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Quantifying the behavioural relevance of hippocampal neurogenesis

Lazic, Stanley and Fuss, J and Gass, P (2014) Quantifying the behavioural relevance of hippocampal neurogenesis. PLoS ONE, 9 (11). ISSN 1932-6203

Abstract

Few studies that examine the neurogenesis-behaviour relationship formally establish covariation between neurogenesis and behaviour or rule out competing explanations. The behavioural relevance of neurogenesis might therefore be overestimated if other mechanisms account for some, or even all, of the experimental effects. All publicly available data was reanalysed using causal mediation analysis, which can estimate the unique contribution of new hippocampal neurons to behaviour separately from other mechanisms that might be operating. The results from eleven individual studies were then combined to increase precision (representing data from 215 animals) and showed that neurogenesis made a negligible contribution to behaviour (standarised effect = 0.15; 95% CI = -0.04 to 0.34; p = 0.128); other mechanisms accounted for the majority of experimental effects (standardised effect = 1.06; 95% CI = 0.74 to 1.38; p = 1.7e−11).

Item Type: Article
Date Deposited: 13 Oct 2015 13:12
Last Modified: 04 Jul 2016 23:45
URI: https://oak.novartis.com/id/eprint/22459

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