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Flavonoid glycosides from the stem bark of Margaritaria discoidea demonstrate antibacterial and free radical scavenging activities

Ekuadzi, Edmund and Dickson, Rita and Fleischer, Theophilus and Annan, Kofi and Pistorius, Dominik and Oberer, Lukas and Gibbons, Simon (2014) Flavonoid glycosides from the stem bark of Margaritaria discoidea demonstrate antibacterial and free radical scavenging activities. Phytotherapy Research, 28 (5). pp. 784-787.

Abstract

One new flavonoid glycoside, along with three known flavonoid glycosides were isolated from the stem bark of Margaritaria discoidea, which is traditionally used in the management of wounds and skin infections in Ghana. The new flavonoid glycoside was elucidated as hydroxygenkwanin-8-C-[α-rhamnopyranosyl-(1→6)]-β-glucopyranoside on the basis of spectroscopic analysis. The isolated compounds demonstrated free-radical scavenging as well as some level of antibacterial activities. Microorganisms including Staphylococcus aureus are implicated in inhibiting or delaying wound healing. Therefore any agent capable of reducing or eliminating the microbial load present in a wound as well as decreasing the levels of reactive oxygen species (ROS) may facilitate the healing process. These findings therefore provide some support to the ethnopharmacological usage of the plant in the management of wounds.

Item Type: Article
Additional Information: The publication originates from the research internship of a student from Ghana within the scope of the Next Generation Scientist program, organized by the Education Office. The student (Edmund Ekuadzi) broght plants extracts from endemic Ghanaian plants from which he isolated pure compounds using our equipment. It was agreed before the start of the internship that the IP of compounds isolated from these extracts remains with Edmund Ekadzi and his university.
Date Deposited: 13 Oct 2015 13:13
Last Modified: 13 Oct 2015 13:13
URI: https://oak.novartis.com/id/eprint/10363

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