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INHAND: Nonproliferative and Proliferative Lesions of the Rat and Mouse Female Reproductive Tract

Dixon, Darlene and Alison, Roger and Bach, Ute and Colman, Karyn and Foley, George L and Harleman, Johannes and Haworth, Richard and Herbert, Ronald and Heuser, Anke and Long, Greald and Mirsky, Michael and Regan, Karen and van Esch, Eric and Westwood, F Russell and Vidal, Justin and Yoshida, Midori (2014) INHAND: Nonproliferative and Proliferative Lesions of the Rat and Mouse Female Reproductive Tract. Journal of Toxicologic Pathology, 27 (3 & 4 ). 1S-107S. ISSN 0914-9198

Abstract

The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in
Rats and Mice) Project (www.toxpath.org/inhand.asp) is a joint initiative of the Societies of Toxicological
Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally accepted nomenclature for proliferative and non-proliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in the female reproductive tract of laboratory rats and mice, with color photomicrographs illustrating examples of some lesions. The standardized nomenclature presented in this document is also available electronically on the internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions induced by exposure to test materials. There is also a section on normal cyclical changes observed in the ovary, uterus, cervix and vagina to compare normal physiological changes with pathological lesions. A widely accepted and utilized international harmonization of nomenclature for female reproductive tract lesions in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

Item Type: Article
Keywords: diagnostic pathology, nomenclature, female reproductive, ovary, uterus, cervix, vagina
Date Deposited: 13 Oct 2015 13:12
Last Modified: 13 Oct 2015 13:12
URI: https://oak.novartis.com/id/eprint/22950

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