Browse views: by Year, by Function, by GLF, by Subfunction, by Conference, by Journal

Formaldehyde-fixed brain tissue from spontaneously ill α-synuclein transgenic mice induces fatal α-synucleinopathy in transgenic hosts

Schweighauser, Manuel and Bacioglu, Mehtap and Fritschi, Sarah and Shimshek, Derya and Kahle, Philipp and Eisele, Yvonne and Jucker, Mathias (2014) Formaldehyde-fixed brain tissue from spontaneously ill α-synuclein transgenic mice induces fatal α-synucleinopathy in transgenic hosts. Acta Neuropathologica.

Abstract

In summary, the present results indicate that a-synuclein seeds in brain tissue resist formaldehyde fixation as previously reported for Aβ. It is likely, albeit to be proven, that this is also true for aggregated tau other self-propagating pathogenic protein aggregates. These findings can now be exploited to further establish the relationship between the molecular architecture of a-synuclein lesions and individual pathogenesis and thereby exploit archived formalin-fixed brain material.

Item Type: Article
Date Deposited: 13 Oct 2015 13:12
Last Modified: 13 Oct 2015 13:12
URI: https://oak.novartis.com/id/eprint/23773

Search

Email Alerts

Register with OAK to receive email alerts for saved searches.