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Aguiar, Carla J and Rocha-Franco, Joao A and Souza, Pedro A and Santos, Anderson K and Ladeira, Marina and Rocha-Resende, Cibele and Ladeira, Luis O and Resende, Rodrigo R and Botoni, Fernando A and Barrouin Melo, Marcos and Lima, Cristiano X and Carballido, Jose and Cunha, Thiago M and Menezes, Gustavo B and Guatimosim, Silvia and Leite, M Fatima (2014) SUCCINATE CAUSES CARDIOMYOCYTE HYPERTROPHY THROUGH GPR91 ACTIVATION. Cell Communication and Signaling.

Ahene, A and Calonder, C and Davis, S and Kowalchick, J and Nakamura, T and Nouri, P and Vostiar, I and Wang, Y and Wang, J (2014) Automation practices in large molecule bioanalysis: Recommendations from group l5 of the global bioanalytical consortium. AAPS journal. pp. 164-171.

Akkus, Funda and Terbeck, Sylvia and Ametamey, Simon/M and Rufer, Michael and Treyer, Valerie and Burger, Cyrill and Johayem, Annas and Gomez-Mancilla, Baltazar and Sovago, Judit and Buck, Alfred and Hasler, Gregor (2014) Metabotropic Glutamate Receptor 5 Binding in Patients with Obsessive-Compulsive Disorder. International Journal of Neuropsychopharmacology.

Alper, Phillip and Epple, Robert (2014) Discovery of structurally novel, potent and orally efficacious GPR119 agonists. Bioorganic and Medicinal Chemistry Letters, 24 (10). pp. 2383-2387. ISSN 1464-3405

Amato, Anthony A and Sivakumar, Kumaraswamy and Goyal, Namita and David, William S and Salajegheh, Mohammad and Praestgaard, Jens and Trifilieff, Estelle and Trendelenburg, Anne-Ulrike and Laurent, Didier and Glass, David and Roubenoff, Ronenn and Tseng, Brian and Greenberg, Steven A (2014) Treatment of sporadic inclusion body myositis with bimagrumab. Neurology, 83 (24). pp. 2239-2246. ISSN 1526-632X

Ando, Yuichi and Inada-inoue, Megumi and Mitsuma, Ayako and Yoshino, Takayuki and Ohtsu, Atsushi and Noumi, Naoko and Sato, Masahiko and Kakizume, Tomoyuki and Robson, Matthew and Quadt, Cornelia and Doi, Toshihiko (2014) A Phase I dose-escalation study of buparlisib (BKM120), an oral pan-class I PI3K inhibitor, in Japanese patients with advanced solid tumors. Cancer Science, 105 (3). pp. 347-353.

Antczak, Christophe and Somalinga, Balajee and Djaballah, Hakim (2014) Heat shock proteins: A high content assay opportunity to measure cellular stress response. European Drug Target Review.

Arias, Hugo R and Feuerbach, Dominik and Targowska-Duda, Katarzyna M and Kaczor, Agnieszka A and Poso, Antti and Jozwiak, Krzysztof (2014) Pharmacological and molecular studies on the interaction of varenicline with different nicotinic acetylcholine receptor subtypes. Potential mechanism underlying partial agonism at human 42 and 34 subtypes. Biochimica et Biophysica Acta.

Arm, Jonathan and Bottoli, Ivan and Skerjanec, Andrej and Groenewegen, Andrea and Maahs, Suzanne and Owen, Charles and Jones, Ieuan and Lowe, Phil (2014) Efficacy and safety of QGE031, a novel anti-IgE antibody, in atopic subjects. Clinical and Experimental Allergy, 44 (11). pp. 1371-1385.

Arnold, Nicola and Beattie, David and Bradley, Michelle and Brearley, Andrew and Brown, Lyndon and Charlton, Steven and Farr, David Colin and Fozard, John R. and Fullerton, Joe and Gosling, Martin and Hatto, Julia and Janus, Diana and Jones, Darryl and Jordan, Lynne and Lewis, Christine and Maas, Janet and Mercer, Mark and Oakman, Helen and Press, Neil and Profit, Rachael and Schuerch, Friedrich and Sykes, David and Taylor, Roger and Trifilieff, Alexandre and Tuffnell, Andrew and Mccarthy, Clive (2014) The identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone as an inhaled long-acting beta2-adrenoceptor agonist. Bioorganic and Medicinal Chemistry Letters, 24. pp. 4341-4347.

Aronchik, Ida and Appleton, Brent and Basham, Stephen and Crawford, Kenneth and Del Rosario, Merci and Doyle, Laura and Estacio, William and Lindvall, Mika and Luu, Catherine and Venetsanakos, Eleni and Shafer, Cynthia and Jefferson, A.B. (2014) Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancers. Molecular Cancer Research, 12 (5). pp. 803-812. ISSN 1557-3125

Aronchik, Ida and Appleton, Brent and Basham, Stephen and Crawford, Kenneth and Del Rosario, Merci and Doyle, Laura and Estacio, William and Lindvall, Mika and Luu, Catherine and Venetsanakos, Eleni and Shafer, Cynthia and Jefferson, A.B. (2014) Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancers. Molecular Cancer Research, 12 (5). pp. 803-812. ISSN 1557-3125

Auberson, Yves and Troxler, Thomas J. and Zhang, Xuechun and Yang, Charles and Fendt, Markus and Feuerbach, Dominik and Liu, Yu-Chih and Lagu, Bharat and Lerchner, Andreas and Perrone, Mark and Lei, Lijun and Zhang, Chao and Wang, Chunxiu and Wang, Tie-Lin and Bock, Mark (2014) Ergoline-derived Inverse Agonists of the Human H3-Receptor for the Treatment of Narcolepsy. ChemMedChem. ISSN 18607179

Auberson, Yves and Troxler, Thomas J. and Zhang, Xuechun and Yang, Charles and Feuerbach, Dominik and Liu, Yu-Chih and Lagu, Bharat and Perrone, Mark and Lei, Lijun and Shen, Xiaoxia and Zhang, Dushan and Wang, Chunxiu and Wang, Tie-Lin and Bock, Mark (2014) From Ergolines to Indoles: Improved Inhibitors of the Human H3-Receptor for the Treatment of Narcolepsy. ChemMedChem, 10 (2). pp. 266-275. ISSN 18607179

Auld, Douglas (2014) October Literature Search and Review. Assay and Drug Development Technologies. ASSAY and Drug Development Technologies.

Auld, Douglas (2014) September Literature Search and Review. Assay and Drug Development Technologies. Assays and Drug Development Technologies.

Auld, Douglas and Hill, William and Orme, Jonathon (2014) Examining Ligand-based Stabilization of Proteins in Cells with MEK1 Kinase Inhibitors. Assay Drug Development Technologies, 13 (5). pp. 266-276. ISSN 1540-658X1557-8127

Auld, Douglas and Hill, William and Smith, Thomas and Zhang, Ji and Kang, Zhao Bin and Ho, Pei-I and Ardayfio, Ophelia and Bowes, Scott (2014) Applications of quantitative HTS (qHTS) to facilitate assay pilot testing. Journal of Biomolecular Screening, 19 (5). pp. 651-660. ISSN 1087-05711552-454X

Austin, Steven and Dunstan, David and Reilly, John and Wall, Daniel and Ek, Jared and Mckinnon, Michael (2014) The Implementation of Spotfire to Analyze Open-Access Instrumentation Metrics. Chromatography Today, Aug-Se. pp. 2-4.

Avchalumov, Yosef and Sander, Svenja and Porath, Katrin and Hamann, Melanie and Richter, Franziska and Kirschstein, Timo and Köhling, Rüdiger and Richter, Angelika (2014) Role of striatal NMDA receptor subunits in a model of paroxysmal dystonia. Experimental Neurology, 261. pp. 677-684. ISSN 00144886

Azimioara, Mihai and Epple, Robert and Alper, Phillip and Cow, Christopher and Mutnick, Daniel and Nikulin, Victor and Lelais, Gerald and Mcneill, Matthew and Michellys, Pierre and Wang, Zhiliang and Li, Jing and Bao, Dingjiu and Zoll, Jocelyn and Kim, Young and Zimmerman, Matthew and Groessl, Todd and Tuntland, Tove and Mcnamara, Peter and Seidel, Martin and Joseph, Sean and Mecom, John and Reding, Esther and Paliotti, Michael (2014) Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists. Bioorganic and Medicinal Chemistry Letters, 24 (23). pp. 5478-5483. ISSN 1464-3405


Bachelier, Richard and Confavreux, Cyrille and Goehring, Delphine and van der Pluijm, Gabri and Clezardin, Philippe and Carmeli, Yael (2014) Combination of Antiangiogenic Therapies Reduces Osteolysis and Tumor Burden in Experimental Breast Cancer Bone Metastasis. International journal of cancer, 135 (6). pp. 1319-1329. ISSN 1097-0215

Baertschi, Stefan and Baur, Nina and Lueders-Lefevre, Valerie and Voshol, Johannes and Keller, Hansjoerg (2014) Class I and IIa Histone Deacetylases Have Opposite Effects on Sclerostin Gene Regulation. Journal of Biological Chemistry.

Barnes, David and Boiselle, Carri and Chopra, Rajiv and Hoffmaster, Keith and Kato, Mitsunori and Lin, Kai and Pan, Guoyu and Zheng, Rui and Shu, Lei and Ma, Sue and Wang, Jianling and Whiteman, Leah and Xu, Mei and Fu, Jiping (2014) Design and synthesis of lactam-thiophene carboxylic acids as potent hepatitis C virus polymerase inhibitors. Bioorganic & Medicinal Chemistry Letters, 24 (16). pp. 3979-3985. ISSN 0960894X

Barone, Eugenio and Mosser, Sebastien and Frearing, Patrick C (2014) Cofilin-1 activity is modulated by age, Alzheimer's disease pathology and gamma secretase. Biochim Biophys Acta, 1842 (12 Pt ). pp. 2500-2509.

Baskin, KK and Rodriguez, MR and Kansara, S and Chen, W and Carranza, S and Frazier, OH and Glass, DJ and Taegtmeyer, H (2014) MAFbx/Atrogin-1 is required for atrophic remodeling of the unloaded heart. Journal of Molecular and Cellular Cardiology. pp. 168-176.

Bassilana, Frederic and Carlson, Adam and Dasilva, Jennifer and Grosshans, Bianka and Vidal, Solange and Beck, Valerie and Wilmering Wetter, Barbara and Llamas, Luis and Bourret, Aaron and Wu, Xu and Harbinski, Fred and Ruffner, Heinz and Grandi, Paola and Schirle, Markus and Jenkins, Jeremy and Bouwmeester, Antonius and Porter, Jeffrey and Myer, Vic and Finan, Peter and Tallarico, John and Kelleher Iii, Joseph and Seuwen, Klaus and Jain, Rishi and Luchansky, Sarah (2014) Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39. Nature Chemical Biology, 10 (5). pp. 343-349. ISSN 1552-4469

Bauer, Daniel and Averett, Lacey A and De Smedt, Ann and Kleinman, Mark H and Muster, Wolfgang and Pettersen, Betty A and Robles, Catherine (2014) Standardized UV-vis spectra as the foundation for a threshold-based, integrated photosafety evaluation. Regulatory Toxicology and Pharmacology, 68 (1). pp. 70-75. ISSN 02732300

Beale, J and Jayaraman, A and Jackson, DJ and Macintyre, JD and Edwards, MR and Walton, RP and Zhu, J and Ching, YM and Shamji, B and Edwards, M and Westwick, J and Cousins, DJ and Hwang, YY and McKenzie, A and Johnston, SL and Bartlett, NW (2014) Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation. Science Translational Medicine. 256ra134-.

Beck, Jeremy and Springer, Clayton (2014) Quantitative structure-activity relationship models of chemical transformations from matched pairs analyses. Journal of chemical information and modeling, 54 (4). pp. 1226-1234. ISSN 1549-960X

Becker, Dieter and Zhang, Jin and Heimbach, Tycho and Kulmatycki, Kenneth and Shimizu, Jeff and Dole, Kiran and He, Handan and Wanke, Christoph (2014) Novel orally swallowable IntelliCap(®) device to quantify regional drug absorption in human GI tract using diltiazem as model drug. AAPS PharmSciTech, 15 (6). pp. 1490-1497. ISSN 1530-9932

Bell, RE and Khaled, M and Netanely, D and Schubert, S and Golan, T and Buxbaum, A and Janas, MM and Postolsky, B and Goldberg, MS and Shamir, R and Levy, C (2014) Transcription factor/microRNA axis blocks melanoma invasion program by miR-211 targeting NUAK1. Journal of Investigative Dermatology. pp. 441-451.

Berghausen, Joerg and Faller, Bernard (2014) Diagnosing solubility limitations – the example of hydrate formation (revised). ADMET & DMPK.

Bernat, Viachaslau and Brox, Regine and Heinrich, Markus and Auberson, Yves and Tschammer, Nuska (2014) Ligand biased and probe-dependent modulation of the chemokine receptor CXCR3 signaling by negative allosteric modulators. ChemMedChem, 10 (3). pp. 566-574. ISSN 18607179

Bhinder, B and Antczak, C and Shum, D and Radu, C and Mahida, JP and Liu-Sullivan, N and Ibanez, G and Raja, BS and Calder, PA and Djaballah, H (2014) Chemical & RNAi screening at MSKCC: A collaborative platform to discover & repurpose drugs to fight disease. Combinatorial Chemistry and High Throughput Screening. pp. 298-318.

Bhinder, Bhavneet and Antczak, Christophe and Shum, David and Radu, Constantin and Mahida, Jeni and Liu-Sullivan, Nancy and Ibanez, Glorymar and Somalinga Raja, Balajee and Calder, Paul and Djaballah, Hakim (2014) Chemical & RNAi Screening at MSKCC: A Collaborative Platform to Discover & Repurpose Drugs to Fight Disease. Combinatorial Chemistry & High Throughput Screening, 17 (4). pp. 298-318. ISSN 1875-5402

Bialek, P and Parkington, J and Li, X and Gavin, D and Wallace, C and Zhang, J and Root, A and Yan, G and Warner, L and Seeherman, HJ and Yaworsky, PJ (2014) A myostatin and activin decoy receptor enhances bone formation in mice. Bone. pp. 162-171.

Bigaud, Marc and Guerini, Danilo and Billich, Andreas and Bassilana, Frederic and Brinkmann, Volker (2014) Second generation S1P receptor modulators: Research strategies and clinical developments. Biochimica et Biophysica Acta - Molecular and cell Biology of lipids, 1841 (5). pp. 754-758. ISSN 1388-1981

Bill, A and Popa, MO and van Diepen, MT and Gutierrez, A and Lilley, S and Velkova, M and Acheson, K and Choudhury, H and Renaud, NA and Auld, DS and Gosling, M and Groot-Kormelink, PJ and Gaither, LA (2014) Variomics screen identifies the reentrant loop of the calcium-activated chloride channel ANO1 that facilitates channel activation. Journal of Biological Chemistry .

Bin, Huang and Tanja, Lucas and Claudia, Küppers and Xiaomin, Dong and Maike, Krause and Alexander, Bepperling and Johannes, Buchner and Voshol, Johannes and Andreas, Weiss and Gerrits, Bertran and Stefan, Kochanek (2014) Scalable production of full-length normal and mutant huntingtin in human cells and its biochemical characterization. PLOS ONE.

Blackford, J and Brimacombe, KR and Dougherty, EJ and Pradhan, M and Shen, M and Li, Z and Auld, DS and Chow, CC and Austin, CP and Stoney, S (2014) Research resource: Modulators of glucocorticoid receptor activity identified by a new high-throughput screening assay. Molecular Endocrinology. pp. 1194-1206.

Blasco, Francesca and Fu, Yilong and Chen, Yen Liang and Herve, Maxime Marcel and Gu, Feng and Shi, Pei-Yong (2014) Development of a FACS-based assay for evaluating antiviral potency of compound in dengue infected peripheral blood mononuclear cells. Journal of Virological Methods, 196. pp. 18-24. ISSN 1879-0984

Boettcher, Andreas and Gradoux, Nathalie and Lorthiois, Edwige and Brandl, Trixi and Orain, David and Schiering, Nikolaus and Cumin, Frederic and Woelcke, Julian and Hassiepen, Ulrich (2014) Fluorescence Lifetime-based Competitive Binding Assays for Measuring the Binding Potency of Protease Inhibitors In Vitro. Journal of Biochemical Screening, 19 (6). pp. 870-877. ISSN 1087-05711552-454X

Bonapace, Laura and coissieux, marie-may and wyckoff, jeffrey and Mertz, Kirsten D. and Varga, Zsuzsanna and Junt, Tobias and Bentires-Alj, Mohamed (2014) Discontinuation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis. Nature, 515 (7525). pp. 130-133.

Bonapace, Laura and wyckoff, Jeffrey and Mertz, Kirsten D. and Varga, Zsuzsanna and coissieux, marie-may and Junt, Tobias and Bentires-Alj, Mohamed (2014) Cessation of CCL2 Inhibition Precipitates Breast Cancer Metastases and Death. Nature.

Bots, M and Verbrugge, I and Martin, BP and Salmon, JM and Ghisi, M and Baker, A and Stanley, K and Shortt, J and Ossenkoppele, GJ and Zuber, J and Rappaport, AR and Atadja, P and Lowe, SW and Johnstone, RW (2014) Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors. Blood. pp. 1341-1352.

Boudon, Stephanie Marie and Morandi, Gregory and Prideaux, Brendan and Staab, Dieter and Junker Walker, Ursula and Odermatt, Alex and Stoeckli, Markus and Bauer, Daniel (2014) EVALUATION OF SPARFLOXACIN PHOTOTOXICITY USING MASS SPECTROMETRY IMAGING. Journal of the American Society for Mass Spectrometry, 25 (10). pp. 1803-1809. ISSN 1879-1123

Boudon, Stephanie Marie and Plappert Helbig, Ulla and Odermatt, Alex and Bauer, Daniel (2014) CHARACTERIZATION OF VEMURAFENIB PHOTOTOXICITY IN A MOUSE MODEL. Toxicological Sciences, 137 (1). pp. 259-267. ISSN 1096-60801096-0929

Boudreaux, Ramon D and Perticone, Jacqueline I and Ellman, Rachel and Lenfest, Scott E and Bloomfield, Susan A and Hogan, Harry A (2014) Sequential High-Impact Loading and Zoledronic Acid Before Hindlimb Unloading Protects Against Decrements in Bone Microarchitecture and Strength. Published Thesis:

Bourgailh, Julien and Garnier, Maxime and Nufer, Robert and Pirard, Hans and Walles, Markus and Swart, Pieter Jacob (2014) ViewLux Microplate Imager for Metabolite Profiling: Validation and Applications in Drug Development. J Anal Bioanal Tech.

Boutouyrie-Dumont, B (2014) How to link biomarkers using physiologically based pharmacokinetic models. Biomarkers in Medicine. p. 74.

Boutouyrie-Dumont, B (2014) An IL-17-mediated paracrine network promotes tumor resistance to antiangiogenic therapy. Biomarkers in Medicine. p. 73.

Boutouyrie-Dumont, B (2014) A new biomarker to identify high-risk renal transplant patients. Biomarkers in Medicine. p. 75.

Boutouyrie-Dumont, Bruno (2014) How to link biomarkers using physiologically based pharmacokinetic models. Biomarkers in Medicine, 8 (1). pp. 73-75. ISSN 1752-0363

Boutouyrie-Dumont, Bruno (2014) An IL-17-mediated paracrine network promotes tumor resistance to antiangiogenic therapy. Biomarkers in Medicine, 8 (1). pp. 73-75. ISSN 1752-0363

Boutouyrie-Dumont, Bruno (2014) A new biomarker to identify high-risk renal transplant patients. Biomarkers in Medicine, 8 (1). pp. 73-75. ISSN 1752-0363

Boyce, SE and Tirunagari, N and Niedziela-Majka, A and Perry, J and Wong, M and Kan, E and Lagpacan, L and Barauskas, O and Hung, M and Fenaux, M and Appleby, T and Watkins, WJ and Schmitz, U and Sakowicz, R (2014) Structural and regulatory elements of HCV NS5B polymerase - beta-loop and C-terminal tail - Are required for activity of allosteric thumb site II inhibitors. PLoS ONE.

Breitschaft, A and Hu, K and Darstein, C and Ligueros-Saylan, M and Jordaan, P and Song, D and Hudson, M and Shah, R (2014) Effects of Subcutaneous Pasireotide on Cardiac Repolarization in Healthy Volunteers: A Single-Center, Phase I, Randomized, Four-Way Crossover Study. JOURNAL OF CLINICAL PHARMACOLOGY. pp. 75-86.

Brennan, MA and Gleeson, JP and O'Brien, FJ and McNamara, LM (2014) Effects of Ageing, Prolonged Estrogen Deficiency and Zoledronate on Bone Tissue Mineral Distribution. Journal of the Mechanical Behavior of Biomedical Materials, 29. pp. 161-170.

Briegel, A and Wong, ML and Hodges, HL and Oikonomou, CM and Piasta, KN and Harris, MJ and Fowler, DJ and Thompson, LK and Falke, JJ and Kiessling, LL and Jensen, GJ (2014) New insights into bacterial chemoreceptor array structure and assembly from electron cryotomography. Biochemistry. pp. 1575-1585.

Briggs, Katharine and Barber, Chris and Cases, Montse and Marc, Philippe and Steger-Hartmann, Thomas (2014) Value of shared preclinical safety studies – the eTOX database. Toxicology Reports.

Brigida, I and Sauer, AV and Ferrua, F and Giannelli, S and Scaramuzza, S and Pistoia, V and Castiello, MC and Barendregt, BH and Cicalese, MP and Casiraghi, M and Brombin, C and Puck, J and Muller, K and Notarangelo, LD and Montin, D and Van Montfrans, JM and Roncarolo, MG and Traggiai, E and Van Dongen, JJM and Van Der Burg, M and Aiuti, A (2014) B-cell development and functions and therapeutic options in adenosine deaminase-deficient patients. Journal of Allergy and Clinical Immunology. pp. 799-806.

Bulliard, Yannick and Zhang, Jimin and Jolicoeur, Rose and Brogdon, Jennifer and Dranoff, Glenn and Wilson, Nicholas (2014) OX86 mediates depletion of OX40-expressing intratumoral regulatory T cells through Fc receptor co-engagement, leading to potent anti-tumor efficacy. OX40 engagement depletes intratumoral Tregs via activating FcγRs, leading to antitumor efficacy. pp. 1-6.

Bunzendahl, Sina and Basler, Anne and Kneuer, Rainer and Babu, Suresh (2014) Characterization of Small Immunoconjugates (< 40 kDa) Using Capillary Electrophoresis–Mass Spectrometry. Agilent Application Note .

Bush, CO and Pokrovskii, MV and Saito, R and Morganelli, P and Canales, E and Clarke, MO and Lazerwith, SE and Golde, J and Reid, BG and Babaoglu, K and Pagratis, N and Zhong, W and Delaney, WE and Paulson, MS and Beran, RKF (2014) A small-Molecule inhibitor of hepatitis C virus infectivity. Antimicrobial Agents and Chemotherapy. pp. 386-396.

Bushee, JL and Dunne, CE and Argikar, UA (2014) An in vitro approach to investigate ocular metabolism of a topical, selective beta1-adrenergic blocking agent, betaxolol. Xenobiotica. pp. 1-10.

Bushee, Jennifer and Liang, Guiqing and Dunne, Christine and Harriman, Shawn and Argikar, Upendra (2014) Identification of saturated and unsaturated fatty acids as microsomal degradation by-products by direct high resolution -ESI-MS/MS. Xenobiotica.

Butcher, Joshua and Stanley, Shyla and Brooks, Steven and Chantler, Paul and Wu, Fan and Frisbee, Jefferson (2014) IMPACT OF INCREASED INTRAMUSCULAR PERFUSION HETEROGENEITY ON SKELETAL MUSCLE MICROVASCULAR HEMATOCRIT IN THE METABOLIC SYNDROME. Microcirculation, 21 (8). pp. 677-687.


Cahill, JF and Darlington, TK and Wang, X and Mayer, J and Spencer, MT and Holecek, JC and Reed, BE and Prather, KA (2014) Development of a High-Pressure Aerodynamic Lens for Focusing Large Particles (4-10 mu m) into the Aerosol Time-of-Flight Mass Spectrometer. Aerosol Science and Technology. pp. 948-956.

Cai, Xinming and Xu, Yongyao and Kim, You-Me and Loureiro, Joe and Huang, Qian (2014) PIKfyve, a class III lipid kinase, is required for TLR-induced Type i IFN production via modulation of ATF3. Journal of Immunology, 192 (7). pp. 3383-3389. ISSN 1550-6606

Cao, F and Townsend, EC and Karatas, H and Xu, J and Li, L and Lee, S and Liu, L and Chen, Y and Ouillette, P and Zhu, J and Hess, JL and Atadja, P and Lei, M and Qin, ZS and Malek, S and Wang, S and Dou, Y (2014) Targeting MLL1 H3K4 Methyltransferase Activity in Mixed-Lineage Leukemia. MOLECULAR CELL. pp. 247-261.

Cao, James and Ying, Xiaoyou and Beyer, Bruce K. and Delise, Anthony (2014) The use of optical imaging to assess the potential for embryo-fetal exposure to an exogenous material after intravaginal administration. Reproductive Toxicology, 48. pp. 138-147.

Carnemolla, A and Labbadia, JP and Lazell, H and Neueder, A and Moussaoui, S and Bates, GP (2014) Contesting the dogma of an age-related heat shock response impairment: implications for cardiac-specific age-related disorders. Hum Mol Genet . pp. 3641-3656.

Carter, Edward and Miron-Buchacra, G. and Goldoni, Silvia and Danahay, Henry and Westwick , John and Watson, M.L. and Tosh, David and Ward, Stephen (2014) Phosphoinositide 3-kinase alpha-dependent regulation of branching morphogenesis in murine embryonic lung: evidence for a role in determining morphogenic properties of FGF7. PLOS ONE.

Casas, J and Brzostek, J and Zarnitsyna, V and Hong, JS and Hoerter, J and Ampudia, J and Zamoyska, R and Zhu, C and Gascoigne, N (2014) Ligand engaged TCR is triggered by active Lck not associated with coreceptor. Nature Communications.

Cases, Montse and Briggs, Katharine and Steger-Hartmann, Thomas and Pognan, Francois and Marc, Philippe and Kleinöder, Thomas and Schwab, Christof H. and Pastor, Manuel and Wichard, Joerg and Sanz, Ferran (2014) The eTOX data-sharing project to advance in silico drug-induced toxicity prediction. International Journal of Molecular Sciences, 15 (11). pp. 21136-21154.

Cavadini, Simone and Fischer, Eric and Goldie, Kenneth and Bohm, Kerstin and Lingaraju Gondichatnahalli, Manjappa and Jones, Matthew and Bunker, Richard and Faty, Mahamadou and Tichkule, Ritesh and Patelic, Radosav and Mohamed, Weaam and Hassiepen, Ulrich and Beckwith, Rohan and Stahlberg, Henning and Thomae, Nicolas (2014) Specificity, plasticity and regulation of cullin-RING ubiquitin E3 ligases by the COP9 signalosome. Nature.

Ceribelli, M and Kelly, PN and Shaffer, AL and Wright, GW and Xiao, W and Yang, Y and Griner, LAM and Guha, R and Shinn, P and Keller, JM and Liu, D and Patel, PR and Ferrer, M and Joshi, S and Nerle, S and Sandy, P and Normant, E and Thomas, CJ and Staudt, LM (2014) Blockade of oncogenic IB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors. Proceedings of the National Academy of Sciences of the United States of America. pp. 11365-11370.

Chan, JG and Tyne, AS and Pang, A and McLachlan, AJ and Perera, V and Chan, JC and Britton, WJ and Chan, HK and Duke, CC and Young, PM and Traini, D (2014) Murine pharmacokinetics of rifapentine delivered as an inhalable dry powder. International Journal of Antimicrobial Agents.

Chan, Stephen and Woollam, Grahame and Trixie, Wagner and Martin U., Schmidt and Lewis, Richard (2014) Can picolinamide be a promising cocrystal former? CrystEngComm, 16. pp. 4365-4368. ISSN 1466-8033

Chandriani, S and DePianto, DJ and N'Diaye, EN and Abbas, AR and Jackman, J and Bevers, IJ and Ramirez-Carrozzi, V and Pappu, R and Kauder, SE and Toy, K and Ha, C and Modrusan, Z and Wu, LC and Collard, HR and Wolters, PJ and Egen, JG and Arron, JR (2014) Endogenously expressed IL-13Ralpha2 attenuates IL-13- mediated responses but does not activate signaling in human lung fibroblasts. Journal of Immunology. pp. 111-119.

Chapman, Kathryn and Chivers, Simon and Gliddon, Dan and Mitchell, David and Robinson, Sally and Sangster, Tim and Sparrow, Susan and Spooner, Neil and Wilson, Amanda (2014) Overcoming the barriers to the uptake of nonclinical microsampling in regulatory safety studies. Drug Discovery Today, 19 (5). pp. 528-532. ISSN 1878-5832

Chapman, Victoria L and Zollinger, Tulipan and Terranova, Remi and Moggs, Jonathan and Kimber, Ian and Dearman, Rebecca (2014) Chemical allergen induced perturbations of the mouse lymph node DNA methylome. Toxicological Sciences, 139 (2). pp. 350-361. ISSN 1096-0929

Chen, G and Chakravarti, N and Aardalen, K and Lazar, AJ and Tetzlaff, MT and Wubbenhorst, B and Kim, SB and Kopetz, S and Ledoux, AA and Gopal, YN and Pereira, CG and Deng, W and Lee, JS and Nathanson, KL and Aldape, KD and Prieto, VG and Stuart, D and Davies, MA (2014) Molecular Profiling of Patient-Matched Brain and Extracranial Melanoma Metastases Implicates the PI3K Pathway as a Therapeutic Target. Clin Cancer Res . pp. 5537-5546.

Chen, Yen Liang and Abdul Ghafar, Nahdiyah and Karuna, Ratnaningrum and Fu, Yilong and Lim, Siew Pheng and Schul, Wouter and Gu, Feng and Yokokawa, Fumiaki and Wang, Gang and Cerny, Daniela and Fink, Katja and Blasco, Francesca and Shi, Pei-Yong (2014) Activation of PBMC by dengue virus infection depotentiates Balapiravir in dengue patients. Journal of Virology, 88 (3). pp. 1740-1747.

Cheng, Hailing and Liu, Pixu and Zhang, Fan and Xu, Erbo and Symonds, Lynn and Bronson, Roderick and Maira, Sauveur-Michel and Di Tomaso, Emmanuelle and Myers, Andrea and Cantley, Lewis and Mills, Gordon and Zhao, Jean (2014) A genetic mouse model of invasive endometrial cancer driven by concurrent loss of pten and Lkb1 is highly responsive to mTOR inhibition. Cancer Research, 74 (1). pp. 15-23. ISSN 0008-5472

Chew, SK and Lu, D and Campos, LS and Scott, KL and Saci, A and Wang, J and Collinson, A and Raine, K and Hinton, J and Teague, JW and Jones, D and Menzies, A and Butler, AP and Gamble, J and O'Meara, S and McLaren, S and Chin, L and Liu, P and Futreal, PA (2014) Polygenic in vivo validation of cancer mutations using transposons - art. no. 455. Genome Biology. 455-.

Chia, J and Tham, KM and Gill, DJ and Bard-Chapeau, EA and Bard, FA (2014) ERK8 is a negative regulator of O-GalNAc glycosylation and cell migration. eLife.

Cho, Hyunhee and Alderman, Ed and Kreder, Natasha and Garcia Caro, Roxana and Leong, Kristen and Hill, William and Pandey, Pramod (2014) Immunometric AMMP assay for rapid analysis of expression constructs for protein production. Competitive, immunometric assay for fusion protein quantification: Protein production prioritization.

Choi, Paul (2014) Quantitative analysis of resistance to NK attacks reveals stepwise killing kinetics. Integrative biology, 6 (12). pp. 1153-1161. ISSN 1757-9708

Choi, Paul and Mitchison, Timothy and Clark, John and Huang, Lino (2014) Screening chemical libraries for modulators of natural killer mediated cytotoxicity. Quantitative analysis of resistance to natural killer attacks reveals stepwise killing kinetics.

Cobos-Correa, Amanda and Kaufmann, Markus (2014) The Impact of Cyclopropane Configuration on the Biological Activity of Cyclopropyl-Epothilones. ChemMedChem, 9 (10). pp. 2227-2232. ISSN 18607179

Collins, LM and Lazic, SE and Barker, RA (2014) A retrospective analysis of hand tapping as a longitudinal marker of disease progression in Huntington's disease. BMC Neurology, 14. p. 35. ISSN 1471-2377

Costa, C and Ebi, H and Martini, M and Beausoleil, SA and Faber, AC and Jakubik, CT and Huang, A and Wang, Y and Nishtala, M and Hall, B and Rikova, K and Zhao, J and Hirsch, E and Benes, CH and Engelman, JA (2014) Measurement of PIP Levels Reveals an Unexpected Role for p110beta in Early Adaptive Responses to p110alpha-Specific Inhibitors in Luminal Breast Cancer. Cancer Cell.

Costales, Abran and Mathur, Michelle and Ramurthy, Savithri and Lan, Jiong and Subramanian, Sharadha and Jain, Rama and Atallah, Gordana and Setti, Lina and Lindvall, Mika and Appleton, Brent and Ornelas, Elizabeth and Feucht, Paul and Warne, Robert and Doyle, Laura and Basham, Stephen and Aronchik, Ida and Jefferson, A.B. and Shafer, Cynthia (2014) 2-Amino-7-Substitued Benzoxazole Analogs as Potent RSK2 Inhibitors. Bioorganic and Medicinal Chemistry Letters, 24 (6). pp. 1592-1596. ISSN 0960894X

Crouse, J and Bedenikovic, G and Wiesel, M and Ibberson, M and Xenarios, I and VonLaer, D and Kalinke, U and Vivier, E and Jonjic, S and Oxenius, A (2014) Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1. Immunity. pp. 961-973.

Cumberbatch, M and Tang, X and Beran, G and Eckersley, S and Wang, X and Ellston, RPA and Dearden, S and Cosulich, S and Smith, PD and Behrens, C and Kim, ES and Su, X and Fan, S and Gray, N and Blowers, DP and Wistuba, II and Womack, C (2014) Identification of a subset of human non-small cell lung cancer patients with high PI3Kbeta and low PTEN expression, more prevalent in squamous cell carcinoma. Clinical Cancer Research. pp. 595-603.


D'Arcy, Allan and Bergfors, Terese and Marsh, May and Jacob, Sandra (2014) Microseed matrix screening for optimization in protein crystallization: what have we learned? Acta Crystallogr F Struct Biol Commun., 70 (Pt 9). pp. 1117-1126. ISSN 2053-230X

DaRosa, PA and Wang, Z and Jiang, X and Pruneda, JN and Cong, F and Klevit, RE and Xu, W (2014) Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal. Nature.

Dales, Natalie and Hubbard, Brian and Winther, Michael and Zhang, Zaihui and Sun, Shaoyi and Leung, Po-Yee and Tran, Jennifer (2014) Systematic evaluation of amide bioisosteres leading to the discovery of novel and potent thiazolylimidazolidinone inhibitors of SCD1 for the treatment of metabolic diseases. Bioorganic and Medicinal Chemistry Letters, 24 (2). pp. 520-525. ISSN 0960-894X

Dales, Natalie and Sun, Shaoyi and Zhang, Zaihui and Hubbard, Brian and Ferreira, Suzie and Winther, Michael (2014) Discovery of thiazolylpyridinone SCD1 inhibitors with preferential liver distribution and reduced mechanism-based adverse effects. Bioorganic and Medicinal Chemistry Letters, 24 (2). pp. 526-531. ISSN 0960-894X

Dales, Natalie and Zhang, Zaihui and Winther, Michael (2014) Opportunities and challenges in developing stearoyl-coenzyme A desaturase-1 inhibitors as novel therapeutics for human disease. Journal of Medicinal Chemistry, 57 (12). pp. 5039-5056. ISSN 1520-4804

Dalvit, Claudio and Invernizzi, Christian and Vulpetti, Anna (2014) Fluorine as hydrogen bond acceptor: Experimental Evidence and Computational Calculations. Chemistry A European Journal.

Darpo, B and Sarapa, N and Garnett, C and Benson, C and Dota, C and Ferber, G and Jarugula, V and Johannesen, L and Keirns, J and Krudys, K and Ortemann-Renon, C and Riley, S and Rogers-Subramaniam, D and Stockbridge, N (2014) The IQ-CSRC Prospective Clinical Phase 1 Study: 'Can Early QT Assessment Using Exposure Response Analysis Replace the Thorough QT Study?'. ANNALS OF NONINVASIVE ELECTROCARDIOLOGY. pp. 70-81.

Das Thakur, M and Stuart, DD (2014) Molecular Pathways: Response and Resistance to BRAF and MEK Inhibitors in BRAF(V600E) Tumors. CLINICAL CANCER RESEARCH. pp. 1074-1080.

Daugvilaite, Viktorija and Arfelt, Kristine and Benned-Jensen, Tau and Sailer, Andreas and Rosenkilde, Mette (2014) Oxysterol-EBI2 signaling in immune regulation and viral infection. European Journal of Immunology, 44. pp. 1904-1912.

Davis, MI and Gross, S and Shen, M and Straley, KS and Pragani, R and Lea, WA and Popovici-Muller, J and DeLaBarre, B and Artin, E and Thorne, N and Auld, DS and Li, Z and Dang, L and Boxer, MB and Simeonov, A (2014) Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1. Journal of Biological Chemistry, 289 (20). pp. 13717-13725. ISSN 0021-92581083-351X

Davis, MI and Simeonov, A and Lea, W and Auld, D (2014) A Kaleidoscope of Colored Beads to Investigate Serine Hydrolases. Assay and Drug Development Technologies. pp. 497-505.

De Buck, Stefan and Jakab, Annamaria and Boehm, Markus and Bootle, Douglas and Quadt, Cornelia and Goggin, Timothy Kieran and Juric, Dejan (2014) Population pharmacokinetics and pharmacodynamics of BYL719, a phosphoinositide 3-kinase antagonist, in adult patients with advanced solid malignancies. British Journal of Clinical Pharmacology.

DePianto, DJ and Chandriani, S and Abbas, AR and Jia, G and N'Diaye, EN and Caplazi, P and Kauder, SE and Biswas, S and Karnik, SK and Ha, C and Modrusan, Z and Matthay, MA and Kukreja, J and Collard, HR and Egen, JG and Wolters, PJ and Arron, JR (2014) Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis. Thorax.

Deng, Y and Shipps, J and Zhao, L and Siddiqui, MA and Popovici-Muller, J and Curran, PJ and Duca, JS and Hruza, AW and Fischmann, TO and Madison, VS and Zhang, R and McNemar, CW and Mayhood, TW and Syto, R and Annis, A and Kirschmeier, P and Lees, EM and Parry, DA and Windsor, WT (2014) Modulating the interaction between CDK2 and cyclin A with a quinoline-based inhibitor. Bioorganic and Medicinal Chemistry Letters. pp. 199-203.

Diagana, Thierry Tidiane and Mcnamara, Case and Roland, Jason and Nagle, Advait and Yeung, Bryan King Sing and Zeeman, Anne-Marie and Winzeler, Elizabeth and Plouffe, David and Kocken, Clemens (2014) KAI407, a potent non 8-aminoquinoline compound that kills Plasmodium cynomolgi dormant liver stage parasites in vitro. Antimicrobial Agents and Chemotherapy.

Diagana, Thierry Tidiane and Yeung, Bryan King Sing and Manjunatha, Ujjini Havaldar and Shi, Pei-Yong and Bodenreider, Christophe and Jones, Catherine (2014) Ten years of drug discovery for the developing world at the Novartis Institute for Tropical Diseases. Nature Reviews Drug Discovery, 14 (6). pp. 442-444. ISSN 1474-1784

Dixon, Darlene and Alison, Roger and Bach, Ute and Colman, Karyn and Foley, George L and Harleman, Johannes and Haworth, Richard and Herbert, Ronald and Heuser, Anke and Long, Greald and Mirsky, Michael and Regan, Karen and van Esch, Eric and Westwood, F Russell and Vidal, Justin and Yoshida, Midori (2014) INHAND: Nonproliferative and Proliferative Lesions of the Rat and Mouse Female Reproductive Tract. Journal of Toxicologic Pathology, 27 (3 & 4 ). 1S-107S. ISSN 0914-9198

Djidja, M and Chang, J and Hadjiprocopis, A and Schmich, F and Sinclair, J and Mrsnik, M and Schoof, EM and Barker, HE and Linding, R and Jorgensen, C and Erler, JT (2014) Identification of hypoxia-regulated proteins using MALDI-mass spectrometry imaging combined with quantitative proteomics. Journal of Proteome Research. pp. 2297-2313.

Doi, Toshihiko and Onozawa, Yusuke and Yoshino, Takayuki and Yamazaki, Kentaro and Junichiro, Watanabe and Akimov, Mikhail and Robson, Matthew and Boku, Narikazu and Ohtsu, Atsushi (2014) Phase I Dose-Escalation Study of the HSP90 Inhibitor AUY922 in Japanese Patients with Advanced Solid Tumors. Cancer Chemotherapy Pharmacology .

Dong, Hongping and Fink, Katja Fink and Roland , Zuest and Lim, Siew Pheng and Cheng-Feng , Qin and Shi, Pei-Yong (2014) Flavivirus RNA methylation. Journal of General Virology, 95 (PART 4). pp. 763-778. ISSN 1465-2099

Dressler, H and Economides, K and Favara, S and Wu, NN and Pang, Z and Polites, HG (2014) The CRE luc Bioluminescence Transgenic Mouse Model for Detecting Ligand Activation of GPCRs. JOURNAL OF BIOMOLECULAR SCREENING. pp. 232-241.

Duan, QL and Lasky-Su, J and Himes, BE and Qiu, W and Litonjua, AA and Damask, A and Lazarus, R and Klanderman, B and Irvin, CG and Peters, SP and Hanrahan, JP and Lima, JJ and Martinez, FD and Mauger, D and Chinchilli, VM and Soto-Quiros, M and Avila, L and Celedon, JC and Lange, C and Weiss, ST and Tantisira, KG (2014) A genome-wide association study of bronchodilator response in asthmatics. Pharmacogenomics Journal. pp. 41-47.

Duca, Jose and Cross, Jason (2014) Quantum Mechanics Approaches to Structurally Informed Design. International Journal of Quantum Chemistry, 114. pp. 305-313. ISSN 1097-461X

Dudal, S and Baltrukonis, D and Crisino, R and Goyal, MJ and Joyce, A and Osterlund, K and Smeraglia, J and Taniguchi, Y and Yang, J (2014) Assay formats: recommendation for best practices and harmonization from the global bioanalysis consortium harmonization team. AAPS Journal. pp. 194-205.

Dumotier, Berengere (2014) A Straightforward Guide to the Basic Science Behind Arrhythmogenesis. Heart , Epub a. ISSN 1355-6037

Dutta, P and O'Connell, KE and Ozkan, SB and Sailer, AW and Dev, KK (2014) The protein interacting with C-kinase (PICK1) interacts with and attenuates parkin-associated endothelial-like (PAEL) receptor-mediated cell death. Journal of Neurochemistry. pp. 360-373.

Dutta, Priyanka and O'Connell, Kara and Ozkan, S. Banu and Sailer, Andreas and Dev, Kumlesh K. (2014) PICK1 interacts with and attenuates PAEL receptor-mediated cell death. Journal of Neurochemistry, 130. pp. 360-373.

da Silva, A and Kronthaler, U and Koppenburg, V and Fink, M and Meyer, I and Papandrikopoulou, A and Hofmann, M and Stangler, T and Visser, J (2014) Target-directed development and preclinical characterization of the proposed biosimilar rituximab GP2013. LEUKEMIA & LYMPHOMA. pp. 1609-1617.

di Paolo, Therese and Gregoire, Laurent and Feuerbach, Dominik and Elbast, Walid and Weiss, Markus and Gomez-Mancilla, Baltazar (2014) AQW051, a novel, and selective nicotinic acetylcholine receptor α7 partial agonist, reduces L-Dopa-induced dyskinesias and extends the duration of L-Dopa effects in parkinsonian monkeys. Parkinsonism Relat Disord.


Eder, Joerg and Sedrani, Richard and Wiesmann, Christian (2014) The discovery of first-in-class drugs: origins and evolution. Nature Reviews Drug Discovery, 13 (8). pp. 577-587. ISSN 1474-17761474-1784

Ehara, Takeru and Kosaka, Takatoshi and Kanazawa, Takanori and Grosche, Philipp and Ostermann, Nils and Cumin, Frederic and Schiering, Nikolaus and Rigel, Dean and Webb, Randy and Maibaum, Juergen Klaus and Yokokawa, Fumiaki and Irie, Osamu Irie and Breitenstein, Werner and Suzuki, Masaki and Kawakami, Shimpei and Konishi, Kazuhide and Hitomi, Yuko and Toyao, Atsushi and Gunji, Hiroki (2014) Structure-based Design of 4-Hydroxy-3,5-Substituted Piperidines as a New Class of Highly Efficacious Oral Direct Renin Inhibitors. ACS Medicinal Chemistry Letters, 5 (7). pp. 787-792.

Eibel, H and Kraus, H and Sic, H and Kienzler, A and Rizzi, M (2014) B cell biology: An overview topical collection on basic and applied science. Current Allergy and Asthma Reports.

Einolf, Heidi (2014) Using Calibration Curve-based Approaches of RIS, R3, Cmax/EC50, and AUC/F2, from mRNA and Activity Induction Data in Human Hepatocytes to Predict Clinical Inducers and Non-inducers of CYP3A4. Drug Metabolism and Disposition, 42 (9). pp. 1379-1391. ISSN 1521-009X

Ekuadzi, E. and Dickson , R.A. and Fleischer, T.C. and Amponsah, I.K. and Pistorius, Dominik and Oberer, Lukas (2014) Chemical Constituents from Gouania longipetala and Glyphaea brevis. Natural Product Research, 28 (15). pp. 1210-1213.

Ekuadzi, Edmund and Dickson, Rita and Fleischer, Theophilus and Annan, Kofi and Pistorius, Dominik and Oberer, Lukas and Gibbons, Simon (2014) Flavonoid glycosides from the stem bark of Margaritaria discoidea demonstrate antibacterial and free radical scavenging activities. Phytotherapy Research, 28 (5). pp. 784-787.

Elbast, Walid and White, Stephen and Adcock, Neil and Hiller, Jim and Knutsson, Magnus and Lausecker, Berthold and Long, Jeff and McDougall, Stuart and Salavert, Fabrice and Sangster, Timothy and Verhaeghe, Tom and van Amsterdam, Peter (2014) European Bioanalysis Forum ‐ Recommendation on Dealing with Internal Standard Variability. Bioanalysis.

Ellinger-Ziegelbauer, H and Toft, DB and Braeuning, A and Couttet, P and DaCosta, A and Dhalluin, S and Eichner, J and Elcombe, CR and Grenet, O and Henderson, C and Kossler, N and Meehan, RR and Ostenfeld, N and Templin, M and Terranova, R and Thompson, JP and Unterberger, EB and Wrodzek, C and Wolf, CR and Moggs, JG (2014) Early microRNA and other non-coding RNA biomarkers for rodent non-genotoxic carcinogens. Toxicology Letters. S23-S23.

Elliott, Luke D and Knowles , Jonathan P and Maskill, Kate G and Ralph, Michael J and Lejeune, Guillaume and Hook, Ben D A and Edwards, Lee and Robinson, Richard and Clemens, Ian and Cox, Brian and Pascoe, David and Koch, Guido and Eberle, Martin and Berry, Malcolm B and Booker-Milburn, Kevin I (2014) Batch vs. Flow Photochemistry: A Thorough Analysis of Yields and Productivities. Chemistry - a European journal, 20 (46). pp. 15226-15232. ISSN 09476539

Eltom, S and Dale, N and Raemdonck, KR and Stevenson, CS and Snelgrove, RJ and Sacitharan, PK and Recchi, C and Wavre-Shapton, S and McAuley, DF and O'Kane, C and Belvisi, MG and Birrell, MA (2014) Respiratory Infections Cause the Release of Extracellular Vesicles: Implications in Exacerbation of Asthma/COPD. PLoS ONE [Electronic Resource]. e101087, 2014-.

Epple, Robert and Azimioara, Mihai and Alper, Phillip and Cow, Christopher and Mutnick, Daniel and Nikulin, Victor and Lelais, Gerald and Mcneill, Matthew and Michellys, Pierre and Wang, Zhiliang and Li, Jing and Bao, Dingjiu and Zoll, Jocelyn and Kim, Young and Zimmerman, Matthew and Groessl, Todd and Tuntland, Tove and Mcnamara, Peter and Seidel, Martin (2014) Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists. Bioorganic and Medicinal Chemistry Letters, 24 (23). pp. 5478-5483. ISSN 1464-3405

Erdemli, Gul and Priest, Birgit (2014) Phenotypic Screening in the 21st Century. Frontiers in Pharmacology , 5. p. 264. ISSN 1663-9812

Ertl, P (2014) Intuitive ordering of scaffolds and scaffold similarity searching using scaffold keys. Journal of Chemical Information & Modeling. pp. 1617-1622.

Ertl, P (2014) Visualization of chemical space for medicinal chemists. J Cheminform . O4-.

Ertl, Peter (2014) Intuitive Ordering of Scaffolds and Scaffold Similarity Searching Using Scaffold Keys. J. Chem. Inf. Comp. Sci., 54 (6). pp. 1617-1622. ISSN 1549-95961549-960X

Ewart, Lorna and Aylott, Mike and Deurinck, Mark and Ju, Haisong and Suter, Willi (2014) AN ANALYSIS OF THE CONSCIOUS DOG TELEMETRY MODEL AND ITS ABILITY TO DETECT AND PREDICT CARDIOVASCULAR CHANGE IN PHASE I. Toxicological sciences, 142 (2). pp. 427-435. ISSN 1096-0929; 1096-6080


Faller, Bernard and Artursson, Per and Avdeef, Alex and Li, Di and Ecker, Gerhard and Houston, Brian and Kansy, Manfred and Kerns, Ed and Kraemer, Stefanie and Lennernaes, Hans and van de Waterbeemd, Han and Sugano, Kiyohiko and Testa, Bernard (2014) Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition. Molecular Pharmacology, 11 (-). pp. 1727-1738. ISSN -

Feng, JY and Cheng, G and Perry, J and Barauskas, O and Xu, Y and Fenaux, M and Eng, S and Tirunagari, N and Peng, B and Yu, M and Tian, Y and Lee, Y and Stepan, G and Lagpacan, LL and Jin, D and Hung, M and Ku, KS and Han, B and Kitrinos, K and Perron, M and Birkus, G and Wong, KA and Zhong, W and Kim, CU and Carey, A and Cho, A and Ray, AS (2014) Inhibition of Hepatitis C Virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug. Antimicrobial Agents and Chemotherapy. pp. 1930-1942.

Fernández-Golbano, Isabel Maria and Giblin, Jonathan and Idrissi, Fatima-Zahra and Grötsch, Helga and del Mar Borrás , Maria and Geli, Maria Isabel (2014) A cross-talk between PI(4,5)P2 and CK2´ modulates actin polymerization during endocytic uptake. Developmental Cell.

Ferreira, Maria Carolina and Whibley, Natasha and Mamo, Anna J and Siebenlist, Ulrich and Chan, Yvonne and Gaffen, Sarah L (2014) The IL-17-induced gene Lipocalin 2 is dispensable for immunity to oral candidiasis. Infection and immunity, 82 (3). pp. 1030-1035. ISSN 1098-5522; 0019-9567

Feuerbach, Dominik and Pezous, Nicole and Weiss, Markus and Shakeri-Nejad, Kasra and Lingenhoehl, Kurt and Hoyer, Daniel and Hurth, Konstanze and Bilbe, Graeme and Pryce, Christopher R and Mcallister, Kevin and Chaperon, Frederique and Kucher, Klaus and Johns, Donald and Blaettler, Thomas and Lopez Lopez, Cristina (2014) AQW051, a novel, potent and selective nicotinic acetylcholine receptor α7 partial agonist: Pharmacological characterisation and Phase I evaluation in healthy subjects. Journal pharmacology and experimental therapeutics.

Finco, Deborah and Grimaldi, Christine and Narayanan, Padman and Walker, M and Kiessling, Andrea and Wolf, Babette and Salcedo, Theodora and Faggioni, R and Schneider, A and Ibrahimov, A and Scesney, S and Serna, D and Prell, R and Stebbings, R (2014) Cytokine release assays: Current practices and future directions. Cytokine, 66 (2). pp. 143-155. ISSN 1043-4666

Fischer, Eric and Boehm, Kerstin and Lydeard, John R. and Lingaraju Gondichatnahalli, Manjappa and Cavadini, Simone and Acker, Vincent and Ottl, Johannes and Harper, Wade J. and Thomae, Nicolas and Stadler, Michael and Yang, Haidi and Nagel, Jane and Hassiepen, Ulrich and Hild, Marc and Forrester, William and Beckwith, Rohan and Schirle, Markus and Jenkins, Jeremy and Serluca-Aegerter, Fabrizio and Tichkule, Ritesh and Schebesta, Michael (2014) The Structure of DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature, 512 (7512). pp. 49-53. ISSN 0028-08361476-4687

Fluhler, Eric and Vazvaei, Faye and Singhal, Puran and Vinck, Petra and Li, Wenkui and Bhatt, Jignesh and de Boer, Theo and Chaudhary, Ajai and Tangiuchi, Masahiro and Rezende, Vinicius and Zhong, Dafang (2014) Repeat Analysis and Incurred Sample Reanalysis: Recommendation for Best Practices and Harmonization from the Global Bioanalysis Consortium Harmonization Team. AAPS Journal, 16 (6). pp. 1167-1174.

Fredenhagen, Andreas and Kuehnoel, Juergen (2014) Evaluation of the optimization space for atmospheric pressure photoionization (APPI) in comparison to APCI. Journal of mass spectrometry, 49 (8). pp. 727-736.

Frisbee, Jefferson C. and Goodwill, Adam G. and Frisbee, Stephanie J. and Butcher, Joshua T. and Wu, Fan and Chantler, Paul D. (2014) Skeletal muscle microvasculopathy in the metabolic syndrome: What is the fundamental problem contributing to increased muscle fatigue. Journal of Physiology.

Fu, B and Kuang, E and Li, W and Avey, D and Li, X and Turpin, Z and Valdes, A and Brulois, K and Myoung, J and Zhu, F (2014) Activation of p90 Ribosomal S6 Kinases (RSKs) by ORF45 of Kaposi Sarcoma-Associated Herpesvirus is Critical for Optimal Production of Infectious Viruses. Journal of Virology .

Fu, D and Zhou, J and Zhu, WS and Manley, PW and Wang, YK and Hood, T and Wylie, A and Xie, XS (2014) Imaging the intracellular distribution of tyrosine kinase inhibitors in living cells with quantitative hyperspectral stimulated Raman scattering. Nature Chemistry . pp. 614-622.

Fu, Dan and Zhou, Jing and Zhu, Wenjing and Manley, Paul W. and Wang, Yingqi and Wylie, Andrew and Hood, Tami and Xie, Xiaoliang Sunney (2014) Quantitative Hyperspectral Stimulated Raman Scattering (SRS) Imaging of Intracellular Tyrosine Kinase Inhibitor Drug Distribution in Living cells. Imaging the intracellular distribution of tyrosine kinase inhibitors in living cells with quantitative hyperspectral stimulated Raman scattering.

Full, F and Jungnickl, D and Reuter, N and Bogner, E and Brulois, K and Scholz, B and Stuerzl, M and Myoung, J and Jung, JU and Stamminger, T and Ensser, A (2014) Kaposi's Sarcoma Associated Herpesvirus Tegument Protein ORF75 Is Essential for Viral Lytic Replication and Plays a Critical Role in the Antagonization of ND10Instituted Intrinsic Immunity - art. no. e1003863. PLOS PATHOGENS. pp. 3863-3.


Gandhi, H and Worch, R and Kurgonaite, K and Hintersteiner, M and Schwille, P and Bokel, C and Weidemann, T (2014) Dynamics and interaction of interleukin-4 receptor subunits in living cells. Biophysical Journal. pp. 2515-2527.

Garcia, Pablo and Langowski, John and Wang, Yingyun and Chen, Min and Castillo, Joseph and Fanton, Christie and Zavorotinskaya, Tatiana and Dai, Yumin and Lu, Jing and Niu, Xiaohong and Basham, Stephen and Chan, Julie and Yu, Jianjun and Doyle, Michael and Feucht, Paul and Warne, Robert and Narberes, Jamie and Tsang, Tiffany and Drueckes, Peter and Trappe, Joerg and Wilson, Chris and Han, Wooseok and Lan, Jiong and Nishiguchi, Gisele and Lindvall, Mika and Bellamacina, Cornelia and Aycinena, Alex and Zang, Richard and Holash, Jocelyn and Burger, Matthew (2014) Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematological Cancers. Clinical Cancer Research, 20 (7). pp. 1834-1845. ISSN 1078-0432

Garnatz, AS and Gao, Z and Broman, M and Martens, S and Earley, JU and Svensson, EC (2014) FOG-2 mediated recruitment of the NuRD complex regulates cardiomyocyte proliferation during heart development. Developmental Biology. pp. 50-61.

Gaugaz, FZ and Redondo-Horcajo, M and Barasoain, I and Diaz, JF and Cobos-Correa, A and Kaufmann, M and Altmann, K (2014) The impact of cyclopropane configuration on the biological activity of cyclopropyl-epothilones. ChemMedChem. pp. 2227-2232.

Gaumann, AK and Drexler, HC and Lang, SA and Stoeltzing, O and Diermeier-Daucher, S and Buchdunger, E and Wood, J and Bold, G and Breier, G (2014) The inhibition of tyrosine kinase receptor signalling in leiomyosarcoma cells using the small molecule kinase inhibitor PTK787/ZK222584 (Vatalanib). International Journal of Oncology. pp. 2267-2277.

Gee, Christine and Peterlik, Daniel and Neuhäuser, Christoph and Bouhelal, Rochdi and Kaupmann, Klemens and Laue, Grit and Uschold-Schmidt, Nicole and Feuerbach, Dominik and Zimmermann, Kaspar and Ofner, Silvio and Cryan, John F. and Van Der Putten, P. Herman and Fendt, Markus and Vranesic, Ivan-Toma and Glatthar, Ralf and Flor, Peter Josef (2014) Inhibition of Amygdala Plasticity, Stress and Anxiety Behavior by Blocking at the Venus Flytrap Domain (VFTD) of the Metabotropic Glutamate Receptor Subtype 7 (mGlu7). Journal of Biological Chemistry, 289 (16). pp. 10975-10987. ISSN ISSN:0021-9258

Genick, Christine and Ottl, Johannes and Scheufler, Clemens (2014) Applications of Biophysics in High Throughput Screening Hit Validation. Journal of Biomolecular Screening, 19 (5). pp. 707-714. ISSN 1087-05711552-454X

Gergely, Peter and Mocsai, Attila and Kovacs, Laszlo (2014) What is the future of targeted therapy in rheumatology: Biologics or small molecules? BMC Medicine, 12 (1). ISSN 17417015

Germano, Davide and Uteng, Marianne and Pognan, Francois and Chibout, Salah-Dine and Wolf, Armin (2014) Determination of Liver Specific Toxicities in Rat Hepatocytes by High Content Imaging during 2-Week Multiple Treatment. Toxicology in Vitro.

Gessier, Francois and Preuss, Inga and Yin, Hong and Rosenkilde, Mette and Laurent, Stephane and Endres, Ralf and Chen, Yu and Marsilje, Thomas and Seuwen, Klaus and Nguyen, Deborah and Sailer, Andreas (2014) Identification and characterization of small molecule modulators of the EBI2 receptor. Journal of Medicinal Chemistry, 57. pp. 3358-3368.

Gimeno-Santos, E and Frei, A and Steurer-Stey, C and de, BJ and Rabinovich, RA and Raste, Y and Hopkinson, NS and Polkey, MI and van, RH and Troosters, T and Kulich, K and Karlsson, N and Puhan, MA and Garcia-Aymerich, J (2014) Determinants and outcomes of physical activity in patients with COPD: a systematic review. Thorax. pp. 731-739.

Girardot, Michael and Hirasawa, Ryutaro and Kacem, Salim and Fritsch, Lauriane and Pontis, Julien and Kota, Satya K. and Filipponi, Doria and Fabbrizio, Eric and Sardet, Claude and Lohmann, Felix and Kadam, Shilpa and Ait-Si-Ali, Slimane and Feil, Robert (2014) PRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G + C-rich regions of the mouse genome. Nucleic Acids Research, 42 (1). pp. 235-248. ISSN 0305-1048

Glass, DJ (2014) Focus on questions, not hypotheses. Nature. p. 306.

Glass, DJ (2014) NIH grants: Focus on questions, not hypotheses. Nature. 306-.

Glass, DJ and Campbell, KP and Rudnicki, MA (2014) Skeletal muscle's 3rd year anniversary. Skeletal Muscle. 3, 2014-.

Glowienke, Susanne and Marterer, Wolfgang (2014) Use of a second, statistically based (Q)SAR (Quantitative Structure Activity Relationships)methodology in Genotoxin Risk Assessment (GRA)assessment of DNA reactive (mutagenic) impurities: Challenges and Opportunities. Use of a second, statistically based (Q)SAR (Quantitative Structure Activity Relationships)methodology in Genotoxin Risk Assessment (GRA)assessment of DNA reactive (mutagenic) impurities: Challenges and Opportunities.

Gomez-Mancilla, Baltazar and Von Raison, Florian and Apostol, George and Ufer, Mike and Gasparini, Fabrizio and Berry Kravis, Elizabeth and Hageman, Randi and Jacquemont, Sébastien (2014) Development of mavoglurant and its potential for the treatment of fragile X syndrome. Expert Opinion on Investigational Drugs.

Gonzalez, L and Lukamowicz-Rajska, M and Thomassen, LCJ and Kirschhock, CEA and Leyns, L and Lison, D and Martens, JA and Elhajouji, A and Kirsch-Volders, M (2014) Co-assessment of cell cycle and micronucleus frequencies demonstrates the influence of serum on the in vitro genotoxic response to amorphous monodisperse silica nanoparticles of varying sizes. Nanotoxicology. pp. 876-884.

Gostissa, M and Schwer, B and Chang, A and Dong, J and Meyers, RM and Marecki, GT and Choi, VW and Chiarle, R and Zarrin, AA and Alt, FW (2014) IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances. Proceedings of the National Academy of Sciences of the United States of America. pp. 2644-2649.

Gowrisankar, S and Lebo, MS (2014) Designing algorithms for determining significance of DNA missense changes. Review. Methods in Molecular Biology. pp. 251-262.

Grahammer, F and Haenisch, N and Steinhardt, F and Sander, L and Roerden, M and Arnold, F and Cordts, T and Wanner, N and Reichardt, W and Kerjaschki, D and Ruegg, MA and Hall, MN and Moulin, P and Busch, H and Boerries, M and Walz, G and Artunc, F and Huber, TB (2014) mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress. Proc Natl Acad Sci U S A.

Grant, Joanna and Lesley, Scott and Xu, Qingping and Deller, Marc and Elsliger, Marc and Deacon, Ashley and Wilson, Ian and Nielsen, Tine (2014) Structural insights into the recognition of phosphopeptide by the FHA domain of Kanadaptin. PLoS ONE, 9 (9). ISSN 1932-6203

Grassian, Alexandra and Pagliarini, Raymond and Chiang, Derek (2014) IDH1 and IDH2 mutations in cholangiocarcinoma. Current Opinion in Gastroenterology. pp. 295-302.

Grondine, Melissa and Gunderson, Karl and Reilly, John and Twomey Iii, Joseph and Vandenberg, Jennifer and Wang, Bing (2014) A combined approach of ion chromatography and quantitative NMR to accurately determine counterion stoichiometry. Journal of Liquid Chromatography and Related Technologies, 37 (10). pp. 1453-1464. ISSN 1082-6076

Grunewald, Jan and Jones, David and Brock, Ansgar and Bursulaya, Badry and Patterson, Paula and Ng, Kenneth and Vo, Michael and Uno, Tetsuo and Hunt, James and Spraggon, Glen and Geierstanger, Bernhard (2014) Site-Specific Dual-Labeling of Proteins Using Small Orthogonal Tags at Neutral pH. ChemBiochem.

Gualtieri, Giovanna (2014) Effects of cigarette smoke on Toll-like receptor (TLR) activation of chronic obstructive pulmonary disease (COPD) macrophages. Clinical and Experimental Immunology, 176 (3). pp. 461-472. ISSN 0009-9104; 1365-2249

Guarente, L (2014) Linking DNA Damage, NAD(+)/SIRT1, and Aging. Cell Metabolism. pp. 706-707.

Guerard, Nicolas and Jordaan, Pierre and Dumotier, Berengere (2014) Analysis of unipolar electrograms in rabbit heart demonstrated the key role of ventricular apicobasal dispersion in arrhythmogenicity. jOURNAL OF CARDIOVASCULAR TOXICOLOGY.

Gueret, Stephanie and Meier, Peter and Roth, Hans-Joerg (2014) Cyclic Carbo-Isosteric Depsipeptides and Peptides as a Novel Class of Peptidomimetic. Organic Letters, 16 (5). pp. 1502-1505.

Gulyas, Balazs and Sovago, Judit and Gomez-Mancilla, Baltazar and Jia, Zhisheng and Gulya, Karoly and Szigeti, Csaba and Schumacher, Martin and Maguire, Paul and Gasparini, Fabrizio and Halldin, Christer (2014) Changes in mGluR5 density, and enkephalin and substance P immunoreactivity in Huntington’s disease. Brain Structure and Function.

Guo, LT and Wang, YS and Nakamura, A and Eiler, D and Kavran, JM and Wong, M and Kiessling, LL and Steitz, TA and O'Donoghue, P and Soll, D (2014) Polyspecific pyrrolysyl-tRNA synthetases from directed evolution. Proceedings of the National Academy of Sciences of the United States of America. pp. 16724-16729.


Haaparanta-Solin, Merja and Snellman, Annijna and Rokka, Johanna and Lopez-Picon, Francisco and Eskola, Olli and Salmona, Mario and Forloni, GianLiigi and Schienin, Mika and Rinne, Juha (2014) Imaging beta-amyloid deposition in transgenic mouse models of Alzheimer's diseae with 18F flutemetamol PET. EJNMMI Res..

Hale, MA and Swift, GH and Hoang, CQ and Deering, TG and Masui, T and Lee, Y and Xue, J and MacDonald, RJ (2014) The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis. Development (Cambridge). pp. 3123-3133.

Hamann, LG (2014) Synthetic strategy: Natural products on demand. Nature Chemistry. pp. 460-461.

Hao, L and Lindenbach, B and Wang, X and Dye, B and Kushner, D and He, Q and Newton, M and Ahlquist, P (2014) Genome-wide analysis of host factors in nodavirus RNA replication. PLoS ONE.

Harrison, SJ and Hsu, AK and Neeson, P and Younes, A and Sureda, A and Engert, A and Prince, HM and Li, M and Savage, P and Bugarini, R and Williams, D and Squier, M and Ritchie, DS (2014) Early thymus and activation-regulated chemokine (TARC) reduction and response following panobinostat treatment in patients with relapsed/refractory Hodgkin lymphoma following autologous stem cell transplant. LEUKEMIA & LYMPHOMA. pp. 1053-1060.

Hartmann, Nicole and Baeriswyl, Lukas and Staedtler, Frank and Peters, Thomas (2014) Evaluation of quantitative miRNA expression platforms in the microRNA quality control (miRQC) study. Nature Methods, 11 (8). pp. 809-8015. ISSN 1548-7091

Hartmann, Nicole and Luesink, Evert and Khokhlovich, Edward and Szustakowski, Joseph and Baeriswyl, Lukas and Peterson, Joshua and Scherer, Andreas and Nirmala, Nanguneri and Staedtler, Frank (2014) The use of haplotype-specific transcripts improves sample annotation consistency. Biomarker Research, 2 (17).

Hartwieg, Constanze and Priess, Jan and Schuetz, Heiner and Rufle, Dominik and Valente, Claudio and Bury, Christophe and La Vecchia, Luigi and Francotte, Eric (2014) 3,5-Disubstituted Piperidine Derivatives - A Scalable Route to all Four Stereoisomers. Organic Process Research and Development, 18 (9). pp. 1120-1127. ISSN 1083-61601520-586X

Hauenstein, AV and Rogers, WE and Shaul, JD and Huang, D and Ghosh, G and Huxford, T (2014) Probing kinase activation and substrate specificity with an engineered monomeric IKK2. Biochemistry. pp. 2064-2073.

He, Michael and Lee, Patrick and Sweeney, Zachary (2014) Promiscuity and the Conformational Rearrangement of Drug-like Molecules: Insight from the Protein Data Bank. ChemMedChem, 10. ISSN 1860-7187

He, Y and Wu, J and Mei, H and Yu, H and Sun, S and Shou, J and Li, H (2014) Histone deacetylase activity is required for embryonic posterior lateral line development. Cell Proliferation. pp. 91-104.

Healy, Mark and Chan, Louis and Poole, Darren and Shen, Di and Donohoe, Timothy (2014) Rhodium-Catalyzed Ketone Alkylation Using Methanol Under Mild Conditions: Formation of Alpha-Branched Products. Angewandte Chemie (International Ed. in English), 53 (3). pp. 761-765. ISSN 14337851

Hechinger, AK and Smith, BA and Flynn, R and Hanke, K and McDonald-Hyman, C and Taylor, PA and Pfeifer, D and Hackanson, B and Leonhardt, F and Prinz, G and Dierbach, H and Schmitt-Graeff, A and Kovarik, J and Blazar, BR and Zeiser, R (2014) Therapeutic activity of multiple common gamma chain cytokine inhibition in acute and chronic GvHD. Blood.

Helena, Kovacs and Gossert, Alvar (2014) Improved NMR experiments with 13C-isotropic mixing for assignment of aromatic and aliphatic side chains in labelled proteins. J Biomol NMR, 58 (2). pp. 101-112. ISSN 1573-5001

Helming, KC and Wang, X and Wilson, BG and Vazquez, F and Haswell, JR and Manchester, HE and Kim, Y and Kryukov, GV and Ghandi, M and Aguirre, AJ and Jagani, Z and Wang, Z and Garraway, LA and Hahn, WC and Roberts, CWM (2014) ARID1B is a specific vulnerability in ARID1A-mutant cancers. NATURE MEDICINE. pp. 251-254.

Henson, Kristin and Lebrec, H and Molinier, B and Boverhof, D and Collinge, M and Freebern, W and Mytych, D and Ochs, H and Wange, R and Yang, Y and Zhou, L and Arrington, J and Christin-Piche, M and Shenton, J (2014) The TDAR Assay in Nonclinical Studies of Pharmaceuticals and Chemicals: Study Design, Data Analysis, Interpretation. Regulatory Toxicology and Pharmacology, 69. pp. 7-21.

Heudi, Olivier and Lanshoeft, Christian and Leuthold, Luc Alexis and Elbast, Walid and Schueller, Fabienne and Picard, Franck and Kretz, Olivier (2014) Laser Diode Thermal Desorption-positive mode Atmospheric Pressure Chemical Ionization Tandem Mass Spectrometry applied for the ultra-fast quantitative analysis of BKM120 in human plasma: method validation and its application to clinical studies. Analytical and Bioanalytical Chemistry.

Hill, Marilyn (2014) NC3Rs/MHRA working group on Recovery animals Global cross-company data sharing to examine the use of recovery animals in safety assessment to support first-in-human clinical trials? Global cross-company data sharing to examine the use of recovery animals in safety assessment to support first-in-human clinical trials (70). pp. 413-429.

Hillemanns, P and Jentschke, M and Evans, TG and Soergel, P and Hass, R (2014) Detection of E6-AP as a potential therapeutic target in cervical specimen of HPV-infected women. ARCHIVES OF GYNECOLOGY AND OBSTETRICS. pp. 1281-1286.

Hintersteiner, Martin and Kallen, Joerg and Gstach, Hubert and Auer, Manfred (2014) Identification and X-ray co-crystal structure of a small-molecule activator of LFA-1-ICAM-1 binding. to be determined, 53 (17). pp. 4322-4326. ISSN 14337851

Hoegenauer, Klemens and Arista, Luca and Schmiedeberg, Niko and Werner, Gudrun and Jaksche, Herbert and Bouhelal, Rochdi and Nguyen, Deborah G. and Bhat, B. Ganesh and Raad, Layla and Rauld, Celine and Carballido, Jose (2014) G-Protein-coupled Bile Acid Receptor 1 (GPBAR1, TGR5) agonists reduce the production of pro-inflammatory cytokines and stabilize the alternative macrophage phenotype. Journal of Medicinal Chemistry, 57 (24). pp. 10343-10354.

Hoepfner, D and Helliwell, SB and Sadlish, H and Schuierer, S and Filipuzzi, I and Brachat, S and Bhullar, B and Plikat, U and Abraham, Y and Altorfer, M and Aust, T and Baeriswyl, L and Cerino, R and Chang, L and Estoppey, D and Eichenberger, J and Frederiksen, M and Hartmann, N and Hohendahl, A and Knapp, B and Krastel, P and Melin, N and Nigsch, F and Oakeley, EJ and Petitjean, V and Petersen, F and Riedl, R and Schmitt, EK and Staedtler, F and Studer, C and Tallarico, JA and Wetzel, S and Fishman, MC and Porter, JA and Movva, NR (2014) High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions. MICROBIOLOGICAL RESEARCH, 169 (2-3). pp. 107-120. ISSN 09445013

Hoepfner, Dominic and Helliwell, Stephen and Sadlish, Heather and Schuierer, Sven and Filipuzzi, Ireos and Brachat, Sophie and Bhullar, Bhupinder and Plikat, Uwe and Abraham, Yann and Altorfer, Marc and Aust, Thomas and Baeriswyl, Lukas and Cerino, Raffaele and Chang, Lena and Estoppey, David and Eichenberger, Juerg and Frederiksen, Mathias and Hartmann, Nicole and Hohendahl, Annika and Knapp, Britta and Krastel, Philipp and Melin, Nicolas and Nigsch, Florian and Oakeley, Edward James and Petitjean, Virginie and Petersen, Frank and Riedl, Ralph and Schmitt, Esther and Staedtler, Frank and Studer, Christian and Tallarico, John and Wetzel, Stefan and Fishman, Mark and Porter, Jeffrey and Movva, Rao (2014) High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions. Microbiological Research, 169 (2-3). pp. 107-120. ISSN 09445013

Hoffmann, Peter (2014) Precliical Safety Biomarkers for Drug-Induced Vascular Injury-Current Status and blueprint for the Future. Toxicologic Pathology, 42 (4). pp. 635-657. ISSN 0192-6233

Hoffmann, Peter (2014) TRANSLATION STRATEGY FOR DRUG-INDUCED VASCULAR INJURY BIOMARKERS. Toxicol Pathol. 2014 Jun;42(4):658-71. doi: 10.1177/0192623314527644. Epub 2014 Apr 24.

Hoffmann, Peter and Mc Lean, Leeanne and Yan, Jing-He and Beckman , David and Barbeau, Stephanie (2014) Absence of permanent effects of aliskiren in juvenile rats. Birth Defects Research (Part B) 101:144–151 (2014).

Hoffmann, Peter and Mc Lean, Leeanne and Yan, Jing-He and Moulin, Pierre (2014) Aliskiren toxicity in juvenile rats is determined by ontogenic regulation of intestinal P-glycoprotein expression. Toxicology and Applied Pharmacology 275 (2014) 36–43.

Hopkins, Neil (2014) The GacS/GacA signal transduction system of Pseudomonas aeruginosa acts exclusively through its control over the transcription of the RsmY and RsmZ regulatory small RNAs. test.

Hu, Ye and Lounkine, Eugen and Bajorath, Juergen (2014) Many Approved Drugs Have Bioactive Analogs With Different Target Annotations. The AAPS Journal, 16 (4). pp. 847-59. ISSN 1550-7416

Huet, Heather and Growney, Joseph and Johnson, Jennifer and Bilic, Sanela and Ostrom, Lance and Zafari, Mohammad and Kowal, Colleen and Yang, Guizhi and Dombrecht, Bruno and Meerschaert, Kris and Cromie, Karen and Mosher, Rebecca and Gao, Hui and Schuller, Alwin and Isaacs, Randi and Sellers, William and Ettenberg, Seth (2014) Multivalent Nanobodies targeting Death Receptor 5 elicit superior tumor cell killing through efficient caspase induction. mAbs.

Huskey, Su-Er and Li, Wenkui and Mangold, James and Flarakos, Jimmy (2014) An industry perspective on tiered approach to the investigation of metabolites in drug development. Bioanalysis, 6 (5). pp. 617-628. ISSN 17576199


Ilyina, N and Kharit, S and Namazova-Baranova, L and Asatryan, A and Benashvili, M and Tkhostova, E and Bhusal, C and Arora, AK (2014) Safety and immunogenicity of meningococcal ACWY CRM -conjugate vaccine in children, adolescents, and adults in Russia. Hum Vaccin Immunother .

Iyer, CC and McGovern, VL and Wise, DO and Glass, DJ and Burghes, AHM (2014) Deletion of atrophy enhancing genes fails to ameliorate the phenotype in a mouse model of spinal muscular atrophy. Neuromuscular Disorders. pp. 436-444.


Jackson, DJ and Makrinioti, H and Rana, BMJ and Shamji, BWH and Trujillo-Torralbo, MB and Footitt, J and Del-Rosario, J and Telcian, AG and Nikonova, A and Zhu, J and Aniscenko, J and Gogsadze, L and Bakhsoliani, E and Traub, S and Dhariwal, J and Porter, J and Hunt, D and Hunt, T and Hunt, T and Stanciu, LA and Khaitov, M and Bartlett, NW and Edwards, MR and Kon, OM and Mallia, P and Papadopoulos, NG and Akdis, CA and Westwick, J and Edwards, MJ and Cousins, DJ and Walton, RP and Johnston, SL (2014) IL-33-Dependent Type 2 Inflammation during Rhinovirus-induced Asthma Exacerbations In Vivo. American Journal of Respiratory and Critical Care Medicine. pp. 1373-1382.

Jackson, GR and Clark, ME and Scott, IU and Walter, LE and Quillen, DA and Brigell, MG (2014) Twelve-Month Natural History of Dark Adaptation in Patients with AMD. Optometry & Vision Science: .

Jacob, Sandra and Jahnke, Wolfgang and Knapp, Stefan (2014) Novel approaches for targeting kinases. Future Medicinal Chemistry, 6 (5). pp. 541-561. ISSN 1756-89191756-8927

Jacquemont, Sébastien and Berry-Kravis, Elisabeth and Hagerman, Randy and Von Raison, Florian and Gasparini, Fabrizio and Apostol, George and Ufer, Mike and Des Portes, Vincent and Gomez-Mancilla, Baltazar (2014) The challenges of clinical trials in fragile X syndrome. Psychopharmacology, 231 (6). pp. 1237-1250. ISSN 0033-3158

Jaeger, Savina and Min, Junxia and Nigsch, Florian and Camargo, Miguel and Hutz, Janna and Cornett, Allen and Cleaver, Stephen and Buckler, Alan and Jenkins, Jeremy (2014) Causal Network Models for Predicting Compound Targets and Driving Pathways in Cancer. Journal of Biomolecular Screening, 19 (5). pp. 791-802. ISSN 1087-05711552-454X

Jayaraman, A and Jackson, DJ and Message, SD and Pearson, RM and Aniscenko, J and Caramori, G and Mallia, P and Papi, A and Shamji, B and Edwards, M and Westwick, J and Hansel, T and Stanciu, LA and Johnston, SL and Bartlett, NW (2014) IL-15 complexes induce NK- and T-cell responses independent of type I IFN signaling during rhinovirus infection. Mucosal Immunology.

Jen, Dennis and Schreiber, Mark and Muller, Ryan and Prince, John (2014) NIBR Open Source Gallery. NIBR Open Source Gallery. p. 1. ISSN 0000-0000

Jiang, Ji and Li, Lilly and Yin, Hequn and Woessner, Ralph and Emotte, Corinne and Li, Ruobing and Khindri, Sanjeev and Hu, Pei (2014) Single- and multiple-dose pharmacokinetics of inhaled indacaterol in healthy Chinese volunteers. European Journal of Drug Metabolism and Pharmacokinetics, 40 (2). pp. 203-208. ISSN 2107-0180

Jiang, W and Schnabel, C and Spyra, M and Mautner, VF and Friedrich, RE and Hagel, C and Manley, PW and Kluwe, L (2014) Efficacy and selectivity of nilotinib on NF1-associated tumors in vitro. JOURNAL OF NEURO-ONCOLOGY. pp. 231-236.

Jimenez-Sanchez, L and Campa, L and Auberson, YP and Adell, A (2014) The Role of GluN2A and GluN2B Subunits on the Effects of NMDA Receptor Antagonists in Modeling Schizophrenia and Treating Refractory Depression. Neuropsychopharmacology. pp. 2673-2680.

Jiménez-Sánchez, Laura and Campa, Leticia and Auberson, Yves and Adell, Albert (2014) NMDA receptor antagonism: from modeling schizophrenia to treating refractory depression. Neuropsychopharmacology.

John, Markus and Harfst, Eva and Loeffler, Juergen and Belleli, Rossella and Bruin, Gerardus and Seuwen, Klaus and Klickstein, Lloyd and Mindeholm, Linda and Widler, Leo and Kneissel, Michaela (2014) AXT914 a novel, orally-active parathyroid hormone-releasing drug in two early studies of healthy volunteers and postmenopausal women. Bone, 64. pp. 204-210. ISSN 8756-3282

Johns, Neil and Hatakeyama, Shinji and Stephens, NA and Degen, Simone and Degen, Martin and Frieauff, W and Lambert, Christian and Greig, C and McDonald, CA and Ross, JA and Roubenoff, Ronenn and Glass, David and Jacobi, Carsten and Kenneth CH, Fearon (2014) Clinical classification of cancer cachexia: phenotypic correlates in human skeletal muscle. PLOS one.

Julius, U and Milton, Mark and Stoellner, Daniela and Rader, D and Gordon, B and Polk, D and Waldmann, E and Parhofer, KG and Moriarty, PM (2014) Effects of lipoprotein apheresis (LA) on serum PCSK9 levels. Atherosclerosis, 235 (2). e59-e60. ISSN 0021-9150

Junttila, MR and Devasthali, V and Cheng, JH and Castillo, J and Metcalfe, C and Clermont, AC and Den, OD and Chan, E and Bou-Reslan, H and Cao, T and Forrest, W and Nannini, MA and French, DM and Carano, R and Merchant, M and Hoeflich, KP and Singh, M (2014) Modeling targeted inhibition of MEK and PI3 kinase in human pancreatic cancer. Mol Cancer Ther .

Juric, D and Castel, P and Griffith, M and Griffith, OL and Won, HH and Ellis, H and Ebbesen, SH and Ainscough, BJ and Ramu, A and Iyer, G and Shah, RH and Huynh, T and Mino-Kenudson, M and Sgroi, D and Isakoff, S and Thabet, A and Elamine, L and Solit, DB and Lowe, SW and Quadt, C and Peters, M and Derti, A and Schegel, R and Huang, A and Mardis, ER and Berger, MF and Baselga, J and Scaltriti, M (2014) Convergent loss of PTEN leads to clinical resistance to a PI(3)Kalpha inhibitor. Nature.


Kariuki-Nyuthe, C and Gomez-Mancilla, B and Stein, DJ (2014) Obsessive compulsive disorder and the glutamatergic system. Current Opinion in Psychiatry. pp. 32-37.

Karuna, Ratnaningrum and Christen, Isabelle and Sailer, Andreas and Bitsch, Francis and Zhang, Juan (2014) Detection of dihydroxycholesterols in human plasma using HPLC-ESI-MS/MS. Steroids.

Kaufman, Kenneth and Linghu, Bolan and Szustakowski, Joseph and Petitjean, Virginie and Altorfer, Marc and Oakeley, Edward James and Husami, Ammar and Yang, Fan and Zhang, Kejian and Filipovich, Alexandra and Ndate, Fall and Harley, John and Nirmala, Nanguneri and Grom, Alexei (2014) Whole-Exome Sequencing Reveals Overlap Between Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis and Familial Hemophagocytic Lymphohistiocytosis. Arthritis and Rheumatology, 66 (12). pp. 3486-3495. ISSN 2326-5205

Kawatkar, SP and Keating, TA and Olivier, NB and Breen, JN and Green, OM and Guler, SY and Hentemann, MF and Loch, JT and McKenzie, AR and Newman, JV and Otterson, LG and Martinez-Botella, G (2014) Antibacterial inhibitors of gram-positive thymidylate kinase: Structure-activity relationships and chiral preference of a new hydrophobic binding region. Journal of Medicinal Chemistry. pp. 4584-4597.

Kazani, Shamsah and Arm, Jonathan and Boyce, Joshua and Chhay, Heng and Dutile, Stefanie and Wechsler, Michael and Govindarajulu, Usha and Ivester, Priscilla and Ainsworth, Hannah and Sergeant, Susan and Chilton, Floyd and Israel, Elliot (2014) LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma. LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma.

Ke, R and Loverdo, C and Qi, H and Olson, CA and Wu, NC and Sun, R and Lloyd-Smith, JO (2014) Modelling clinical data shows active tissue concentration of daclatasvir is 10-fold lower than its plasma concentration. Journal of Antimicrobial Chemotherapy. pp. 724-727.

Keaney, Erin and Connolly, Michael and Dobler, Markus and Karki, Rajeshri and Honda, Ayako and Sokup, Samantha and Karur, Subramanian and Britt, Shawn and Patnaik, Anup and Raman, Prakash and Hamann, Lawrence and Wiedmann, Brigitte and Lamarche, Matthew (2014) 2-Alkyloxazoles as potent and selective PI4KIIIβ inhibitors for the treatment of HCV. Bioorganic and Medicinal Chemistry Letters.

Keenan, CM and Baker, J and Goodman, DG and Harada, T and Bradley, A and Herbert, R and Kaufman, W and Mahler, B and Meseck, Emily and Nolte, T and Rittinghausen, S and Vahle, J and Yoshizawa, K and Kellner, R (2014) International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) Progress to Date and Future Plans. Journal of Toxicologic Pathology. pp. 1533-1601. ISSN 0192-6233 print

Keller, Hansjoerg and Graf-Hausner, Ursula and Heinzelmann, Elsbeth (2014) NTN Biotech – competences across the entire value chain Create human tissues for drug development. lifeSciences plus, 2014 (01). pp. 15-18. ISSN none

Kelley, Marian and Beaver, Christopher and Stevenson, Lauren and Bamford, Ross and Gegwich, Paula and Li, Dongbei and Little, Samantha and Muraganandam, Arumugam and Stoellner, Daniela and Trivedi, Ravi Kumar (2014) CONSENSUS AND RECOMMENDATION OF THE L1 GLOBAL HARMONIZATION TEAM ON RUN ACCEPTANCE FOR LARGE MOLECULE BIOANALYSIS TO SUPPORT PHARMACOKINETICS. AAPS Journal, 16 (2). pp. 221-225.

Khojasteh, SC and Yue, Q and Ma, S and Castanedo, G and Chen, JZ and Lyssikatos, J and Mulder, T and Takahashi, R and Ly, J and Messick, K and Jia, W and Liu, L and Hop, CECA and Wong, H (2014) Investigations into the mechanisms of pyridine ring cleavage in vismodegibs. Drug Metabolism and Disposition. pp. 343-351.

Klawitter, Jost and Bek, Stephan and Zakaria, Marjorie and Zeng, Chenhui and Hornberger, Andrea and Kyler, Corby and Shokati, Tourai and Klawitter, Jelena and Christians, Uwe and Boernsen, K. Olaf (2014) The Fatty Acid Desaturation Index in Human Plasma: Comparison of Different Analytical Methodologies for the Evaluation of Dietary Effects. The Fatty Acid Desaturation Index in Human Plasma: Comparison of Different Analytical Methodologies for the Evaluation of Dietary Effects. ISSN 1618-2650

Klohs, Jan and Rudin, Markus and Shimshek, Derya and Beckmann, Nicolau (2014) Imaging of Cerebrovascular Pathology in Animal Models of Alzheimer`s Disease. Frontiers in Aging Neuroscience.

Kornmann, O and Watz, H and Fuhr, R and Krug, N and Erpenbeck, Veit and Kaiser, Guenther (2014) Omalizumab in patients with allergic (IgE-mediated) asthma and IgE/bodyweight combinations above those in the initially approved dosing table. Pulmonary Pharmacology & Therapeutics.

Korzekwa, K and Tweedie, DJ and Argikar, UA and Whitcher-Johnstone, A and Bell, L and Bickford, S and Nagar, S (2014) A Numerical Method for Analysis of In Vitro Time-dependent Inhibition Data. Part 2. Application to Experimental Data. Drug Metab Dispos .

Korzekwa, Ken and Tweedie, Donald and Argikar, Upendra and Whitcher-Johnstone, Andrea and Bickford, Shari and Bell, Leslie and Nagar, Swati (2014) A numerical method for analysis of in vitro time-dependent inhibition data. Part 2. Application to experimental data. Drug Metabolism and Disposition.

Kramer, Christian and Fuchs, Julian E and Whitebread, Steven and Gedeck, Peter and Liedl, Klaus R (2014) Matched Molecular Pair Analysis: Significance and the Impact of Experimental Uncertainty. Journal of Medicinal Chemistry, 57 (9). pp. 3786-3802. ISSN 0022-2623

Krashes, MJ and Shah, BP and Madara, JC and Olson, DP and Strochlic, DE and Garfield, AS and Vong, L and Pei, H and Watabe-Uchida, M and Uchida, N and Liberles, SD and Lowell, BB (2014) An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger. Nature. pp. 238-242.

Krauser, Joel and Jin, Yi and Walles, Markus and Pfaar, Ulrike and Sutton, James and Wiesmann, Marion and Graf, Daniel and Pflimlin-Fritschy, Veronique and Wolf, Thierry and Camenisch, Gian P. and Swart, Pieter Jacob (2014) Phenotypic and metabolic investigation of a CSF-1R kinase receptor inhibitor (BLZ945) and its pharmacologically active metabolite. Xenbiotica. ISSN 0049-8254 (print), 1366-5928 (electronic)

Kryshtafovych, A and Moult, J and Bales, P and Bazan, JF and Biasini, M and Burgin, A and Chen, C and Cochran, FV and Craig, TK and Das, R and Fass, D and Garcia-Doval, C and Herzberg, O and Lorimer, D and Luecke, H and Ma, X and Nelson, DC and van Raaij, MJ and Rohwer, F and Segall, A and Seguritan, V and Zeth, K and Schwede, T (2014) Challenging the state of the art in protein structure prediction: Highlights of experimental target structures for the 10th critical assessment of techniques for protein structure prediction experiment CASP10. Proteins: Structure, Function and Bioinformatics. pp. 26-42.

Kuchler, Ulrike and Schwarze, Uwe and Dosak, Toni and Heimel, Patrick and Bosshardt, Dieter and Kneissel, Michaela and Gruber, Reinhard (2014) Dental and periodontal phenotype in sclerostin knockout mice. International Journal of Oral Science, 6 (2). pp. 70-76. ISSN 2049-3169

Kunze, A and Huwyler, J and Camenisch, G and Poller, B (2014) Prediction of Organic Anion-Transporting Polypeptide 1B1- and 1B3-Mediated Hepatic Uptake of Statins Based on Transporter Protein Expression and Activity Data. Drug Metabolism & Disposition. pp. 1514-1521.

Kunze, Annett and Camenisch, Gian P. and Poller, Birk and Huwyler, Jörg (2014) Prediction of organic anion-transporting polypeptide 1B1- and 1B3- mediated hepatic uptake of statins based on transporter protein expression and activity data. Drug Metabolism and Disposition, 42 (9). pp. 1514-1521. ISSN 1521-009X

Kunze, Annett and Huwyler, Jörg and Poller, Birk and Gutmann, Heike and Camenisch, Gian P. (2014) In Vitro- in Vivo Extrapolation (IVIVE) Method to Predict Human Renal Clearance of Drugs. Journal of Pharmaceutical Sciences.


Lakshminarayana, Suresh Bangalore and Boshoff, Helena and Cherian, Joseph and Ravindran, Sindhu and Goh, Anne and Jiricek, Jan and Nanjundappa, Mahesh Bangalore and Nayyar, Amit and Gurumurthy, Meera and Singh, Ramandeep and Dick, Thomas and Blasco, Francesca and Dartois, Veronique and Ho, Paul C and Manjunatha, Ujjini Havaldar (2014) Pharmacokinetics-pharmacodynamics analysis of bicyclic nitroimidazole analogues in a murine model of tuberculosis. PLOS ONE, 9 (8).

Lakshminarayana, Suresh Bangalore and Freymond, Celine and Fischli, Christoph and Yu, Jing and Weber, Sebastian and Goh, Anne and Yeung, Bryan King Sing and Ho, Paul C and Dartois, Veronique and Diagana, Thierry Tidiane and Rottmann, Matthias and Blasco, Francesca (2014) Pharmacokinetics-pharmacodynamics analysis of spiroindolone analogs and KAE609 in a murine malaria model. Antimicrobial Agents and Chemotherapy.

Lakshminarayana, Suresh Bangalore and Tan, Bee Huat and Paul C, Ho and Manjunatha, Ujjini Havaldar and Veronique, Dartois and Thomas , Dick and Rao, Srinivasa P.S. (2014) Physico-chemical, in vitro potency, pharmaco-kinetic and dynamic properties of anti-TB drugs. Journal of Antimicrobial Chemotherapy.

Law, Wai Siang and Genin, Jean-Christophe and Miess, Christian and Treton, Gwenola and Warren, Andrew Paul and Lloyd, Peter and Dudal, Sherri and Krantz, Carsten (2014) Use of a generic LC-MS/MS assay to characterize atypical PK profile of a biotherapeutic monoclonal antibody. Bioanalysis, 6 (23). pp. 3225-3235. ISSN 1757-6180

Lazerwith, SE and Lew, W and Morganelli, P and Liu, Q and Canales, E and Clarke, MO and Doerffler, E and Byun, D and Mertzman, M and Ye, H and Chong, L and Xu, L and Appleby, T and Chen, X and Fenaux, M and Hashash, A and Leavitt, SA and Mabery, E and Matles, M and Mwangi, JW and Tian, Y and Lee, Y and Zhang, J and Zhu, C and Murray, BP and Watkins, WJ (2014) Discovery of GS-9669, a thumb site II non-nucleoside inhibitor of NS5B for the treatment of genotype 1 chronic hepatitis C infection. Journal of Medicinal Chemistry. pp. 1893-1901.

Lazic, SE and Fuss, J and Gass, P (2014) Quantifying the behavioural relevance of hippocampal neurogenesis. PLoS One. e113855-.

Lazic, Stanley and Fuss, J and Gass, P (2014) Quantifying the behavioural relevance of hippocampal neurogenesis. PLoS ONE, 9 (11). ISSN 1932-6203

Legerlotz, Kirsten and Dorn, Jonas and Richter, Jens and Rausch, Martin and Leupin, Olivier (2014) Age-dependent regulation of tendon crimp structure, cell length and gap width with strain. Acta Biomaterialia, 10 (10). pp. 4447-4455. ISSN 1878-7568

Legros, C and Devavry, S and Caignard, S and Tessier, C and Delagrange, P and Ouvry, C and Boutin, JA and Nosjean, O (2014) Melatonin MT1 and MT2 receptors display different molecular pharmacologies only in the G-protein coupled state. British Journal of Pharmacology. pp. 186-201.

Lehmann, Hansjoerg and La Vecchia, Luigi and Brocklehurst, Cara (2014) Enabling Technologies in Pharmaceutical Industry Scale-up of Hazardous Reactions in Continuous Flow. Chimica Oggi - Chemistry Today.

Lemaitre, RN and Johnson, CO and Hesselson, S and Sotoodhenia, N and McKnight, B and Sitlani, CM and Rea, TD and King, IB and Kwok, PY and Mak, A and Li, G and Brody, J and Larson, E and Mozaffarian, D and Psaty, BM and Huertas-Vazquez, A and Tardif, JC and Albert, CM and Lyytikainen, LP and Arking, DE and Kaab, S and Huikuri, HV and Krijthe, BP and Eijgelsheim, M and Wang, YA and Reinier, K and Lehtimaki, T and Pulit, SL and Brugada, R and Muller-Nurasyid, M and Newton-Cheh, CH and Karhunen, PJ and Stricker, BH and Goyette, P and Rotter, JI and Chugh, SS and Chakravarti, A and Jouven, X and Siscovick, DS (2014) Common variation in fatty acid metabolic genes and risk of incident sudden cardiac arrest. Heart Rhythm. pp. 471-477.

Leong, Franz Joel Wen and Lefevre, Gilbert and Magnusson, Baldur (2014) Protocol No. CKAE609X2201 A proof-of-concept open label, 3-day repeated dose study to assess efficacy, safety, tolerability and pharmacokinetics of KAE609 in adult patients with acute, uncomplicated Plasmodium falciparum or vivax malaria mono-infection. New England Journal of Medicine.

Leong, Franz Joel Wen and Li, Ruobing and Jain, Jay Prakash and Lefevre, Gilbert and Magnusson, Baldur and Diagana, Thierry Tidiane and Pertel, Peter (2014) A first-in-human randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study of novel spiroindolone KAE609, to assess the safety, tolerability and pharmacokinetics in healthy adult volunteers. Antimicrobial agents and chemotherapy, 58 (10). pp. 6209-6214. ISSN 1098-6596

Leong, Franz Joel Wen and Zhao, Rong and Zeng, Shuqi and Magnusson, Baldur and Diagana, Thierry Tidiane and Pertel, Peter (2014) A first-in-human randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study of novel imidazolopiperazine KAF156, to assess safety, tolerability and pharmacokinetics in healthy adult volunteers. Antimicrobial agents and chemotherapy, 58 (11). pp. 6437-6443. ISSN 1098-6596

Leong, Franz Joel Wen and Zhao, Rong and Zeng, Shuqi and Magnusson, Baldur and Diagana, Thierry Tidiane and Pertel, Peter (2014) A first-in-human randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study of novel imidazolopiperazine KAF156, to assess safety, tolerability and pharmacokinetics in healthy adult volunteers. Antimicrobial agents and chemotherapy, 58 (11). pp. 6437-6443. ISSN 1098-6596

Letz, Saskia and Haag, Christine and Schulze, Egbert and Frank-Raue, Karin and Raue, Friedhelm and Hofner, Benjamin and Mayr, Bernhard and Schöfl, Christof (2014) Amino alcohol- (NPS-2143) and quinazolinone-derived calcilytics (ATF936 and AXT914) differentially mitigate excessive signalling of calcium-sensing receptor mutants causing bartter syndrome type 5 and autosomal dominant hypocalcemia. Amino alcohol- (NPS-2143) and quinazolinone-derived calcilytics (ATF936 and AXT914) differentially mitigate excessive signalling of calcium-sensing receptor mutants causing bartter syndrome type 5 and autosomal dominant hypocalcemia, 9 (12). e115178/1-e115178/11. ISSN 1932-6203

Letzkus, Martin and Luesink, Evert and Starck-Schwertz, Sandrine and Bigaud, Marc and Mirza, Fareed and Hartmann, Nicole and Gerstmayer, Bernhard and Janssen, Uwe and Scherer, Andreas and Schumacher, Martin and Verles, Aurelie and Vitaliti Garami, Alessandra and Nirmala, Nanguneri and Johnson, Keith J and Staedtler, Frank (2014) Gene expression profiling of immunomagnetically separated cells directly from stabilized whole blood for multicenter clinical trials. Journal of Clinical and Translational Medicine, 3. p. 36. ISSN 2001-1326

Lewis, Ian and Schaefer, Michael and Wagner, Beatrix and Oberer, Lukas and Sager, Emine and Wipfli, Peter and Vorherr, Thomas (2014) A Detailed Investigation on Conformation, Permeability and PK Properties of Two Related Cyclohexapeptides. International Journal of Peptide Research and Therapeutics. ISSN 1573-3904

Lewis, Ian and Schmid, Herbert and Kneuer, Rainer and Hoyer, Daniel and Silva, Antonio and Weckbecker, Gisbert and Bruns, Christian and Pless, Janos (2014) SOM230: a new therapeutic modality for Cushing's disease. Chimia, 68 (7-8). pp. 483-484. ISSN 0009-4293

Lewis, Richard and Wood, Dave (2014) Modern 2D QSAR for Drug Discovery. computational molecular science, 4. pp. 505-522.

Li, E and Zhang, Y (2014) DNA methylation in mammals. Cold Spring Harbor perspectives in biology.

Li, J and Zhu, S and Kozono, D and Ng, K and Futalan, D and Shen, Y and Akers, JC and Steed, T and Kushwaha, D and Schlabach, M and Carter, BS and Kwon, C and Furnari, F and Cavenee, W and Elledge, S and Chen, CC (2014) Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma. Oncotarget. pp. 882-893.

Li, Jie and Zhu, Shan and Kozono, David and Ng, Kimberly and Futalan, Diahnn and Shen, Ying and Akers, Johnny C and Steed, Tyler and Kushwaha, Deepa and Schlabach, Michael and Carter, Bob S and Kwon, Chang-Hyuk and Furnari, Frank and Cavenee, Webster and Elledge, Stephen and Chen, Clark C (2014) Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma. Oncotarget, 5 (4). pp. 882-93. ISSN 1949-2553

Li, Jie and Zhu, Shan and Kozono, David and Ng, Kimberly and Futalan, Diahnn and Shen, Ying and Akers, Johnny C and Steed, Tyler and Kushwaha, Deepa and Schlabach, Michael and Carter, Bob S and Kwon, Chang-Hyuk and Furnari, Frank and Cavenee, Webster and Elledge, Stephen and Chen, Clark C (2014) Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma. Oncotarget, 5 (4). pp. 882-893. ISSN 1949-2553

Li, Nanxin and Lee, Christian and Michellys, Pierre and Kim, Sungjoon and Pferdekamper, Annemarie and Li, Jie and Kasibhatla, Shailaja and Sun, Xiuying and Hua, Su and Mcnamara, Peter and Harris, Jennifer and Friboulet, Luc and Katayama, Ryohei and Gainor, Justin and Crystal, Adam and Awad, Mark and Yanagitani, Noriko and Mahmood, Sidra and Lockerman, Elizabeth and Fujita, Naoya and Nishio, Makoto and Shaw, Alice and Engelman, Jeffery and Sun, Frank (2014) The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer. Cancer Discovery, 4 (6). pp. 662-673. ISSN 2159-8290

Li, Wenkui and Doherty, John and Moench, Paul and Flarakos, Jimmy and Tse, Francis (2014) LC-MS/MS bioanalysis of loratadine (Claritin) in dried blood spot (DBS) samples collected by subjects in a clinical research study. Journal of Chromatography B.

Li, Wenkui and Luo, Suyi and Rebello, Sam and Flarakos, Jimmy and Tse, Francis (2014) A semi-automated high performance liquid chromatography-tandem mass spectrometric method for determination of LCI699, an 11-hyroxylase inhibitor, in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci, 960. pp. 182-193.

Li, Y and Zhang, T (2014) Targeting cancer stem cells by curcumin and clinical applications. CANCER LETTERS. pp. 197-205.

Li, Zhizhong and Glass, David and Clay, Ieuan and Ramanujan, Krishnan and Zhang, Yunyu and Brachat, Sophie and Gong, Chenguang (2014) A Long Non-coding RNA, LncMyoD, Regulates Skeletal Muscle Differentiation by Blocking IMP2-mediated protein translation. Developmental cell, 34 (2). pp. 181-191. ISSN 1878-1551; 1534-5807

Li, Zhizhong and Glass, David and Gilbert, Jason and Zhang, Yunyu and Eash, John (2014) HMGA2-IGF2BP2 Axis Regulates Muscle Stem Cell Activation and Myogenesis. Dev Cell, 23 (6). pp. 1176-1188.

Lingaraju Gondichatnahalli, Manjappa and Bunker, Richard and Renatus, Martin and Hassiepen, Ulrich and Thomae, Nicolas and Fischer, Eric and Cavadini, Simone and Hess, Daniel (2014) Crystal structure of the human COP9 signalosome holoenzyme. Nature, 512 (7513). pp. 161-165. ISSN 0028-08361476-4687

Liu, Edwin and McDaniel, Kristen and Case, Stephanie and Yu, Liping and Gerhartz, Bernd and Ostermann, Nils and Fankhauser, Gabriela and Hungerford, Valerie and Zou, Chao and Luyten, Marcel and Seidl, Katherine and Michels, Aaron (2014) Exploring T cell reactivity to gliadin in young children with newly-diagnosed Celiac disease. Autoimmune Diseases, 2014. pp. 1-8. ISSN 0076-6879

Liu, Jun and Patel, Manishha and Hsieh, Hsin-I and Ng, Nicholas and Batalov, Sergey and Orth, Anthony and Zhou, Zongxiang and Harris, Jennifer (2014) Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening. BMC Cancer, 14 (944). pp. 1-13. ISSN NA

Liu, Jun and Peters, Eric and Yang, Jiayi and DeRan, Michael and Shen, Che-Hung and Julien, Fitamant and Asara, John and Bardeesy, Nabeel and Zheng, Bin and Wu, Xu (2014) Cellular Metabolism Regulates Hippo–YAP Signaling through AMPK-mediated Phosphorylation and Stabilization of Angiomotin Like-1 Protein. Cell reports, 9 (2). pp. 495-503. ISSN 2211-1247

Liu, Y and Zhou, S and Wan, Y and Wu, A and Palmisano, M (2014) The impact of co-administration of ketoconazole and rifampicin on the pharmacokinetics of apremilast in healthy volunteers. British Journal of Clinical Pharmacology. pp. 1050-1057.

Lombardo, Franco and Berellini, Giuliano and Stringer, Rowan and Obach, Scott and Varma, Manthena (2014) Clearance mechanism assignment and total clearance prediction in human based upon in silico models. Journal of Medicinal Chemistry, 57 (10). pp. 4397-4405. ISSN 1520-4804

London, Anne and Alabi, Buola and Mackay, Kasey and Lihon, Michael and He, Yaqin (2014) Gel filtration chromatography as a method for removing bacterial endotoxin from antibody preparations. Biotechnology Progress.

London, Anne and Patel, Kunal and Quinn, Lisa and Lemmerer, Martin (2014) Application of coupled affinity-sizing chromatography for the detection of proteolyzed HSA-tagged proteins. Protein Expression and Purification.

Longo, Francesco and Russo, Isabella and Shimshek, Derya and Greggio, Elisa and Morari, Michele (2014) Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging. Neurobiology of Disease.

Lorthiois, Edwige and Cumin, Frederic and Ehrhardt, Claus and Kosaka, Takatoshi and Sellner, Holger and Ostermann, Nils and Wagner, Beatrix and Maibaum, Juergen Klaus and Francotte, Eric (2014) Trans-(3S,4S)-Disubstituted Pyrrolidines as Inhibitors of the Human Aspartyl Protease Renin. Part I: Prime Site exploration using an amino linker. Bioorganic and medicinal chemistry letters, 25 (8). pp. 1782-1786. ISSN 0960894X

Luisier, Raphaelle and Unterberger, Elif and Goodman, Jay and Schwarz, Michael and Moggs, Jonathan and Terranova, Remi and van Nimwegen, Erik (2014) Computational modeling identifies key gene regulatory interactions underlying phenobarbital-mediated tumor promotion. Nucleic Acid Research (NAR).

Luu, Van Tong and Goujon, Jean-Yves and Meisterhans, Christian and Frommherz, Matthias and Bauer, Carsten (2014) Synthesis of a high specific activity methyl sulfone tritium isotopologue of fevipiprant (NVP-QAW039). Journal of Radiolabelled Compounds and Radiopharmaceuticals.


Mac Sweeney, Aengus and Grosche, Philipp and Combrink, Keith and Erbel, Paulus and Hughes, Nicola and Bernardi, Anna and Ramage, Paul and Jarrousse Coscoy, Nadine and Ellis, David and Melkko, Samu and Sirockin, Finton and Altmann, Eva (2014) Discovery and structure-based optimization of potent adenain inhibitors. Discovery and structure-based optimization of potent adenain inhibitors, 5 (8). pp. 937-941. ISSN 1948-5875

MacArthur, DG and Manolio, TA and Dimmock, DP and Rehm, HL and Shendure, J and Abecasis, GR and Adams, DR and Altman, RB and Antonarakis, SE and Ashley, EA and Barrett, JC and Biesecker, LG and Conrad, DF and Cooper, GM and Cox, NJ and Daly, MJ and Gerstein, MB and Goldstein, DB and Hirschhorn, JN and Leal, SM and Pennacchio, LA and Stamatoyannopoulos, JA and Sunyaev, SR and Valle, D and Voight, BF and Winckler, W and Gunter, C (2014) Guidelines for investigating causality of sequence variants in human disease. Nature. pp. 469-476.

MacKenzie, Amanda and Caltabiano, Gianluigi and Kent, Toby and Jenkins, Laura and Lappin, Jennifer and Hudson, Brian and Nicklin, Stuart and Fawcett, Lindsay and Lane, Rebecca and Charlton, Steven and Milligan, Graeme (2014) The antiallergic mast cell stabilizers lodoxamide and bufrolin as the first high and equipotent agonists of human and rat GPR35. Molecular Pharmacology, 85 (1). pp. 91-104. ISSN 0026895X

Maciejewski, M and Barlow, PN and Tjandra, N (2014) Decoding the components of dynamics in three-domain proteins. Journal of Computational Chemistry, 35 (7). pp. 518-525. ISSN 01928651

Maclennan, Calman Alexander and Micoli, Francesca (2014) Vaccines against invasive Salmonella disease: Current status and future directions. Human Vaccines and Immunotherapeutics, 10 (6). pp. 1478-1493. ISSN 2164-554X

Mah, Robert and Thomas, Jason and Shafer, Cynthia (2014) Drug Discovery Considerations in the Development of Covalent Inhibitors. Bioorganic and Medicinal Chemistry Letters, 24 (1). pp. 33-39. ISSN 0960894X

Mah, Robert and Thomas, Jason and Shafer, Cynthia (2014) Drug Discovery Considerations in the Development of Covalent Inhibitors. Bioorganic and Medicinal Chemistry Letters, 24 (1). pp. 33-39. ISSN 0960894X

Maier, FC and Wehrl, HF and Schmid, AM and Mannheim, JG and Wiehr, S and Lerdkrai, C and Calaminus, C and Stahlschmidt, A and Ye, L and Burnet, M and Stiller, D and Sabri, O and Reischl, G and Staufenbiel, M and Garaschuk, O and Jucker, M and Pichler, BJ (2014) Longitudinal PET-MRI reveals beta-amyloid deposition and rCBF dynamics and connects vascular amyloidosis to quantitative loss of perfusion. Nature Medicine . pp. 1485-1492.

Mair, KM and Wright, AF and Duggan, N and Rowlands, DJ and Hussey, MJ and Roberts, S and Fullerton, J and Nilsen, M and Loughlin, L and Thomas, M and MacLean, MR (2014) Sex-Dependent Influence of Endogenous Estrogen in Pulmonary Hypertension. American Journal of Respiratory and Critical Care Medicine. pp. 456-467.

Maire, CL and Ramkissoon, S and Hayashi, M and Haidar, S and Ramkissoon, L and Ditomaso, E and Ligon, KL (2014) Pten loss in Olig2 expressing neural progenitor cells and oligodendrocytes leads to interneuron dysplasia and leukodystrophy. Stem Cells. pp. 313-326.

Malik, Hasnain and Taylor, Buck and Kerrigan, John and Grob, Jonathan and Houk, Ken and Du Bois, Justin and Hamann, Lawrence and Patterson, Andrew (2014) Non-Directed Allylic C–H Acetoxylation in the Presence of Lewis Basic Heterocycles. Chemical Science.

Manevski, Nenad and Swart, Pieter Jacob and Balavenkatraman, Kamal Kumar and Bertschi, Barbara and Camenisch, Gian P. and Kretz, Olivier and Schiller, Hilmar and Walles, Markus and Barbara , Ling and Reto , Wettstein and Dirk J, Schaefer and Peter, Itin and Chess, Joanna and Pognan, Francois and Wolf, Armin and Litherland, Karine (2014) Phase II Metabolism in Human skin: Skin Explants Show Activities of Glucuronidation, Sulfation, N-Acetylation, Catechol Methylation, and Glutathione Conjugation. Biochemical Pharmacology.

Mannick, Joan and Del Giudice, Giuseppe and Valiante, Nick and Lattanzi, Maria and Praestgaard, Jens and Huang, Baisong and Lonetto, Michael and Kovarik, John M. and Maecker, Holden and Carson, Simon and Glass, David and Klickstein, Lloyd (2014) Effects of mTOR Inhibition on Immunosenescence in the Elderly. Science Translational Medicine.

Marelli, Udaya K and Frank, Andreas O and Wahl, Bernhard and La Pietra, Valeria and Novellino, Ettore and Marinelli, Luciana and Herdtweck, Eberhardt and Groll, Michael and Kessler, Horst (2014) Receptor-Bound Conformation of Cilengitide Better Represented by Its Solution-State Structure than the Solid-State Structure. Receptor-Bound Conformation of Cilengitide Better Represented by Its Solution-State Structure than the Solid-State Structure, 20 (44). ISSN 09476539

Martin, Eric and Cao, Edward (2014) Euclidean Chemical Spaces from Molecular Fingerprints: Hamming Distance and Hempels Ravens. Journal of Computer-Aided Molecular Design.

Marzinzik, Andreas and Voegtle, Markus and Rondeau, Jean-Michel and Billich, Andreas and Pelle, Xavier and Manetsch, Roman and Monastyrskyi, Andrii (2014) Kinetic target guided synthesis for the identification of macrophage migration inhibitory factor inhibitors (MIF). Thesis.

Masadeh, AS and Atassi, F and Shatnawi, MTM (2014) Total scattering atomic pair distribution function: The use of the total scattering atomic pair distribution function methods in pharmaceutical analysis. Pharmazeutische Industrie. pp. 1283-1291.

Mateus Rodrigues, Diogo Filipe and Kittelmann, Matthias and Eggimann, Fabian and Bachler, Thorsten and Abad, Sandra and Hanlon, Steven and Camattari, Andrea and Glieder, Anton and Wirz, Beat and Winkler, Margit and Luetz, Stephan (2014) Production of recombinant human aldehyde oxidase in E. coli and optimization of its application for preparative synthesis of oxidized drug metabolites. ChemCatChem, 6 (4). pp. 1028-1042.

Mathai, John C. and Yu, Weiqun and Kim, Jae Hun and Zhou, Ge and Liao, Yi and Sun, Tung-Tien and Fredberg, Jeffrey J. and Zeidel, Mark L. (2014) Hypercompliant Apical Membranes of Bladder Umbrella Cells. Biophysical Journal, 107 (6). pp. 1273-1279. ISSN 00063495

Mayer, Nikola and Beuvink, Iwan and Traggiai, Elisabetta (2014) EVALUATING SINGLE CELL PCR TO DISSECT THE HUMAN B CELL REPERTOIRE. master thesis.

McBride, Christopher and Levine, Barry and Xia, Yi and Bellamacina, Cornelia and Machajewski, Timothy and Gao, Zhenhai and Renhowe, Paul and Antonios-Mccrea Jr., Bill and Barsanti, Paul and Brinner, Kristin and Costales, Abran and Doughan, Brandon and Lin, Xiaodong and Louie, Alicia and McKenna, Maureen and Mendenhall, Kris and Poon, Daniel and Rico, Alice and Wang, Michael and Williams, Teresa and Abrams, Tinya and Fong, Susan and Hendrickson, Thomas and Lei, Dachuan and Lin, Julie and Menezes, Daniel Lopes De and Pryer, Nancy and Taverna, Pietro and Zhou, Yasheen and Shafer, Cynthia (2014) Design, Structure Activity Relationship and in vivo Characterization of the Clinical Candidate NVP-HSP990. Journal of Medicinal Chemistry, 57 (21). pp. 9124-9129. ISSN 0022-26231520-4804

McInnes, Iain B. and Sieper, J and Braun, J and Emery, P and Van der Heijde, D and Isaacs, J and Dahmen, G and Wollenhaupt, J and Schulze-Koops, H and Kogan, J and Ma, Shenglin and Schumacher, Martin and Bertolino, Arthur and Hueber, Wolfgang and Tak, Paul-Peter (2014) Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: A 24-week, randomised, double-blind, placebo-controlled, phase ii proof-of-concept trial. Annals of the Rheumatic Diseases, 73 (2). pp. 349-356. ISSN 0003-4967

Mckenna, Jeff and Talbot, Eric and Richardson, Melodie and Toste, F. Dean (2014) Gold Catalysed Redox Synthesis of Imidazo[1,2a]pyridine using Pyridine N-Oxide and Alkynes. Gold Catalysed Redox Synthesis of Imidazo[1,2a]pyridine using Pyridine N-Oxide and Alkynes, 356. pp. 687-691.

Mckenna, Jeff and Talbot, Eric and Toste, F. Dean and Fernandes, Talita (2014) First Asymmetric Palladium-Catalyzed Fluoro-arylation of Styrenes. Asymmetric Palladium-Catalyzed Directed intermolecular Fluoro-arylation of Styrenes, 136. pp. 4101-4104.

Mckeown, Stephen and Zecri, Frederic and Fortier, Eric and Taggart, Andrew and Sviridenko, Lilya and Adams, Christopher and Mcallister, Kathryn and Pin, Sokhom (2014) The design and implementation of a generic lipopeptide scanning platform to enable the identification of 'locally acting' agonists for the apelin receptor. Bioorganic and Medicinal Chemistry Letters, 24 (20). pp. 4871-4875. ISSN 1464-3405

Mcpate, Mark and Bhalay, Gurdip and Beckett, Martin and Gosling, Martin and Groot Kormelink, Paul and Lane, Rebecca and Kent, Toby and Van Diepen, Michiel and Tranter, Pamela and Verkuijl, Martin (2014) The development of automated patch clamp assays for canonical transient receptor potential channels TRPC3, 6, and 7. Assay and Drug Development Technologies, 12 (5). pp. 282-292. ISSN 15578127

Meehan, R and Lempiainen, H and Braeuning, A and Muller, A and Vitobello, A and Ellinger-Ziegelbauer, H and Henderson, C and Schwarz, M and Terranova, R and Moggs, J and Wolf, CR and Thomson, J (2014) Drug induced changes in the mouse liver epigenome. Toxicology Letters. S16-S16.

Meier, Thomas and Keller, Hansjoerg (2014) 3D-DRUCKER Leben aus dem Drucker. ZHAW Impact, 26 (14). pp. 32-36. ISSN keine

Meininger, V and Pradat, PF and Corse, A and Al-Sarraj, S and Rix, BB and Caress, JB and Cudkowicz, M and Kolb, SJ and Lange, D and Leigh, PN and Meyer, T and Milleri, S and Morrison, KE and Orrell, RW and Peters, G and Rothstein, JD and Shefner, J and Lavrov, A and Williams, N and Overend, P and Price, J and Bates, S and Bullman, J and Krull, D and Berges, A and Abila, B and Meno-Tetang, G and Wurthner, J (2014) Safety, pharmacokinetic, and functional effects of the nogo-a monoclonal antibody in amyotrophic lateral sclerosis: a randomized, first-in-human clinical trial. PLoS ONE. e97803-.

Meissner, Axel and van der Plas, Anton A and van Dasselaar, Nick T and Deelder, André M and van Hilten, Jacobus J and Mayboroda, Oleg A (2014) 1H-NMR metabolic profiling of cerebrospinal fluid in patients with complex regional pain syndrome-related dystonia. Pain, 155 (1). pp. 190-196. ISSN 1872-6623

Menezes, DL and Holt, J and Tang, Y and Feng, J and Barsanti, P and Pan, Y and Ghoddusi, M and Zhang, W and Thomas, G and Holash, J and Lees, E and Taricani, L (2014) A Synthetic Lethal Screen Reveals Enhanced Sensitivity to ATR Inhibitor Treatment in Mantle Cell Lymphoma with ATM Loss-of-function. Molecular Cancer Research .

Mercier, Alexandre and Arias, Carolina and Madrid, Alexis and Holdorf, Meghan and Ganem, Donald (2014) Site-Specific Association with Host and Viral Chromatin by KSHV LANA and its Reversal during Lytic Reactivation. Site-specific association with host and viral chromatin by KSHV LANA and its reversal during lytic reactivation.

Mesrouze, Yannick and Hau, Jean-Christophe and Erdmann, Dirk and Zimmermann, Catherine and Fontana, Patrizia and Schmelzle, Tobias and Chene, Patrick (2014) The surprising features of the TEAD4-Vgll1 protein-protein interaction. ChemBioChem, 15 (4). pp. 537-542. ISSN 1439-4227

Metcalfe, H and Lea, A and Hughes, S and Smith, F and Khalaf, H and Abbot Banner, K and Singh, D (2014) Effects of cigarette smoke on Toll-like receptor (TLR) activation of chronic obstructive pulmonary disease (COPD) macrophages. Clinical and Experimental Immunology, 176 (3). pp. 461-472. ISSN 1365-2249

Michaut, Lydia and Laurent, Nathalie and Kentsch, Kerstin and Spindeldreher, Sebastian and Deckert-Salva, Fabienne (2014) STABILITY OF ANTI-IMMUNOTHERAPEUTIC ANTIBODIES IN FROZEN HUMAN SERUM SAMPLES. Bioanalysis, 6 (10). 1395-1407 . ISSN 1757-6180

Michaut, Lydia and Laurent, Nathalie and Kentsch, Kerstin and Spindeldreher, Sebastian and Deckert-Salva, Fabienne (2014) STABILITY TESTING OF ANTI-VACCINE ANTIBODIES IN HUMAN SERUM. Bioanalysis, 6 (10). pp. 1395-1407. ISSN 1757-6180

Miklayc, Pika and Ehinger, Konstantin and Thompson, Kristin and Hobi, Nina and Shimshek, Derya and Frick, Manfred (2014) Surfactant Secretion in LRRK2 Knock-Out Rats: Changes in Lamellar Body Morphology and Rate of Exocytosis. PLoS one.

Milicevic Sephton, Selena and Müller, Adrienne and Mu, Lijing and Keller, Claudia and Rüdisühli, Sonja and Auberson, Yves and Schibli, Roger and Krämer, Stefanie and Ametamey, Simon (2014) Preclinical Evaluation and Test–Retest Studies of 18F-PSS232, a Novel Radioligand for Targeting Metabotropic Glutamate Receptor 5 (mGlu5). Neuroimage.

Minuesa, Gerard and Antczak, Christophe and Shum, David and Radu, Constantin and Bhinder, Bhavneet and Li, Yueming and Djaballah, Hakim and Kharas, Michael (2014) A 1536-well Fluorescence Polarization Assay to Screen for Modulators of the MUSASHI Family of RNA-Binding Proteins. Combinatorial Chemistry & High Throughput Screening, 17 (7). pp. 596-609. ISSN 1875-5402

Mir, Anis Khusro and Elain, Gaelle and Jeanneau, Karine and Dev, Kumlesh and Rutkowska, Aleksandra (2014) The selective anti-IL17A monoclonal antibody secukinumab (AIN457) attenuates IL17A-induced levels of IL6 in human astrocytes., 62 (5). pp. 725-735. ISSN 0894-1491

Monsma, DJ and Cherba, DM and Richardson, PJ and Vance, S and Rangarajan, S and Dylewski, D and Scott, SB and Beuschel, NL and Axtell, R and Mitchell, D and Lester, E and Junewick, JJ and Webb, CP and Monks, NR (2014) Precision Medicine in Rhabdomyosarcoma: Using Patient Derived Xenografts as models of drug efficacy and acquired resistance. Pediatric blood & cancer, 61 (9). pp. 1570-1577. ISSN 15455009

Montagner, A and Delgado, MB and Tallichet-Blanc, C and Chan, JSK and Sng, MK and Mottaz, H and Degueurce, G and Lippi, Y and Moret, C and Baruchet, M and Antsiferova, M and Werner, S and Hohl, D and Al, ST and Farmer, PJ and Tan, NS and Michalik, L and Wahli, W (2014) Src is activated by the nuclear receptor peroxisome proliferator-activated receptor beta/ in ultraviolet radiation-induced skin cancer. EMBO Molecular Medicine. pp. 80-98.

Montagner, Alexandra and Delgado, Maria and Tallichet, Corrine and Chan, Jeremy and Sng, Ming and Mottaz, Helene and Degeurce, Gwendoline and Moret, Catherine and Baruchet, Michael and Farmer, Pierre and Nguan, Tan and Michalik, Liliane and Wahli, Walter (2014) Src is activated by the nuclear receptor peroxisome proliferator-activated receptor b/d in ultraviolet radiation-induced skin cancer. EMBO molecular medicine, 6 (1). pp. 80-98. ISSN 17574676

Montarolo, F and Raffaele, C and Perga, S and Martire, S and Finardi, A and Furlan, R and Hintermann, S and Bertolotto, A (2014) Effects of Isoxazolo-Pyridinone 7e, a Potent Activator of the Nurr1 Signaling Pathway, on Experimental Autoimmune Encephalomyelitis in Mice. PLoS ONE. e108791-.

Montarolo, Francesca and Raffaele, Chiara and Perga, Simona and Martire, Serena and Finardi, Annamaria and Furlan, Roberto and Hintermann, Samuel and Bertolotto, Antonio (2014) Effects of Isoxazolo-Pyridinone 7e, a Potent Activator of the Nurr1 Signaling Pathway, on Experimental Autoimmune Encephalomyelitis in Mice. PLOS One.

Mora-Blanco, E. Lorena and Mishina, Yuji and Tillman, Erik and Cho, Yoon-Jae and Thom, Christopher and Pomeroy, Scott and Shao, Wenlin and Roberts, Charles (2014) Activation of β-catenin/TCF targets following loss of the tumor suppressor SNF5. Oncogene, 33 (7). pp. 933-938. ISSN 0950-9232

Morse, Alyson and McDonald , Michelle M. and Kelly, N. H. and Melville, K. M. and Schindeler, Aaron and Kramer, Ina and Kneissel, Michaela and van der Meulen, MCH and Little, David G. (2014) Mechanical load increases in bone formation via a Sclerostin-independent pathway. Journal of Bone and Mineral Research.


Namoto, Kenji and Sirockin, Finton and Ostermann, Nils and Gessier, Francois and Flohr, Stefanie and Sedrani, Richard and Gerhartz, Bernd and Trappe, Joerg and Hassiepen, Ulrich and Duttaroy, Alokesh and Ferreira, Suzie and Sutton, Jon M. and Clark, David E. and Fenton, Gary and Beswick, Mandy and Baeschlin, Daniel (2014) Discovery of C-(1-aryl-cyclohexyl)-methylamines as selective, orally available inhibitors of dipeptidyl peptidase IV. Bioorganic & Medicinal Chemistry Letters, 24 (3). pp. 731-736.

Naninck, Eva F. G. and Hoeijmakers, Lianne and Kakava-Georgiadou, Nefeli and Meesters, Astrid and Lazic, Stanley and Lucassen, Paul J. and Korosi, Aniko (2014) Chronic early-life stress alters developmental and adult neurogenesis and impairs cognitive function in mice. Hippocampus, 25 (3). pp. 309-328. ISSN 10509631

Neuber, T and Frese, K and Jaehrling, J and Jager, S and Daubert, D and Felderer, K and Linnemann, M and Hohne, A and Kaden, S and Kolln, J and Tiller, T and Brocks, B and Ostendorp, R and Pabst, S (2014) Characterization and screening of IgG binding to the neonatal Fc receptor. mAbs. pp. 928-942.

Neuder, Andreas and Achilli, Francesca and Moussaoui, Saliha and Bates, Gillian P (2014) Identification of two novel heat shock factor isoforms - HSF1 isoform ratio regulates the level of transcription of heat shock protein genes.*. TBD, 289 (29). ISSN 0021-92581083-351X

Ng, Jia Tsing and Dekker, Carien and Kroemer, Markus and Osborne, Michael and von Delft, Frank (2014) Using Textons to Rank Crystallization Droplets by Likely Presence of Crystals. Acta Crystallographica Section D, D70 (10). pp. 2702-2718. ISSN 1399-0047

Ngaemthao, W and Suriyachadkun, C and Chunhametha, S and Niemhom, N and Thawai, C and Sanglier, J (2014) Planobispora takensis sp. nov., isolated from soil. International Journal of Systematic and Evolutionary Microbiology. pp. 1180-1185.

Nguyen, TH and Mentre, F and Levi, M and Yu, J and Guedj, J (2014) A pharmacokinetic - viral kinetic model describes the effect of alisporivir monotherapy or in combination with peg-IFN on hepatitis C virologic response. Clinical Pharmacology and Therapeutics.

Nirmala, Nanguneri and Grom, Alexei and Gram, Hermann (2014) Biomarkers in systemic juvenile idiopathic arthritis: A comparison with biomarkers in cryopyrin-associated periodic syndromes. Current Opinion in Rheumatology, 26 (5). pp. 543-552. ISSN 1531-6963

Nithya, Paranthaman and Vilmos, Kertez and Moench, Paul and Catoire, Alexandre and Flarakos, Jimmy and Gary, VanBerkel (2014) Liquid Microjunction Surface Sampling-HPLC-MS/MS Profiling of Acetaminophen, Terfenadine and Their Metabolites in Whole-Body Rat Thin Tissue Sections. Bioanalysis, 6 (19). pp. 2599-2606. ISSN 1757-6180

Noble, Christian Guy and Li, Shi Hua and Dong, Hongping and Chew, Kelly and Shi, Pei-Yong (2014) Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine. Antiviral Research, 111. pp. 78-81. ISSN 01663542

Noe, A and Howard, C and Thuren, T and Taylor, A and Skerjanec, A (2014) Pharmacokinetic and Pharmacodynamic Characteristics of Single-Dose Canakinumab in Patients With Type 2 Diabetes Mellitus. Clinical Therapeutics.

niemi, natalie and sacoman, juliana and westrate, laura and lanning, nathan and Gaither, Larry and mackeigan, jeffery (2014) The pseudophosphatase MK-STYX physically and genetically interacts with the mitochondrial phosphatase PTPMT1. PLoS ONE, 9 (4). ISSN 1932-6203


Ofner, Silvio and Vranesic, Ivan-Toma and Bilbe, Graeme and Bouhelal, Rochdi and Ertl, Peter and hart, terry and rasetti, vittorio and Mcallister, Kevin and Kuhn, Rainer R and Gasparini, Fabrizio (2014) AFQ056/mavoglurant, a novel clinically effective mGluR5 antagonist: Identification, SAR and pharmacological characterization. Bioorganic and Medicinal Chemistry, 22 (21). pp. 5790-5803. ISSN 1464-3391

Okujava, R and Guye, P and Lu, Y and Mistl, C and Polus, F and Vayssier-Taussat, M and Halin, C and Rolink, AG and Dehio, C (2014) A Translocated Effector Required for Bartonella Dissemination from Derma to Blood Safeguards Migratory Host Cells from Damage by Co-translocated Effectors. PLoS Pathogens.

Overby, Darryl R. and Zhou, Enhua and Vargas-Pinto, Rocio and Pedrigi, Ryan M. and Fuchshofer, Rudolf and Braakman, Sietse T. and Gupta, Ritika and Perkumas, Kristin M. and Sherwood, Joseph M. and Vahabikashi, Amir and Dang, Quynh and Kim, Jae Hun and Ethier, C. Ross and Stamer, W. Daniel and Fredberg, Jeffrey J. and Johnson, Mark (2014) Schlemm’s canal, pore formation, and outflow dysfunction in glaucoma. PNAS, 111 (38). ISSN 0027-84241091-6490


Paisley, Derek and Bevan, Luke and Choy, Kate and Gross, Carina (2014) The Pneumonectomy Model of Compensatory Lung Growth: insights into lung regeneration. Pharmacology and Therapeutics.

Papadimitropoulos, Adam and Piccinini, Elia and Brachat, Sophie and Braccini, Alessandra and Wendt, David and Barbero, Andrea and Jacobi, Carsten and Martin, Ivan (2014) Human mesenchymal stromal cell expansion in a 3D scaffold-based system under direct perfusion. Human mesenchymal stromal cell expansion in a 3D scaffold-based system under direct perfusion.

Parameswaran, Reshmi and Lim, Min and Groffen, John and Gram, Hermann and Mclaughlin, Margaret and Heisterkamp, Nora (2014) Effector-mediated eradication of precursor B acute lymphoblastic leukemia with a novel Fc-engineered monoclonal antibody targeting the BAFF-R. Molecular Cancer Therapeutics, 13 (6). pp. 1567-1577. ISSN 1538-8514

Parameswaran, Reshmi and Lim, Min and Groffen, John and Gram, Hermann and Mclaughlin, Margaret and Heisterkamp, Nora and Fei, Fei and Abdel-Azim, Hisham and Arutyunyan, Anna and Schiffer, Isabelle and Huet, Heather (2014) Effector-mediated eradication of precursor B acute lymphoblastic leukemia with a novel Fc-engineered monoclonal antibody targeting the BAFF-R. Molecular Cancer Therapeutics, 13 (6). pp. 1567-1577. ISSN 1538-8514

Paranthaman, Nithya and Kertesz, Vilmos and Moench, Paul and Catoire, Alexandre and Flarakos, Jimmy and Van Berkel, Gary J. (2014) Liquid microjunction surface sampling of acetaminophen, terfenadine and their metabolites in thin tissue sections. Bioanalysis, 6 (19). pp. 2599-2606. ISSN 1757-6180

Park, HJ and Guariento, M and Maciejewski, M and Hauhart, R and Tham, W and Cowman, AF and Schmidt, CQ and Mertens, HDT and Kathryn, LM and Hourcade, DE and Barlow, PN and Atkinson, JP (2014) Using mutagenesis and structural biology to map the binding site for the plasmodium falciparum merozoite protein PfRh4 on the human immune adherence receptor. Journal of Biological Chemistry, 289 (1). pp. 450-463. ISSN 0021-92581083-351X

Pasca, SP and Panagiotakos, G and Dolmetsch, RE (2014) Generating human neurons in vitro and using them to understand neuropsychiatric disease. Annual Review of Neuroscience. pp. 479-501.

Pasche, Emilie and Gobeill, Julien and Kreim, Olivier and Oezdemir-Zaech, Fatma and Vachon, Therese and Lovis, Christian and Ruch, Patrick (2014) Development and tuning of an original search engine for patent libraries in medicinal chemistry. BMC bioinformatics, 60 (5). pp. 407-415. ISSN 1468-2044

Pasquale, LR and Jiwani, AZ and Zehavi-Dorin, T and Majd, A and Rhee, DJ and Chen, T and Turalba, A and Shen, L and Brauner, S and Grosskreutz, C and Gardiner, M and Chen, S and Borboli-Gerogiannis, S and Greenstein, SH and Chang, K and Ritch, R and Loomis, S and Kang, JH and Wiggs, JL and Levkovitch-Verbin, H (2014) Solar exposure and residential geographic history in relation to exfoliation syndrome in the United States and Israel. JAMA Ophthalmology. pp. 1439-1445.

Pastukhov, Oleksandr and Schwalm, Stephanie and Zangemeister-Wittke, Uwe and Fabbro, Doriano and Bornancin, Frederic and Japtok, Lukasz and Kleuser, Burkhard and Pfeilschifter, Josef and Huwiler, Andrea (2014) The ceramide kinase inhibitor NVP-231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death. British Journal of Pharmacology, 171 (24). pp. 5829-5844. ISSN 1476-5381

Patapoutian, Ardem and Qiu, Zhaozhu and Bandell, Michael and Mathur, Jayanti (2014) Piezo1, a mechanically activated ion channel, is required for vascular development in mice. Proceedings of the National Academy of Sciences of the United States of America, 111 (28). pp. 10347-10352. ISSN 1091-6490

Patnaik, A and Weiss, GJ and Papadopoulos, KP and Hofmeister, CC and Tibes, R and Tolcher, A and Isaacs, R and Jac, J and Han, M and Payumo, FC and Cotreau, MM and Ramanathan, RK (2014) Phase i ficlatuzumab monotherapy or with erlotinib for refractory advanced solid tumours and multiple myeloma. British Journal of Cancer. pp. 272-280.

Persson, BD and Jaffe, AB and Fearns, R and Danahay, H (2014) Respiratory Syncytial Virus Can Infect Basal Cells and Alter Human Airway Epithelial Differentiation. Plos One.

Peters, Eric and Sipila, Kalle and Haag, Sabrina and Denessiouk, Konstantin and Kapyla, Jarmo and Denesyuk, Alexander and Hansen, Uwe and Konttinen, Yrjo and Johnson, Mark and Holmdahl, Rikard and Heino, Jyrki (2014) Citrullination of collagen II affects integrin-mediated cell adhesion in a receptor-specific manner. FASEB Journal, 28 (8). pp. 3758-3768. ISSN 1530-6860

Peukert, Stefan and Hughes, Richard and Nunez, Jill and He, Guo and Yan , Zhao and Jain, Rishi and Llamas, Luis and Luchansky, Sarah and Carlson, Adam and Liang, Guiqing and Kunjathoor, Vidya and Pietropaolo, Michael and Shapiro, Jeffrey and Castellana, Anja and Wu, Xiaoping and Bose, Avirup (2014) Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists. ACS MedChemLetters.

Pham, HV and Paton, RS and Ross, AG and Danishefsky, SJ and Houk, KN (2014) Intramolecular Diels-Alder Reactions of Cycloalkenones: Stereoselectivity, Lewis Acid Acceleration, and Halogen Substituent Effects. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. pp. 2397-2403.

Phillips, Dean and Gao, Wenqi and Yang, Yang and Zhang, Guobao and Lerario, Isabelle and Lau, Thomas and Jiang, Jiqing and Wang, Xia and Nguyen, Deborah and Bhat, Barkur and Trotter, Carol and Welzel, Gustav and Sullivan, Heather and Landry, Jannine and Chen, Yali and Joseph, Sean and Li, Chun and Gordon, William and Richmond, Wendy and Johnson, Kevin and Bretz, Angela and Bursulaya, Badry and Pan, Shifeng and Mcnamara, Peter and Seidel, Martin (2014) Discovery of trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as potent, orally bioavailable TGR5 (GPBAR1) agonists: Structure-activity relationships, lead optimization, and chronic in vivo efficacy. Journal of Medicinal Chemistry, 57 (8). pp. 3263-3282. ISSN 1520-4804

Pierog, P and Krishna, M and Yamniuk, A and Chauhan, A and DeSilva, B (2014) Detection of drug specific circulating immune complexes from in vivo cynomolgus monkey serum samples. Journal of Immunology Methods.

Pihl, Susanne and Michaut, Lydia and Hendriks, Jenny and Loebbert, Ralph and Ryding, Janka and Nemansky, Martin and Vermet, Laurent and Companjen, Arjen (2014) EBF Recommendation for stability testing of anti-drug antibodies; lessons learned from anti-vaccine antibody stability studies. Bioanalysis, 6 (10). pp. 1409-1413. ISSN 1757-6180

Pirard, Bernard and Ertl, Peter (2014) Evaluation of a Semi-Automated Workflow for Fragment Growing. Journal of Chemical Information and Modeling, 55 (1). pp. 180-193. ISSN 1549-960X

Pissani, F and Malherbe, DC and Schuman, JT and Robins, H and Park, BS and Krebs, SJ and Barnett, SW and Haigwood, NL (2014) Improvement of antibody responses by HIV envelope DNA and protein co-immunization. VACCINE. pp. 507-513.

Plappert Helbig, Ulla and Guérard , Melanie (2014) Inter-laboratory comparison of the in vivo comet assay including three image analysis systems. Environmental and Molecular Mutagenesis, 55 (2). pp. 114-121.

Plappert Helbig, Ulla and Van der Leede, Bas-jan and Doherty, Ann and Guérard, Melanie and Howe, Jonathan and Thybaud, Véronique (2014) Performance and data interpretation of the in vivo comet assay in pharmaceutical industry: EFPIA survey results. Current Topics in Genotoxicity Testing of Mutation Research – Genetic Toxicology and Environmental Mutagenesis, 775–77. pp. 81-88.

Poor, Stephen and Qiu, Yubin and Woolfenden, Amber and Fassbender, Elizabeth and Delpero, Andrea and Meredith, Erik and Buchanan, Natasha and Yong, kim and Hanks, Shawn and Shen, Siyuan and Gebuhr, Tom and Jaffee, Bruce and Dryja, Ted (2014) Reliability of the mouse model of choroidal neovascularization induced by laser photocoagulation. Investigations of Ophthalmic Visual Sciences.

Pop, MS and Stransky, N and Garvie, CW and Theurillat, JP and Hartman, EC and Lewis, TA and Zhong, C and Culyba, EK and Lin, F and Daniels, DS and Pagliarini, R and Ronco, L and Koehler, AN and Garraway, LA (2014) A Small Molecule That Binds and Inhibits the ETV1 Transcription Factor Oncoprotein. Mol Cancer Ther . pp. 1492-1502.

Portal, CF and Seifert, JM and Buehler, C and Meisner-Kober, NC and Auer, M (2014) Novel 1:1 Labeling and Purification Process for C-Terminal Thioester and Single Cysteine Recombinant Proteins Using Generic Peptidic Toolbox Reagents. BIOCONJUGATE CHEMISTRY. pp. 1213-1222.

Porter, David and Bradley, Michelle and Brown, Zarin and Canova, Riccardo and Charlton, Steven and Cox, Brian and Hunt, Peter and Kolarik, David and Lewis, Sarah and O'Connor, Des and Reilly, John and Spanka, Carsten and Tedaldi, Lauren and Watson, Simon and Wermuth, Roland and Press, Neil (2014) The Discovery of Potent, Orally Bioavailable Pyrazolo and Triazolopyrimidine CXCR2 Receptor Antagonists. Biorganic and Medicinal Chemistry Letters, 24 (1). pp. 72-76.

Porter, David and Bradley, Michelle and Brown, Zarin and Charlton, Steven and Cox, Brian and Hunt, Peter and Janus, Diana and Lewis, Sarah and Oakley, Paul and O'Connor, Des and Reilly, John and Smith, Nichola and Press, Neil (2014) The Discovery of Potent, Orally Bioavailable Pyrimidine-5-carbonitrile-6-alkyl CXCR2 Receptor Antagonists. Biorganic & Medicinal Chemistry Letters.

Portmann, T and Yang, M and Mao, R and Panagiotakos, G and Ellegood, J and Dolen, G and Bader, PL and Grueter, BA and Goold, C and Fisher, E and Clifford, K and Rengarajan, P and Kalikhman, D and Loureiro, D and Saw, NL and Zhengqui, Z and Miller, MA and Lerch, JP and Henkelman, RM and Shamloo, M and Malenka, RC and Crawley, JN and Dolmetsch, RE (2014) Behavioral Abnormalities and Circuit Defects in the Basal Ganglia of a Mouse Model of 16p11.2 Deletion Syndrome. Cell reports.

Preuss, Inga and Ludwig, Marie-Gabrielle and Baumgarten, Birgit and Bassilana, Frederic and Gessier, Francois and Seuwen, Klaus and Sailer, Andreas (2014) Transcriptional regulation and functional characterization of the oxysterol / EBI2 system in primary human macrophages. Biochemical and Biophysical Research Communication, 446. pp. 663-668.

Proietti, M and Cornacchione, V and RezzonicoJost, T and Romagnani, A and Faliti, CE and Perruzza, L and Rigoni, R and Radaelli, E and Caprioli, F and Preziuso, S and Brannetti, B and Thelen, M and McCoy, KD and Slack, E and Traggiai, E and Grassi, F (2014) ATP-gated ionotropic P2X7 receptor controls follicular T helper cell numbers in peyer's patches to promote host-microbiota mutualism. Immunity. pp. 789-801.


Qi, H and Olson, CA and Wu, NC and Ke, R and Loverdo, C and Chu, V and Truong, S and Remenyi, R and Chen, Z and Du, Y and Su, S and Al-Mawsawi, LQ and Wu, T and Chen, S and Lin, C and Zhong, W and Lloyd-Smith, JO and Sun, R (2014) A Quantitative High-Resolution Genetic Profile Rapidly Identifies Sequence Determinants of Hepatitis C Viral Fitness and Drug Sensitivity. PLoS Pathogens.

Qiu, W and Rogers, AJ and Damask, A and Raby, BA and Klanderman, BJ and Duan, QL and Tyagi, S and Niu, S and Anderson, C and Cahir-Mcfarland, E and Mariani, TJ and Carey, V and Tantisira, KG (2014) Pharmacogenomics: novel loci identification via integrating gene differential analysis and eQTL analysis. Human Molecular Genetics. pp. 5017-5024.


Rahal, Rami and Frick, Mareike and Romero, Rodrigo and Ruddy, David and Derti, Adnan and Rakiec, Daniel and Naylor, Tara and Kauffmann, Audrey and Pfister-Wagner, Estelle and Fritsch, Christine and Kovats, Steven and Kim, Sunkyu and Dietze, Kerstin and Dorket, Bernd and Tzankov, Alexandar and Hummel, Michael and Monahan, John and Morrissey, Michael and Sellers, William and Lenz, Georg and Cooke, Vesselina and Bhang, Hyo-Eun and Farsidjani, Alireza and Hernandez-Ilizaliturri, Francisco J and Mavis, Cory and Stegmeier, Frank (2014) Pharmacological and genomic profiling identifies NF-κB-targeted treatment strategies for mantle cell lymphoma. Nature Medicine, 20 (1). pp. 87-92. ISSN 1078-8956

Ramsden, Emma and Moulin, Pierre and Lee, David and Christ, Andreas Dominik (2014) QAX576, AN ANTI–INTERLEUKIN (IL)-13 MONOCLONAL ANTIBODY, FOR THE TREATMENT OF PATIENTS WITH FISTULISING CROHN’S DISEASE (CD): RESULTS OF A PROOF-OF-CONCEPT STUDY. United European Gastroenterology Week 2014.

Rascol, Olivier and Fox, Susan and Gasparini, Fabrizio and Kenney, Christopher and DiPaolo, Thérèse and Gomez-Mancilla, Baltazar (2014) Use of metabotropic glutamate 5-receptor antagonists for treatment of levodopa-induced dyskinesias. Parkinsonism and Related Disorders, 20 (9). pp. 947-956. ISSN 1873-5126

Ravenscroft, Neil and Cescutti, Paola and Stefanetti, Giuseppe and Londero, Silvia and Rondini, Simona and Maclennan, Calman Alexander (2014) Structural analysis of O-polysaccharide chains extracted from different Salmonella Typhimurium strains. Carbohydrate Research, 385. pp. 1-8. ISSN 1873-426X

Ravindran, Madhu Sudhan and Rao, Srinivasa P.S. and Cheng, Xiamin and Shukla, Ankit and Cazenave-Gassiot, Amaury and Yao, Shao Q. and Wenk, Markus R. (2014) Targeting lipid esterases in mycobacteria grown under different physiological conditions using activity based profiling with tetrahydrolipstatin. Molecular & cellular proteomics : MCP, 13 (2). pp. 435-448. ISSN 1535-9484

Reck, Folkert (2014) Optimization of Physicochemical Properties and Safety Profile of Novel Bacterial Topoisomerase Type II Inhibitors (NBTIs) with activity against Pseudomonas aeruginosa. Optimization of Physicochemical Properties and Safety Profile of Novel Bacterial Topoisomerase Type II Inhibitors (NBTIs) with activity against Pseudomonas aeruginosa .

Repko, Brian (2014) "Big Data" Bioinformatics Models for Distributed, Parallel and Concurrent Processing. Slideshare / Twitter.

Reuter, Björn and Grudzenski, Saskia and Handwerker, E and Meairs, S and Heiler, P and Schad, L and Staufenbiel, Matthias and Hennerici, Michael P and Fatar, Marc (2014) Thrombolysis in experimental cerebral amyloid angiopathy and the risk of secondary intracerebral hemorrhage. Stroke, 45 (8). pp. 2411-2416. ISSN 0039-2499

Rieffel, Sebastien and Klopp, Julia and Roest, Susan and Carnal, Simon and Marti, Sabrina and Gerhartz, Bernd and Shrestha, Binesh (2014) Insect cell culture in reagent bottles. Insect cell culture in reagent bottles, 1. pp. 155-161. ISSN 2215-0161

Rieffel, Sebastien and Klopp, Julia and Roest, Susan and Carnal, Simon and Marti, Sabrina and Gerhartz, Bernd and Shrestha, Binesh (2014) Insect cell culture in reagent bottles. MethodsX, 1. pp. 155-161. ISSN 2215-0161

Rimann, Markus and Graf-Hausner, Ursula and Keller, Hansjoerg (2014) Bioprinting und in vitro Modelle zur Wirkstoffentwicklung. ZHAW transfer, 2014 (3). p. 5. ISSN none

Ringel, Frauke and Kaeda, Jaspal and Schwarz, Michaela and Oberender, Christian and Grille, Peggy and Doerken, Bernd and Marque, Fanny and Manley, Paul W. and Radimerski, Thomas and le Coutre, Philippe (2014) Effects of the JAK2-selective inhibitors NVP-BSK805 and NVP-BVB808 in BCR-ABL or JAK2 mutation-positive cell lines. Haematologica, 132 (1). pp. 75-86. ISSN 1421-9662

Riniker, Sereina and Wang, Yuan and Jenkins, Jeremy and Landrum, Gregory (2014) Using information from historical high-throughput screens to predict active compounds. Journal of chemical information and modeling, 54 (7). pp. 1880-1891. ISSN 1549-960X

Robbe, Marie-France and Both, Jean-Pierre and Prideaux, Brendan and Klinkert, Ivo and Picauld, Vincent and Schramm, Thorsten and Hester, Alfons and Guevara, Victor and Stoeckli, Markus and Roempp, Andreas and Heeren, Ron and Spengler, Bernhard and Haan, Serge (2014) Software tools of the Computis European project to process mass spectrometry images. European Journal of Mass Spectrometry, 20 (5). pp. 351-360. ISSN 1356-1049

Robbins, PF and Kassim, SH and Tran, TL and Crystal, JS and Morgan, RA and Feldman, SA and Yang, JC and Dudly, ME and Wunderlich, JR and Sherry, RM and Kammula, US and Hughes, MS and Restifo, NP and Raffeld, M and Lee, CR and Li, YF and El-Gamil, M and Rosenberg, SA (2014) Yeast PP4 Interacts with ATR Homolog Ddc2-Mec1 and Regulates Checkpoint Signaling. Clinical Cancer Research.

Robbins, PF and Kassim, SH and Tran, TL and Crystal, JS and Morgan, RA and Feldman, SA and Yang, JC and Dudly, ME and Wunderlich, JR and Sherry, RM and Kammula, US and Hughes, MS and Restifo, NP and Raffeld, M and Lee, CR and Li, YF and El-Gamil, M and Rosenberg, SA (2014) A pilot trial using lymphocytes genetically engineered with an NY-ESO-1-reactive T cell receptor: Long term follow up and correlates with response. Clinical Cancer Research.

Robinson, Paul and Watson, Catherine and Taylor, Ann and Maldonado-Lutomirsky, Mario and Zhang, Yiming and Bertagna, Xavier and Pivonello, Rosario and Fleseriu, Maria and Hamrahian, Amir H and Boscaro, Marco and Biller, Beverly MK (2014) LCI699, a potent 11β-hydroxylase inhibitor, normalizes urinary cortisol in patients with Cushing’s disease: results from a multicenter, proof-of-concept study. Journal of Clinical Endocrinology and Metabolism.

Rodon, J and Tawbi, HA and Thomas, AL and Stoller, RG and Turtschi, CP and Baselga, J and Sarantopoulos, J and Mahalingam, D and Shou, Y and Moles, MA and Yang, L and Granvil, C and Hurh, E and Rose, KL and Amakye, DD and Dummer, R and Mita, AC (2014) A Phase I, Multicenter, Open-Label, First-in-Human, Dose-Escalation Study of the Oral Smoothened Inhibitor Sonidegib (LDE225) in Patients with Advanced Solid Tumors. CLINICAL CANCER RESEARCH. pp. 1900-1909.

Rooney, L and Vidal, A and D'Souza, AM and Devereux, N and Masick, B and Boissel, V and West, R and Head, V and Stringer, R and Lao, J and Petrus, MJ and Patapoutian, A and Nash, M and Stoakley, N and Panesar, M and Verkuyl, JM and Schumacher, AM and Petrassi, HM and Tully, DC (2014) Discovery, Optimization, and Biological Evaluation of 5-(2-(Trifluoromethyl)phenyl)indazoles as a Novel Class of Transient Receptor Potential A1 (TRPA1) Antagonists. Journal of Medicinal Chemistry. pp. 5129-5140.

Rooney, Lisa and D'Souza, Anne-Marie and Devereux, Nicholas and Boissel, Valerie and West, Ryan and Stringer, Rowan and Head, Victoria and Nash, Mark and Tully, David and Petrassi, Hank and Masick, Brian and Lao, Jianmin and Vidal-Biggart, Agnes and Petrus, Matthew and Schumacher, Andrew and Verkuijl, Martin and Stoakley, Natalie and Panesar, Moh and Patapoutian, Ardem (2014) Discovery, optimization, and biological evaluation of 5-(2- (trifluoromethyl)phenyl)indazoles as a novel class of transient receptor potential A1 (TRPA1) antagonists. Journal of Medicinal Chemistry, 57 (12). pp. 5129-5140. ISSN 1520-4804

Rooney, Lisa and D'Souza, Anne-Marie and Devereux, Nicholas and Boissel, Valerie and West, Ryan and Stringer, Rowan and Head, Victoria and Nash, Mark and Tully, David and Petrassi, Hank and Masick, Brian and Lao, Jianmin and Vidal-Biggart, Agnes and Petrus, Matthew and Schumacher, Andrew and Verkuijl, Martin and Stoakley, Natalie and Panesar, Moh and Patapoutian, Ardem (2014) Discovery, optimization, and biological evaluation of 5-(2- (trifluoromethyl)phenyl)indazoles as a novel class of transient receptor potential A1 (TRPA1) antagonists. Journal of Medicinal Chemistry, 57 (12). pp. 5129-5140. ISSN 1520-4804

Roschger, Andreas and Roschger, Paul and Keplinger, Petra and Klaushofer, Klaus and Abdullah, Sami and Kneissel, Michaela and Rauch, Frank (2014) Effect of Sclerostin Antibody Treatment in a Mouse Model of Severe Osteogenesis Imperfecta. Bone.

Ross, NT and Wilson, CJ (2014) In vitro clinical trials: the future of cell-based profiling. Frontiers in Pharmacology.

Rossi, Omar and Pesce, Isabella and Giannelli, Carlo and Aprea, Susanna and Caboni, Mariaelena and Citiulo, Francesco and Valentini, Sara and Ferlenghi, Ilaria and Maclennan, Calman Alexander and D'Oro, Ugo and Saul, Allan James and Gerke, Christiane E A (2014) Modulation of endotoxicity of Shigella Generalized Modules for Membrane Antigens (GMMA) by genetic lipid A modifications: relative activation of TLR4 and TLR2 pathways in different mutants. Journal of Biological Chemistry.

Rotty, Berenice and Kallen, Joerg (2014) Caractérisation de cristaux de complexes protéines-ligands. Master Thesis, Universite Toulouse.

Rotty, Berenice and Kallen, Joerg (2014) Caractérisation de cristaux de complexes protéines-ligands. Master Thesis Univ. Toulouse.

Ruan, Hongyu and Saur, Taixiang and Yao, Wei-Dong (2014) Dopamine-enabled anti-Hebbian timing-dependent plasticity in the prefrontal circuitry. Frontiers in Neural Circuits.

Rubinfeld, Hadara and Kammer, Adi and Cohen, Ortal and Gorshtein, Alexander and Cohen, Zvi / R and Hadani, Moshe and Werner, Haim and Shimon, Ilan (2014) IGF-1 Induces proliferation in Human Pituitary Tumors - Functional Blockade of IGF-1 Receptor as a Novel Therapeutic Approach in Non-functioning Tumors. Molecular and Cellular Endocrinology.

Ruda, VM and Chandwani, R and Sehgal, A and Bogorad, RL and Akinc, A and Charisse, K and Tarakhovsky, A and Novobrantseva, TI and Koteliansky, V (2014) The roles of individual mammalian argonautes in RNA interference in vivo. PLoS ONE.

Ruffell, B and Chang-Strachan, D and Chan, V and Rosenbusch, A and Ho, CM and Pryer, N and Daniel, D and Hwang, ES and Rugo, HS and Coussens, LM (2014) Macrophage IL-10 Blocks CD8(+) T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells. Cancer Cell. pp. 623-637.

Ruffner, Heinz and Graf-Hausner, Ursula and Stephanie, Mathes (2014) The use of skin models in drug development. Advanced Drug Delivery Reviews.


SEQC Consortium, MAQC-III Consortium and Oakeley, Edward James and Staedtler, Frank and Derti, Adnan (2014) A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium. Nature Biotechnology, Advanc (Advanc).

Sackton, KL and Dimova, N and Zeng, X and Tian, W and Zhang, M and Sackton, TB and Meaders, J and Pfaff, KL and Sigoillot, F and Yu, H and Luo, X and King, RW (2014) Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C. Nature.

Sadlish, Heather and Hassan, Asm Quamrul and Zhou, Wenlai and Kirby, Christina and Schuhmann, Tim and Studer, Christian and Chang, Lena and Hoepfner, Dominic and Sellers, William and Movva, Rao and Aust, Thomas and Riedl, Ralph and Quinn, Christopher and Krastel, Philipp and Schmitt, Esther and Baird, Jason and Chung, Franklin and Chen, Jinyun and Schitter, Anne and Pagliarini, Raymond and Chen, Yaoyu and Quinn, D and Mayer, Matthias and Kityk, Roman (2014) A novel allosteric means of inhibiting heat shock 70 proteins. Chemistry and Biology.

Sala-Cunill, Anna and Björkqvist, Jenny and Senter, Riccardo and Guilarte, Mar and Cardona, Victoria and Labrador, Moises and Nickel, Katrin F. and Lynn, Butler and Olga, Luengo and Kumar, Parvin and Labberton, Linda and Long, Andy and Di Gennaro, Antonio and Kenne, Ellinor and Jämsä, Anne and Krieger, Thorsten and Schlüter, Hartmut and Fuchs, Tobias and Flohr, Stefanie and Hassiepen, Ulrich and Cumin, Frederic and McCrea, Keith and Maas, Coen and Stavrou, Evi and Renné, Thomas (2014) ACTIVATION OF THE PLASMA CONTACT SYSTEM IN ANAPHYLAXIS – INSIGHT TO SEVERE MAST CELL-MEDIATED ALLERGIC REACTIONS. Journal of Allergy and Clinical Immunology, 135 (4). pp. 1031-1043. ISSN 00916749

Salcius, Michael and Bauer, Andras and Hao, Qin and Li, Shu and Tutter, Antonin and Raphael, Jacob and Haggarty, Stephen and Tallarico, John and Michaud, Gregory and Jahnke, Wolfgang (2014) SEC-TID: A label-free method for small-molecule target identification. Journal of Biomolecular Screening, 19 (6). pp. 917-927. ISSN 1552-454X

Sames, Dalibor and Genovino, Julien (2014) Access to drug metabolites via C-H functionalization: Copper-catalyzed aerobic oxidation of N,N-dimethylalkylamines in complex pharmaceuticals. Tetrahedron Letters, 56 (23). pp. 3066-3069. ISSN 1873-3581

San-Miguel, JF and Hungria, VT and Yoon, SS and Beksac, M and Dimopoulos, MA and Elghandour, A and Jedrzejczak, WW and Gunther, A and Nakorn, TN and Siritanaratkul, N and Corradini, P and Chuncharunee, S and Lee, JJ and Schlossman, RL and Shelekhova, T and Yong, K and Tan, D and Numbenjapon, T and Cavenagh, JD and Hou, J and LeBlanc, R and Nahi, H and Qiu, L and Salwender, H and Pulini, S and Moreau, P and Warzocha, K and White, D and Blade, J and Chen, W and de la Rubia, J and Gimsing, P and Lonial, S and Kaufman, JL and Ocio, EM and Veskovski, L and Sohn, SK and Wang, MC and Lee, JH and Einsele, H and Sopala, M and Corrado, C and Bengoudifa, BR and Binlich, F and Richardson, PG (2014) Panobinostat plus bortezomib and dexamethasone versus placebo plus bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma: a multicentre, randomised, double-blind phase 3 trial. Lancet Oncology. pp. 1195-1206.

Sanchini, Silvano and Perruccio, Francesca and Piizzi, Grazia (2014) Rational design, synthesis and biological evaluation of modular fluorogenic substrates with high affinity and selectivity for PTP1B. ChemBioChem, 15 (7). pp. 961-976. ISSN 1439-7633

Sasseville, Vito and Mansfield, Keith and Brees, Dominique (2014) Safety biomarkers in preclinical development: translational potential. Veterinary pathology, 51 (1). pp. 281-291. ISSN 1544-2217

Schlaeppi, Jean-Marc and Lavoisier, Alexandra (2014) Early developability screen of therapeutic antibody candidates using Taylor dispersion analysis and UV area imaging detection. MAbs , 7 (1). pp. 77-83. ISSN 1942-0870 (Print), 1942-0862 (Online)

Schneider, Andreas and Erden, Zeynep and von Krogh, Georg (2014) COORDINATING KNOWLEDGE CREATION IN MULTIDISCIPLINARY TEAMS: EVIDENCE FROM EARLY-STAGE DRUG DISCOVERY. Academy of Management Journal. ISSN 0001-42731948-0989

Schuemann, Jens and Boudon, Stephanie Marie and Ulrich, Peter and Loll, Nathalie and Garcia, Deborah and Schaffner, Rene and Streich, Jeannine and Kittel, Birgit and Bauer, Daniel (2014) Integrated Preclinical Photosafety Testing Strategy for Systemically Applied Pharmaceuticals. Toxicological Sciences, 139 (1). pp. 245-256. ISSN 10960929

Schweighauser, Manuel and Bacioglu, Mehtap and Fritschi, Sarah and Shimshek, Derya and Kahle, Philipp and Eisele, Yvonne and Jucker, Mathias (2014) Formaldehyde-fixed brain tissue from spontaneously ill α-synuclein transgenic mice induces fatal α-synucleinopathy in transgenic hosts. Acta Neuropathologica.

Selzer, P and Potticary, J (2014) Interview with Paul Selzer. Future Medicinal Chemistry, 6 (3). pp. 263-266. ISSN 1756-89191756-8927

Selzer, Paul (2014) Interview in Future Medicinal Chemistry. Future Medicinal Chemistry.

Sewell, F and Chapman, K and Baldrick, P and Brewster, D and Broadmeadow, A and Brown, P and Burns-Naas, LA and Clarke, J and Constan, A and Couch, J and Czupalla, O and Danks, A and DeGeorge, J and Haan, LD and Hettinger, K and Hill, M and Festag, M and Jacobs, A and Jacobson-Kram, D and Kopytek, S and Lorenz, H and Moesgaard, SG and Moore, E and Pasanen, M and Perry, R and Ragan, I and Robinson, S and Schmitt, PM and Short, B and Lima, BS and Smith, D and Sparrow, S and Bekkum, YV and Jones, D (2014) Recommendations from a global cross-company data sharing initiative on the incorporation of recovery phase animals in safety assessment studies to support first-in-human clinical trials. Regul Toxicol Pharmacol .

Sexton, BS and Avey, D and Druliner, BR and Fincher, JA and Vera, DL and Grau, DJ and Borowsky, ML and Gupta, S and Girimurugan, SB and Chicken, E and Zhang, J and Noble, WS and Zhu, F and Kingston, RE and Dennis, JH (2014) The spring-loaded genome: Nucleosome redistributions are widespread, transient, and DNA-directed. Genome Research. pp. 251-259.

Shan, C and Elf, S and Ji, Q and Kang, HB and Zhou, L and Hitosugi, T and Jin, L and Lin, R and Zhang, L and Seo, JH and Xie, J and Tucker, M and Gu, TL and Sudderth, J and Jiang, L and DeBerardinis, RJ and Wu, S and Li, Y and Mao, H and Chen, PR and Wang, D and Chen, GZ and Lonial, S and Arellano, ML and Khoury, HJ and Khuri, FR and Lee, BH and Brat, DJ and Ye, K and Boggon, TJ and He, C and Kang, S and Fan, J and Chen, J (2014) Lysine Acetylation Activates 6-Phosphogluconate Dehydrogenase to Promote Tumor Growth. Molecular Cell.

Sharif, Naj and Katoli, Parvaneh and Kelly, Curtis and Li, Linya and Xu, Shouxi and Wang, Yu and Klekar, Laura and Earnest, David and Yacoub, Shenouda and Hamilton, Gwen and Jacobson, Nasreen and Shepard, Allan and Ellis, Dorette (2014) Trabecular meshwork bradykinin receptors: mRNA levels, immunohistochemical visualization, signaling processes pharmacology and linkage to IOP changes. J Ocular Pharmacology & Therapeutics, 30 (1). pp. 21-34.

Shaw, Alice T. and Kim, Dong-Wan and Mehra, Ranee and Tan, Daniel S.W. and Felip, Enriquetta and Chow, Laura Q.M. and Camidge, D. Ross and Vansteenkiste, Johan and Sharma, Sunil and De Pas, Tommaso and Riely, Gregory J. and Solomon, Benjamin J. and Wolf, Juergen and Thomas, Michael and Schuler, Martin and Liu, Geoffrey and Santoro, Armando and Lau, Yi-Yang Yvonne and Goldwasser, Meredith and Boral, Anthony and Engelman, Jeffrey A. (2014) LDK378 in Anaplastic Lymphoma Kinase-Rearranged Non–Small-Cell Lung Cancer. New England Journal of Medicine, 370 (13). pp. 1189-1197.

Shaw, Duncan and Hollingworth, Gregory and Soldermann, Nicolas and Sprague, Elizabeth and Schuler, Walter and Vangrevelinghe, Eric and Duggan, Nicholas and Thomas, Matthew and Kosaka, Takatoshi and Waters, Nigel and Van Eis, Maurice (2014) Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension. Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension, 24 (20). pp. 4812-4817.

Sherman, Woody and Kramer, Christian and Jean Christophe, Mozziconacci (2014) Improving docking results via reranking of ensembles of ligand poses in multiple X-ray protein conformations with MM-GBSA. Journal Chemnical Information Modeling, 54 (10). pp. 2697-2717. ISSN 1549-95961549-960X

Shi, Pei-Yong and Caillet-Saguy, Célia and Julien, Lescar and Stéphane , Bressanelli (2014) Polymerases of hepatitis C viruses and flaviviruses: Structural and mechanistic insights and drug development. Antiviral research.

Shi, Pei-Yong and Gu, Feng (2014) Dengue drug discovery and development. Clinical Investigation.

Shiwarski, Daniel and Shao , Chunbo and Bill, Anke and kim, jean and xiao, dong and bertrand, carol and seethala, raja and sano, daisuke and myers, jeffery and ha, patrick and grandis, jennifer and Gaither, Larry and puthenveedu, manojkumar and duvvuri, umamaheswar (2014) To "grow" or "go": TMEM16A expression as a switch between tumor growth and metastasis in SCCHN. Clinical cancer research : an official journal of the American Association for Cancer Research, 20 (17). pp. 4673-4688. ISSN 1078-0432

Shou, Y and Robinson, DM and Amakye, DD and Rose, KL and Cho, YJ and Ligon, KL and Sharp, T and Haider, AS and Bandaru, R and Ando, Y and Geoerger, B and Doz, F and Ashley, DM and Hargrave, DR and Casanova, M and Tawbi, HA and Rodon, J and Thomas, AL and Mita, AC and MacDonald, TJ and Kieran, MW (2014) A Five-Gene Hedgehog Signature Developed as a Patient Preselection Tool for Hedgehog Inhibitor Therapy in Medulloblastoma. Clinical Cancer Research .

Shultz, Michael (2014) Improving the plausibility of success with inefficient metrics. ACS Medicinal Chemistry Letters, 5 (1). pp. 2-5. ISSN 1948-5875

Sibley, Cailin H. and Chioato, Andrea and Felix, Sandra Daniela and Colin, Laurence and Chakraborty, Abhijit and Abrams, Ken and Goldbach-Mansky, Raphaela (2014) A 24 Month Open Label Study of Canakinumab in Neonatal-Onset Multisystem Inflammatory Disease. Annals of the Rheumatic Diseases.

Simansour, Maud and Thiemeyer, Anke and Klein, Jessica and Stoehr, Natacha and Bernhard, Mario and Fodor, Barna and Galimberti, Ivan (2014) Assessment of neuronal cell type specific transcriptional effects of three pathological sequence variants of the FMR1 gene promoter. Master Thesis.

Simon, Oliver and Bates, Roderick W. and Tang, Chi H. (2014) A synthesis of 5-Hydroxysedamine using Hydroformylation. Tetrahedron, 70 (12). pp. 2134-2140. ISSN 00404020

Six, David and Yuan, Yanqiu and Leeds, Jennifer and Meredith, Timothy (2014) Deletion of the beta-Acetoacetyl Synthase FabY in Pseudomonas aeruginosa induces hypoacylation of lipopolysaccharide. Antimicrobial Agents and Chemotherapy, 58 (1). pp. 153-161. ISSN 1098-6596

Smith, D and Artursson, P and Avdeef, A and Di, L and Ecker, GF and Faller, B and Houston, JB and Kansy, M and Kerns, EH and Kramer, SD and Lennernas, H and Van De Waterbeemd, H and Sugano, K and Testa, B (2014) Passive lipoidal diffusion and carrier-mediated cell uptake are both important mechanisms of membrane permeation in drug disposition. Molecular Pharmaceutics. pp. 1727-1738.

Smith, Paul William and Diagana, Thierry Tidiane and Yeung, Bryan King Sing (2014) Progressing the global antimalarial portfolio: Finding drugs that target multiple Plasmodium life stages. Parasitology.

Smurnyy, Y and Cai, M and Wu, H and McWhinnie, E and Tallarico, JA and Yang, Y and Feng, Y (2014) DNA sequencing and CRISPR-Cas9 gene editing for target validation in mammalian cells. Nat Chem Biol .

Smurnyy, Yegor and Cai, Mi and Wu, Hua and Mc Whinnie, Elizabeth and Tallarico, John and Yang, Yi and Feng, Yan (2014) CRISPR Mediated Target Validation of ERCC3 as the Target of Triptolide. Nature Chemical Biology.

Snelder, N and Ploeger, BA and Luttringer, O and Rigel, DF and Fu, F and Beil, M and Stanski, DR and Danhof, M (2014) Drug effects on the CVS in conscious rats: separating cardiac output into heart rate and stroke volume using PKPD modelling. British Journal of Pharmacology. pp. 5076-5092.

Soncini, D and Caffa, I and Zoppoli, G and Cea, M and Cagnetta, A and Passalacqua, M and Mastracci, L and Boero, S and Montecucco, F and Sociali, G and Lasiglie, D and Damonte, P and Grozio, A and Mannino, E and Poggi, A and D'Agostino, VG and Monacelli, F and Provenzani, A and Odetti, P and Ballestrero, A and Bruzzone, S and Nencioni, A (2014) Nicotinamide Phosphoribosyltransferase Promotes Epithelial-to-Mesenchymal Transition as a Soluble Factor Independent of Its Enzymatic Activity. Journal of Biological Chemistry . pp. 34189-34204.

Spanka, Carsten and Schaumann, Ernst (2014) Synlett Account: Alkynyl Silyl Sulfides as Versatile Thioketene Equivalents. Synlett, 25 (17). pp. 2415-2428. ISSN 0936-5214

Stalter, Isabel and Memmert, Klaus (2014) Etablierung von Ko-Kultivierungstechniken zur Anwendung in miniaturisierten Testsystemen für antibiotische Aktivität. Master Thesis at Hochschule Albstadt-Sigmaringen, n.a. (n.a.). pp. 1-100. ISSN n.a.

Stockmann, C and Palmen, TG and Schroer, K and Kunze, G and Gellissen, G and Buchs, J (2014) Definition of culture conditions for arxula adeninivorans, a rational basis for studying heterologous gene expression in this dimorphic yeast. Journal of Industrial Microbiology and Biotechnology. pp. 965-976.

Stoellner, Daniela and Dudal, Sherri and Staack, Roland and Scheel Fjording, Marianne and Vieser, Eva and Pascual, Marie-Helene and Brudny-Kloeppel, Margarete and Seemann, Dietmar and Golob, Michaela (2014) How the bioanalyst plays a key role in interdisciplinary project teams in the development of biotherapeutics – a reflection of the European Bioanalysis Forum. Bioanalysis, 6 (10). pp. 1339-1348.

Stringer, Rowan and Weber, Eckhard and Culshaw, Andrew and Mckenna, Jeff and Williams, Gareth and Rose, Jonathan and Sohal, Bindi (2014) Preclinical metabolism and pharmacokinetics of NVS-CRF38, a potent and orally bioavailable corticotrophin-releasing factor-1 antagonist. Xenobiotica, 44 (10). pp. 902-912. ISSN 0049-8254

Stringer, Rowan and Weber, Eckhard and Tigani, Bruno and Lavan, Paul and Stephen, Medhurst and Sohal, Bindi (2014) 1-aminobenzotriazole modulates oral drug pharmacokinetics through cytochrome P450 inhibition and delay of gastric emptying in rats. Drug Metabolism and Disposition, 42 (7). pp. 1117-1124. ISSN 1521-009X

Stringer, Rowan and Williams, Gareth and Picard, Franck and Sohal, Bindi and Mckenna, Jeff and Krauser, Joel (2014) Application of a deuterium replacement strategy to modulate the pharmacokinetics of NVS-CRF38, a novel CRF1 antagonist. Drug Metabolism and Disposition, 42 (5). pp. 954-962. ISSN 1521-009X

Subramanian, Sharadha and Costales, Abran and Poon, Daniel and Shafer, Cynthia and Stuart, Darrin (2014) Design and synthesis of orally bioavailable benzimidazole reverse amides as pan RAF kinase inhibitors. ACS Medicinal Chemistry Letters, 5 (9). pp. 989-992. ISSN 1948-5875

Sultan, Marc and Amstislavskiy, Vyacheslav and Risch, Thomas and Schuette, Moritz and Dökel, Simon and Ralser, Meyriem and Balzereit, Daniela and Lehrach, Hans and Yaspo, Marie-Laure (2014) Influence of RNA extraction methods and library selection schemes on RNA-seq data. BMC Genomics.

Sunkara, Gangadhar and Jiang, Xuemin and Reynolds, Christine and Serra, Denise and Zhang, Yiming and Ligueros-Saylan, Monica and Ayalasomayajula, Surya and Winter, Serge and Jarugula, Venkateswar (2014) Effect of food on the oral bioavailability of amlodipine/valsartan and amlodipine/valsartan/hydrochlorothiazide fixed dose combination tablets in healthy subjects. Clinical Pharmacology in Drug Development, 3 (6). pp. 487-492. ISSN 2160763X

Supek, Frantisek and Mathison, Casey and Khare, Shilpi and Molteni, Valentina and Nagle, Advait and Gelb, Michael and Buckner, Frederick (2014) Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis. Chemical reviews, 114 (22). pp. 11305-11347. ISSN 1520-6890

Sverdlov, Oleksandr and Wong, Weng Kee (2014) Novel Statistical Designs for Phase I/II and Phase II Clinical Trials With Dose-Finding Objectives. Therapeutic Innovation and Regulatory Science, 48 (5). pp. 601-612. ISSN 2168-4804

Sykes, David and Parry, Cheryl and Reilly, John and Wright, Penny and Fairhurst, Robin and Charlton, Steven (2014) Observed drug-receptor association rates are governed by membrane affinity: The importance of establishing "micro-pharmacokinetic/pharmacodynamic relationships" at the β2-adrenoceptor. Molecular Pharmacology, 85 (4). pp. 608-617. ISSN 0026-895X

Szikra, T and Trenholm, S and Drinnenberg, A and Juttner, J and Raics, Z and Farrow, K and Biel, M and Awatramani, G and Clark, DA and Sahel, JA and da Silveira, RA and Roska, B (2014) Rods in daylight act as relay cells for cone-driven horizontal cell-mediated surround inhibition. Nat Neurosci .


Tan, M and Wu, B and Chen, I and Chai, C and Chou, S and Yeh, J and Chen, I and Wu, J and Jeng, AY and Dai, Z (2014) Dual ECE/NEP inhibition improved diastolic function and ameliorated cardiac remodeling in rats with myocardial dysfunction secondary to pressure overload by aortic banding. Experimental and Clinical Cardiology. pp. 358-368.

Targowska-Duda, Katarzyna M and Feuerbach, Dominik and Biala, Grazyna and Jozwiak, Krzysztof and Arias, Hugo R (2014) Antidepressant activity in mice elicited by 3-furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of the α7 nicotinic acetylcholine receptor. European Journal of Pharmacology.

Tarselli, Mike (2014) Review of Hallelujah Moments. Nature Chemistry.

Tarselli, Mike (2014) Science NextGen 12 - Global Collaboration. Science Magazine NextGen 12.

Taylor, SJ and Thien, CB and Dagger, SA and Duyvestyn, JM and Grove, CS and Lee, BH and Gilliland, DG and Langdon, WY (2014) Loss of c-Cbl E3 ubiquitin ligase activity enhances the development of myeloid leukemia in FLT3-ITD mutant mice. Experimental Hematology.

Terwisscha van Scheltinga , Anton G.T. and Berghuis, Paul and Nienhuis, Hilde H and Schröder, Carolien P (2014) Visualizing dual downregulation of IGF-1R and VEGF by Hsp90 inhibition effect in triple negative breast cancer. European Journal of Cancer, 50 (14). pp. 2508-2516. ISSN 09598049

Theofilopoulos, Spyrido and Griffiths, William and Crick, Peter and Yang, Shanzheng and Meljon, Anna and Ogundare, Michael and Kitambi, Satish and Lockhart, Andrew and Tuschl, Karin and Clayton, Peter and Morris, Andrew and Martinez, Adelaida and Reddy, Ashwin and Martinuzzi, Andrea and Bassi, Maria and Honda, Akira and Mizuochi, Tatsuki and Kimura, Akihiro and Nittono, Hiroshi and De Michele, Guiseppe and Carbone, Rosa and Criscuolo, Chiara and Yau, Joyce and Seckl, Jonathan and Schüle, Rebecca and Schöls, Ludger and Sailer, Andreas and Kuhle, Jens and Fraidakis, Matthew and Gustafsson, Jan-Ake and Steffensen, Knut and Björkhem, Ingemar and Ernfors, Patrik and Sjövall, Jan and Arenas, Ernest and Wang, Yuqin (2014) Identification of Cholestenoic acids that Regulate Motor Neuron Survival via Liver X Receptors. Journal of Clinical Investigation, 124 (11). pp. 4829-4842.

Thiruppathi, M and Sheng, JR and Li, L and Prabhakar, BS and Meriggioli, MN (2014) Recombinant IgG2a Fc (M045) multimers effectively suppress experimental autoimmune myasthenia gravis. Journal of Autoimmunity.

Thoma, EC and Merkl, C and Heckel, T and Haab, R and Knoflach, F and Nowaczyk, C and Flint, N and Jagasia, R and Jensen, ZS and Truong, HH and Petitjean, P and Jessberger, S and Graf, M and Iacone, R (2014) Chemical conversion of human fibroblasts into functional schwann cells. Stem Cell Reports. pp. 539-547.

Thoma, Gebhard and Blanz, Joachim and Drueckes, Peter and Kittelmann, Matthias and Smith, Alexander Baxter and Van Eis, Maurice and Vangrevelinghe, Eric and Zerwes, Hans-Guenter and Che, Jianwei and He, Xiaohui and Jin, Yunho and Lee, Christian and Michellys, Pierre and Uno, Tetsuo and Liu, Hong and Buehlmayer, Peter (2014) Novel Syk inhibitors with high potency in presence of blood. Bioorganic and Medicinal Chemistry Letters, 24. pp. 2278-2282.

Thoma, Gebhard and Drueckes, Peter and Zerwes, Hans-Guenter (2014) Selective inhibitors of the Janus Kinase Jak3 – are they effective? Bioorganic & Medicibal Chemistry Letters, 24 (19). pp. 4617-4621. ISSN 0960894X

Thompson, Joel and Nagel, Jane and Hoving, Sjouke and Gerrits, Bertran and Bauer, Andreas and Thomas, Jason and Kirschner, Marc and Schirle, Markus and Luchansky, Sarah (2014) Quantitative Lys-ϵ-Gly-Gly (diGly) Proteomics Coupled with Inducible RNAi Reveals Ubiquitin-mediated Proteolysis of DNA Damage-inducible Transcript 4 (DDIT4) by the E3 Ligase HUWE1. The Journal of Biological Chemistry, 289 (42). pp. 28942-28955. ISSN 0021-9258

Thomson, JP and Moggs, Jonathan and Wolf, RC and Meehan, RR (2014) Epigenetic profiles as defined signatures of xenobiotic exposure. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 764-76. pp. 3-9. ISSN 1879-3592

Thomson, John P and Moggs, Jonathan and Wolf, Roland and Meehan, Richard R (2014) Epigenetic profiles as defined signatures of xenobiotic exposure. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 764-76. pp. 3-9. ISSN 1879-3592

Tian, Y and Voineagu, I and Pasca, SP and Won, H and Chandran, V and Horvath, S and Dolmetsch, RE and Geschwind, DH (2014) Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome. Genome Medicine. 75, 2014-.

Timsit, Yoav and Negishi, Masahiko (2014) Coordinated regulation of nuclear receptor CAR by CCRP/DNAJC7, HSP70 and the ubiquitin-proteasome system. PLoS ONE, 9 (5). ISSN 1932-6203

Tocheva, AS and Mansour, S and Holt, RIG and Gadola, SD (2014) Qualitative differences in the iNKT repertoire of people with recent onset type 1 diabetes mellitus. Immunology. p. 132.

Toso, Alberto and Proietti, Michelle and Revandkar, Ajinkya and Zhang, Jiangwen and Guccini, Ilaria and Sarti, Manuela and Pinton, Sandra and Marini, Camilla and Scanziani, Eugenio and Catapano, Carlo and Pandolfi, Pier Paolo and Grassi, Fabio and Alimonti, Andrea (2014) Reactivation of senescence surveillance in Pten loss induced cellular senescence. Cell Reports.

Traeger, U and Andre, R and Lahiri, N and Magnusson-Lind, A and Weiss, A and Grueninger, S and McKinnon, C and Sirinathsinghji, E and Kahlon, S and Pfister, EL and Moser, R and Hummerich, H and Antoniou, M and Bates, GP and Luthi-Carter, R and Lowdell, MW and Bjoerkqvist, M and Ostroff, GR and Aronin, N and Tabrizi, SJ (2014) HTT-lowering reverses Huntington's disease immune dysfunction caused by NF kappa B pathway dysregulation. BRAIN. pp. 819-833.

Trager, U and Andre, R and Magnusson-Lind, A and Miller, JRC and Connolly, C and Weiss, A and Grueninger, S and Silajdzic, E and Smith, DL and Leavitt, BR and Bates, GP and Bjorkqvist, M and Tabrizi, SJ (2014) Characterisation of immune cell function in fragment and full-length Huntington's disease mouse models. Neurobiology of Disease. pp. 388-398.

Traggiai, Elisabetta and Volpi , Stefano and Walter , Jolan and Walker , Melissa and Sims , Katherine (2014) Powering the immune system: Mitochondria in immune function and deficiency. Journal of Immunology Research, 2014. ISSN 2314-7156

Tran, Que Tien and Pearlstein, Robert and Williams, Sarah and Reilly, John and Krucker, Thomas and Erdemli, Gul (2014) Structure-kinetic relationship of carbapenem antibacterials permeating through E. coli OmpC porin. Proteins: Structure, Function and Bioinformatics, 82 (11). pp. 2998-3012. ISSN 08873585

Tran, Que Tien and Pearlstein, Robert and Williams, Sarah and Reilly, John and Krucker, Thomas and Erdemli, Gul (2014) Structure-kinetic relationship of carbapenem antibacterials permeating through E. coli OmpC porin. Proteins: Structure, Function, and Bioinformatics, 82 (11). pp. 2998-3012. ISSN 1097-0134

Trifilieff, Estelle and Minetti, Giulia and Sheppard, Kelly-Ann and Hatakeyama, Shinji and Feige, Jerome and Ibebunjo, Chikwendu and Feige, Jerome and Morvan, Frederic and Hartmann, Steffen and Rivet, Helene and Koelbing, Claudia and Glass, David (2014) An Antibody Blocking Activin Receptors type II Induces Strong Skeletal Muscle Hypertrophy and Protects from Atrophy. Molecular and Cellular Biology.

Turner, Oliver and Morton, Dan and Sistare, Frank and Nambiar, Prashant and Zaher, Radi and Bower, Nancy (2014) Alternative Mouse Models for Future Cancer Risk Assessment. Toxicologic Pathology, 42 (5). pp. 1-8.


Ullrich, Thomas and Fernandes Gomes Dos Santos, Paulo Antonio and Perrone, Mark and Weiler, Sven and Keller, Hansjoerg and Sasmal, Sanjita and Boorgu, Venkatesham and Pasagadi, Srinivasu and Cheera, Srisailam and Rajagopalan, Sujatha and Bhumireddy, Archana and Shashikumar, Dhanya and Chelur, Shekar and Belliappa, Charamanna and Pandit, Chetan and Krishnamurthy, Narasimharao and Mukherjee, Subhendu and Ramanathan, Anuradha and Ghadiyaram, Chakshusmathi and Ramachandra, Murali and Lagu, Bharat and Bock, Mark G. (2014) 3-Alkoxy-pyrrolo[1,2-b]pyrazolines as novel selective androgen receptor modulators (SARMs) with physicochemical properties suitable for transdermal administration. Journal of Medicinal Chemistry, 57 (17). pp. 7396-7411. ISSN 0022-26231520-4804

Urban, Laszlo and Maciejewski, Mateusz and Lounkine, Eugen and Whitebread, Steven and Jenkins, Jeremy and Hamon, Jacques and Fekete, Alexander and Mueller, Patrick (2014) Translation of off-target effects: Prediction of ADRs by integrated experimental and computational approaches. Toxicology Research, 3 (6). pp. 433-444. ISSN 2045-452X2045-4538

Urban, Laszlo and Nagy, Istvan and Andreou, Annan and Sousa-Valente, Joao (2014) TRANSIENT RECEPTOR POTENTIAL ION CHANNELS IN PRIMARY SENSORY NEURONS AS TARGETS FOR NOVEL ANALGESICS. British Journal of Pharmacology, 171 (10). pp. 2508-2527. ISSN 00071188


Vaarhorst, Anika A M and Verhoeven, Aswin and Weller, Claudia M and Böhringer, Stefan and Göraler, Sibel and Meissner, Axel and Deelder, André M and Henneman, Peter and Gorgels, Anton P M and van den Brandt, Piet A and Schouten, Leo J and van Greevenbroek, Marleen M and Merry, Audrey H H and Verschuren, W M Monique and van den Maagdenberg, Arn M J M and van Dijk, Ko Willems and Isaacs, Aaron and Boomsma, Dorret and Oostra, Ben A and van Duijn, Cornelia M and Jukema, J Wouter and Boer, Jolanda M A and Feskens, Edith and Heijmans, Bastiaan T and Slagboom, P Eline (2014) A metabolomic profile is associated with the risk of incident coronary heart disease. American heart journal, 168 (1). 45-52.e7. ISSN 1097-6744; 0002-8703

Valastyan, Lynn (2014) Researchers Advance Protein-Protein Interactions as Small Molecule Drug Targets. SLAS advertising for Webinar series.

Van Looy, T and Wozniak, A and Floris, G and Sciot, R and Li, H and Van Leeuw, L and Fletcher, J and Manley, Paul W. and Debiec-Rychter, M and Schöffski, P (2014) Phosphoinositide 3-kinase inhibitors combined with imatinib in patient-derived xenograft models of gastrointestinal stromal tumors: Rationale and efficacy. Clinical Cancer Research, 20 (23). pp. 6071-6082. ISSN 1557-3265

Vapurcuyan, Arpine and Hanna, Imad and Pelis, Ryan and Renfro, Larry and Ingraham, Leslie and Parker, Sonda (2014) A plasma concentration of α-ketoglutarate 1 influences the kinetic interaction of ligands with OAT1. Molecular Pharmacology.

Vaupel, Andrea and Bold, Guido and Valat, Therese-Marie and Kallen, Joerg and Masuya, Keiichi and Furet, Pascal and de Pover, Alain and Hergovich-Lisztwan, Joanna (2014) Tetra-substituted imidazoles as a new class of inhibitors of the p53-MDM2 interaction. Bioorganic and Medicinal Chemistry Letters, 24 (9). pp. 2110-2114. ISSN 0960894X

Velez-Vega, Camilo and Mckay, Daniel and Aravamuthan, Vibhas and Pearlstein, Robert and Duca, Jose (2014) Time-averaged distributions of solute and solvent motions: exploring proton wires of GFP and PfM2DH. Journal of chemical information and modeling, 54 (12). pp. 3344-3361. ISSN 1549-960X

Vidal, Solange and Clay, Ieuan and Ludwig, Marie-Gabrielle and Suply, Thomas and Seuwen, Klaus (2014) The G protein-coupled pH-sensing receptor OGR1 is a regulator of intestinal inflammation. IBD.

Vliegenthart, A and Starkey Lewis, P and Tucker, C and Del Pozo, J and Rider, S and Antoine, D and Dubost, Valerie and Westphal, Magdalena and Moulin, Pierre and Bailey, M and Moggs, Jonathan and Goldring, C and Park, K and Dear, J (2014) Retro-orbital blood acquisition facilitates circulating microRNA measurement in zebrafish with paracetamol hepatotoxicity. Zebrafish, 11 (3). pp. 219-226. ISSN 1557-8542

Von Lueder, TG and Wang, BH and Kompa, AR and Huang, L and Webb, R and Jordaan, P and Atar, D and Krum, H (2014) The Angiotensin-Receptor Neprilysin Inhibitor LCZ696 Attenuates Cardiac Remodeling and Dysfunction After Myocardial Infarction by Reducing Cardiac Fibrosis and Hypertrophy. Circ Heart Fail .

Vranesic, Ivan-Toma and Ofner, Silvio and Flor, Peter Josef and Bilbe, Graeme and Bouhelal, Rochdi and Enz, Albert and Desrayaud, Sandrine and Mcallister, Kevin and Kuhn, Rainer and Gasparini, Fabrizio (2014) AFQ056/Mavoglurant a novel clinically effective mGluR5 antagonist: Identification, SAR and pharmacological characterization. Bioorganic Medicinal Chemistry, 22 (21). pp. 5790-5803. ISSN 09680896

Vázquez-Gómeza, E and Arias, HR and Miranda-Morales, M and Mihailescu, S and Feuerbach, Dominik and García-Colunga, J (2014) Bupropion-induced inhibition of α7 nicotinic acetylcholine receptors expressed in heterologous cells, neurons from dorsal raphe nucleus and hippocampus. EuropeanJournalofPharmacology.

van, BM and Wilcken, R and McLaughlin, SH and Rutherford, TJ and Johnson, CM (2014) Structure of the SAS-6 cartwheel hub from Leishmania major. eLife.

van Dijk, KD and Bidinosti, M and Weiss, A and Raijmakers, P and Berendse, HW and van de Berg, WDJ (2014) Reduced alpha-synuclein levels in cerebrospinal fluid in Parkinson's disease are unrelated to clinical and imaging measures of disease severity. EUROPEAN JOURNAL OF NEUROLOGY. pp. 388-394.

van Vliet, Erwin and Danesian, Mardas and Beilmann, Mario and Davies, Anthony and Fava, Eugenio and Fleck, Roland and Julé, Yvon and Kansy, Manfred and Kustermann, Stefan and Macko, Peter and Mund, William and Roth, Adrian and Sachse, Christoph and Shah, Imran and Uteng, Marianne and van de Water, Bob and Hartung, Thomas and Leist, Marcel (2014) Current approaches and future role of high content imaging in safety sciences and drug discovery. Alternatives to Animal Experimentation (ALTEX).

von Blanckenburg, Friedhelm and Oelze, Marcus and Schmid, Dietmar and Moeller, Kirsten and Gschwind, Hans-Peter and Slade, Alan and Stitah, Sylvie and Kaufmann, Daniel and Swart, Pieter Jacob (2014) An iron stable isotope comparison between human erythrocytes and plasma. Metallomics, 6 (11). pp. 2052-2061. ISSN 1756591X


Wachtel, Marco and Rakic, Jelena and Okoniewski, Michal and Bode, Peter and Niggli, Felix and Beat W., Schäfer 1 (2014) FGFR-mediated anti-apoptotic signaling identifies novel subgroups in alveolar rhabdomyosarcoma. International journal of cancer, 135 (7). pp. 1543-1552. ISSN 00207136

Waldron, Levi and Riester, Markus and Birrer, Michael (2014) Molecular subtypes of high-grade serous ovarian cancer: the search goes on! JNCI J Natl Cancer Inst , 106 (10).

Walitza, S and Marinova, Z and Lazic, Stanley and Remschmidt, H and Herpertz-Dahlmann, B and Wendland, JR (2014) Trio study and meta-analysis support the association of genetic variation at the serotonin transporter with early-onset obsessive-compulsive disorder. Neuroscience Letters, 580. pp. 100-103. ISSN 03043940

Wang, Shirley and Olt, Sabine and Schoefmann, Nicole and Stuetz, Anton and Winiski, Anthony and Wolff-Winiski, Barbara (2014) SPINK5 knockdown in organotypic human skin culture as a model system for Netherton syndrome: effect of genetic inhibition of serine proteases. Experimental Dermatology, 23 (7). pp. 524-526.

Wassermann, AM (2014) Structure-activity relationship analysis on the basis of matched molecular pairs. J Cheminform , 6 (Suppl ). O14. ISSN 1758-2946

Wassermann, Anne and Lounkine, Eugen and Whitebread, Steven and Chen, Shanni and Hughes, Kevin and Guo, Hongqiu and Kutlina, Elena and Fekete, Alexander and Urban, Laszlo and Klumpp, Martin and Glick, Meir (2014) A Screening Pattern Recognition Method Finds New and Divergent Targets for Drugs and Natural Products. ACS Chemical Biology, 9 (7). pp. 1622-1631. ISSN 1554-89291554-8937

Weaver, Margaret (2014) Naphthoquine oral dose range finding study in the dog. This will be shared only with Kunming, not published..

Wegner, Malgorzata and Neddermann, Daniel and Piorunska-Stolzmann, Maria and Jagodzinski, Pawel (2014) Role of epigenetic mechanisms in the development of chronic complications of diabetes. Diabetes Research and Clinical Practice, 105 (2). pp. 164-175. ISSN 0168-8227

Wei, J and Freytag, M and Schober, Y and Nockher, WA and Mautner, VF and Friedrich, RE and Manley, PW and Kluwe, L and Kurtz, A (2014) Nilotinib is more potent than imatinib for treating plexiform neurofibroma in vitro and in vivo. PLoS ONE. e107760-.

Weidensteiner, Claudia and Allegrini, Peter Roland and Ferretti, Stephane Raymond and Mcsheehy, Paul M.J. (2014) Tumour T1 changes in vivo are highly predictive of response to chemotherapy and reflect the number of viable tumour cells. BMC cancer, 14. p. 88. ISSN 1471-2407

Weiler, S and Braendlin, N and Beerli, C and Bergsdorf, C and Schubart, A and Srinivas, H and Oberhauser, B and Billich, A (2014) Orally Active 7-Substituted (4-Benzylphthalazin-1-yl)-2-methylpiperazin-1-ylnicotinonitriles as Active-Site Inhibitors of Sphingosine 1-Phosphate Lyase for the Treatment of Multiple Sclerosis. Journal of Medicinal Chemistry. pp. 5074-5084.

Weiler, Sven and Braendlin, Nadine and Beerli, Christian and Bergsdorf, Christian and Schubart Wellensiek, Anna and Srinivas, Honnappa and Oberhauser, Berndt and Billich, Andreas (2014) Orally Active 7-Substituted (4-Benzyl-phthalazin-1-yl)-2-methyl-piperazin-1-yl]-nicotinonitriles as Active-site Inhibitors of Sphingosine-1-Phosphate Lyase for the Treatment of Multiple Sclerosis. Journal of Medicinal Chemistry, 57 (12). pp. 5074-5084. ISSN 0022-26231520-4804

Wendling, Thierry and Ogungbenro, Kayode and Pigeolet, Etienne and Dumitras, Swati and Woessner, Ralph and Aarons, Leon (2014) Model-based evaluation of the impact of formulation and food intake on the complex oral absorption of mavoglurant in healthy subjects. Pharmaceutical Research.

Westwood, AJ and Beiser, A and Decarli, C and Harris, TB and Chen, TC and He, XM and Roubenoff, R and Pikula, A and Au, R and Braverman, LE and Wolf, PA and Vasan, RS and Seshadri, S (2014) Insulin-like growth factor-1 and risk of Alzheimer dementia and brain atrophy. Neurology. pp. 1613-1619.

Whalen, EJ and Johnson, AK and Lewis, SJ (2014) Hemodynamic responses elicited by systemic injections of isotonic and hypertonic saline in hemorrhaged rats. Microvascular Research. pp. 22-29.

White, K and Dempsie, Y and Caruso, P and Wallace, E and McDonald, RA and Stevens, H and Hatley, ME and Van, RE and Morrell, NW and Maclean, MR and Baker, AH (2014) Endothelial apoptosis in pulmonary hypertension is controlled by a microRNA/programmed cell death 4/caspase-3 axis. Hypertension. pp. 185-194.

Willis, MS and Wadosky, KM and Rodriguez, JE and Schisler, JC and Lockyer, P and Hilliard, EG and Glass, DJ and Patterson, C (2014) Muscle ring finger 1 and muscle ring finger 2 are necessary but functionally redundant during developmental cardiac growth and regulate E2F1-mediated gene expression in vivo. Cell Biochemistry and Function. pp. 39-50.

Wilson, BG and Helming, KC and Wang, X and Kim, Y and Vazquez, F and Jagani, Z and Hahn, WC and Roberts, CWM (2014) Residual Complexes Containing SMARCA2 (BRM) Underlie the Oncogenic Drive of SMARCA4 (BRG1) Mutation. MOLECULAR AND CELLULAR BIOLOGY. pp. 1136-1144.

Winkler, Gian Christian and Lovsin Barle, Ester and Galati, Giuseppe and Kluwe, William (2014) Functional differentiation of cytotoxic cancer drugs and targeted cancer therapeutics. Regulatory Toxicology and Pharmacology, on lin.

Wong, matthew H and Xue, Aiqun and Julovi, Sohel M and Pavlakis, Nick and Samra, Jas S and Hugh, Thomas J and Gill, Anthony J and Peters, Lyndsay and Baxter, Robert C and Smith, Ross C (2014) NVP-BYL719, a novel PI3K-alpha selective inhibitor, overcomes acquired erlotinib resistance via upregulation of the PI3K/Akt/ mTOR pathway in pancreatic ductal adenocarcinoma. Clinical Cancer Research.

Worley, KC and Warren, WC and Rogers, J and Locke, D and Muzny, DM and Mardis, ER and Weinstock, GM and Tardif, SD and Aagaard, KM and Archidiacono, N and Arul, RN and Batzer, MA and Beal, K and Brejova, B and Capozzi, O and Capuano, SB and Casola, C and Chandrabose, MM and Cree, A and Diep, DM and De Jong, PJ and Cruz-Herrera del, RR and Delehaunty, KD and Dinh, HH and Eichler, EE and Fitzgerald, S and Flicek, P and Fontenot, CC and Fowler, RG and Fronick, C and Fulton, LA and Fulton, RS and Gabisi, RA and Gerlach, D and Graves, TA and Gunaratne, PH and Hahn, MW and Haig, D and Han, Y and Harris, RA and Herrero, J and Hillier, LW and Hubley, R and Hughes, JF and Hume, J and Jhangiani, SN and Jorde, LB and Joshi, V and Karakor, E and Konkel, MK and Kosiol, C and LKovar, C and Kriventseva, EV and Lee, SL and Lewis, LR and Liu, Y and Lopez, J and Lopez-Otin, C and Lorente-Galdos, B and Mansfield, KG and Marques-Bonet, T and Minx, P and Misceo, D and Moncrieff, JS and Morgan, MB and Nazareth, LV and Newsham, I and Nguyen, NB and Okwuonu, GO and Prabhakar, S and Perales, L and Pu, L and Puente, XS and Quesada, V and Ranck, MC and Raney, BJ and Raveendran, M and Deiros, DR and Rocchi, M and Rodriguez, D and Ross, C and Ruffier, M and Ruiz, SJ and Sajjadian, S and Santibanez, J and Schrider, DR and Searle, S and Skaletsky, H and Soibam, B and Smit, AFA and Tennakoon, JB and Tomaska, L and Ullmer, B and Vejnar, CE and Ventura, M and Vilella, AJ and Vinar, T and Vogel, J and Walker, JA and Wang, Q and Warner, CM and Wildman, DE and Witherspoon, DJ and Wright, RA and Wu, Y and Xiao, W and Xing, J and Zdobnov, EM and Zhu, B and Gibbs, RA and Wilson, RK (2014) The common marmoset genome provides insight into primate biology and evolution. Nature Genetics. pp. 850-857.

Wucher, Andreas and Tian, Hua and Winograd, Nicholas (2014) A Mixed Cluster Ion Beam to Enhance the Ionization Efficiency in Molecular Secondary Ion Mass Spectrometry. Rapid Communications in Mass Spectrometry, 28 (4). pp. 396-400. ISSN 1097-0231


Xia, B and Barve, A and Heimbach, T and Zhang, T and Gu, H and Wang, L and Einolf, H and Alexander, N and Hanna, I and Ke, J and Mangold, JB and He, H and Sunkara, G (2014) Physiologically based pharmacokinetic modeling for assessing the clinical drug-drug interaction of alisporivir. Eur J Pharm Sci . pp. 103-112.

Xiang, F and Murray, S and Liu, X (2014) Analysis of transplant urgency and benefit via multiple imputation. Stat Med .

Xie, Xuping and Lee, Le Tian and Chandrasekaran, Ramya and Reynaud, Aline and Wang, Qingyin and Dong, Hongping and Kang, Congbao and Yuan, Zhiming and Lescar, Julien and Shi, Pei-Yong (2014) Dimerization of flavivirus NS4B protein. Journal of Virology, 88 (6). pp. 3379-3391. ISSN 0022-538X

Xu, Haiyan and Shou, Jianyong and Li, En (2014) TET-catalyzed 5-methylcytosine hydroxylation is dynamically regulated by metabolites. Cell research, 24 (8). pp. 1017-1020. ISSN 1748-7838

Xu, T and Yang, L and Yan, C and Wang, X and Huang, P and Zhao, F and Zhao, L and Zhang, M and Jia, W and Wang, X and Liu, Y (2014) The IRE1alpha-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic beta-cells. Cell research.


Yan, Jing-He and Meyers, Charles and Lee, Zachary and Danis, Kathryn and Neelakantham, Srikanth Raju and Majumdar, Tapan and Rebello, Sam and Sunkara, Gangadhar and Chen, Jin (2014) Pharmacokinetic and pharmacodynamic drug-drug interaction assessment between pradigastat and digoxin or warfarin. Journal of Clinical Pharmacology.

Yang, H and Lin, H and Xu, H and Zhang, L and Cheng, L and Wen, B and Shou, J and Guan, K and Xiong, Y and Ye, D (2014) TET-catalyzed 5-methylcytosine hydroxylation is dynamically regulated by metabolites. Cell Res .

Yang, H and Robinson, M and Corsa, AC and Peng, B and Cheng, G and Tian, Y and Wang, Y and Pakdaman, R and Shen, M and Qi, X and Mo, H and Tay, C and Krawczyk, S and Sheng, XC and Kim, CU and Yang, C and Delaney IV, WE (2014) Preclinical characterization of the novel hepatitis C virus NS3 protease inhibitor GS-9451. Antimicrobial Agents and Chemotherapy. pp. 647-653.

Yang, Ziping (2014) Recommendations for Validation of LC-MS/MS Bioanalytical Methods for Protein Biotherapeutics. The AAPS Journal.

Yilmazel, B and Hu, YH and Sigoillot, F and Smith, JA and Shamu, CE and Perrimon, N and Mohr, SE (2014) Online GESS: prediction of miRNA-like off-target effects in large-scale RNAi screen data by seed region analysis. Bmc Bioinformatics.

Yu, DX and Di Giorgio, FP and Yao, J and Marchetto, MC and Brennand, K and Wright, R and Mei, A and McHenry, L and Lisuk, D and Grasmick, JM and Silberman, P and Silberman, G and Jappelli, R and Gage, FH (2014) Modeling hippocampal neurogenesis using human pluripotent stem cells. Stem Cell Reports. pp. 295-310.

Yu, J and Sun, H and Pang, M and Chuang, W and Sarin, SK and Flisiak, R and Stein, DS (2014) Population pharmacokinetics and pharmacodynamics of albinterferon alfa-2b in patients treated for hepatitis C virus genotype 2/3. Anti-Infective Agents. pp. 58-67.

Yun Shan, Goh and Necchi, Francesca and O'Shaughnessy, Colette and Micoli, Francesca and Gavini, Massimiliano and Msefula, Chisomo and Gondwe, Esther and Mandala, Wilson and Gordon, Melita and Saul, Allan James and Maclennan, Calman Alexander (2014) HIV-associated bactericidal and inhibitory immunity to Salmonella in Africans. Journal of Immunology.


Zeiger, Errol and Gollapudi, Bhaskar and Aardema , Marilyn and Auerbach, Scott and Boverhof, Darrell and Custer, Laura and Dedon, Peter and Honma, Masamitsu and Ishida, Seiichi and Kasinski, Andrea and Kim, James and Manjanatha, Mugimane and Marlowe, Jenny and Pfuhler, Stefan and Pogribny, Igor and Slikker, William and Stankowski, Leon and Tanir, Jennifer and Tice, Raymond and van Benthem, Jan and White, Paul and Witt, Kristine and Thybaud, Veronique (2014) Genetic Toxicology: Opportunities to Integrate New Approaches. Environmental and Molecular Mutagenesis.

Zhang, JG and Ho, T and Callendrello, AL and Clark, RJ and Santone, EA and Kinsman, S and Xiao, D and Fox, LG and Einolf, HJ and Stresser, DM (2014) Evaluation of Calibration Curve-Based Approaches to Predict Clinical Inducers and Noninducers of CYP3A4 with Plated Human Hepatocytes. Drug Metab Dispos . pp. 1379-1391.

Zhang, Xian and Parker, Christian and Abraham, Yann (2014) Multiparametric Analysis of Screening Data: Growing Beyond the Single Dimension. Journal of Biomolecular Screening, 19 (5). pp. 628-639.

Zhang, Y and Chen, MH and Ibrahim, JG and Zeng, D and Chen, Q and Pan, Z and Xue, X (2014) Bayesian gamma frailty models for survival data with semi-competing risks and treatment switching. Lifetime Data Analysis. pp. 76-105.

Zhang, Yi-Xiang and Sicinska, Ewa and Czaplinski , Jeffrey and Remillard, Stephen and Moss, Samuel and Wang, Yuchuan and Brain, Christopher and Loo, Alice and Snyder, Eric and Demetri, George and Kim, Sunkyu and Kung, Andrew and Wagner, Andrew (2014) Antiproliferative effects of CDK4/6 inhibition in CDK4-amplified human liposarcoma in vitro and in vivo. Molecular Therapeutics.

Zhao, Nan and Zhao, Xia and Xu, Junyu and Zhao, Rong and Cui, Yimin (2014) 单次和多次口服氟伐他汀钠缓释片与速释胶囊人体药动学对比研究. The Chinese Journal of Clinical Pharmacology.

Zhou, Enhua and Watson, Christa and Pizzo, Richard and Cohen, Joel and Dang, Quynh and de Barros, Pedro Macul Ferreira and Park, Chan Young and Chen, Cheng and Brain, Joseph D. and Butler, James P. and Ruberti, Jeffrey W. and Fredberg, Jeffrey J. and Demokritou, Philip (2014) Assessing the impact of engineered nanoparticles on wound healing using a novel in-vitro bioassay. Nanomedicine, 9 (18). pp. 2803-2815. ISSN 1743-58891748-6963

Zhou,, Penghui and Shaffer, Donald and Alvarez Arias, Diana A. and Nakazaki,, Yukoh and Pos, Wouter and Torres, Alexis J. and Cremasco, Viviana and Dougan, Stephanie K. and Cowley, Glenn S. and Elpek, Kutlu and Brogdon, Jennifer and Lamb, John and Ploegh, Hidde L. and Root, David E. and Love, Christopher and Dranoff, Glenn and Hacohen, Nir and Cantor, Harvey and Wucherpfennig, Kai W. (2014) In vivo Discovery of Immunotherapy Targets in the Tumor Microenvironment. Nature.

Zhu, J and Davoli, T and Perriera, JM and Chin, CR and Gaiha, GD and John, SP and Sigiollot, FD and Gao, G and Xu, Q and Qu, H and Pertel, T and Sims, JS and Smith, JA and Baker, RE and Maranda, L and Ng, A and Elledge, SJ and Brass, AL (2014) Comprehensive Identification of Host Modulators of HIV-1 Replication using Multiple Orthologous RNAi Reagents. Cell Reports. pp. 752-766.

Zimmermann, MO and Lange, A and Wilcken, R and Cieslik, MB and Exner, TE and Joerger, AC and Koch, P and Boeckler, FM (2014) Halogen-enriched fragment libraries as chemical probes for harnessing halogen bonding in fragment-based lead discovery. Future Medicinal Chemistry. pp. 617-639.

Zollinger, Markus and Lozac'H, Frederic and Hurh, Eunju and Emotte, Corinne and Bauly, Hounayda and Swart, Pieter Jacob (2014) Absorption, distribution, metabolism, and excretion (ADME) of 14C-sonidegib (LDE225) in healthy volunteers. Cancer Chemotherapy and Pharmacology, 74 (1). pp. 63-75. ISSN 1432-0843

This list was generated on Thu Jun 30 06:25:07 2022 UTC.


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