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Heat shock proteins: A high content assay opportunity to measure cellular stress response

Antczak, Christophe and Somalinga, Balajee and Djaballah, Hakim (2014) Heat shock proteins: A high content assay opportunity to measure cellular stress response. European Drug Target Review.

Abstract

Heat shock proteins (HSPs) have been proposed as therapeutic targets for novel anticancer agents. However, candidates have thus far failed due to low tolerability, limiting their efficacy. This failure highlights our current inability to predict drug toxicity in patients, a Holy Grail in modern drug discovery. Paradoxically, the fundamental role of the tightly regulated HSPs in maintaining homeostasis may constitute an opportunity to monitor drug toxicity. We propose to incorporate the quantification of HSP induction as a key indicator of cellular stress response in multiplexed, high content cell based assay readouts to enhance the predictive power of in vitro drug toxicity profiling outcome.

Item Type: Article
Date Deposited: 13 Oct 2015 13:12
Last Modified: 06 Jul 2016 23:45
URI: https://oak.novartis.com/id/eprint/22437

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