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Design, Structure Activity Relationship and in vivo Characterization of the Clinical Candidate NVP-HSP990

McBride, Christopher and Levine, Barry and Xia, Yi and Bellamacina, Cornelia and Machajewski, Timothy and Gao, Zhenhai and Renhowe, Paul and Antonios-Mccrea Jr., Bill and Barsanti, Paul and Brinner, Kristin and Costales, Abran and Doughan, Brandon and Lin, Xiaodong and Louie, Alicia and McKenna, Maureen and Mendenhall, Kris and Poon, Daniel and Rico, Alice and Wang, Michael and Williams, Teresa and Abrams, Tinya and Fong, Susan and Hendrickson, Thomas and Lei, Dachuan and Lin, Julie and Menezes, Daniel Lopes De and Pryer, Nancy and Taverna, Pietro and Zhou, Yasheen and Shafer, Cynthia (2014) Design, Structure Activity Relationship and in vivo Characterization of the Clinical Candidate NVP-HSP990. Journal of Medicinal Chemistry, 57 (21). pp. 9124-9129. ISSN 0022-26231520-4804

Abstract

From a commercial hit (1), a novel dihydroquinazolinone scaffold was developed. The SAR of the series was developed which led to the selection of NVP-HSP990 as a clinical candidate.

Item Type: Article
Date Deposited: 02 May 2016 23:45
Last Modified: 02 May 2016 23:45
URI: https://oak.novartis.com/id/eprint/21284

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