brulois, K, Scholz, B, Stuerzl, M, Myoung, J, Jung, JU, Stamminger, T and Ensser, A (2014) Kaposi's Sarcoma Associated Herpesvirus Tegument Protein ORF75 Is Essential for Viral Lytic Replication and Plays a Critical Role in the Antagonization of ND10Instituted Intrinsic Immunity - art. no. e1003863. PLOS PATHOGENS. pp. 3863-3.

G

Gandhi, H, Worch, R, Kurgonaite, K, Hintersteiner, M, Schwille, P, Bokel, C and Weidemann, T (2014) Dynamics and interaction of interleukin-4 receptor subunits in living cells. Biophysical Journal. pp. 2515-2527.

Garcia, Pablo, Langowski, John, Wang, Yingyun, Chen, Min, Castillo, Joseph, Fanton, Christie, Zavorotinskaya, Tatiana, Dai, Yumin, Lu, Jing, Niu, Xiaohong, Basham, Stephen, Chan, Julie, Yu, Jianjun, Doyle, Michael, Feucht, Paul, Warne, Robert, Narberes, Jamie, Tsang, Tiffany, Drueckes, Peter, Trappe, Joerg, Wilson, Chris, Han, Wooseok, Lan, Jiong, Nishiguchi, Gisele, Lindvall, Mika, Bellamacina, Cornelia, Aycinena, Alex, Zang, Richard, Holash, Jocelyn and Burger, Matthew (2014) Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematological Cancers. Clinical Cancer Research, 20 (7). pp. 1834-1845. ISSN 1078-0432

Garnatz, AS, Gao, Z, Broman, M, Martens, S, Earley, JU and Svensson, EC (2014) FOG-2 mediated recruitment of the NuRD complex regulates cardiomyocyte proliferation during heart development. Developmental Biology. pp. 50-61.

Gaugaz, FZ, Redondo-Horcajo, M, Barasoain, I, Diaz, JF, Cobos-Correa, A, Kaufmann, M and Altmann, K (2014) The impact of cyclopropane configuration on the biological activity of cyclopropyl-epothilones. ChemMedChem. pp. 2227-2232.

Gaumann, AK, Drexler, HC, Lang, SA, Stoeltzing, O, Diermeier-Daucher, S, Buchdunger, E, Wood, J, Bold, G and Breier, G (2014) The inhibition of tyrosine kinase receptor signalling in leiomyosarcoma cells using the small molecule kinase inhibitor PTK787/ZK222584 (Vatalanib). International Journal of Oncology. pp. 2267-2277.

Gee, Christine, Peterlik, Daniel, Neuhäuser, Christoph, Bouhelal, Rochdi, Kaupmann, Klemens, Laue, Grit, Uschold-Schmidt, Nicole, Feuerbach, Dominik, Zimmermann, Kaspar, Ofner, Silvio, Cryan, John F., Van Der Putten, P. Herman, Fendt, Markus, Vranesic, Ivan-Toma, Glatthar, Ralf and Flor, Peter Josef (2014) Inhibition of Amygdala Plasticity, Stress and Anxiety Behavior by Blocking at the Venus Flytrap Domain (VFTD) of the Metabotropic Glutamate Receptor Subtype 7 (mGlu7). Journal of Biological Chemistry, 289 (16). pp. 10975-10987. ISSN ISSN:0021-9258

Genick, Christine, Ottl, Johannes and Scheufler, Clemens (2014) Applications of Biophysics in High Throughput Screening Hit Validation. Journal of Biomolecular Screening, 19 (5). pp. 707-714. ISSN 1087-05711552-454X

Gergely, Peter, Mocsai, Attila and Kovacs, Laszlo (2014) What is the future of targeted therapy in rheumatology: Biologics or small molecules? BMC Medicine, 12 (1). ISSN 17417015

Germano, Davide, Uteng, Marianne, Pognan, Francois, Chibout, Salah-Dine and Wolf, Armin (2014) Determination of Liver Specific Toxicities in Rat Hepatocytes by High Content Imaging during 2-Week Multiple Treatment. Toxicology in Vitro.

Gessier, Francois, Preuss, Inga, Yin, Hong, Rosenkilde, Mette, Laurent, Stephane, Endres, Ralf, Chen, Yu, Marsilje, Thomas, Seuwen, Klaus, Nguyen, Deborah and Sailer, Andreas (2014) Identification and characterization of small molecule modulators of the EBI2 receptor. Journal of Medicinal Chemistry, 57. pp. 3358-3368.

Gimeno-Santos, E, Frei, A, Steurer-Stey, C, de, BJ, Rabinovich, RA, Raste, Y, Hopkinson, NS, Polkey, MI, van, RH, Troosters, T, Kulich, K, Karlsson, N, Puhan, MA and Garcia-Aymerich, J (2014) Determinants and outcomes of physical activity in patients with COPD: a systematic review. Thorax. pp. 731-739.

Girardot, Michael, Hirasawa, Ryutaro, Kacem, Salim, Fritsch, Lauriane, Pontis, Julien, Kota, Satya K., Filipponi, Doria, Fabbrizio, Eric, Sardet, Claude, Lohmann, Felix, Kadam, Shilpa, Ait-Si-Ali, Slimane and Feil, Robert (2014) PRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G + C-rich regions of the mouse genome. Nucleic Acids Research, 42 (1). pp. 235-248. ISSN 0305-1048

Glass, DJ (2014) Focus on questions, not hypotheses. Nature. p. 306.

Glass, DJ (2014) NIH grants: Focus on questions, not hypotheses. Nature. 306-.

Glass, DJ, Campbell, KP and Rudnicki, MA (2014) Skeletal muscle's 3rd year anniversary. Skeletal Muscle. 3, 2014-.

Glowienke, Susanne and Marterer, Wolfgang (2014) Use of a second, statistically based (Q)SAR (Quantitative Structure Activity Relationships)methodology in Genotoxin Risk Assessment (GRA)assessment of DNA reactive (mutagenic) impurities: Challenges and Opportunities. Use of a second, statistically based (Q)SAR (Quantitative Structure Activity Relationships)methodology in Genotoxin Risk Assessment (GRA)assessment of DNA reactive (mutagenic) impurities: Challenges and Opportunities.

Gomez-Mancilla, Baltazar, Von Raison, Florian, Apostol, George, Ufer, Mike, Gasparini, Fabrizio, Berry Kravis, Elizabeth, Hageman, Randi and Jacquemont, Sébastien (2014) Development of mavoglurant and its potential for the treatment of fragile X syndrome. Expert Opinion on Investigational Drugs.

Gonzalez, L, Lukamowicz-Rajska, M, Thomassen, LCJ, Kirschhock, CEA, Leyns, L, Lison, D, Martens, JA, Elhajouji, A and Kirsch-Volders, M (2014) Co-assessment of cell cycle and micronucleus frequencies demonstrates the influence of serum on the in vitro genotoxic response to amorphous monodisperse silica nanoparticles of varying sizes. Nanotoxicology. pp. 876-884.

Gostissa, M, Schwer, B, Chang, A, Dong, J, Meyers, RM, Marecki, GT, Choi, VW, Chiarle, R, Zarrin, AA and Alt, FW (2014) IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances. Proceedings of the National Academy of Sciences of the United States of America. pp. 2644-2649.

Gowrisankar, S and Lebo, MS (2014) Designing algorithms for determining significance of DNA missense changes. Review. Methods in Molecular Biology. pp. 251-262.

Grahammer, F, Haenisch, N, Steinhardt, F, Sander, L, Roerden, M, Arnold, F, Cordts, T, Wanner, N, Reichardt, W, Kerjaschki, D, Ruegg, MA, Hall, MN, Moulin, P, Busch, H, Boerries, M, Walz, G, Artunc, F and Huber, TB (2014) mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress. Proc Natl Acad Sci U S A.

Grant, Joanna, Lesley, Scott, Xu, Qingping, Deller, Marc, Elsliger, Marc, Deacon, Ashley, Wilson, Ian and Nielsen, Tine (2014) Structural insights into the recognition of phosphopeptide by the FHA domain of Kanadaptin. PLoS ONE, 9 (9). ISSN 1932-6203

Grassian, Alexandra, Pagliarini, Raymond and Chiang, Derek (2014) IDH1 and IDH2 mutations in cholangiocarcinoma. Current Opinion in Gastroenterology. pp. 295-302.

Grondine, Melissa, Gunderson, Karl, Reilly, John, Twomey Iii, Joseph, Vandenberg, Jennifer and Wang, Bing (2014) A combined approach of ion chromatography and quantitative NMR to accurately determine counterion stoichiometry. Journal of Liquid Chromatography and Related Technologies, 37 (10). pp. 1453-1464. ISSN 1082-6076

Grunewald, Jan, Jones, David, Brock, Ansgar, Bursulaya, Badry, Patterson, Paula, Ng, Kenneth, Vo, Michael, Uno, Tetsuo, Hunt, James, Spraggon, Glen and Geierstanger, Bernhard (2014) Site-Specific Dual-Labeling of Proteins Using Small Orthogonal Tags at Neutral pH. ChemBiochem.

Gualtieri, Giovanna (2014) Effects of cigarette smoke on Toll-like receptor (TLR) activation of chronic obstructive pulmonary disease (COPD) macrophages. Clinical and Experimental Immunology, 176 (3). pp. 461-472. ISSN 0009-9104; 1365-2249

Guarente, L (2014) Linking DNA Damage, NAD(+)/SIRT1, and Aging. Cell Metabolism. pp. 706-707.

Guerard, Nicolas, Jordaan, Pierre and Dumotier, Berengere (2014) Analysis of unipolar electrograms in rabbit heart demonstrated the key role of ventricular apicobasal dispersion in arrhythmogenicity. jOURNAL OF CARDIOVASCULAR TOXICOLOGY.

Gueret, Stephanie, Meier, Peter and Roth, Hans-Joerg (2014) Cyclic Carbo-Isosteric Depsipeptides and Peptides as a Novel Class of Peptidomimetic. Organic Letters, 16 (5). pp. 1502-1505.

Gulyas, Balazs, Sovago, Judit, Gomez-Mancilla, Baltazar, Jia, Zhisheng , Gulya, Karoly, Szigeti, Csaba, Schumacher, Martin, Maguire, Paul, Gasparini, Fabrizio and Halldin, Christer (2014) Changes in mGluR5 density, and enkephalin and substance P immunoreactivity in Huntington’s disease. Brain Structure and Function.

Guo, LT, Wang, YS, Nakamura, A, Eiler, D, Kavran, JM, Wong, M, Kiessling, LL, Steitz, TA, O'Donoghue, P and Soll, D (2014) Polyspecific pyrrolysyl-tRNA synthetases from directed evolution. Proceedings of the National Academy of Sciences of the United States of America. pp. 16724-16729.

H

Haaparanta-Solin, Merja, Snellman, Annijna, Rokka, Johanna, Lopez-Picon, Francisco, Eskola, Olli, Salmona, Mario, Forloni, GianLiigi, Schienin, Mika and Rinne, Juha (2014) Imaging beta-amyloid deposition in transgenic mouse models of Alzheimer's diseae with 18F flutemetamol PET. EJNMMI Res..

Hale, MA, Swift, GH, Hoang, CQ, Deering, TG, Masui, T, Lee, Y, Xue, J and MacDonald, RJ (2014) The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis. Development (Cambridge). pp. 3123-3133.

Hamann, LG (2014) Synthetic strategy: Natural products on demand. Nature Chemistry. pp. 460-461.

Hao, L, Lindenbach, B, Wang, X, Dye, B, Kushner, D, He, Q, Newton, M and Ahlquist, P (2014) Genome-wide analysis of host factors in nodavirus RNA replication. PLoS ONE.

Harrison, SJ, Hsu, AK, Neeson, P, Younes, A, Sureda, A, Engert, A, Prince, HM, Li, M, Savage, P, Bugarini, R, Williams, D, Squier, M and Ritchie, DS (2014) Early thymus and activation-regulated chemokine (TARC) reduction and response following panobinostat treatment in patients with relapsed/refractory Hodgkin lymphoma following autologous stem cell transplant. LEUKEMIA & LYMPHOMA. pp. 1053-1060.

Hartmann, Nicole, Baeriswyl, Lukas, Staedtler, Frank and Peters, Thomas (2014) Evaluation of quantitative miRNA expression platforms in the microRNA quality control (miRQC) study. Nature Methods, 11 (8). pp. 809-8015. ISSN 1548-7091

Hartmann, Nicole, Luesink, Evert, Khokhlovich, Edward, Szustakowski, Joseph, Baeriswyl, Lukas, Peterson, Joshua, Scherer, Andreas, Nirmala, Nanguneri and Staedtler, Frank (2014) The use of haplotype-specific transcripts improves sample annotation consistency. Biomarker Research, 2 (17).

Hartwieg, Constanze, Priess, Jan, Schuetz, Heiner, Rufle, Dominik, Valente, Claudio, Bury, Christophe, La Vecchia, Luigi and Francotte, Eric (2014) 3,5-Disubstituted Piperidine Derivatives - A Scalable Route to all Four Stereoisomers. Organic Process Research and Development, 18 (9). pp. 1120-1127. ISSN 1083-61601520-586X

Hauenstein, AV, Rogers, WE, Shaul, JD, Huang, D, Ghosh, G and Huxford, T (2014) Probing kinase activation and substrate specificity with an engineered monomeric IKK2. Biochemistry. pp. 2064-2073.

He, Michael, Lee, Patrick and Sweeney, Zachary (2014) Promiscuity and the Conformational Rearrangement of Drug-like Molecules: Insight from the Protein Data Bank. ChemMedChem, 10. ISSN 1860-7187

He, Y, Wu, J, Mei, H, Yu, H, Sun, S, Shou, J and Li, H (2014) Histone deacetylase activity is required for embryonic posterior lateral line development. Cell Proliferation. pp. 91-104.

Healy, Mark, Chan, Louis, Poole, Darren, Shen, Di and Donohoe, Timothy (2014) Rhodium-Catalyzed Ketone Alkylation Using Methanol Under Mild Conditions: Formation of Alpha-Branched Products. Angewandte Chemie (International Ed. in English), 53 (3). pp. 761-765. ISSN 14337851

Hechinger, AK, Smith, BA, Flynn, R, Hanke, K, McDonald-Hyman, C, Taylor, PA, Pfeifer, D, Hackanson, B, Leonhardt, F, Prinz, G, Dierbach, H, Schmitt-Graeff, A, Kovarik, J, Blazar, BR and Zeiser, R (2014) Therapeutic activity of multiple common gamma chain cytokine inhibition in acute and chronic GvHD. Blood.

Helena, Kovacs and Gossert, Alvar (2014) Improved NMR experiments with 13C-isotropic mixing for assignment of aromatic and aliphatic side chains in labelled proteins. J Biomol NMR, 58 (2). pp. 101-112. ISSN 1573-5001

Helming, KC, Wang, X, Wilson, BG, Vazquez, F, Haswell, JR, Manchester, HE, Kim, Y, Kryukov, GV, Ghandi, M, Aguirre, AJ, Jagani, Z, Wang, Z, Garraway, LA, Hahn, WC and Roberts, CWM (2014) ARID1B is a specific vulnerability in ARID1A-mutant cancers. NATURE MEDICINE. pp. 251-254.

Henson, Kristin, Lebrec, H, Molinier, B, Boverhof, D, Collinge, M, Freebern, W, Mytych, D, Ochs, H, Wange, R, Yang, Y, Zhou, L, Arrington, J, Christin-Piche, M and Shenton, J (2014) The TDAR Assay in Nonclinical Studies of Pharmaceuticals and Chemicals: Study Design, Data Analysis, Interpretation. Regulatory Toxicology and Pharmacology, 69. pp. 7-21.

Heudi, Olivier, Lanshoeft, Christian, Leuthold, Luc Alexis, Elbast, Walid, Schueller, Fabienne, Picard, Franck and Kretz, Olivier (2014) Laser Diode Thermal Desorption-positive mode Atmospheric Pressure Chemical Ionization Tandem Mass Spectrometry applied for the ultra-fast quantitative analysis of BKM120 in human plasma: method validation and its application to clinical studies. Analytical and Bioanalytical Chemistry.

Hill, Marilyn (2014) NC3Rs/MHRA working group on Recovery animals Global cross-company data sharing to examine the use of recovery animals in safety assessment to support first-in-human clinical trials? Global cross-company data sharing to examine the use of recovery animals in safety assessment to support first-in-human clinical trials (70). pp. 413-429.

Hillemanns, P, Jentschke, M, Evans, TG, Soergel, P and Hass, R (2014) Detection of E6-AP as a potential therapeutic target in cervical specimen of HPV-infected women. ARCHIVES OF GYNECOLOGY AND OBSTETRICS. pp. 1281-1286.

Hintersteiner, Martin, Kallen, Joerg, Gstach, Hubert and Auer, Manfred (2014) Identification and X-ray co-crystal structure of a small-molecule activator of LFA-1-ICAM-1 binding. to be determined, 53 (17). pp. 4322-4326. ISSN 14337851

Hoegenauer, Klemens, Arista, Luca, Schmiedeberg, Niko, Werner, Gudrun, Jaksche, Herbert, Bouhelal, Rochdi, Nguyen, Deborah G., Bhat, B. Ganesh, Raad, Layla, Rauld, Celine and Carballido, Jose (2014) G-Protein-coupled Bile Acid Receptor 1 (GPBAR1, TGR5) agonists reduce the production of pro-inflammatory cytokines and stabilize the alternative macrophage phenotype. Journal of Medicinal Chemistry, 57 (24). pp. 10343-10354.

Hoepfner, D, Helliwell, SB, Sadlish, H, Schuierer, S, Filipuzzi, I, Brachat, S, Bhullar, B, Plikat, U, Abraham, Y, Altorfer, M, Aust, T, Baeriswyl, L, Cerino, R, Chang, L, Estoppey, D, Eichenberger, J, Frederiksen, M, Hartmann, N, Hohendahl, A, Knapp, B, Krastel, P, Melin, N, Nigsch, F, Oakeley, EJ, Petitjean, V, Petersen, F, Riedl, R, Schmitt, EK, Staedtler, F, Studer, C, Tallarico, JA, Wetzel, S, Fishman, MC, Porter, JA and Movva, NR (2014) High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions. MICROBIOLOGICAL RESEARCH, 169 (2-3). pp. 107-120. ISSN 09445013

Hoepfner, Dominic, Helliwell, Stephen, Sadlish, Heather, Schuierer, Sven, Filipuzzi, Ireos, Brachat, Sophie, Bhullar, Bhupinder, Plikat, Uwe, Abraham, Yann, Altorfer, Marc, Aust, Thomas, Baeriswyl, Lukas, Cerino, Raffaele, Chang, Lena, Estoppey, David, Eichenberger, Juerg, Frederiksen, Mathias, Hartmann, Nicole, Hohendahl, Annika, Knapp, Britta, Krastel, Philipp, Melin, Nicolas, Nigsch, Florian, Oakeley, Edward James, Petitjean, Virginie, Petersen, Frank, Riedl, Ralph, Schmitt, Esther, Staedtler, Frank, Studer, Christian, Tallarico, John, Wetzel, Stefan, Fishman, Mark, Porter, Jeffrey and Movva, Rao (2014) High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions. Microbiological Research, 169 (2-3). pp. 107-120. ISSN 09445013

Hoffmann, Peter (2014) Precliical Safety Biomarkers for Drug-Induced Vascular Injury-Current Status and blueprint for the Future. Toxicologic Pathology, 42 (4). pp. 635-657. ISSN 0192-6233

Hoffmann, Peter (2014) TRANSLATION STRATEGY FOR DRUG-INDUCED VASCULAR INJURY BIOMARKERS. Toxicol Pathol. 2014 Jun;42(4):658-71. doi: 10.1177/0192623314527644. Epub 2014 Apr 24.

Hoffmann, Peter, Mc Lean, Leeanne, Yan, Jing-He, Beckman , David and Barbeau, Stephanie (2014) Absence of permanent effects of aliskiren in juvenile rats. Birth Defects Research (Part B) 101:144–151 (2014).

Hoffmann, Peter, Mc Lean, Leeanne, Yan, Jing-He and Moulin, Pierre (2014) Aliskiren toxicity in juvenile rats is determined by ontogenic regulation of intestinal P-glycoprotein expression. Toxicology and Applied Pharmacology 275 (2014) 36–43.

Hopkins, Neil (2014) The GacS/GacA signal transduction system of Pseudomonas aeruginosa acts exclusively through its control over the transcription of the RsmY and RsmZ regulatory small RNAs. test.

Hu, Ye, Lounkine, Eugen and Bajorath, Juergen (2014) Many Approved Drugs Have Bioactive Analogs With Different Target Annotations. The AAPS Journal, 16 (4). pp. 847-59. ISSN 1550-7416

Huet, Heather, Growney, Joseph, Johnson, Jennifer, Bilic, Sanela, Ostrom, Lance, Zafari, Mohammad, Kowal, Colleen, Yang, Guizhi, Dombrecht, Bruno, Meerschaert, Kris, Cromie, Karen, Mosher, Rebecca, Gao, Hui, Schuller, Alwin, Isaacs, Randi, Sellers, William and Ettenberg, Seth (2014) Multivalent Nanobodies targeting Death Receptor 5 elicit superior tumor cell killing through efficient caspase induction. mAbs.

Huskey, Su-Er, Li, Wenkui, Mangold, James and Flarakos, Jimmy (2014) An industry perspective on tiered approach to the investigation of metabolites in drug development. Bioanalysis, 6 (5). pp. 617-628. ISSN 17576199

I

Ilyina, N, Kharit, S, Namazova-Baranova, L, Asatryan, A, Benashvili, M, Tkhostova, E, Bhusal, C and Arora, AK (2014) Safety and immunogenicity of meningococcal ACWY CRM -conjugate vaccine in children, adolescents, and adults in Russia. Hum Vaccin Immunother .

Iyer, CC, McGovern, VL, Wise, DO, Glass, DJ and Burghes, AHM (2014) Deletion of atrophy enhancing genes fails to ameliorate the phenotype in a mouse model of spinal muscular atrophy. Neuromuscular Disorders. pp. 436-444.

J

Jackson, DJ, Makrinioti, H, Rana, BMJ, Shamji, BWH, Trujillo-Torralbo, MB, Footitt, J, Del-Rosario, J, Telcian, AG, Nikonova, A, Zhu, J, Aniscenko, J, Gogsadze, L, Bakhsoliani, E, Traub, S, Dhariwal, J, Porter, J, Hunt, D, Hunt, T, Hunt, T, Stanciu, LA, Khaitov, M, Bartlett, NW, Edwards, MR, Kon, OM, Mallia, P, Papadopoulos, NG, Akdis, CA, Westwick, J, Edwards, MJ, Cousins, DJ, Walton, RP and Johnston, SL (2014) IL-33-Dependent Type 2 Inflammation during Rhinovirus-induced Asthma Exacerbations In Vivo. American Journal of Respiratory and Critical Care Medicine. pp. 1373-1382.

Jackson, GR, Clark, ME, Scott, IU, Walter, LE, Quillen, DA and Brigell, MG (2014) Twelve-Month Natural History of Dark Adaptation in Patients with AMD. Optometry & Vision Science: .

Jacob, Sandra, Jahnke, Wolfgang and Knapp, Stefan (2014) Novel approaches for targeting kinases. Future Medicinal Chemistry, 6 (5). pp. 541-561. ISSN 1756-89191756-8927

Jacquemont, Sébastien, Berry-Kravis, Elisabeth, Hagerman, Randy, Von Raison, Florian, Gasparini, Fabrizio, Apostol, George, Ufer, Mike, Des Portes, Vincent and Gomez-Mancilla, Baltazar (2014) The challenges of clinical trials in fragile X syndrome. Psychopharmacology, 231 (6). pp. 1237-1250. ISSN 0033-3158

Jaeger, Savina, Min, Junxia, Nigsch, Florian, Camargo, Miguel, Hutz, Janna, Cornett, Allen, Cleaver, Stephen, Buckler, Alan and Jenkins, Jeremy (2014) Causal Network Models for Predicting Compound Targets and Driving Pathways in Cancer. Journal of Biomolecular Screening, 19 (5). pp. 791-802. ISSN 1087-05711552-454X

Jayaraman, A, Jackson, DJ, Message, SD, Pearson, RM, Aniscenko, J, Caramori, G, Mallia, P, Papi, A, Shamji, B, Edwards, M, Westwick, J, Hansel, T, Stanciu, LA, Johnston, SL and Bartlett, NW (2014) IL-15 complexes induce NK- and T-cell responses independent of type I IFN signaling during rhinovirus infection. Mucosal Immunology.

Jen, Dennis, Schreiber, Mark, Muller, Ryan and Prince, John (2014) NIBR Open Source Gallery. NIBR Open Source Gallery. p. 1. ISSN 0000-0000

Jiang, Ji, Li, Lilly, Yin, Hequn, Woessner, Ralph, Emotte, Corinne, Li, Ruobing, Khindri, Sanjeev and Hu, Pei (2014) Single- and multiple-dose pharmacokinetics of inhaled indacaterol in healthy Chinese volunteers. European Journal of Drug Metabolism and Pharmacokinetics, 40 (2). pp. 203-208. ISSN 2107-0180

Jiang, W, Schnabel, C, Spyra, M, Mautner, VF, Friedrich, RE, Hagel, C, Manley, PW and Kluwe, L (2014) Efficacy and selectivity of nilotinib on NF1-associated tumors in vitro. JOURNAL OF NEURO-ONCOLOGY. pp. 231-236.

Jimenez-Sanchez, L, Campa, L, Auberson, YP and Adell, A (2014) The Role of GluN2A and GluN2B Subunits on the Effects of NMDA Receptor Antagonists in Modeling Schizophrenia and Treating Refractory Depression. Neuropsychopharmacology. pp. 2673-2680.

Jiménez-Sánchez, Laura, Campa, Leticia, Auberson, Yves and Adell, Albert (2014) NMDA receptor antagonism: from modeling schizophrenia to treating refractory depression. Neuropsychopharmacology.

John, Markus, Harfst, Eva, Loeffler, Juergen, Belleli, Rossella, Bruin, Gerardus, Seuwen, Klaus, Klickstein, Lloyd, Mindeholm, Linda, Widler, Leo and Kneissel, Michaela (2014) AXT914 a novel, orally-active parathyroid hormone-releasing drug in two early studies of healthy volunteers and postmenopausal women. Bone, 64. pp. 204-210. ISSN 8756-3282

Johns, Neil, Hatakeyama, Shinji, Stephens, NA, Degen, Simone, Degen, Martin, Frieauff, W, Lambert, Christian, Greig, C, McDonald, CA, Ross, JA, Roubenoff, Ronenn, Glass, David, Jacobi, Carsten and Kenneth CH, Fearon (2014) Clinical classification of cancer cachexia: phenotypic correlates in human skeletal muscle. PLOS one.

Julius, U, Milton, Mark, Stoellner, Daniela, Rader, D, Gordon, B, Polk, D, Waldmann, E, Parhofer, KG and Moriarty, PM (2014) Effects of lipoprotein apheresis (LA) on serum PCSK9 levels. Atherosclerosis, 235 (2). e59-e60. ISSN 0021-9150

Junttila, MR, Devasthali, V, Cheng, JH, Castillo, J, Metcalfe, C, Clermont, AC, Den, OD, Chan, E, Bou-Reslan, H, Cao, T, Forrest, W, Nannini, MA, French, DM, Carano, R, Merchant, M, Hoeflich, KP and Singh, M (2014) Modeling targeted inhibition of MEK and PI3 kinase in human pancreatic cancer. Mol Cancer Ther .

Juric, D, Castel, P, Griffith, M, Griffith, OL, Won, HH, Ellis, H, Ebbesen, SH, Ainscough, BJ, Ramu, A, Iyer, G, Shah, RH, Huynh, T, Mino-Kenudson, M, Sgroi, D, Isakoff, S, Thabet, A, Elamine, L, Solit, DB, Lowe, SW, Quadt, C, Peters, M, Derti, A, Schegel, R, Huang, A, Mardis, ER, Berger, MF, Baselga, J and Scaltriti, M (2014) Convergent loss of PTEN leads to clinical resistance to a PI(3)Kalpha inhibitor. Nature.

K

Kariuki-Nyuthe, C, Gomez-Mancilla, B and Stein, DJ (2014) Obsessive compulsive disorder and the glutamatergic system. Current Opinion in Psychiatry. pp. 32-37.

Karuna, Ratnaningrum, Christen, Isabelle, Sailer, Andreas, Bitsch, Francis and Zhang, Juan (2014) Detection of dihydroxycholesterols in human plasma using HPLC-ESI-MS/MS. Steroids.

Kaufman, Kenneth, Linghu, Bolan, Szustakowski, Joseph, Petitjean, Virginie, Altorfer, Marc, Oakeley, Edward James, Husami, Ammar, Yang, Fan, Zhang, Kejian, Filipovich, Alexandra, Ndate, Fall, Harley, John, Nirmala, Nanguneri and Grom, Alexei (2014) Whole-Exome Sequencing Reveals Overlap Between Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis and Familial Hemophagocytic Lymphohistiocytosis. Arthritis and Rheumatology, 66 (12). pp. 3486-3495. ISSN 2326-5205

Kawatkar, SP, Keating, TA, Olivier, NB, Breen, JN, Green, OM, Guler, SY, Hentemann, MF, Loch, JT, McKenzie, AR, Newman, JV, Otterson, LG and Martinez-Botella, G (2014) Antibacterial inhibitors of gram-positive thymidylate kinase: Structure-activity relationships and chiral preference of a new hydrophobic binding region. Journal of Medicinal Chemistry. pp. 4584-4597.

Kazani, Shamsah, Arm, Jonathan, Boyce, Joshua, Chhay, Heng, Dutile, Stefanie, Wechsler, Michael, Govindarajulu, Usha, Ivester, Priscilla, Ainsworth, Hannah, Sergeant, Susan, Chilton, Floyd and Israel, Elliot (2014) LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma. LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma.

Ke, R, Loverdo, C, Qi, H, Olson, CA, Wu, NC, Sun, R and Lloyd-Smith, JO (2014) Modelling clinical data shows active tissue concentration of daclatasvir is 10-fold lower than its plasma concentration. Journal of Antimicrobial Chemotherapy. pp. 724-727.

Keaney, Erin, Connolly, Michael, Dobler, Markus, Karki, Rajeshri, Honda, Ayako, Sokup, Samantha, Karur, Subramanian, Britt, Shawn, Patnaik, Anup, Raman, Prakash, Hamann, Lawrence, Wiedmann, Brigitte and Lamarche, Matthew (2014) 2-Alkyloxazoles as potent and selective PI4KIIIβ inhibitors for the treatment of HCV. Bioorganic and Medicinal Chemistry Letters.

Keenan, CM, Baker, J, Goodman, DG, Harada, T, Bradley, A, Herbert, R, Kaufman, W, Mahler, B, Meseck, Emily, Nolte, T, Rittinghausen, S, Vahle, J, Yoshizawa, K and Kellner, R (2014) International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) Progress to Date and Future Plans. Journal of Toxicologic Pathology. pp. 1533-1601. ISSN 0192-6233 print

Keller, Hansjoerg, Graf-Hausner, Ursula and Heinzelmann, Elsbeth (2014) NTN Biotech – competences across the entire value chain Create human tissues for drug development. lifeSciences plus, 2014 (01). pp. 15-18. ISSN none

Kelley, Marian, Beaver, Christopher, Stevenson, Lauren, Bamford, Ross, Gegwich, Paula, Li, Dongbei, Little, Samantha, Muraganandam, Arumugam, Stoellner, Daniela and Trivedi, Ravi Kumar (2014) CONSENSUS AND RECOMMENDATION OF THE L1 GLOBAL HARMONIZATION TEAM ON RUN ACCEPTANCE FOR LARGE MOLECULE BIOANALYSIS TO SUPPORT PHARMACOKINETICS. AAPS Journal, 16 (2). pp. 221-225.

Khojasteh, SC, Yue, Q, Ma, S, Castanedo, G, Chen, JZ, Lyssikatos, J, Mulder, T, Takahashi, R, Ly, J, Messick, K, Jia, W, Liu, L, Hop, CECA and Wong, H (2014) Investigations into the mechanisms of pyridine ring cleavage in vismodegibs. Drug Metabolism and Disposition. pp. 343-351.

Klawitter, Jost, Bek, Stephan, Zakaria, Marjorie, Zeng, Chenhui, Hornberger, Andrea, Kyler, Corby, Shokati, Tourai, Klawitter, Jelena, Christians, Uwe and Boernsen, K. Olaf (2014) The Fatty Acid Desaturation Index in Human Plasma: Comparison of Different Analytical Methodologies for the Evaluation of Dietary Effects. The Fatty Acid Desaturation Index in Human Plasma: Comparison of Different Analytical Methodologies for the Evaluation of Dietary Effects. ISSN 1618-2650

Klohs, Jan, Rudin, Markus, Shimshek, Derya and Beckmann, Nicolau (2014) Imaging of Cerebrovascular Pathology in Animal Models of Alzheimer`s Disease. Frontiers in Aging Neuroscience.

Kornmann, O, Watz, H, Fuhr, R, Krug, N, Erpenbeck, Veit and Kaiser, Guenther (2014) Omalizumab in patients with allergic (IgE-mediated) asthma and IgE/bodyweight combinations above those in the initially approved dosing table. Pulmonary Pharmacology & Therapeutics.

Korzekwa, K, Tweedie, DJ, Argikar, UA, Whitcher-Johnstone, A, Bell, L, Bickford, S and Nagar, S (2014) A Numerical Method for Analysis of In Vitro Time-dependent Inhibition Data. Part 2. Application to Experimental Data. Drug Metab Dispos .

Korzekwa, Ken, Tweedie, Donald, Argikar, Upendra, Whitcher-Johnstone, Andrea, Bickford, Shari, Bell, Leslie and Nagar, Swati (2014) A numerical method for analysis of in vitro time-dependent inhibition data. Part 2. Application to experimental data. Drug Metabolism and Disposition.

Kramer, Christian, Fuchs, Julian E, Whitebread, Steven, Gedeck, Peter and Liedl, Klaus R (2014) Matched Molecular Pair Analysis: Significance and the Impact of Experimental Uncertainty. Journal of Medicinal Chemistry, 57 (9). pp. 3786-3802. ISSN 0022-2623

Krashes, MJ, Shah, BP, Madara, JC, Olson, DP, Strochlic, DE, Garfield, AS, Vong, L, Pei, H, Watabe-Uchida, M, Uchida, N, Liberles, SD and Lowell, BB (2014) An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger. Nature. pp. 238-242.

Krauser, Joel, Jin, Yi, Walles, Markus, Pfaar, Ulrike, Sutton, James, Wiesmann, Marion, Graf, Daniel, Pflimlin-Fritschy, Veronique, Wolf, Thierry, Camenisch, Gian P. and Swart, Pieter Jacob (2014) Phenotypic and metabolic investigation of a CSF-1R kinase receptor inhibitor (BLZ945) and its pharmacologically active metabolite. Xenbiotica. ISSN 0049-8254 (print), 1366-5928 (electronic)

Kryshtafovych, A, Moult, J, Bales, P, Bazan, JF, Biasini, M, Burgin, A, Chen, C, Cochran, FV, Craig, TK, Das, R, Fass, D, Garcia-Doval, C, Herzberg, O, Lorimer, D, Luecke, H, Ma, X, Nelson, DC, van Raaij, MJ, Rohwer, F, Segall, A, Seguritan, V, Zeth, K and Schwede, T (2014) Challenging the state of the art in protein structure prediction: Highlights of experimental target structures for the 10th critical assessment of techniques for protein structure prediction experiment CASP10. Proteins: Structure, Function and Bioinformatics. pp. 26-42.

Kuchler, Ulrike, Schwarze, Uwe, Dosak, Toni, Heimel, Patrick, Bosshardt, Dieter, Kneissel, Michaela and Gruber, Reinhard (2014) Dental and periodontal phenotype in sclerostin knockout mice. International Journal of Oral Science, 6 (2). pp. 70-76. ISSN 2049-3169

Kunze, A, Huwyler, J, Camenisch, G and Poller, B (2014) Prediction of Organic Anion-Transporting Polypeptide 1B1- and 1B3-Mediated Hepatic Uptake of Statins Based on Transporter Protein Expression and Activity Data. Drug Metabolism & Disposition. pp. 1514-1521.

Kunze, Annett, Camenisch, Gian P., Poller, Birk and Huwyler, Jörg (2014) Prediction of organic anion-transporting polypeptide 1B1- and 1B3- mediated hepatic uptake of statins based on transporter protein expression and activity data. Drug Metabolism and Disposition, 42 (9). pp. 1514-1521. ISSN 1521-009X

Kunze, Annett, Huwyler, Jörg, Poller, Birk, Gutmann, Heike and Camenisch, Gian P. (2014) In Vitro- in Vivo Extrapolation (IVIVE) Method to Predict Human Renal Clearance of Drugs. Journal of Pharmaceutical Sciences.

L

Lakshminarayana, Suresh Bangalore, Boshoff, Helena, Cherian, Joseph, Ravindran, Sindhu, Goh, Anne, Jiricek, Jan, Nanjundappa, Mahesh Bangalore, Nayyar, Amit, Gurumurthy, Meera, Singh, Ramandeep, Dick, Thomas, Blasco, Francesca, Dartois, Veronique, Ho, Paul C and Manjunatha, Ujjini Havaldar (2014) Pharmacokinetics-pharmacodynamics analysis of bicyclic nitroimidazole analogues in a murine model of tuberculosis. PLOS ONE, 9 (8).

Lakshminarayana, Suresh Bangalore, Freymond, Celine, Fischli, Christoph, Yu, Jing, Weber, Sebastian, Goh, Anne, Yeung, Bryan King Sing, Ho, Paul C, Dartois, Veronique, Diagana, Thierry Tidiane, Rottmann, Matthias and Blasco, Francesca (2014) Pharmacokinetics-pharmacodynamics analysis of spiroindolone analogs and KAE609 in a murine malaria model. Antimicrobial Agents and Chemotherapy.

Lakshminarayana, Suresh Bangalore, Tan, Bee Huat, Paul C, Ho, Manjunatha, Ujjini Havaldar, Veronique, Dartois, Thomas , Dick and Rao, Srinivasa P.S. (2014) Physico-chemical, in vitro potency, pharmaco-kinetic and dynamic properties of anti-TB drugs. Journal of Antimicrobial Chemotherapy.

Law, Wai Siang, Genin, Jean-Christophe, Miess, Christian, Treton, Gwenola, Warren, Andrew Paul, Lloyd, Peter, Dudal, Sherri and Krantz, Carsten (2014) Use of a generic LC-MS/MS assay to characterize atypical PK profile of a biotherapeutic monoclonal antibody. Bioanalysis, 6 (23). pp. 3225-3235. ISSN 1757-6180

Lazerwith, SE, Lew, W, Morganelli, P, Liu, Q, Canales, E, Clarke, MO, Doerffler, E, Byun, D, Mertzman, M, Ye, H, Chong, L, Xu, L, Appleby, T, Chen, X, Fenaux, M, Hashash, A, Leavitt, SA, Mabery, E, Matles, M, Mwangi, JW, Tian, Y, Lee, Y, Zhang, J, Zhu, C, Murray, BP and Watkins, WJ (2014) Discovery of GS-9669, a thumb site II non-nucleoside inhibitor of NS5B for the treatment of genotype 1 chronic hepatitis C infection. Journal of Medicinal Chemistry. pp. 1893-1901.

Lazic, SE, Fuss, J and Gass, P (2014) Quantifying the behavioural relevance of hippocampal neurogenesis. PLoS One. e113855-.

Lazic, Stanley, Fuss, J and Gass, P (2014) Quantifying the behavioural relevance of hippocampal neurogenesis. PLoS ONE, 9 (11). ISSN 1932-6203

Legerlotz, Kirsten, Dorn, Jonas, Richter, Jens, Rausch, Martin and Leupin, Olivier (2014) Age-dependent regulation of tendon crimp structure, cell length and gap width with strain. Acta Biomaterialia, 10 (10). pp. 4447-4455. ISSN 1878-7568

Legros, C, Devavry, S, Caignard, S, Tessier, C, Delagrange, P, Ouvry, C, Boutin, JA and Nosjean, O (2014) Melatonin MT1 and MT2 receptors display different molecular pharmacologies only in the G-protein coupled state. British Journal of Pharmacology. pp. 186-201.

Lehmann, Hansjoerg, La Vecchia, Luigi and Brocklehurst, Cara (2014) Enabling Technologies in Pharmaceutical Industry Scale-up of Hazardous Reactions in Continuous Flow. Chimica Oggi - Chemistry Today.

Lemaitre, RN, Johnson, CO, Hesselson, S, Sotoodhenia, N, McKnight, B, Sitlani, CM, Rea, TD, King, IB, Kwok, PY, Mak, A, Li, G, Brody, J, Larson, E, Mozaffarian, D, Psaty, BM, Huertas-Vazquez, A, Tardif, JC, Albert, CM, Lyytikainen, LP, Arking, DE, Kaab, S, Huikuri, HV, Krijthe, BP, Eijgelsheim, M, Wang, YA, Reinier, K, Lehtimaki, T, Pulit, SL, Brugada, R, Muller-Nurasyid, M, Newton-Cheh, CH, Karhunen, PJ, Stricker, BH, Goyette, P, Rotter, JI, Chugh, SS, Chakravarti, A, Jouven, X and Siscovick, DS (2014) Common variation in fatty acid metabolic genes and risk of incident sudden cardiac arrest. Heart Rhythm. pp. 471-477.

Leong, Franz Joel Wen, Lefevre, Gilbert and Magnusson, Baldur (2014) Protocol No. CKAE609X2201 A proof-of-concept open label, 3-day repeated dose study to assess efficacy, safety, tolerability and pharmacokinetics of KAE609 in adult patients with acute, uncomplicated Plasmodium falciparum or vivax malaria mono-infection. New England Journal of Medicine.

Leong, Franz Joel Wen, Li, Ruobing, Jain, Jay Prakash, Lefevre, Gilbert, Magnusson, Baldur, Diagana, Thierry Tidiane and Pertel, Peter (2014) A first-in-human randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study of novel spiroindolone KAE609, to assess the safety, tolerability and pharmacokinetics in healthy adult volunteers. Antimicrobial agents and chemotherapy, 58 (10). pp. 6209-6214. ISSN 1098-6596

Leong, Franz Joel Wen, Zhao, Rong, Zeng, Shuqi, Magnusson, Baldur, Diagana, Thierry Tidiane and Pertel, Peter (2014) A first-in-human randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study of novel imidazolopiperazine KAF156, to assess safety, tolerability and pharmacokinetics in healthy adult volunteers. Antimicrobial agents and chemotherapy, 58 (11). pp. 6437-6443. ISSN 1098-6596

Leong, Franz Joel Wen, Zhao, Rong, Zeng, Shuqi, Magnusson, Baldur, Diagana, Thierry Tidiane and Pertel, Peter (2014) A first-in-human randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study of novel imidazolopiperazine KAF156, to assess safety, tolerability and pharmacokinetics in healthy adult volunteers. Antimicrobial agents and chemotherapy, 58 (11). pp. 6437-6443. ISSN 1098-6596

Letz, Saskia, Haag, Christine, Schulze, Egbert, Frank-Raue, Karin, Raue, Friedhelm, Hofner, Benjamin, Mayr, Bernhard and Schöfl, Christof (2014) Amino alcohol- (NPS-2143) and quinazolinone-derived calcilytics (ATF936 and AXT914) differentially mitigate excessive signalling of calcium-sensing receptor mutants causing bartter syndrome type 5 and autosomal dominant hypocalcemia. Amino alcohol- (NPS-2143) and quinazolinone-derived calcilytics (ATF936 and AXT914) differentially mitigate excessive signalling of calcium-sensing receptor mutants causing bartter syndrome type 5 and autosomal dominant hypocalcemia, 9 (12). e115178/1-e115178/11. ISSN 1932-6203

Letzkus, Martin, Luesink, Evert, Starck-Schwertz, Sandrine, Bigaud, Marc, Mirza, Fareed, Hartmann, Nicole, Gerstmayer, Bernhard, Janssen, Uwe, Scherer, Andreas, Schumacher, Martin, Verles, Aurelie, Vitaliti Garami, Alessandra, Nirmala, Nanguneri, Johnson, Keith J and Staedtler, Frank (2014) Gene expression profiling of immunomagnetically separated cells directly from stabilized whole blood for multicenter clinical trials. Journal of Clinical and Translational Medicine, 3. p. 36. ISSN 2001-1326

Lewis, Ian, Schaefer, Michael, Wagner, Beatrix, Oberer, Lukas, Sager, Emine, Wipfli, Peter and Vorherr, Thomas (2014) A Detailed Investigation on Conformation, Permeability and PK Properties of Two Related Cyclohexapeptides. International Journal of Peptide Research and Therapeutics. ISSN 1573-3904

Lewis, Ian, Schmid, Herbert, Kneuer, Rainer, Hoyer, Daniel, Silva, Antonio, Weckbecker, Gisbert, Bruns, Christian and Pless, Janos (2014) SOM230: a new therapeutic modality for Cushing's disease. Chimia, 68 (7-8). pp. 483-484. ISSN 0009-4293

Lewis, Richard and Wood, Dave (2014) Modern 2D QSAR for Drug Discovery. computational molecular science, 4. pp. 505-522.

Li, E and Zhang, Y (2014) DNA methylation in mammals. Cold Spring Harbor perspectives in biology.

Li, J, Zhu, S, Kozono, D, Ng, K, Futalan, D, Shen, Y, Akers, JC, Steed, T, Kushwaha, D, Schlabach, M, Carter, BS, Kwon, C, Furnari, F, Cavenee, W, Elledge, S and Chen, CC (2014) Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma. Oncotarget. pp. 882-893.

Li, Jie, Zhu, Shan, Kozono, David, Ng, Kimberly, Futalan, Diahnn, Shen, Ying, Akers, Johnny C, Steed, Tyler, Kushwaha, Deepa, Schlabach, Michael, Carter, Bob S, Kwon, Chang-Hyuk, Furnari, Frank, Cavenee, Webster, Elledge, Stephen and Chen, Clark C (2014) Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma. Oncotarget, 5 (4). pp. 882-93. ISSN 1949-2553

Li, Jie, Zhu, Shan, Kozono, David, Ng, Kimberly, Futalan, Diahnn, Shen, Ying, Akers, Johnny C, Steed, Tyler, Kushwaha, Deepa, Schlabach, Michael, Carter, Bob S, Kwon, Chang-Hyuk, Furnari, Frank, Cavenee, Webster, Elledge, Stephen and Chen, Clark C (2014) Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma. Oncotarget, 5 (4). pp. 882-893. ISSN 1949-2553

Li, Nanxin, Lee, Christian, Michellys, Pierre, Kim, Sungjoon, Pferdekamper, Annemarie, Li, Jie, Kasibhatla, Shailaja, Sun, Xiuying, Hua, Su, Mcnamara, Peter, Harris, Jennifer, Friboulet, Luc, Katayama, Ryohei, Gainor, Justin, Crystal, Adam, Awad, Mark, Yanagitani, Noriko, Mahmood, Sidra, Lockerman, Elizabeth, Fujita, Naoya, Nishio, Makoto, Shaw, Alice, Engelman, Jeffery and Sun, Frank (2014) The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer. Cancer Discovery, 4 (6). pp. 662-673. ISSN 2159-8290

Li, Wenkui, Doherty, John, Moench, Paul, Flarakos, Jimmy and Tse, Francis (2014) LC-MS/MS bioanalysis of loratadine (Claritin) in dried blood spot (DBS) samples collected by subjects in a clinical research study. Journal of Chromatography B.

Li, Wenkui, Luo, Suyi, Rebello, Sam, Flarakos, Jimmy and Tse, Francis (2014) A semi-automated high performance liquid chromatography-tandem mass spectrometric method for determination of LCI699, an 11-hyroxylase inhibitor, in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci, 960. pp. 182-193.

Li, Y and Zhang, T (2014) Targeting cancer stem cells by curcumin and clinical applications. CANCER LETTERS. pp. 197-205.

Li, Zhizhong, Glass, David, Clay, Ieuan, Ramanujan, Krishnan, Zhang, Yunyu, Brachat, Sophie and Gong, Chenguang (2014) A Long Non-coding RNA, LncMyoD, Regulates Skeletal Muscle Differentiation by Blocking IMP2-mediated protein translation. Developmental cell, 34 (2). pp. 181-191. ISSN 1878-1551; 1534-5807

Li, Zhizhong, Glass, David, Gilbert, Jason, Zhang, Yunyu and Eash, John (2014) HMGA2-IGF2BP2 Axis Regulates Muscle Stem Cell Activation and Myogenesis. Dev Cell, 23 (6). pp. 1176-1188.

Lingaraju Gondichatnahalli, Manjappa, Bunker, Richard, Renatus, Martin, Hassiepen, Ulrich, Thomae, Nicolas, Fischer, Eric, Cavadini, Simone and Hess, Daniel (2014) Crystal structure of the human COP9 signalosome holoenzyme. Nature, 512 (7513). pp. 161-165. ISSN 0028-08361476-4687

Liu, Edwin, McDaniel, Kristen, Case, Stephanie, Yu, Liping, Gerhartz, Bernd, Ostermann, Nils, Fankhauser, Gabriela, Hungerford, Valerie, Zou, Chao, Luyten, Marcel, Seidl, Katherine and Michels, Aaron (2014) Exploring T cell reactivity to gliadin in young children with newly-diagnosed Celiac disease. Autoimmune Diseases, 2014. pp. 1-8. ISSN 0076-6879

Liu, Jun, Patel, Manishha, Hsieh, Hsin-I, Ng, Nicholas, Batalov, Sergey, Orth, Anthony, Zhou, Zongxiang and Harris, Jennifer (2014) Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening. BMC Cancer, 14 (944). pp. 1-13. ISSN NA

Liu, Jun, Peters, Eric, Yang, Jiayi, DeRan, Michael, Shen, Che-Hung, Julien, Fitamant, Asara, John, Bardeesy, Nabeel, Zheng, Bin and Wu, Xu (2014) Cellular Metabolism Regulates Hippo–YAP Signaling through AMPK-mediated Phosphorylation and Stabilization of Angiomotin Like-1 Protein. Cell reports, 9 (2). pp. 495-503. ISSN 2211-1247

Liu, Y, Zhou, S, Wan, Y, Wu, A and Palmisano, M (2014) The impact of co-administration of ketoconazole and rifampicin on the pharmacokinetics of apremilast in healthy volunteers. British Journal of Clinical Pharmacology. pp. 1050-1057.

Lombardo, Franco, Berellini, Giuliano, Stringer, Rowan, Obach, Scott and Varma, Manthena (2014) Clearance mechanism assignment and total clearance prediction in human based upon in silico models. Journal of Medicinal Chemistry, 57 (10). pp. 4397-4405. ISSN 1520-4804

London, Anne, Alabi, Buola, Mackay, Kasey, Lihon, Michael and He, Yaqin (2014) Gel filtration chromatography as a method for removing bacterial endotoxin from antibody preparations. Biotechnology Progress.

London, Anne, Patel, Kunal, Quinn, Lisa and Lemmerer, Martin (2014) Application of coupled affinity-sizing chromatography for the detection of proteolyzed HSA-tagged proteins. Protein Expression and Purification.

Longo, Francesco, Russo, Isabella, Shimshek, Derya, Greggio, Elisa and Morari, Michele (2014) Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging. Neurobiology of Disease.

Lorthiois, Edwige, Cumin, Frederic, Ehrhardt, Claus, Kosaka, Takatoshi, Sellner, Holger, Ostermann, Nils, Wagner, Beatrix, Maibaum, Juergen Klaus and Francotte, Eric (2014) Trans-(3S,4S)-Disubstituted Pyrrolidines as Inhibitors of the Human Aspartyl Protease Renin. Part I: Prime Site exploration using an amino linker. Bioorganic and medicinal chemistry letters, 25 (8). pp. 1782-1786. ISSN 0960894X

Luisier, Raphaelle, Unterberger, Elif, Goodman, Jay, Schwarz, Michael, Moggs, Jonathan, Terranova, Remi and van Nimwegen, Erik (2014) Computational modeling identifies key gene regulatory interactions underlying phenobarbital-mediated tumor promotion. Nucleic Acid Research (NAR).

Luu, Van Tong, Goujon, Jean-Yves, Meisterhans, Christian, Frommherz, Matthias and Bauer, Carsten (2014) Synthesis of a high specific activity methyl sulfone tritium isotopologue of fevipiprant (NVP-QAW039). Journal of Radiolabelled Compounds and Radiopharmaceuticals.

M

Mac Sweeney, Aengus, Grosche, Philipp, Combrink, Keith, Erbel, Paulus, Hughes, Nicola, Bernardi, Anna, Ramage, Paul, Jarrousse Coscoy, Nadine, Ellis, David, Melkko, Samu, Sirockin, Finton and Altmann, Eva (2014) Discovery and structure-based optimization of potent adenain inhibitors. Discovery and structure-based optimization of potent adenain inhibitors, 5 (8). pp. 937-941. ISSN 1948-5875

MacArthur, DG, Manolio, TA, Dimmock, DP, Rehm, HL, Shendure, J, Abecasis, GR, Adams, DR, Altman, RB, Antonarakis, SE, Ashley, EA, Barrett, JC, Biesecker, LG, Conrad, DF, Cooper, GM, Cox, NJ, Daly, MJ, Gerstein, MB, Goldstein, DB, Hirschhorn, JN, Leal, SM, Pennacchio, LA, Stamatoyannopoulos, JA, Sunyaev, SR, Valle, D, Voight, BF, Winckler, W and Gunter, C (2014) Guidelines for investigating causality of sequence variants in human disease. Nature. pp. 469-476.

MacKenzie, Amanda, Caltabiano, Gianluigi, Kent, Toby, Jenkins, Laura, Lappin, Jennifer, Hudson, Brian, Nicklin, Stuart, Fawcett, Lindsay, Lane, Rebecca, Charlton, Steven and Milligan, Graeme (2014) The antiallergic mast cell stabilizers lodoxamide and bufrolin as the first high and equipotent agonists of human and rat GPR35. Molecular Pharmacology, 85 (1). pp. 91-104. ISSN 0026895X

Maciejewski, M, Barlow, PN and Tjandra, N (2014) Decoding the components of dynamics in three-domain proteins. Journal of Computational Chemistry, 35 (7). pp. 518-525. ISSN 01928651

Maclennan, Calman Alexander and Micoli, Francesca (2014) Vaccines against invasive Salmonella disease: Current status and future directions. Human Vaccines and Immunotherapeutics, 10 (6). pp. 1478-1493. ISSN 2164-554X

Mah, Robert, Thomas, Jason and Shafer, Cynthia (2014) Drug Discovery Considerations in the Development of Covalent Inhibitors. Bioorganic and Medicinal Chemistry Letters, 24 (1). pp. 33-39. ISSN 0960894X

Mah, Robert, Thomas, Jason and Shafer, Cynthia (2014) Drug Discovery Considerations in the Development of Covalent Inhibitors. Bioorganic and Medicinal Chemistry Letters, 24 (1). pp. 33-39. ISSN 0960894X

Maier, FC, Wehrl, HF, Schmid, AM, Mannheim, JG, Wiehr, S, Lerdkrai, C, Calaminus, C, Stahlschmidt, A, Ye, L, Burnet, M, Stiller, D, Sabri, O, Reischl, G, Staufenbiel, M, Garaschuk, O, Jucker, M and Pichler, BJ (2014) Longitudinal PET-MRI reveals beta-amyloid deposition and rCBF dynamics and connects vascular amyloidosis to quantitative loss of perfusion. Nature Medicine . pp. 1485-1492.

Mair, KM, Wright, AF, Duggan, N, Rowlands, DJ, Hussey, MJ, Roberts, S, Fullerton, J, Nilsen, M, Loughlin, L, Thomas, M and MacLean, MR (2014) Sex-Dependent Influence of Endogenous Estrogen in Pulmonary Hypertension. American Journal of Respiratory and Critical Care Medicine. pp. 456-467.

Maire, CL, Ramkissoon, S, Hayashi, M, Haidar, S, Ramkissoon, L, Ditomaso, E and Ligon, KL (2014) Pten loss in Olig2 expressing neural progenitor cells and oligodendrocytes leads to interneuron dysplasia and leukodystrophy. Stem Cells. pp. 313-326.

Malik, Hasnain, Taylor, Buck, Kerrigan, John, Grob, Jonathan, Houk, Ken, Du Bois, Justin, Hamann, Lawrence and Patterson, Andrew (2014) Non-Directed Allylic C–H Acetoxylation in the Presence of Lewis Basic Heterocycles. Chemical Science.

Manevski, Nenad, Swart, Pieter Jacob, Balavenkatraman, Kamal Kumar, Bertschi, Barbara, Camenisch, Gian P., Kretz, Olivier, Schiller, Hilmar, Walles, Markus, Barbara , Ling, Reto , Wettstein, Dirk J, Schaefer, Peter, Itin, Chess, Joanna, Pognan, Francois, Wolf, Armin and Litherland, Karine (2014) Phase II Metabolism in Human skin: Skin Explants Show Activities of Glucuronidation, Sulfation, N-Acetylation, Catechol Methylation, and Glutathione Conjugation. Biochemical Pharmacology.

Mannick, Joan, Del Giudice, Giuseppe, Valiante, Nick, Lattanzi, Maria, Praestgaard, Jens, Huang, Baisong, Lonetto, Michael, Kovarik, John M., Maecker, Holden, Carson, Simon, Glass, David and Klickstein, Lloyd (2014) Effects of mTOR Inhibition on Immunosenescence in the Elderly. Science Translational Medicine.

Marelli, Udaya K, Frank, Andreas O, Wahl, Bernhard, La Pietra, Valeria, Novellino, Ettore, Marinelli, Luciana, Herdtweck, Eberhardt, Groll, Michael and Kessler, Horst (2014) Receptor-Bound Conformation of Cilengitide Better Represented by Its Solution-State Structure than the Solid-State Structure. Receptor-Bound Conformation of Cilengitide Better Represented by Its Solution-State Structure than the Solid-State Structure, 20 (44). ISSN 09476539

Martin, Eric and Cao, Edward (2014) Euclidean Chemical Spaces from Molecular Fingerprints: Hamming Distance and Hempels Ravens. Journal of Computer-Aided Molecular Design.

Marzinzik, Andreas, Voegtle, Markus, Rondeau, Jean-Michel, Billich, Andreas, Pelle, Xavier, Manetsch, Roman and Monastyrskyi, Andrii (2014) Kinetic target guided synthesis for the identification of macrophage migration inhibitory factor inhibitors (MIF). Thesis.

Masadeh, AS, Atassi, F and Shatnawi, MTM (2014) Total scattering atomic pair distribution function: The use of the total scattering atomic pair distribution function methods in pharmaceutical analysis. Pharmazeutische Industrie. pp. 1283-1291.

Mateus Rodrigues, Diogo Filipe, Kittelmann, Matthias, Eggimann, Fabian, Bachler, Thorsten, Abad, Sandra, Hanlon, Steven, Camattari, Andrea, Glieder, Anton, Wirz, Beat, Winkler, Margit and Luetz, Stephan (2014) Production of recombinant human aldehyde oxidase in E. coli and optimization of its application for preparative synthesis of oxidized drug metabolites. ChemCatChem, 6 (4). pp. 1028-1042.

Mathai, John C., Yu, Weiqun , Kim, Jae Hun , Zhou, Ge , Liao, Yi , Sun, Tung-Tien , Fredberg, Jeffrey J. and Zeidel, Mark L. (2014) Hypercompliant Apical Membranes of Bladder Umbrella Cells. Biophysical Journal, 107 (6). pp. 1273-1279. ISSN 00063495

Mayer, Nikola, Beuvink, Iwan and Traggiai, Elisabetta (2014) EVALUATING SINGLE CELL PCR TO DISSECT THE HUMAN B CELL REPERTOIRE. master thesis.

McBride, Christopher, Levine, Barry, Xia, Yi, Bellamacina, Cornelia, Machajewski, Timothy, Gao, Zhenhai, Renhowe, Paul, Antonios-Mccrea Jr., Bill, Barsanti, Paul, Brinner, Kristin, Costales, Abran, Doughan, Brandon, Lin, Xiaodong, Louie, Alicia, McKenna, Maureen, Mendenhall, Kris, Poon, Daniel, Rico, Alice, Wang, Michael, Williams, Teresa, Abrams, Tinya, Fong, Susan, Hendrickson, Thomas, Lei, Dachuan, Lin, Julie, Menezes, Daniel Lopes De, Pryer, Nancy, Taverna, Pietro, Zhou, Yasheen and Shafer, Cynthia (2014) Design, Structure Activity Relationship and in vivo Characterization of the Clinical Candidate NVP-HSP990. Journal of Medicinal Chemistry, 57 (21). pp. 9124-9129. ISSN 0022-26231520-4804

McInnes, Iain B., Sieper, J, Braun, J, Emery, P, Van der Heijde, D, Isaacs, J, Dahmen, G, Wollenhaupt, J, Schulze-Koops, H, Kogan, J, Ma, Shenglin, Schumacher, Martin, Bertolino, Arthur, Hueber, Wolfgang and Tak, Paul-Peter (2014) Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: A 24-week, randomised, double-blind, placebo-controlled, phase ii proof-of-concept trial. Annals of the Rheumatic Diseases, 73 (2). pp. 349-356. ISSN 0003-4967

Mckenna, Jeff, Talbot, Eric, Richardson, Melodie and Toste, F. Dean (2014) Gold Catalysed Redox Synthesis of Imidazo[1,2a]pyridine using Pyridine N-Oxide and Alkynes. Gold Catalysed Redox Synthesis of Imidazo[1,2a]pyridine using Pyridine N-Oxide and Alkynes, 356. pp. 687-691.

Mckenna, Jeff, Talbot, Eric, Toste, F. Dean and Fernandes, Talita (2014) First Asymmetric Palladium-Catalyzed Fluoro-arylation of Styrenes. Asymmetric Palladium-Catalyzed Directed intermolecular Fluoro-arylation of Styrenes, 136. pp. 4101-4104.

Mckeown, Stephen, Charlton, Steven, Cox, Brian, Fitch, Helen, Howson, Christopher, Leblanc, Catherine, Meyer, Arndt, Rosethorne, Elizabeth and Stanley, Emily (2014) Identification of novel IP receptor agonists using historical ligand biased chemical arrays. Bioorganic & medicinal chemistry letters, 24 (10). pp. 2247-2250. ISSN 1464-3405

Mckeown, Stephen, Zecri, Frederic, Fortier, Eric, Taggart, Andrew, Sviridenko, Lilya, Adams, Christopher, Mcallister, Kathryn and Pin, Sokhom (2014) The design and implementation of a generic lipopeptide scanning platform to enable the identification of 'locally acting' agonists for the apelin receptor. Bioorganic and Medicinal Chemistry Letters, 24 (20). pp. 4871-4875. ISSN 1464-3405

Mcpate, Mark, Bhalay, Gurdip, Beckett, Martin, Gosling, Martin, Groot Kormelink, Paul, Lane, Rebecca, Kent, Toby, Van Diepen, Michiel, Tranter, Pamela and Verkuijl, Martin (2014) The development of automated patch clamp assays for canonical transient receptor potential channels TRPC3, 6, and 7. Assay and Drug Development Technologies, 12 (5). pp. 282-292. ISSN 15578127

Meehan, R, Lempiainen, H, Braeuning, A, Muller, A, Vitobello, A, Ellinger-Ziegelbauer, H, Henderson, C, Schwarz, M, Terranova, R, Moggs, J, Wolf, CR and Thomson, J (2014) Drug induced changes in the mouse liver epigenome. Toxicology Letters. S16-S16.

Meier, Thomas and Keller, Hansjoerg (2014) 3D-DRUCKER Leben aus dem Drucker. ZHAW Impact, 26 (14). pp. 32-36. ISSN keine

Meininger, V, Pradat, PF, Corse, A, Al-Sarraj, S, Rix, BB, Caress, JB, Cudkowicz, M, Kolb, SJ, Lange, D, Leigh, PN, Meyer, T, Milleri, S, Morrison, KE, Orrell, RW, Peters, G, Rothstein, JD, Shefner, J, Lavrov, A, Williams, N, Overend, P, Price, J, Bates, S, Bullman, J, Krull, D, Berges, A, Abila, B, Meno-Tetang, G and Wurthner, J (2014) Safety, pharmacokinetic, and functional effects of the nogo-a monoclonal antibody in amyotrophic lateral sclerosis: a randomized, first-in-human clinical trial. PLoS ONE. e97803-.

Meissner, Axel, van der Plas, Anton A, van Dasselaar, Nick T, Deelder, André M, van Hilten, Jacobus J and Mayboroda, Oleg A (2014) 1H-NMR metabolic profiling of cerebrospinal fluid in patients with complex regional pain syndrome-related dystonia. Pain, 155 (1). pp. 190-196. ISSN 1872-6623

Menezes, DL, Holt, J, Tang, Y, Feng, J, Barsanti, P, Pan, Y, Ghoddusi, M, Zhang, W, Thomas, G, Holash, J, Lees, E and Taricani, L (2014) A Synthetic Lethal Screen Reveals Enhanced Sensitivity to ATR Inhibitor Treatment in Mantle Cell Lymphoma with ATM Loss-of-function. Molecular Cancer Research .

Mercier, Alexandre, Arias, Carolina, Madrid, Alexis, Holdorf, Meghan and Ganem, Donald (2014) Site-Specific Association with Host and Viral Chromatin by KSHV LANA and its Reversal during Lytic Reactivation. Site-specific association with host and viral chromatin by KSHV LANA and its reversal during lytic reactivation.

Mesrouze, Yannick, Hau, Jean-Christophe, Erdmann, Dirk, Zimmermann, Catherine, Fontana, Patrizia, Schmelzle, Tobias and Chene, Patrick (2014) The surprising features of the TEAD4-Vgll1 protein-protein interaction. ChemBioChem, 15 (4). pp. 537-542. ISSN 1439-4227

Metcalfe, H, Lea, A, Hughes, S, Smith, F, Khalaf, H, Abbot Banner, K and Singh, D (2014) Effects of cigarette smoke on Toll-like receptor (TLR) activation of chronic obstructive pulmonary disease (COPD) macrophages. Clinical and Experimental Immunology, 176 (3). pp. 461-472. ISSN 1365-2249

Michaut, Lydia, Laurent, Nathalie, Kentsch, Kerstin, Spindeldreher, Sebastian and Deckert-Salva, Fabienne (2014) STABILITY OF ANTI-IMMUNOTHERAPEUTIC ANTIBODIES IN FROZEN HUMAN SERUM SAMPLES. Bioanalysis, 6 (10). 1395-1407 . ISSN 1757-6180

Michaut, Lydia, Laurent, Nathalie, Kentsch, Kerstin, Spindeldreher, Sebastian and Deckert-Salva, Fabienne (2014) STABILITY TESTING OF ANTI-VACCINE ANTIBODIES IN HUMAN SERUM. Bioanalysis, 6 (10). pp. 1395-1407. ISSN 1757-6180

Miklayc, Pika, Ehinger, Konstantin, Thompson, Kristin, Hobi, Nina, Shimshek, Derya and Frick, Manfred (2014) Surfactant Secretion in LRRK2 Knock-Out Rats: Changes in Lamellar Body Morphology and Rate of Exocytosis. PLoS one.

Milicevic Sephton, Selena, Müller, Adrienne, Mu, Lijing, Keller, Claudia, Rüdisühli, Sonja, Auberson, Yves, Schibli, Roger, Krämer, Stefanie and Ametamey, Simon (2014) Preclinical Evaluation and Test–Retest Studies of 18F-PSS232, a Novel Radioligand for Targeting Metabotropic Glutamate Receptor 5 (mGlu5). Neuroimage.

Minuesa, Gerard, Antczak, Christophe, Shum, David, Radu, Constantin, Bhinder, Bhavneet, Li, Yueming, Djaballah, Hakim and Kharas, Michael (2014) A 1536-well Fluorescence Polarization Assay to Screen for Modulators of the MUSASHI Family of RNA-Binding Proteins. Combinatorial Chemistry & High Throughput Screening, 17 (7). pp. 596-609. ISSN 1875-5402

Mir, Anis Khusro, Elain, Gaelle, Jeanneau, Karine, Dev, Kumlesh and Rutkowska, Aleksandra (2014) The selective anti-IL17A monoclonal antibody secukinumab (AIN457) attenuates IL17A-induced levels of IL6 in human astrocytes. http://onlinelibrary.wiley.com/doi/10.1002/glia.22637/abstract, 62 (5). pp. 725-735. ISSN 0894-1491

Monsma, DJ, Cherba, DM, Richardson, PJ, Vance, S, Rangarajan, S, Dylewski, D, Scott, SB, Beuschel, NL, Axtell, R, Mitchell, D, Lester, E, Junewick, JJ, Webb, CP and Monks, NR (2014) Precision Medicine in Rhabdomyosarcoma: Using Patient Derived Xenografts as models of drug efficacy and acquired resistance. Pediatric blood & cancer, 61 (9). pp. 1570-1577. ISSN 15455009

Montagner, A, Delgado, MB, Tallichet-Blanc, C, Chan, JSK, Sng, MK, Mottaz, H, Degueurce, G, Lippi, Y, Moret, C, Baruchet, M, Antsiferova, M, Werner, S, Hohl, D, Al, ST, Farmer, PJ, Tan, NS, Michalik, L and Wahli, W (2014) Src is activated by the nuclear receptor peroxisome proliferator-activated receptor beta/ in ultraviolet radiation-induced skin cancer. EMBO Molecular Medicine. pp. 80-98.

Montagner, Alexandra, Delgado, Maria, Tallichet, Corrine, Chan, Jeremy, Sng, Ming, Mottaz, Helene, Degeurce, Gwendoline, Moret, Catherine, Baruchet, Michael, Farmer, Pierre, Nguan, Tan, Michalik, Liliane and Wahli, Walter (2014) Src is activated by the nuclear receptor peroxisome proliferator-activated receptor b/d in ultraviolet radiation-induced skin cancer. EMBO molecular medicine, 6 (1). pp. 80-98. ISSN 17574676

Montarolo, F, Raffaele, C, Perga, S, Martire, S, Finardi, A, Furlan, R, Hintermann, S and Bertolotto, A (2014) Effects of Isoxazolo-Pyridinone 7e, a Potent Activator of the Nurr1 Signaling Pathway, on Experimental Autoimmune Encephalomyelitis in Mice. PLoS ONE. e108791-.

Montarolo, Francesca, Raffaele, Chiara, Perga, Simona, Martire, Serena, Finardi, Annamaria, Furlan, Roberto, Hintermann, Samuel and Bertolotto, Antonio (2014) Effects of Isoxazolo-Pyridinone 7e, a Potent Activator of the Nurr1 Signaling Pathway, on Experimental Autoimmune Encephalomyelitis in Mice. PLOS One.

Mora-Blanco, E. Lorena, Mishina, Yuji, Tillman, Erik, Cho, Yoon-Jae, Thom, Christopher, Pomeroy, Scott, Shao, Wenlin and Roberts, Charles (2014) Activation of β-catenin/TCF targets following loss of the tumor suppressor SNF5. Oncogene, 33 (7). pp. 933-938. ISSN 0950-9232

Morse, Alyson, McDonald , Michelle M., Kelly, N. H., Melville, K. M., Schindeler, Aaron, Kramer, Ina, Kneissel, Michaela, van der Meulen, MCH and Little, David G. (2014) Mechanical load increases in bone formation via a Sclerostin-independent pathway. Journal of Bone and Mineral Research.

N

Namoto, Kenji, Sirockin, Finton, Ostermann, Nils, Gessier, Francois, Flohr, Stefanie, Sedrani, Richard, Gerhartz, Bernd, Trappe, Joerg, Hassiepen, Ulrich, Duttaroy, Alokesh, Ferreira, Suzie, Sutton, Jon M., Clark, David E., Fenton, Gary, Beswick, Mandy and Baeschlin, Daniel (2014) Discovery of C-(1-aryl-cyclohexyl)-methylamines as selective, orally available inhibitors of dipeptidyl peptidase IV. Bioorganic & Medicinal Chemistry Letters, 24 (3). pp. 731-736.

Naninck, Eva F. G., Hoeijmakers, Lianne, Kakava-Georgiadou, Nefeli, Meesters, Astrid, Lazic, Stanley, Lucassen, Paul J. and Korosi, Aniko (2014) Chronic early-life stress alters developmental and adult neurogenesis and impairs cognitive function in mice. Hippocampus, 25 (3). pp. 309-328. ISSN 10509631

Neuber, T, Frese, K, Jaehrling, J, Jager, S, Daubert, D, Felderer, K, Linnemann, M, Hohne, A, Kaden, S, Kolln, J, Tiller, T, Brocks, B, Ostendorp, R and Pabst, S (2014) Characterization and screening of IgG binding to the neonatal Fc receptor. mAbs. pp. 928-942.

Neuder, Andreas, Achilli, Francesca, Moussaoui, Saliha and Bates, Gillian P (2014) Identification of two novel heat shock factor isoforms - HSF1 isoform ratio regulates the level of transcription of heat shock protein genes.*. TBD, 289 (29). ISSN 0021-92581083-351X

Ng, Jia Tsing, Dekker, Carien, Kroemer, Markus, Osborne, Michael and von Delft, Frank (2014) Using Textons to Rank Crystallization Droplets by Likely Presence of Crystals. Acta Crystallographica Section D, D70 (10). pp. 2702-2718. ISSN 1399-0047

Ngaemthao, W, Suriyachadkun, C, Chunhametha, S, Niemhom, N, Thawai, C and Sanglier, J (2014) Planobispora takensis sp. nov., isolated from soil. International Journal of Systematic and Evolutionary Microbiology. pp. 1180-1185.

Nguyen, TH, Mentre, F, Levi, M, Yu, J and Guedj, J (2014) A pharmacokinetic - viral kinetic model describes the effect of alisporivir monotherapy or in combination with peg-IFN on hepatitis C virologic response. Clinical Pharmacology and Therapeutics.

Nirmala, Nanguneri, Grom, Alexei and Gram, Hermann (2014) Biomarkers in systemic juvenile idiopathic arthritis: A comparison with biomarkers in cryopyrin-associated periodic syndromes. Current Opinion in Rheumatology, 26 (5). pp. 543-552. ISSN 1531-6963

Nithya, Paranthaman, Vilmos, Kertez, Moench, Paul, Catoire, Alexandre, Flarakos, Jimmy and Gary, VanBerkel (2014) Liquid Microjunction Surface Sampling-HPLC-MS/MS Profiling of Acetaminophen, Terfenadine and Their Metabolites in Whole-Body Rat Thin Tissue Sections. Bioanalysis, 6 (19). pp. 2599-2606. ISSN 1757-6180

Noble, Christian Guy, Li, Shi Hua, Dong, Hongping, Chew, Kelly and Shi, Pei-Yong (2014) Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine. Antiviral Research, 111. pp. 78-81. ISSN 01663542

Noe, A, Howard, C, Thuren, T, Taylor, A and Skerjanec, A (2014) Pharmacokinetic and Pharmacodynamic Characteristics of Single-Dose Canakinumab in Patients With Type 2 Diabetes Mellitus. Clinical Therapeutics.

niemi, natalie, sacoman, juliana, westrate, laura, lanning, nathan, Gaither, Larry and mackeigan, jeffery (2014) The pseudophosphatase MK-STYX physically and genetically interacts with the mitochondrial phosphatase PTPMT1. PLoS ONE, 9 (4). ISSN 1932-6203

O

Ofner, Silvio, Vranesic, Ivan-Toma, Bilbe, Graeme, Bouhelal, Rochdi, Ertl, Peter, hart, terry, rasetti, vittorio, Mcallister, Kevin, Kuhn, Rainer R and Gasparini, Fabrizio (2014) AFQ056/mavoglurant, a novel clinically effective mGluR5 antagonist: Identification, SAR and pharmacological characterization. Bioorganic and Medicinal Chemistry, 22 (21). pp. 5790-5803. ISSN 1464-3391

Okujava, R, Guye, P, Lu, Y, Mistl, C, Polus, F, Vayssier-Taussat, M, Halin, C, Rolink, AG and Dehio, C (2014) A Translocated Effector Required for Bartonella Dissemination from Derma to Blood Safeguards Migratory Host Cells from Damage by Co-translocated Effectors. PLoS Pathogens.

Overby, Darryl R. , Zhou, Enhua, Vargas-Pinto, Rocio, Pedrigi, Ryan M. , Fuchshofer, Rudolf , Braakman, Sietse T. , Gupta, Ritika , Perkumas, Kristin M. , Sherwood, Joseph M. , Vahabikashi, Amir , Dang, Quynh , Kim, Jae Hun , Ethier, C. Ross , Stamer, W. Daniel , Fredberg, Jeffrey J. and Johnson, Mark (2014) Schlemm’s canal, pore formation, and outflow dysfunction in glaucoma. PNAS, 111 (38). ISSN 0027-84241091-6490

P

Paisley, Derek, Bevan, Luke, Choy, Kate and Gross, Carina (2014) The Pneumonectomy Model of Compensatory Lung Growth: insights into lung regeneration. Pharmacology and Therapeutics.

Papadimitropoulos, Adam, Piccinini, Elia, Brachat, Sophie, Braccini, Alessandra , Wendt, David, Barbero, Andrea, Jacobi, Carsten and Martin, Ivan (2014) Human mesenchymal stromal cell expansion in a 3D scaffold-based system under direct perfusion. Human mesenchymal stromal cell expansion in a 3D scaffold-based system under direct perfusion.

Parameswaran, Reshmi, Lim, Min, Groffen, John, Gram, Hermann, Mclaughlin, Margaret and Heisterkamp, Nora (2014) Effector-mediated eradication of precursor B acute lymphoblastic leukemia with a novel Fc-engineered monoclonal antibody targeting the BAFF-R. Molecular Cancer Therapeutics, 13 (6). pp. 1567-1577. ISSN 1538-8514

Parameswaran, Reshmi, Lim, Min, Groffen, John, Gram, Hermann, Mclaughlin, Margaret, Heisterkamp, Nora, Fei, Fei, Abdel-Azim, Hisham, Arutyunyan, Anna, Schiffer, Isabelle and Huet, Heather (2014) Effector-mediated eradication of precursor B acute lymphoblastic leukemia with a novel Fc-engineered monoclonal antibody targeting the BAFF-R. Molecular Cancer Therapeutics, 13 (6). pp. 1567-1577. ISSN 1538-8514

Paranthaman, Nithya, Kertesz, Vilmos, Moench, Paul, Catoire, Alexandre, Flarakos, Jimmy and Van Berkel, Gary J. (2014) Liquid microjunction surface sampling of acetaminophen, terfenadine and their metabolites in thin tissue sections. Bioanalysis, 6 (19). pp. 2599-2606. ISSN 1757-6180

Park, HJ, Guariento, M, Maciejewski, M, Hauhart, R, Tham, W, Cowman, AF, Schmidt, CQ, Mertens, HDT, Kathryn, LM, Hourcade, DE, Barlow, PN and Atkinson, JP (2014) Using mutagenesis and structural biology to map the binding site for the plasmodium falciparum merozoite protein PfRh4 on the human immune adherence receptor. Journal of Biological Chemistry, 289 (1). pp. 450-463. ISSN 0021-92581083-351X

Pasca, SP, Panagiotakos, G and Dolmetsch, RE (2014) Generating human neurons in vitro and using them to understand neuropsychiatric disease. Annual Review of Neuroscience. pp. 479-501.

Pasche, Emilie, Gobeill, Julien, Kreim, Olivier, Oezdemir-Zaech, Fatma, Vachon, Therese, Lovis, Christian and Ruch, Patrick (2014) Development and tuning of an original search engine for patent libraries in medicinal chemistry. BMC bioinformatics, 60 (5). pp. 407-415. ISSN 1468-2044

Pasquale, LR, Jiwani, AZ, Zehavi-Dorin, T, Majd, A, Rhee, DJ, Chen, T, Turalba, A, Shen, L, Brauner, S, Grosskreutz, C, Gardiner, M, Chen, S, Borboli-Gerogiannis, S, Greenstein, SH, Chang, K, Ritch, R, Loomis, S, Kang, JH, Wiggs, JL and Levkovitch-Verbin, H (2014) Solar exposure and residential geographic history in relation to exfoliation syndrome in the United States and Israel. JAMA Ophthalmology. pp. 1439-1445.

Pastukhov, Oleksandr, Schwalm, Stephanie, Zangemeister-Wittke, Uwe, Fabbro, Doriano, Bornancin, Frederic, Japtok, Lukasz, Kleuser, Burkhard, Pfeilschifter, Josef and Huwiler, Andrea (2014) The ceramide kinase inhibitor NVP-231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death. British Journal of Pharmacology, 171 (24). pp. 5829-5844. ISSN 1476-5381

Patapoutian, Ardem, Qiu, Zhaozhu, Bandell, Michael and Mathur, Jayanti (2014) Piezo1, a mechanically activated ion channel, is required for vascular development in mice. Proceedings of the National Academy of Sciences of the United States of America, 111 (28). pp. 10347-10352. ISSN 1091-6490

Patnaik, A, Weiss, GJ, Papadopoulos, KP, Hofmeister, CC, Tibes, R, Tolcher, A, Isaacs, R, Jac, J, Han, M, Payumo, FC, Cotreau, MM and Ramanathan, RK (2014) Phase i ficlatuzumab monotherapy or with erlotinib for refractory advanced solid tumours and multiple myeloma. British Journal of Cancer. pp. 272-280.

Persson, BD, Jaffe, AB, Fearns, R and Danahay, H (2014) Respiratory Syncytial Virus Can Infect Basal Cells and Alter Human Airway Epithelial Differentiation. Plos One.

Peters, Eric, Sipila, Kalle, Haag, Sabrina, Denessiouk, Konstantin, Kapyla, Jarmo, Denesyuk, Alexander, Hansen, Uwe, Konttinen, Yrjo, Johnson, Mark, Holmdahl, Rikard and Heino, Jyrki (2014) Citrullination of collagen II affects integrin-mediated cell adhesion in a receptor-specific manner. FASEB Journal, 28 (8). pp. 3758-3768. ISSN 1530-6860

Peukert, Stefan, Hughes, Richard, Nunez, Jill, He, Guo, Yan , Zhao, Jain, Rishi, Llamas, Luis, Luchansky, Sarah, Carlson, Adam, Liang, Guiqing, Kunjathoor, Vidya, Pietropaolo, Michael, Shapiro, Jeffrey, Castellana, Anja, Wu, Xiaoping and Bose, Avirup (2014) Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists. ACS MedChemLetters.

Pham, HV, Paton, RS, Ross, AG, Danishefsky, SJ and Houk, KN (2014) Intramolecular Diels-Alder Reactions of Cycloalkenones: Stereoselectivity, Lewis Acid Acceleration, and Halogen Substituent Effects. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. pp. 2397-2403.

Phillips, Dean, Gao, Wenqi, Yang, Yang, Zhang, Guobao, Lerario, Isabelle, Lau, Thomas, Jiang, Jiqing, Wang, Xia, Nguyen, Deborah, Bhat, Barkur, Trotter, Carol, Welzel, Gustav, Sullivan, Heather, Landry, Jannine, Chen, Yali, Joseph, Sean, Li, Chun, Gordon, William, Richmond, Wendy, Johnson, Kevin, Bretz, Angela, Bursulaya, Badry, Pan, Shifeng, Mcnamara, Peter and Seidel, Martin (2014) Discovery of trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as potent, orally bioavailable TGR5 (GPBAR1) agonists: Structure-activity relationships, lead optimization, and chronic in vivo efficacy. Journal of Medicinal Chemistry, 57 (8). pp. 3263-3282. ISSN 1520-4804

Pierog, P, Krishna, M, Yamniuk, A, Chauhan, A and DeSilva, B (2014) Detection of drug specific circulating immune complexes from in vivo cynomolgus monkey serum samples. Journal of Immunology Methods.

Pihl, Susanne, Michaut, Lydia, Hendriks, Jenny, Loebbert, Ralph, Ryding, Janka, Nemansky, Martin, Vermet, Laurent and Companjen, Arjen (2014) EBF Recommendation for stability testing of anti-drug antibodies; lessons learned from anti-vaccine antibody stability studies. Bioanalysis, 6 (10). pp. 1409-1413. ISSN 1757-6180

Pirard, Bernard and Ertl, Peter (2014) Evaluation of a Semi-Automated Workflow for Fragment Growing. Journal of Chemical Information and Modeling, 55 (1). pp. 180-193. ISSN 1549-960X

Pissani, F, Malherbe, DC, Schuman, JT, Robins, H, Park, BS, Krebs, SJ, Barnett, SW and Haigwood, NL (2014) Improvement of antibody responses by HIV envelope DNA and protein co-immunization. VACCINE. pp. 507-513.

Plappert Helbig, Ulla and Guérard , Melanie (2014) Inter-laboratory comparison of the in vivo comet assay including three image analysis systems. Environmental and Molecular Mutagenesis, 55 (2). pp. 114-121.

Plappert Helbig, Ulla, Van der Leede, Bas-jan, Doherty, Ann, Guérard, Melanie , Howe, Jonathan and Thybaud, Véronique (2014) Performance and data interpretation of the in vivo comet assay in pharmaceutical industry: EFPIA survey results. Current Topics in Genotoxicity Testing of Mutation Research – Genetic Toxicology and Environmental Mutagenesis, 775–77. pp. 81-88.

Poor, Stephen, Qiu, Yubin, Woolfenden, Amber, Fassbender, Elizabeth, Delpero, Andrea, Meredith, Erik, Buchanan, Natasha, Yong, kim, Hanks, Shawn, Shen, Siyuan, Gebuhr, Tom, Jaffee, Bruce and Dryja, Ted (2014) Reliability of the mouse model of choroidal neovascularization induced by laser photocoagulation. Investigations of Ophthalmic Visual Sciences.

Pop, MS, Stransky, N, Garvie, CW, Theurillat, JP, Hartman, EC, Lewis, TA, Zhong, C, Culyba, EK, Lin, F, Daniels, DS, Pagliarini, R, Ronco, L, Koehler, AN and Garraway, LA (2014) A Small Molecule That Binds and Inhibits the ETV1 Transcription Factor Oncoprotein. Mol Cancer Ther . pp. 1492-1502.

Portal, CF, Seifert, JM, Buehler, C, Meisner-Kober, NC and Auer, M (2014) Novel 1:1 Labeling and Purification Process for C-Terminal Thioester and Single Cysteine Recombinant Proteins Using Generic Peptidic Toolbox Reagents. BIOCONJUGATE CHEMISTRY. pp. 1213-1222.

Porter, David, Bradley, Michelle, Brown, Zarin, Canova, Riccardo, Charlton, Steven, Cox, Brian, Hunt, Peter, Kolarik, David, Lewis, Sarah, O'Connor, Des, Reilly, John, Spanka, Carsten, Tedaldi, Lauren, Watson, Simon, Wermuth, Roland and Press, Neil (2014) The Discovery of Potent, Orally Bioavailable Pyrazolo and Triazolopyrimidine CXCR2 Receptor Antagonists. Biorganic and Medicinal Chemistry Letters, 24 (1). pp. 72-76.

Porter, David, Bradley, Michelle, Brown, Zarin, Charlton, Steven, Cox, Brian, Hunt, Peter, Janus, Diana, Lewis, Sarah, Oakley, Paul, O'Connor, Des, Reilly, John, Smith, Nichola and Press, Neil (2014) The Discovery of Potent, Orally Bioavailable Pyrimidine-5-carbonitrile-6-alkyl CXCR2 Receptor Antagonists. Biorganic & Medicinal Chemistry Letters.

Portmann, T, Yang, M, Mao, R, Panagiotakos, G, Ellegood, J, Dolen, G, Bader, PL, Grueter, BA, Goold, C, Fisher, E, Clifford, K, Rengarajan, P, Kalikhman, D, Loureiro, D, Saw, NL, Zhengqui, Z, Miller, MA, Lerch, JP, Henkelman, RM, Shamloo, M, Malenka, RC, Crawley, JN and Dolmetsch, RE (2014) Behavioral Abnormalities and Circuit Defects in the Basal Ganglia of a Mouse Model of 16p11.2 Deletion Syndrome. Cell reports.

Preuss, Inga, Ludwig, Marie-Gabrielle, Baumgarten, Birgit, Bassilana, Frederic, Gessier, Francois, Seuwen, Klaus and Sailer, Andreas (2014) Transcriptional regulation and functional characterization of the oxysterol / EBI2 system in primary human macrophages. Biochemical and Biophysical Research Communication, 446. pp. 663-668.

Proietti, M, Cornacchione, V, RezzonicoJost, T, Romagnani, A, Faliti, CE, Perruzza, L, Rigoni, R, Radaelli, E, Caprioli, F, Preziuso, S, Brannetti, B, Thelen, M, McCoy, KD, Slack, E, Traggiai, E and Grassi, F (2014) ATP-gated ionotropic P2X7 receptor controls follicular T helper cell numbers in peyer's patches to promote host-microbiota mutualism. Immunity. pp. 789-801.

Q

Qi, H, Olson, CA, Wu, NC, Ke, R, Loverdo, C, Chu, V, Truong, S, Remenyi, R, Chen, Z, Du, Y, Su, S, Al-Mawsawi, LQ, Wu, T, Chen, S, Lin, C, Zhong, W, Lloyd-Smith, JO and Sun, R (2014) A Quantitative High-Resolution Genetic Profile Rapidly Identifies Sequence Determinants of Hepatitis C Viral Fitness and Drug Sensitivity. PLoS Pathogens.

Qiu, W, Rogers, AJ, Damask, A, Raby, BA, Klanderman, BJ, Duan, QL, Tyagi, S, Niu, S, Anderson, C, Cahir-Mcfarland, E, Mariani, TJ, Carey, V and Tantisira, KG (2014) Pharmacogenomics: novel loci identification via integrating gene differential analysis and eQTL analysis. Human Molecular Genetics. pp. 5017-5024.

R

Rahal, Rami, Frick, Mareike, Romero, Rodrigo, Ruddy, David, Derti, Adnan, Rakiec, Daniel, Naylor, Tara, Kauffmann, Audrey, Pfister-Wagner, Estelle, Fritsch, Christine, Kovats, Steven, Kim, Sunkyu, Dietze, Kerstin, Dorket, Bernd, Tzankov, Alexandar, Hummel, Michael, Monahan, John, Morrissey, Michael, Sellers, William, Lenz, Georg, Cooke, Vesselina, Bhang, Hyo-Eun, Farsidjani, Alireza, Hernandez-Ilizaliturri, Francisco J, Mavis, Cory and Stegmeier, Frank (2014) Pharmacological and genomic profiling identifies NF-κB-targeted treatment strategies for mantle cell lymphoma. Nature Medicine, 20 (1). pp. 87-92. ISSN 1078-8956

Ramsden, Emma, Moulin, Pierre, Lee, David and Christ, Andreas Dominik (2014) QAX576, AN ANTI–INTERLEUKIN (IL)-13 MONOCLONAL ANTIBODY, FOR THE TREATMENT OF PATIENTS WITH FISTULISING CROHN’S DISEASE (CD): RESULTS OF A PROOF-OF-CONCEPT STUDY. United European Gastroenterology Week 2014.

Rascol, Olivier, Fox, Susan, Gasparini, Fabrizio, Kenney, Christopher, DiPaolo, Thérèse and Gomez-Mancilla, Baltazar (2014) Use of metabotropic glutamate 5-receptor antagonists for treatment of levodopa-induced dyskinesias. Parkinsonism and Related Disorders, 20 (9). pp. 947-956. ISSN 1873-5126

Ravenscroft, Neil, Cescutti, Paola, Stefanetti, Giuseppe, Londero, Silvia, Rondini, Simona and Maclennan, Calman Alexander (2014) Structural analysis of O-polysaccharide chains extracted from different Salmonella Typhimurium strains. Carbohydrate Research, 385. pp. 1-8. ISSN 1873-426X

Ravindran, Madhu Sudhan, Rao, Srinivasa P.S., Cheng, Xiamin, Shukla, Ankit, Cazenave-Gassiot, Amaury, Yao, Shao Q. and Wenk, Markus R. (2014) Targeting lipid esterases in mycobacteria grown under different physiological conditions using activity based profiling with tetrahydrolipstatin. Molecular & cellular proteomics : MCP, 13 (2). pp. 435-448. ISSN 1535-9484

Reck, Folkert (2014) Optimization of Physicochemical Properties and Safety Profile of Novel Bacterial Topoisomerase Type II Inhibitors (NBTIs) with activity against Pseudomonas aeruginosa. Optimization of Physicochemical Properties and Safety Profile of Novel Bacterial Topoisomerase Type II Inhibitors (NBTIs) with activity against Pseudomonas aeruginosa .

Repko, Brian (2014) "Big Data" Bioinformatics Models for Distributed, Parallel and Concurrent Processing. Slideshare / Twitter.

Reuter, Björn, Grudzenski, Saskia, Handwerker, E, Meairs, S, Heiler, P, Schad, L, Staufenbiel, Matthias, Hennerici, Michael P and Fatar, Marc (2014) Thrombolysis in experimental cerebral amyloid angiopathy and the risk of secondary intracerebral hemorrhage. Stroke, 45 (8). pp. 2411-2416. ISSN 0039-2499

Rieffel, Sebastien, Klopp, Julia, Roest, Susan, Carnal, Simon, Marti, Sabrina, Gerhartz, Bernd and Shrestha, Binesh (2014) Insect cell culture in reagent bottles. Insect cell culture in reagent bottles, 1. pp. 155-161. ISSN 2215-0161

Rieffel, Sebastien, Klopp, Julia, Roest, Susan, Carnal, Simon, Marti, Sabrina, Gerhartz, Bernd and Shrestha, Binesh (2014) Insect cell culture in reagent bottles. MethodsX, 1. pp. 155-161. ISSN 2215-0161

Rimann, Markus, Graf-Hausner, Ursula and Keller, Hansjoerg (2014) Bioprinting und in vitro Modelle zur Wirkstoffentwicklung. ZHAW transfer, 2014 (3). p. 5. ISSN none

Ringel, Frauke, Kaeda, Jaspal, Schwarz, Michaela, Oberender, Christian, Grille, Peggy, Doerken, Bernd, Marque, Fanny, Manley, Paul W., Radimerski, Thomas and le Coutre, Philippe (2014) Effects of the JAK2-selective inhibitors NVP-BSK805 and NVP-BVB808 in BCR-ABL or JAK2 mutation-positive cell lines. Haematologica, 132 (1). pp. 75-86. ISSN 1421-9662

Riniker, Sereina, Wang, Yuan, Jenkins, Jeremy and Landrum, Gregory (2014) Using information from historical high-throughput screens to predict active compounds. Journal of chemical information and modeling, 54 (7). pp. 1880-1891. ISSN 1549-960X

Robbe, Marie-France, Both, Jean-Pierre, Prideaux, Brendan, Klinkert, Ivo, Picauld, Vincent, Schramm, Thorsten, Hester, Alfons, Guevara, Victor, Stoeckli, Markus, Roempp, Andreas, Heeren, Ron, Spengler, Bernhard and Haan, Serge (2014) Software tools of the Computis European project to process mass spectrometry images. European Journal of Mass Spectrometry, 20 (5). pp. 351-360. ISSN 1356-1049

Robbins, PF, Kassim, SH, Tran, TL, Crystal, JS, Morgan, RA, Feldman, SA, Yang, JC, Dudly, ME, Wunderlich, JR, Sherry, RM, Kammula, US, Hughes, MS, Restifo, NP, Raffeld, M, Lee, CR, Li, YF, El-Gamil, M and Rosenberg, SA (2014) Yeast PP4 Interacts with ATR Homolog Ddc2-Mec1 and Regulates Checkpoint Signaling. Clinical Cancer Research.

Robbins, PF, Kassim, SH, Tran, TL, Crystal, JS, Morgan, RA, Feldman, SA, Yang, JC, Dudly, ME, Wunderlich, JR, Sherry, RM, Kammula, US, Hughes, MS, Restifo, NP, Raffeld, M, Lee, CR, Li, YF, El-Gamil, M and Rosenberg, SA (2014) A pilot trial using lymphocytes genetically engineered with an NY-ESO-1-reactive T cell receptor: Long term follow up and correlates with response. Clinical Cancer Research.

Robinson, Paul, Watson, Catherine, Taylor, Ann, Maldonado-Lutomirsky, Mario, Zhang, Yiming, Bertagna, Xavier, Pivonello, Rosario, Fleseriu, Maria, Hamrahian, Amir H, Boscaro, Marco and Biller, Beverly MK (2014) LCI699, a potent 11β-hydroxylase inhibitor, normalizes urinary cortisol in patients with Cushing’s disease: results from a multicenter, proof-of-concept study. Journal of Clinical Endocrinology and Metabolism.

Rodon, J, Tawbi, HA, Thomas, AL, Stoller, RG, Turtschi, CP, Baselga, J, Sarantopoulos, J, Mahalingam, D, Shou, Y, Moles, MA, Yang, L, Granvil, C, Hurh, E, Rose, KL, Amakye, DD, Dummer, R and Mita, AC (2014) A Phase I, Multicenter, Open-Label, First-in-Human, Dose-Escalation Study of the Oral Smoothened Inhibitor Sonidegib (LDE225) in Patients with Advanced Solid Tumors. CLINICAL CANCER RESEARCH. pp. 1900-1909.

Rooney, L, Vidal, A, D'Souza, AM, Devereux, N, Masick, B, Boissel, V, West, R, Head, V, Stringer, R, Lao, J, Petrus, MJ, Patapoutian, A, Nash, M, Stoakley, N, Panesar, M, Verkuyl, JM, Schumacher, AM, Petrassi, HM and Tully, DC (2014) Discovery, Optimization, and Biological Evaluation of 5-(2-(Trifluoromethyl)phenyl)indazoles as a Novel Class of Transient Receptor Potential A1 (TRPA1) Antagonists. Journal of Medicinal Chemistry. pp. 5129-5140.

Rooney, Lisa, D'Souza, Anne-Marie, Devereux, Nicholas, Boissel, Valerie, West, Ryan, Stringer, Rowan, Head, Victoria, Nash, Mark, Tully, David, Petrassi, Hank, Masick, Brian, Lao, Jianmin, Vidal-Biggart, Agnes, Petrus, Matthew, Schumacher, Andrew, Verkuijl, Martin, Stoakley, Natalie, Panesar, Moh and Patapoutian, Ardem (2014) Discovery, optimization, and biological evaluation of 5-(2- (trifluoromethyl)phenyl)indazoles as a novel class of transient receptor potential A1 (TRPA1) antagonists. Journal of Medicinal Chemistry, 57 (12). pp. 5129-5140. ISSN 1520-4804

Rooney, Lisa, D'Souza, Anne-Marie, Devereux, Nicholas, Boissel, Valerie, West, Ryan, Stringer, Rowan, Head, Victoria, Nash, Mark, Tully, David, Petrassi, Hank, Masick, Brian, Lao, Jianmin, Vidal-Biggart, Agnes, Petrus, Matthew, Schumacher, Andrew, Verkuijl, Martin, Stoakley, Natalie, Panesar, Moh and Patapoutian, Ardem (2014) Discovery, optimization, and biological evaluation of 5-(2- (trifluoromethyl)phenyl)indazoles as a novel class of transient receptor potential A1 (TRPA1) antagonists. Journal of Medicinal Chemistry, 57 (12). pp. 5129-5140. ISSN 1520-4804

Roschger, Andreas, Roschger, Paul, Keplinger, Petra, Klaushofer, Klaus, Abdullah, Sami, Kneissel, Michaela and Rauch, Frank (2014) Effect of Sclerostin Antibody Treatment in a Mouse Model of Severe Osteogenesis Imperfecta. Bone.

Ross, NT and Wilson, CJ (2014) In vitro clinical trials: the future of cell-based profiling. Frontiers in Pharmacology.

Rossi, Omar, Pesce, Isabella, Giannelli, Carlo, Aprea, Susanna, Caboni, Mariaelena, Citiulo, Francesco, Valentini, Sara, Ferlenghi, Ilaria, Maclennan, Calman Alexander, D'Oro, Ugo, Saul, Allan James and Gerke, Christiane E A (2014) Modulation of endotoxicity of Shigella Generalized Modules for Membrane Antigens (GMMA) by genetic lipid A modifications: relative activation of TLR4 and TLR2 pathways in different mutants. Journal of Biological Chemistry.

Rotty, Berenice and Kallen, Joerg (2014) Caractérisation de cristaux de complexes protéines-ligands. Master Thesis, Universite Toulouse.

Rotty, Berenice and Kallen, Joerg (2014) Caractérisation de cristaux de complexes protéines-ligands. Master Thesis Univ. Toulouse.

Ruan, Hongyu, Saur, Taixiang and Yao, Wei-Dong (2014) Dopamine-enabled anti-Hebbian timing-dependent plasticity in the prefrontal circuitry. Frontiers in Neural Circuits.

Rubinfeld, Hadara, Kammer, Adi, Cohen, Ortal, Gorshtein, Alexander, Cohen, Zvi / R, Hadani, Moshe, Werner, Haim and Shimon, Ilan (2014) IGF-1 Induces proliferation in Human Pituitary Tumors - Functional Blockade of IGF-1 Receptor as a Novel Therapeutic Approach in Non-functioning Tumors. Molecular and Cellular Endocrinology.

Ruda, VM, Chandwani, R, Sehgal, A, Bogorad, RL, Akinc, A, Charisse, K, Tarakhovsky, A, Novobrantseva, TI and Koteliansky, V (2014) The roles of individual mammalian argonautes in RNA interference in vivo. PLoS ONE.

Ruffell, B, Chang-Strachan, D, Chan, V, Rosenbusch, A, Ho, CM, Pryer, N, Daniel, D, Hwang, ES, Rugo, HS and Coussens, LM (2014) Macrophage IL-10 Blocks CD8(+) T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells. Cancer Cell. pp. 623-637.

Ruffner, Heinz, Graf-Hausner, Ursula and Stephanie, Mathes (2014) The use of skin models in drug development. Advanced Drug Delivery Reviews.

S

SEQC Consortium, MAQC-III Consortium, Oakeley, Edward James, Staedtler, Frank and Derti, Adnan (2014) A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium. Nature Biotechnology, Advanc (Advanc).

Sackton, KL, Dimova, N, Zeng, X, Tian, W, Zhang, M, Sackton, TB, Meaders, J, Pfaff, KL, Sigoillot, F, Yu, H, Luo, X and King, RW (2014) Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C. Nature.

Sadlish, Heather, Hassan, Asm Quamrul, Zhou, Wenlai, Kirby, Christina, Schuhmann, Tim, Studer, Christian, Chang, Lena, Hoepfner, Dominic, Sellers, William, Movva, Rao, Aust, Thomas, Riedl, Ralph, Quinn, Christopher, Krastel, Philipp, Schmitt, Esther, Baird, Jason, Chung, Franklin, Chen, Jinyun, Schitter, Anne, Pagliarini, Raymond, Chen, Yaoyu, Quinn, D, Mayer, Matthias and Kityk, Roman (2014) A novel allosteric means of inhibiting heat shock 70 proteins. Chemistry and Biology.

Sala-Cunill, Anna, Björkqvist, Jenny, Senter, Riccardo, Guilarte, Mar, Cardona, Victoria, Labrador, Moises, Nickel, Katrin F., Lynn, Butler, Olga, Luengo, Kumar, Parvin, Labberton, Linda, Long, Andy, Di Gennaro, Antonio, Kenne, Ellinor, Jämsä, Anne, Krieger, Thorsten, Schlüter, Hartmut, Fuchs, Tobias, Flohr, Stefanie, Hassiepen, Ulrich, Cumin, Frederic, McCrea, Keith, Maas, Coen, Stavrou, Evi and Renné, Thomas (2014) ACTIVATION OF THE PLASMA CONTACT SYSTEM IN ANAPHYLAXIS – INSIGHT TO SEVERE MAST CELL-MEDIATED ALLERGIC REACTIONS. Journal of Allergy and Clinical Immunology, 135 (4). pp. 1031-1043. ISSN 00916749

Salcius, Michael, Bauer, Andras, Hao, Qin, Li, Shu, Tutter, Antonin, Raphael, Jacob, Haggarty, Stephen, Tallarico, John, Michaud, Gregory and Jahnke, Wolfgang (2014) SEC-TID: A label-free method for small-molecule target identification. Journal of Biomolecular Screening, 19 (6). pp. 917-927. ISSN 1552-454X

Sames, Dalibor and Genovino, Julien (2014) Access to drug metabolites via C-H functionalization: Copper-catalyzed aerobic oxidation of N,N-dimethylalkylamines in complex pharmaceuticals. Tetrahedron Letters, 56 (23). pp. 3066-3069. ISSN 1873-3581

San-Miguel, JF, Hungria, VT, Yoon, SS, Beksac, M, Dimopoulos, MA, Elghandour, A, Jedrzejczak, WW, Gunther, A, Nakorn, TN, Siritanaratkul, N, Corradini, P, Chuncharunee, S, Lee, JJ, Schlossman, RL, Shelekhova, T, Yong, K, Tan, D, Numbenjapon, T, Cavenagh, JD, Hou, J, LeBlanc, R, Nahi, H, Qiu, L, Salwender, H, Pulini, S, Moreau, P, Warzocha, K, White, D, Blade, J, Chen, W, de la Rubia, J, Gimsing, P, Lonial, S, Kaufman, JL, Ocio, EM, Veskovski, L, Sohn, SK, Wang, MC, Lee, JH, Einsele, H, Sopala, M, Corrado, C, Bengoudifa, BR, Binlich, F and Richardson, PG (2014) Panobinostat plus bortezomib and dexamethasone versus placebo plus bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma: a multicentre, randomised, double-blind phase 3 trial. Lancet Oncology. pp. 1195-1206.

Sanchini, Silvano, Perruccio, Francesca and Piizzi, Grazia (2014) Rational design, synthesis and biological evaluation of modular fluorogenic substrates with high affinity and selectivity for PTP1B. ChemBioChem, 15 (7). pp. 961-976. ISSN 1439-7633

Sasseville, Vito, Mansfield, Keith and Brees, Dominique (2014) Safety biomarkers in preclinical development: translational potential. Veterinary pathology, 51 (1). pp. 281-291. ISSN 1544-2217

Schlaeppi, Jean-Marc and Lavoisier, Alexandra (2014) Early developability screen of therapeutic antibody candidates using Taylor dispersion analysis and UV area imaging detection. MAbs , 7 (1). pp. 77-83. ISSN 1942-0870 (Print), 1942-0862 (Online)

Schneider, Andreas, Erden, Zeynep and von Krogh, Georg (2014) COORDINATING KNOWLEDGE CREATION IN MULTIDISCIPLINARY TEAMS: EVIDENCE FROM EARLY-STAGE DRUG DISCOVERY. Academy of Management Journal. ISSN 0001-42731948-0989

Schuemann, Jens, Boudon, Stephanie Marie, Ulrich, Peter, Loll, Nathalie, Garcia, Deborah, Schaffner, Rene, Streich, Jeannine, Kittel, Birgit and Bauer, Daniel (2014) Integrated Preclinical Photosafety Testing Strategy for Systemically Applied Pharmaceuticals. Toxicological Sciences, 139 (1). pp. 245-256. ISSN 10960929

Schweighauser, Manuel, Bacioglu, Mehtap, Fritschi, Sarah, Shimshek, Derya, Kahle, Philipp, Eisele, Yvonne and Jucker, Mathias (2014) Formaldehyde-fixed brain tissue from spontaneously ill α-synuclein transgenic mice induces fatal α-synucleinopathy in transgenic hosts. Acta Neuropathologica.

Selzer, P and Potticary, J (2014) Interview with Paul Selzer. Future Medicinal Chemistry, 6 (3). pp. 263-266. ISSN 1756-89191756-8927

Selzer, Paul (2014) Interview in Future Medicinal Chemistry. Future Medicinal Chemistry.

Sewell, F, Chapman, K, Baldrick, P, Brewster, D, Broadmeadow, A, Brown, P, Burns-Naas, LA, Clarke, J, Constan, A, Couch, J, Czupalla, O, Danks, A, DeGeorge, J, Haan, LD, Hettinger, K, Hill, M, Festag, M, Jacobs, A, Jacobson-Kram, D, Kopytek, S, Lorenz, H, Moesgaard, SG, Moore, E, Pasanen, M, Perry, R, Ragan, I, Robinson, S, Schmitt, PM, Short, B, Lima, BS, Smith, D, Sparrow, S, Bekkum, YV and Jones, D (2014) Recommendations from a global cross-company data sharing initiative on the incorporation of recovery phase animals in safety assessment studies to support first-in-human clinical trials. Regul Toxicol Pharmacol .

Sexton, BS, Avey, D, Druliner, BR, Fincher, JA, Vera, DL, Grau, DJ, Borowsky, ML, Gupta, S, Girimurugan, SB, Chicken, E, Zhang, J, Noble, WS, Zhu, F, Kingston, RE and Dennis, JH (2014) The spring-loaded genome: Nucleosome redistributions are widespread, transient, and DNA-directed. Genome Research. pp. 251-259.

Shan, C, Elf, S, Ji, Q, Kang, HB, Zhou, L, Hitosugi, T, Jin, L, Lin, R, Zhang, L, Seo, JH, Xie, J, Tucker, M, Gu, TL, Sudderth, J, Jiang, L, DeBerardinis, RJ, Wu, S, Li, Y, Mao, H, Chen, PR, Wang, D, Chen, GZ, Lonial, S, Arellano, ML, Khoury, HJ, Khuri, FR, Lee, BH, Brat, DJ, Ye, K, Boggon, TJ, He, C, Kang, S, Fan, J and Chen, J (2014) Lysine Acetylation Activates 6-Phosphogluconate Dehydrogenase to Promote Tumor Growth. Molecular Cell.

Sharif, Naj, Katoli, Parvaneh, Kelly, Curtis, Li, Linya, Xu, Shouxi, Wang, Yu, Klekar, Laura, Earnest, David, Yacoub, Shenouda, Hamilton, Gwen, Jacobson, Nasreen, Shepard, Allan and Ellis, Dorette (2014) Trabecular meshwork bradykinin receptors: mRNA levels, immunohistochemical visualization, signaling processes pharmacology and linkage to IOP changes. J Ocular Pharmacology & Therapeutics, 30 (1). pp. 21-34.

Shaw, Alice T., Kim, Dong-Wan, Mehra, Ranee, Tan, Daniel S.W., Felip, Enriquetta, Chow, Laura Q.M., Camidge, D. Ross, Vansteenkiste, Johan, Sharma, Sunil, De Pas, Tommaso, Riely, Gregory J., Solomon, Benjamin J., Wolf, Juergen, Thomas, Michael, Schuler, Martin, Liu, Geoffrey, Santoro, Armando, Lau, Yi-Yang Yvonne, Goldwasser, Meredith, Boral, Anthony and Engelman, Jeffrey A. (2014) LDK378 in Anaplastic Lymphoma Kinase-Rearranged Non–Small-Cell Lung Cancer. New England Journal of Medicine, 370 (13). pp. 1189-1197.

Shaw, Duncan, Hollingworth, Gregory, Soldermann, Nicolas, Sprague, Elizabeth, Schuler, Walter, Vangrevelinghe, Eric, Duggan, Nicholas, Thomas, Matthew, Kosaka, Takatoshi, Waters, Nigel and Van Eis, Maurice (2014) Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension. Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension, 24 (20). pp. 4812-4817.

Sherman, Woody, Kramer, Christian and Jean Christophe, Mozziconacci (2014) Improving docking results via reranking of ensembles of ligand poses in multiple X-ray protein conformations with MM-GBSA. Journal Chemnical Information Modeling, 54 (10). pp. 2697-2717. ISSN 1549-95961549-960X

Shi, Pei-Yong, Caillet-Saguy, Célia, Julien, Lescar and Stéphane , Bressanelli (2014) Polymerases of hepatitis C viruses and flaviviruses: Structural and mechanistic insights and drug development. Antiviral research.

Shi, Pei-Yong and Gu, Feng (2014) Dengue drug discovery and development. Clinical Investigation.

Shiwarski, Daniel, Shao , Chunbo, Bill, Anke, kim, jean, xiao, dong, bertrand, carol, seethala, raja, sano, daisuke, myers, jeffery, ha, patrick, grandis, jennifer, Gaither, Larry, puthenveedu, manojkumar and duvvuri, umamaheswar (2014) To "grow" or "go": TMEM16A expression as a switch between tumor growth and metastasis in SCCHN. Clinical cancer research : an official journal of the American Association for Cancer Research, 20 (17). pp. 4673-4688. ISSN 1078-0432

Shou, Y, Robinson, DM, Amakye, DD, Rose, KL, Cho, YJ, Ligon, KL, Sharp, T, Haider, AS, Bandaru, R, Ando, Y, Geoerger, B, Doz, F, Ashley, DM, Hargrave, DR, Casanova, M, Tawbi, HA, Rodon, J, Thomas, AL, Mita, AC, MacDonald, TJ and Kieran, MW (2014) A Five-Gene Hedgehog Signature Developed as a Patient Preselection Tool for Hedgehog Inhibitor Therapy in Medulloblastoma. Clinical Cancer Research .

Shultz, Michael (2014) Improving the plausibility of success with inefficient metrics. ACS Medicinal Chemistry Letters, 5 (1). pp. 2-5. ISSN 1948-5875

Sibley, Cailin H., Chioato, Andrea, Felix, Sandra Daniela, Colin, Laurence, Chakraborty, Abhijit, Abrams, Ken and Goldbach-Mansky, Raphaela (2014) A 24 Month Open Label Study of Canakinumab in Neonatal-Onset Multisystem Inflammatory Disease. Annals of the Rheumatic Diseases.

Simansour, Maud, Thiemeyer, Anke, Klein, Jessica, Stoehr, Natacha, Bernhard, Mario, Fodor, Barna and Galimberti, Ivan (2014) Assessment of neuronal cell type specific transcriptional effects of three pathological sequence variants of the FMR1 gene promoter. Master Thesis.

Simon, Oliver, Bates, Roderick W. and Tang, Chi H. (2014) A synthesis of 5-Hydroxysedamine using Hydroformylation. Tetrahedron, 70 (12). pp. 2134-2140. ISSN 00404020

Six, David, Yuan, Yanqiu, Leeds, Jennifer and Meredith, Timothy (2014) Deletion of the beta-Acetoacetyl Synthase FabY in Pseudomonas aeruginosa induces hypoacylation of lipopolysaccharide. Antimicrobial Agents and Chemotherapy, 58 (1). pp. 153-161. ISSN 1098-6596

Smith, D, Artursson, P, Avdeef, A, Di, L, Ecker, GF, Faller, B, Houston, JB, Kansy, M, Kerns, EH, Kramer, SD, Lennernas, H, Van De Waterbeemd, H, Sugano, K and Testa, B (2014) Passive lipoidal diffusion and carrier-mediated cell uptake are both important mechanisms of membrane permeation in drug disposition. Molecular Pharmaceutics. pp. 1727-1738.

Smith, Paul William, Diagana, Thierry Tidiane and Yeung, Bryan King Sing (2014) Progressing the global antimalarial portfolio: Finding drugs that target multiple Plasmodium life stages. Parasitology.

Smurnyy, Y, Cai, M, Wu, H, McWhinnie, E, Tallarico, JA, Yang, Y and Feng, Y (2014) DNA sequencing and CRISPR-Cas9 gene editing for target validation in mammalian cells. Nat Chem Biol .

Smurnyy, Yegor, Cai, Mi, Wu, Hua, Mc Whinnie, Elizabeth, Tallarico, John, Yang, Yi and Feng, Yan (2014) CRISPR Mediated Target Validation of ERCC3 as the Target of Triptolide. Nature Chemical Biology.

Snelder, N, Ploeger, BA, Luttringer, O, Rigel, DF, Fu, F, Beil, M, Stanski, DR and Danhof, M (2014) Drug effects on the CVS in conscious rats: separating cardiac output into heart rate and stroke volume using PKPD modelling. British Journal of Pharmacology. pp. 5076-5092.

Soncini, D, Caffa, I, Zoppoli, G, Cea, M, Cagnetta, A, Passalacqua, M, Mastracci, L, Boero, S, Montecucco, F, Sociali, G, Lasiglie, D, Damonte, P, Grozio, A, Mannino, E, Poggi, A, D'Agostino, VG, Monacelli, F, Provenzani, A, Odetti, P, Ballestrero, A, Bruzzone, S and Nencioni, A (2014) Nicotinamide Phosphoribosyltransferase Promotes Epithelial-to-Mesenchymal Transition as a Soluble Factor Independent of Its Enzymatic Activity. Journal of Biological Chemistry . pp. 34189-34204.

Spanka, Carsten and Schaumann, Ernst (2014) Synlett Account: Alkynyl Silyl Sulfides as Versatile Thioketene Equivalents. Synlett, 25 (17). pp. 2415-2428. ISSN 0936-5214

Stalter, Isabel and Memmert, Klaus (2014) Etablierung von Ko-Kultivierungstechniken zur Anwendung in miniaturisierten Testsystemen für antibiotische Aktivität. Master Thesis at Hochschule Albstadt-Sigmaringen, n.a. (n.a.). pp. 1-100. ISSN n.a.

Stockmann, C, Palmen, TG, Schroer, K, Kunze, G, Gellissen, G and Buchs, J (2014) Definition of culture conditions for arxula adeninivorans, a rational basis for studying heterologous gene expression in this dimorphic yeast. Journal of Industrial Microbiology and Biotechnology. pp. 965-976.

Stoellner, Daniela, Dudal, Sherri, Staack, Roland, Scheel Fjording, Marianne, Vieser, Eva, Pascual, Marie-Helene, Brudny-Kloeppel, Margarete, Seemann, Dietmar and Golob, Michaela (2014) How the bioanalyst plays a key role in interdisciplinary project teams in the development of biotherapeutics – a reflection of the European Bioanalysis Forum. Bioanalysis, 6 (10). pp. 1339-1348.

Stringer, Rowan, Weber, Eckhard, Culshaw, Andrew, Mckenna, Jeff, Williams, Gareth, Rose, Jonathan and Sohal, Bindi (2014) Preclinical metabolism and pharmacokinetics of NVS-CRF38, a potent and orally bioavailable corticotrophin-releasing factor-1 antagonist. Xenobiotica, 44 (10). pp. 902-912. ISSN 0049-8254

Stringer, Rowan, Weber, Eckhard, Tigani, Bruno, Lavan, Paul, Stephen, Medhurst and Sohal, Bindi (2014) 1-aminobenzotriazole modulates oral drug pharmacokinetics through cytochrome P450 inhibition and delay of gastric emptying in rats. Drug Metabolism and Disposition, 42 (7). pp. 1117-1124. ISSN 1521-009X

Stringer, Rowan, Williams, Gareth, Picard, Franck, Sohal, Bindi, Mckenna, Jeff and Krauser, Joel (2014) Application of a deuterium replacement strategy to modulate the pharmacokinetics of NVS-CRF38, a novel CRF1 antagonist. Drug Metabolism and Disposition, 42 (5). pp. 954-962. ISSN 1521-009X

Subramanian, Sharadha, Costales, Abran, Poon, Daniel, Shafer, Cynthia and Stuart, Darrin (2014) Design and synthesis of orally bioavailable benzimidazole reverse amides as pan RAF kinase inhibitors. ACS Medicinal Chemistry Letters, 5 (9). pp. 989-992. ISSN 1948-5875

Sultan, Marc, Amstislavskiy, Vyacheslav, Risch, Thomas, Schuette, Moritz, Dökel, Simon, Ralser, Meyriem, Balzereit, Daniela, Lehrach, Hans and Yaspo, Marie-Laure (2014) Influence of RNA extraction methods and library selection schemes on RNA-seq data. BMC Genomics.

Sunkara, Gangadhar, Jiang, Xuemin, Reynolds, Christine, Serra, Denise, Zhang, Yiming, Ligueros-Saylan, Monica, Ayalasomayajula, Surya, Winter, Serge and Jarugula, Venkateswar (2014) Effect of food on the oral bioavailability of amlodipine/valsartan and amlodipine/valsartan/hydrochlorothiazide fixed dose combination tablets in healthy subjects. Clinical Pharmacology in Drug Development, 3 (6). pp. 487-492. ISSN 2160763X

Supek, Frantisek, Mathison, Casey, Khare, Shilpi, Molteni, Valentina, Nagle, Advait, Gelb, Michael and Buckner, Frederick (2014) Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis. Chemical reviews, 114 (22). pp. 11305-11347. ISSN 1520-6890

Sverdlov, Oleksandr, Wong, Weng Kee and Ryeznik, Yevgen (2014) Adaptive Clinical Trial Designs for Phase I Cancer Studies. Statistics surveys, 8. pp. 2-44. ISSN 1935-7516

Sverdlov, Oleksandr and Wong, Weng Kee (2014) Novel Statistical Designs for Phase I/II and Phase II Clinical Trials With Dose-Finding Objectives. Therapeutic Innovation and Regulatory Science, 48 (5). pp. 601-612. ISSN 2168-4804

Sykes, David, Parry, Cheryl, Reilly, John, Wright, Penny, Fairhurst, Robin and Charlton, Steven (2014) Observed drug-receptor association rates are governed by membrane affinity: The importance of establishing "micro-pharmacokinetic/pharmacodynamic relationships" at the β2-adrenoceptor. Molecular Pharmacology, 85 (4). pp. 608-617. ISSN 0026-895X

Szikra, T, Trenholm, S, Drinnenberg, A, Juttner, J, Raics, Z, Farrow, K, Biel, M, Awatramani, G, Clark, DA, Sahel, JA, da Silveira, RA and Roska, B (2014) Rods in daylight act as relay cells for cone-driven horizontal cell-mediated surround inhibition. Nat Neurosci .

T

Tan, M, Wu, B, Chen, I, Chai, C, Chou, S, Yeh, J, Chen, I, Wu, J, Jeng, AY and Dai, Z (2014) Dual ECE/NEP inhibition improved diastolic function and ameliorated cardiac remodeling in rats with myocardial dysfunction secondary to pressure overload by aortic banding. Experimental and Clinical Cardiology. pp. 358-368.

Targowska-Duda, Katarzyna M, Feuerbach, Dominik, Biala, Grazyna, Jozwiak, Krzysztof and Arias, Hugo R (2014) Antidepressant activity in mice elicited by 3-furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of the α7 nicotinic acetylcholine receptor. European Journal of Pharmacology.

Tarselli, Mike (2014) Review of Hallelujah Moments. Nature Chemistry.

Tarselli, Mike (2014) Science NextGen 12 - Global Collaboration. Science Magazine NextGen 12.

Taylor, SJ, Thien, CB, Dagger, SA, Duyvestyn, JM, Grove, CS, Lee, BH, Gilliland, DG and Langdon, WY (2014) Loss of c-Cbl E3 ubiquitin ligase activity enhances the development of myeloid leukemia in FLT3-ITD mutant mice. Experimental Hematology.

Terwisscha van Scheltinga , Anton G.T., Berghuis, Paul, Nienhuis, Hilde H and Schröder, Carolien P (2014) Visualizing dual downregulation of IGF-1R and VEGF by Hsp90 inhibition effect in triple negative breast cancer. European Journal of Cancer, 50 (14). pp. 2508-2516. ISSN 09598049

Theofilopoulos, Spyrido, Griffiths, William, Crick, Peter, Yang, Shanzheng, Meljon, Anna, Ogundare, Michael, Kitambi, Satish, Lockhart, Andrew, Tuschl, Karin, Clayton, Peter, Morris, Andrew, Martinez, Adelaida, Reddy, Ashwin, Martinuzzi, Andrea, Bassi, Maria, Honda, Akira, Mizuochi, Tatsuki, Kimura, Akihiro, Nittono, Hiroshi, De Michele, Guiseppe, Carbone, Rosa, Criscuolo, Chiara, Yau, Joyce, Seckl, Jonathan, Schüle, Rebecca, Schöls, Ludger, Sailer, Andreas, Kuhle, Jens, Fraidakis, Matthew, Gustafsson, Jan-Ake, Steffensen, Knut, Björkhem, Ingemar, Ernfors, Patrik, Sjövall, Jan, Arenas, Ernest and Wang, Yuqin (2014) Identification of Cholestenoic acids that Regulate Motor Neuron Survival via Liver X Receptors. Journal of Clinical Investigation, 124 (11). pp. 4829-4842.

Thiruppathi, M, Sheng, JR, Li, L, Prabhakar, BS and Meriggioli, MN (2014) Recombinant IgG2a Fc (M045) multimers effectively suppress experimental autoimmune myasthenia gravis. Journal of Autoimmunity.

Thoma, EC, Merkl, C, Heckel, T, Haab, R, Knoflach, F, Nowaczyk, C, Flint, N, Jagasia, R, Jensen, ZS, Truong, HH, Petitjean, P, Jessberger, S, Graf, M and Iacone, R (2014) Chemical conversion of human fibroblasts into functional schwann cells. Stem Cell Reports. pp. 539-547.

Thoma, Gebhard, Blanz, Joachim, Drueckes, Peter, Kittelmann, Matthias, Smith, Alexander Baxter, Van Eis, Maurice, Vangrevelinghe, Eric, Zerwes, Hans-Guenter, Che, Jianwei, He, Xiaohui, Jin, Yunho, Lee, Christian, Michellys, Pierre, Uno, Tetsuo, Liu, Hong and Buehlmayer, Peter (2014) Novel Syk inhibitors with high potency in presence of blood. Bioorganic and Medicinal Chemistry Letters, 24. pp. 2278-2282.

Thoma, Gebhard, Drueckes, Peter and Zerwes, Hans-Guenter (2014) Selective inhibitors of the Janus Kinase Jak3 – are they effective? Bioorganic & Medicibal Chemistry Letters, 24 (19). pp. 4617-4621. ISSN 0960894X

Thompson, Joel, Nagel, Jane, Hoving, Sjouke, Gerrits, Bertran, Bauer, Andreas, Thomas, Jason, Kirschner, Marc, Schirle, Markus and Luchansky, Sarah (2014) Quantitative Lys-ϵ-Gly-Gly (diGly) Proteomics Coupled with Inducible RNAi Reveals Ubiquitin-mediated Proteolysis of DNA Damage-inducible Transcript 4 (DDIT4) by the E3 Ligase HUWE1. The Journal of Biological Chemistry, 289 (42). pp. 28942-28955. ISSN 0021-9258

Thomson, JP, Moggs, Jonathan, Wolf, RC and Meehan, RR (2014) Epigenetic profiles as defined signatures of xenobiotic exposure. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 764-76. pp. 3-9. ISSN 1879-3592

Thomson, John P, Moggs, Jonathan, Wolf, Roland and Meehan, Richard R (2014) Epigenetic profiles as defined signatures of xenobiotic exposure. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 764-76. pp. 3-9. ISSN 1879-3592

Tian, Y, Voineagu, I, Pasca, SP, Won, H, Chandran, V, Horvath, S, Dolmetsch, RE and Geschwind, DH (2014) Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome. Genome Medicine. 75, 2014-.

Timsit, Yoav and Negishi, Masahiko (2014) Coordinated regulation of nuclear receptor CAR by CCRP/DNAJC7, HSP70 and the ubiquitin-proteasome system. PLoS ONE, 9 (5). ISSN 1932-6203

Tocheva, AS, Mansour, S, Holt, RIG and Gadola, SD (2014) Qualitative differences in the iNKT repertoire of people with recent onset type 1 diabetes mellitus. Immunology. p. 132.

Toso, Alberto, Proietti, Michelle, Revandkar, Ajinkya, Zhang, Jiangwen, Guccini, Ilaria, Sarti, Manuela, Pinton, Sandra, Marini, Camilla, Scanziani, Eugenio, Catapano, Carlo, Pandolfi, Pier Paolo, Grassi, Fabio and Alimonti, Andrea (2014) Reactivation of senescence surveillance in Pten loss induced cellular senescence. Cell Reports.

Traeger, U, Andre, R, Lahiri, N, Magnusson-Lind, A, Weiss, A, Grueninger, S, McKinnon, C, Sirinathsinghji, E, Kahlon, S, Pfister, EL, Moser, R, Hummerich, H, Antoniou, M, Bates, GP, Luthi-Carter, R, Lowdell, MW, Bjoerkqvist, M, Ostroff, GR, Aronin, N and Tabrizi, SJ (2014) HTT-lowering reverses Huntington's disease immune dysfunction caused by NF kappa B pathway dysregulation. BRAIN. pp. 819-833.

Trager, U, Andre, R, Magnusson-Lind, A, Miller, JRC, Connolly, C, Weiss, A, Grueninger, S, Silajdzic, E, Smith, DL, Leavitt, BR, Bates, GP, Bjorkqvist, M and Tabrizi, SJ (2014) Characterisation of immune cell function in fragment and full-length Huntington's disease mouse models. Neurobiology of Disease. pp. 388-398.

Traggiai, Elisabetta, Volpi , Stefano , Walter , Jolan , Walker , Melissa and Sims , Katherine (2014) Powering the immune system: Mitochondria in immune function and deficiency. Journal of Immunology Research, 2014. ISSN 2314-7156

Tran, Que Tien, Pearlstein, Robert, Williams, Sarah, Reilly, John, Krucker, Thomas and Erdemli, Gul (2014) Structure-kinetic relationship of carbapenem antibacterials permeating through E. coli OmpC porin. Proteins: Structure, Function and Bioinformatics, 82 (11). pp. 2998-3012. ISSN 08873585

Tran, Que Tien, Pearlstein, Robert, Williams, Sarah, Reilly, John, Krucker, Thomas and Erdemli, Gul (2014) Structure-kinetic relationship of carbapenem antibacterials permeating through E. coli OmpC porin. Proteins: Structure, Function, and Bioinformatics, 82 (11). pp. 2998-3012. ISSN 1097-0134

Trifilieff, Estelle, Minetti, Giulia, Sheppard, Kelly-Ann, Hatakeyama, Shinji, Feige, Jerome, Ibebunjo, Chikwendu, Feige, Jerome, Morvan, Frederic, Hartmann, Steffen, Rivet, Helene, Koelbing, Claudia and Glass, David (2014) An Antibody Blocking Activin Receptors type II Induces Strong Skeletal Muscle Hypertrophy and Protects from Atrophy. Molecular and Cellular Biology.

Turner, Oliver, Morton, Dan, Sistare, Frank, Nambiar, Prashant, Zaher, Radi and Bower, Nancy (2014) Alternative Mouse Models for Future Cancer Risk Assessment. Toxicologic Pathology, 42 (5). pp. 1-8.

U

Ullrich, Thomas, Fernandes Gomes Dos Santos, Paulo Antonio, Perrone, Mark, Weiler, Sven, Keller, Hansjoerg, Sasmal, Sanjita, Boorgu, Venkatesham, Pasagadi, Srinivasu, Cheera, Srisailam, Rajagopalan, Sujatha , Bhumireddy, Archana, Shashikumar, Dhanya, Chelur, Shekar, Belliappa, Charamanna, Pandit, Chetan, Krishnamurthy, Narasimharao, Mukherjee, Subhendu, Ramanathan, Anuradha, Ghadiyaram, Chakshusmathi , Ramachandra, Murali, Lagu, Bharat and Bock, Mark G. (2014) 3-Alkoxy-pyrrolo[1,2-b]pyrazolines as novel selective androgen receptor modulators (SARMs) with physicochemical properties suitable for transdermal administration. Journal of Medicinal Chemistry, 57 (17). pp. 7396-7411. ISSN 0022-26231520-4804

Urban, Laszlo, Maciejewski, Mateusz, Lounkine, Eugen, Whitebread, Steven, Jenkins, Jeremy, Hamon, Jacques, Fekete, Alexander and Mueller, Patrick (2014) Translation of off-target effects: Prediction of ADRs by integrated experimental and computational approaches. Toxicology Research, 3 (6). pp. 433-444. ISSN 2045-452X2045-4538

Urban, Laszlo, Nagy, Istvan, Andreou, Annan and Sousa-Valente, Joao (2014) TRANSIENT RECEPTOR POTENTIAL ION CHANNELS IN PRIMARY SENSORY NEURONS AS TARGETS FOR NOVEL ANALGESICS. British Journal of Pharmacology, 171 (10). pp. 2508-2527. ISSN 00071188

V

Vaarhorst, Anika A M, Verhoeven, Aswin, Weller, Claudia M, Böhringer, Stefan, Göraler, Sibel, Meissner, Axel, Deelder, André M, Henneman, Peter, Gorgels, Anton P M, van den Brandt, Piet A, Schouten, Leo J, van Greevenbroek, Marleen M, Merry, Audrey H H, Verschuren, W M Monique, van den Maagdenberg, Arn M J M, van Dijk, Ko Willems, Isaacs, Aaron, Boomsma, Dorret, Oostra, Ben A, van Duijn, Cornelia M, Jukema, J Wouter, Boer, Jolanda M A, Feskens, Edith, Heijmans, Bastiaan T and Slagboom, P Eline (2014) A metabolomic profile is associated with the risk of incident coronary heart disease. American heart journal, 168 (1). 45-52.e7. ISSN 1097-6744; 0002-8703

Valastyan, Lynn (2014) Researchers Advance Protein-Protein Interactions as Small Molecule Drug Targets. SLAS advertising for Webinar series.

Van Looy, T, Wozniak, A, Floris, G, Sciot, R, Li, H, Van Leeuw, L, Fletcher, J, Manley, Paul W., Debiec-Rychter, M and Schöffski, P (2014) Phosphoinositide 3-kinase inhibitors combined with imatinib in patient-derived xenograft models of gastrointestinal stromal tumors: Rationale and efficacy. Clinical Cancer Research, 20 (23). pp. 6071-6082. ISSN 1557-3265

Vapurcuyan, Arpine, Hanna, Imad, Pelis, Ryan, Renfro, Larry, Ingraham, Leslie and Parker, Sonda (2014) A plasma concentration of α-ketoglutarate 1 influences the kinetic interaction of ligands with OAT1. Molecular Pharmacology.

Vaupel, Andrea, Bold, Guido, Valat, Therese-Marie, Kallen, Joerg, Masuya, Keiichi, Furet, Pascal, de Pover, Alain and Hergovich-Lisztwan, Joanna (2014) Tetra-substituted imidazoles as a new class of inhibitors of the p53-MDM2 interaction. Bioorganic and Medicinal Chemistry Letters, 24 (9). pp. 2110-2114. ISSN 0960894X

Velez-Vega, Camilo, Mckay, Daniel, Aravamuthan, Vibhas, Pearlstein, Robert and Duca, Jose (2014) Time-averaged distributions of solute and solvent motions: exploring proton wires of GFP and PfM2DH. Journal of chemical information and modeling, 54 (12). pp. 3344-3361. ISSN 1549-960X

Vidal, Solange, Clay, Ieuan, Ludwig, Marie-Gabrielle, Suply, Thomas and Seuwen, Klaus (2014) The G protein-coupled pH-sensing receptor OGR1 is a regulator of intestinal inflammation. IBD.

Vliegenthart, A, Starkey Lewis, P, Tucker, C, Del Pozo, J, Rider, S, Antoine, D, Dubost, Valerie, Westphal, Magdalena, Moulin, Pierre, Bailey, M, Moggs, Jonathan, Goldring, C, Park, K and Dear, J (2014) Retro-orbital blood acquisition facilitates circulating microRNA measurement in zebrafish with paracetamol hepatotoxicity. Zebrafish, 11 (3). pp. 219-226. ISSN 1557-8542

Von Lueder, TG, Wang, BH, Kompa, AR, Huang, L, Webb, R, Jordaan, P, Atar, D and Krum, H (2014) The Angiotensin-Receptor Neprilysin Inhibitor LCZ696 Attenuates Cardiac Remodeling and Dysfunction After Myocardial Infarction by Reducing Cardiac Fibrosis and Hypertrophy. Circ Heart Fail .

Vranesic, Ivan-Toma, Ofner, Silvio, Flor, Peter Josef, Bilbe, Graeme, Bouhelal, Rochdi, Enz, Albert, Desrayaud, Sandrine, Mcallister, Kevin, Kuhn, Rainer and Gasparini, Fabrizio (2014) AFQ056/Mavoglurant a novel clinically effective mGluR5 antagonist: Identification, SAR and pharmacological characterization. Bioorganic Medicinal Chemistry, 22 (21). pp. 5790-5803. ISSN 09680896

Vázquez-Gómeza, E, Arias, HR, Miranda-Morales, M, Mihailescu, S, Feuerbach, Dominik and García-Colunga, J (2014) Bupropion-induced inhibition of α7 nicotinic acetylcholine receptors expressed in heterologous cells, neurons from dorsal raphe nucleus and hippocampus. EuropeanJournalofPharmacology.

van, BM, Wilcken, R, McLaughlin, SH, Rutherford, TJ and Johnson, CM (2014) Structure of the SAS-6 cartwheel hub from Leishmania major. eLife.

van Dijk, KD, Bidinosti, M, Weiss, A, Raijmakers, P, Berendse, HW and van de Berg, WDJ (2014) Reduced alpha-synuclein levels in cerebrospinal fluid in Parkinson's disease are unrelated to clinical and imaging measures of disease severity. EUROPEAN JOURNAL OF NEUROLOGY. pp. 388-394.

van Vliet, Erwin, Danesian, Mardas, Beilmann, Mario, Davies, Anthony, Fava, Eugenio , Fleck, Roland, Julé, Yvon, Kansy, Manfred, Kustermann, Stefan, Macko, Peter, Mund, William, Roth, Adrian, Sachse, Christoph, Shah, Imran, Uteng, Marianne, van de Water, Bob, Hartung, Thomas and Leist, Marcel (2014) Current approaches and future role of high content imaging in safety sciences and drug discovery. Alternatives to Animal Experimentation (ALTEX).

von Blanckenburg, Friedhelm, Oelze, Marcus, Schmid, Dietmar, Moeller, Kirsten, Gschwind, Hans-Peter, Slade, Alan, Stitah, Sylvie, Kaufmann, Daniel and Swart, Pieter Jacob (2014) An iron stable isotope comparison between human erythrocytes and plasma. Metallomics, 6 (11). pp. 2052-2061. ISSN 1756591X

W

Wachtel, Marco, Rakic, Jelena, Okoniewski, Michal, Bode, Peter, Niggli, Felix and Beat W., Schäfer 1 (2014) FGFR-mediated anti-apoptotic signaling identifies novel subgroups in alveolar rhabdomyosarcoma. International journal of cancer, 135 (7). pp. 1543-1552. ISSN 00207136

Waldron, Levi, Riester, Markus and Birrer, Michael (2014) Molecular subtypes of high-grade serous ovarian cancer: the search goes on! JNCI J Natl Cancer Inst , 106 (10).

Walitza, S, Marinova, Z, Lazic, Stanley, Remschmidt, H, Herpertz-Dahlmann, B and Wendland, JR (2014) Trio study and meta-analysis support the association of genetic variation at the serotonin transporter with early-onset obsessive-compulsive disorder. Neuroscience Letters, 580. pp. 100-103. ISSN 03043940

Wang, Shirley, Olt, Sabine, Schoefmann, Nicole, Stuetz, Anton, Winiski, Anthony and Wolff-Winiski, Barbara (2014) SPINK5 knockdown in organotypic human skin culture as a model system for Netherton syndrome: effect of genetic inhibition of serine proteases. Experimental Dermatology, 23 (7). pp. 524-526.

Wassermann, AM (2014) Structure-activity relationship analysis on the basis of matched molecular pairs. J Cheminform , 6 (Suppl ). O14. ISSN 1758-2946

Wassermann, Anne, Lounkine, Eugen, Whitebread, Steven, Chen, Shanni, Hughes, Kevin, Guo, Hongqiu, Kutlina, Elena, Fekete, Alexander, Urban, Laszlo, Klumpp, Martin and Glick, Meir (2014) A Screening Pattern Recognition Method Finds New and Divergent Targets for Drugs and Natural Products. ACS Chemical Biology, 9 (7). pp. 1622-1631. ISSN 1554-89291554-8937

Weaver, Margaret (2014) Naphthoquine oral dose range finding study in the dog. This will be shared only with Kunming, not published..

Wegner, Malgorzata, Neddermann, Daniel, Piorunska-Stolzmann, Maria and Jagodzinski, Pawel (2014) Role of epigenetic mechanisms in the development of chronic complications of diabetes. Diabetes Research and Clinical Practice, 105 (2). pp. 164-175. ISSN 0168-8227

Wei, J, Freytag, M, Schober, Y, Nockher, WA, Mautner, VF, Friedrich, RE, Manley, PW, Kluwe, L and Kurtz, A (2014) Nilotinib is more potent than imatinib for treating plexiform neurofibroma in vitro and in vivo. PLoS ONE. e107760-.

Weidensteiner, Claudia, Allegrini, Peter Roland, Ferretti, Stephane Raymond and Mcsheehy, Paul M.J. (2014) Tumour T1 changes in vivo are highly predictive of response to chemotherapy and reflect the number of viable tumour cells. BMC cancer, 14. p. 88. ISSN 1471-2407

Weiler, S, Braendlin, N, Beerli, C, Bergsdorf, C, Schubart, A, Srinivas, H, Oberhauser, B and Billich, A (2014) Orally Active 7-Substituted (4-Benzylphthalazin-1-yl)-2-methylpiperazin-1-ylnicotinonitriles as Active-Site Inhibitors of Sphingosine 1-Phosphate Lyase for the Treatment of Multiple Sclerosis. Journal of Medicinal Chemistry. pp. 5074-5084.

Weiler, Sven, Braendlin, Nadine, Beerli, Christian, Bergsdorf, Christian, Schubart Wellensiek, Anna, Srinivas, Honnappa, Oberhauser, Berndt and Billich, Andreas (2014) Orally Active 7-Substituted (4-Benzyl-phthalazin-1-yl)-2-methyl-piperazin-1-yl]-nicotinonitriles as Active-site Inhibitors of Sphingosine-1-Phosphate Lyase for the Treatment of Multiple Sclerosis. Journal of Medicinal Chemistry, 57 (12). pp. 5074-5084. ISSN 0022-26231520-4804

Wendling, Thierry, Ogungbenro, Kayode, Pigeolet, Etienne, Dumitras, Swati, Woessner, Ralph and Aarons, Leon (2014) Model-based evaluation of the impact of formulation and food intake on the complex oral absorption of mavoglurant in healthy subjects. Pharmaceutical Research.

Westwood, AJ, Beiser, A, Decarli, C, Harris, TB, Chen, TC, He, XM, Roubenoff, R, Pikula, A, Au, R, Braverman, LE, Wolf, PA, Vasan, RS and Seshadri, S (2014) Insulin-like growth factor-1 and risk of Alzheimer dementia and brain atrophy. Neurology. pp. 1613-1619.

Whalen, EJ, Johnson, AK and Lewis, SJ (2014) Hemodynamic responses elicited by systemic injections of isotonic and hypertonic saline in hemorrhaged rats. Microvascular Research. pp. 22-29.

White, K, Dempsie, Y, Caruso, P, Wallace, E, McDonald, RA, Stevens, H, Hatley, ME, Van, RE, Morrell, NW, Maclean, MR and Baker, AH (2014) Endothelial apoptosis in pulmonary hypertension is controlled by a microRNA/programmed cell death 4/caspase-3 axis. Hypertension. pp. 185-194.

Willis, MS, Wadosky, KM, Rodriguez, JE, Schisler, JC, Lockyer, P, Hilliard, EG, Glass, DJ and Patterson, C (2014) Muscle ring finger 1 and muscle ring finger 2 are necessary but functionally redundant during developmental cardiac growth and regulate E2F1-mediated gene expression in vivo. Cell Biochemistry and Function. pp. 39-50.

Wilson, BG, Helming, KC, Wang, X, Kim, Y, Vazquez, F, Jagani, Z, Hahn, WC and Roberts, CWM (2014) Residual Complexes Containing SMARCA2 (BRM) Underlie the Oncogenic Drive of SMARCA4 (BRG1) Mutation. MOLECULAR AND CELLULAR BIOLOGY. pp. 1136-1144.

Winkler, Gian Christian, Lovsin Barle, Ester, Galati, Giuseppe and Kluwe, William (2014) Functional differentiation of cytotoxic cancer drugs and targeted cancer therapeutics. Regulatory Toxicology and Pharmacology, on lin.

Wong, matthew H, Xue, Aiqun, Julovi, Sohel M, Pavlakis, Nick, Samra, Jas S, Hugh, Thomas J, Gill, Anthony J, Peters, Lyndsay, Baxter, Robert C and Smith, Ross C (2014) NVP-BYL719, a novel PI3K-alpha selective inhibitor, overcomes acquired erlotinib resistance via upregulation of the PI3K/Akt/ mTOR pathway in pancreatic ductal adenocarcinoma. Clinical Cancer Research.

Worley, KC, Warren, WC, Rogers, J, Locke, D, Muzny, DM, Mardis, ER, Weinstock, GM, Tardif, SD, Aagaard, KM, Archidiacono, N, Arul, RN, Batzer, MA, Beal, K, Brejova, B, Capozzi, O, Capuano, SB, Casola, C, Chandrabose, MM, Cree, A, Diep, DM, De Jong, PJ, Cruz-Herrera del, RR, Delehaunty, KD, Dinh, HH, Eichler, EE, Fitzgerald, S, Flicek, P, Fontenot, CC, Fowler, RG, Fronick, C, Fulton, LA, Fulton, RS, Gabisi, RA, Gerlach, D, Graves, TA, Gunaratne, PH, Hahn, MW, Haig, D, Han, Y, Harris, RA, Herrero, J, Hillier, LW, Hubley, R, Hughes, JF, Hume, J, Jhangiani, SN, Jorde, LB, Joshi, V, Karakor, E, Konkel, MK, Kosiol, C, LKovar, C, Kriventseva, EV, Lee, SL, Lewis, LR, Liu, Y, Lopez, J, Lopez-Otin, C, Lorente-Galdos, B, Mansfield, KG, Marques-Bonet, T, Minx, P, Misceo, D, Moncrieff, JS, Morgan, MB, Nazareth, LV, Newsham, I, Nguyen, NB, Okwuonu, GO, Prabhakar, S, Perales, L, Pu, L, Puente, XS, Quesada, V, Ranck, MC, Raney, BJ, Raveendran, M, Deiros, DR, Rocchi, M, Rodriguez, D, Ross, C, Ruffier, M, Ruiz, SJ, Sajjadian, S, Santibanez, J, Schrider, DR, Searle, S, Skaletsky, H, Soibam, B, Smit, AFA, Tennakoon, JB, Tomaska, L, Ullmer, B, Vejnar, CE, Ventura, M, Vilella, AJ, Vinar, T, Vogel, J, Walker, JA, Wang, Q, Warner, CM, Wildman, DE, Witherspoon, DJ, Wright, RA, Wu, Y, Xiao, W, Xing, J, Zdobnov, EM, Zhu, B, Gibbs, RA and Wilson, RK (2014) The common marmoset genome provides insight into primate biology and evolution. Nature Genetics. pp. 850-857.

Wu, Bin, Guo, Fengfeng, Parmentier, Michael and Gallou, Fabrice (2014) Micelle enabled Hofmann Rearrangement in water. Organic process research & development. ISSN 1520-586X; 1083-6160

Wucher, Andreas, Tian, Hua and Winograd, Nicholas (2014) A Mixed Cluster Ion Beam to Enhance the Ionization Efficiency in Molecular Secondary Ion Mass Spectrometry. Rapid Communications in Mass Spectrometry, 28 (4). pp. 396-400. ISSN 1097-0231

X

Xia, B, Barve, A, Heimbach, T, Zhang, T, Gu, H, Wang, L, Einolf, H, Alexander, N, Hanna, I, Ke, J, Mangold, JB, He, H and Sunkara, G (2014) Physiologically based pharmacokinetic modeling for assessing the clinical drug-drug interaction of alisporivir. Eur J Pharm Sci . pp. 103-112.

Xiang, F, Murray, S and Liu, X (2014) Analysis of transplant urgency and benefit via multiple imputation. Stat Med .

Xie, Xuping, Lee, Le Tian, Chandrasekaran, Ramya, Reynaud, Aline, Wang, Qingyin, Dong, Hongping, Kang, Congbao, Yuan, Zhiming, Lescar, Julien and Shi, Pei-Yong (2014) Dimerization of flavivirus NS4B protein. Journal of Virology, 88 (6). pp. 3379-3391. ISSN 0022-538X

Xu, Haiyan, Shou, Jianyong and Li, En (2014) TET-catalyzed 5-methylcytosine hydroxylation is dynamically regulated by metabolites. Cell research, 24 (8). pp. 1017-1020. ISSN 1748-7838

Xu, T, Yang, L, Yan, C, Wang, X, Huang, P, Zhao, F, Zhao, L, Zhang, M, Jia, W, Wang, X and Liu, Y (2014) The IRE1alpha-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic beta-cells. Cell research.

Y

Yan, Jing-He, Meyers, Charles, Lee, Zachary, Danis, Kathryn, Neelakantham, Srikanth Raju, Majumdar, Tapan, Rebello, Sam, Sunkara, Gangadhar and Chen, Jin (2014) Pharmacokinetic and pharmacodynamic drug-drug interaction assessment between pradigastat and digoxin or warfarin. Journal of Clinical Pharmacology.

Yang, H, Lin, H, Xu, H, Zhang, L, Cheng, L, Wen, B, Shou, J, Guan, K, Xiong, Y and Ye, D (2014) TET-catalyzed 5-methylcytosine hydroxylation is dynamically regulated by metabolites. Cell Res .

Yang, H, Robinson, M, Corsa, AC, Peng, B, Cheng, G, Tian, Y, Wang, Y, Pakdaman, R, Shen, M, Qi, X, Mo, H, Tay, C, Krawczyk, S, Sheng, XC, Kim, CU, Yang, C and Delaney IV, WE (2014) Preclinical characterization of the novel hepatitis C virus NS3 protease inhibitor GS-9451. Antimicrobial Agents and Chemotherapy. pp. 647-653.

Yang, Ziping (2014) Recommendations for Validation of LC-MS/MS Bioanalytical Methods for Protein Biotherapeutics. The AAPS Journal.

Yilmazel, B, Hu, YH, Sigoillot, F, Smith, JA, Shamu, CE, Perrimon, N and Mohr, SE (2014) Online GESS: prediction of miRNA-like off-target effects in large-scale RNAi screen data by seed region analysis. Bmc Bioinformatics.

Yu, DX, Di Giorgio, FP, Yao, J, Marchetto, MC, Brennand, K, Wright, R, Mei, A, McHenry, L, Lisuk, D, Grasmick, JM, Silberman, P, Silberman, G, Jappelli, R and Gage, FH (2014) Modeling hippocampal neurogenesis using human pluripotent stem cells. Stem Cell Reports. pp. 295-310.

Yu, J, Sun, H, Pang, M, Chuang, W, Sarin, SK, Flisiak, R and Stein, DS (2014) Population pharmacokinetics and pharmacodynamics of albinterferon alfa-2b in patients treated for hepatitis C virus genotype 2/3. Anti-Infective Agents. pp. 58-67.

Yun Shan, Goh, Necchi, Francesca, O'Shaughnessy, Colette, Micoli, Francesca, Gavini, Massimiliano, Msefula, Chisomo, Gondwe, Esther, Mandala, Wilson, Gordon, Melita, Saul, Allan James and Maclennan, Calman Alexander (2014) HIV-associated bactericidal and inhibitory immunity to Salmonella in Africans. Journal of Immunology.

Z

Zeiger, Errol , Gollapudi, Bhaskar, Aardema , Marilyn , Auerbach, Scott , Boverhof, Darrell, Custer, Laura, Dedon, Peter, Honma, Masamitsu, Ishida, Seiichi, Kasinski, Andrea, Kim, James, Manjanatha, Mugimane, Marlowe, Jenny, Pfuhler, Stefan, Pogribny, Igor, Slikker, William, Stankowski, Leon, Tanir, Jennifer, Tice, Raymond, van Benthem, Jan , White, Paul, Witt, Kristine and Thybaud, Veronique (2014) Genetic Toxicology: Opportunities to Integrate New Approaches. Environmental and Molecular Mutagenesis.

Zhang, JG, Ho, T, Callendrello, AL, Clark, RJ, Santone, EA, Kinsman, S, Xiao, D, Fox, LG, Einolf, HJ and Stresser, DM (2014) Evaluation of Calibration Curve-Based Approaches to Predict Clinical Inducers and Noninducers of CYP3A4 with Plated Human Hepatocytes. Drug Metab Dispos . pp. 1379-1391.

Zhang, Xian, Parker, Christian and Abraham, Yann (2014) Multiparametric Analysis of Screening Data: Growing Beyond the Single Dimension. Journal of Biomolecular Screening, 19 (5). pp. 628-639.

Zhang, Y, Chen, MH, Ibrahim, JG, Zeng, D, Chen, Q, Pan, Z and Xue, X (2014) Bayesian gamma frailty models for survival data with semi-competing risks and treatment switching. Lifetime Data Analysis. pp. 76-105.

Zhang, Yi-Xiang, Sicinska, Ewa, Czaplinski , Jeffrey, Remillard, Stephen, Moss, Samuel, Wang, Yuchuan, Brain, Christopher, Loo, Alice, Snyder, Eric, Demetri, George, Kim, Sunkyu, Kung, Andrew and Wagner, Andrew (2014) Antiproliferative effects of CDK4/6 inhibition in CDK4-amplified human liposarcoma in vitro and in vivo. Molecular Therapeutics.

Zhao, Nan, Zhao, Xia, Xu, Junyu, Zhao, Rong and Cui, Yimin (2014) 单次和多次口服氟伐他汀钠缓释片与速释胶囊人体药动学对比研究. The Chinese Journal of Clinical Pharmacology.

Zhou, Enhua, Watson, Christa, Pizzo, Richard , Cohen, Joel , Dang, Quynh , de Barros, Pedro Macul Ferreira, Park, Chan Young , Chen, Cheng , Brain, Joseph D. , Butler, James P. , Ruberti, Jeffrey W. , Fredberg, Jeffrey J. and Demokritou, Philip (2014) Assessing the impact of engineered nanoparticles on wound healing using a novel in-vitro bioassay. Nanomedicine, 9 (18). pp. 2803-2815. ISSN 1743-58891748-6963

Zhou,, Penghui, Shaffer, Donald, Alvarez Arias, Diana A., Nakazaki,, Yukoh, Pos, Wouter, Torres, Alexis J., Cremasco, Viviana, Dougan, Stephanie K., Cowley, Glenn S., Elpek, Kutlu, Brogdon, Jennifer, Lamb, John, Ploegh, Hidde L., Root, David E., Love, Christopher, Dranoff, Glenn, Hacohen, Nir, Cantor, Harvey and Wucherpfennig, Kai W. (2014) In vivo Discovery of Immunotherapy Targets in the Tumor Microenvironment. Nature.

Zhu, J, Davoli, T, Perriera, JM, Chin, CR, Gaiha, GD, John, SP, Sigiollot, FD, Gao, G, Xu, Q, Qu, H, Pertel, T, Sims, JS, Smith, JA, Baker, RE, Maranda, L, Ng, A, Elledge, SJ and Brass, AL (2014) Comprehensive Identification of Host Modulators of HIV-1 Replication using Multiple Orthologous RNAi Reagents. Cell Reports. pp. 752-766.

Zimmermann, MO, Lange, A, Wilcken, R, Cieslik, MB, Exner, TE, Joerger, AC, Koch, P and Boeckler, FM (2014) Halogen-enriched fragment libraries as chemical probes for harnessing halogen bonding in fragment-based lead discovery. Future Medicinal Chemistry. pp. 617-639.

Zollinger, Markus, Lozac'H, Frederic, Hurh, Eunju, Emotte, Corinne, Bauly, Hounayda and Swart, Pieter Jacob (2014) Absorption, distribution, metabolism, and excretion (ADME) of 14C-sonidegib (LDE225) in healthy volunteers. Cancer Chemotherapy and Pharmacology, 74 (1). pp. 63-75. ISSN 1432-0843