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Activation of β-catenin/TCF targets following loss of the tumor suppressor SNF5

Mora-Blanco, E. Lorena and Mishina, Yuji and Tillman, Erik and Cho, Yoon-Jae and Thom, Christopher and Pomeroy, Scott and Shao, Wenlin and Roberts, Charles (2014) Activation of β-catenin/TCF targets following loss of the tumor suppressor SNF5. Oncogene, 33 (7). pp. 933-938. ISSN 0950-9232

Abstract

The SWI/SNF chromatin remodeling complex is a master regulator of developmental cell-fate decisions, although the key target pathways are poorly characterized. Here, we interrogated the contribution of the SWI/SNF subunit and tumor suppressor SNF5 to the regulation of developmental pathways using conditional mouse and cell culture models. We find that loss of SNF5 phenocopies β-catenin hyperactivation and that SNF5 is essential for regulating Wnt/β-catenin pathway target expression. These data provide insight into chromatin-based mechanisms that underlie developmental regulation and elucidate the emerging theme that mutation of this tumor suppressor complex can activate developmental pathways by uncoupling them from upstream control. © 2014 Macmillan Publishers Limited.

Item Type: Article
Keywords: beta-catenin chromatin remodeling epigenetics Swi/Snf tumor suppressor
Date Deposited: 25 Oct 2017 00:45
Last Modified: 25 Jan 2019 00:46
URI: https://oak.novartis.com/id/eprint/6486

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