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Quantifying the behavioural relevance of hippocampal neurogenesis

Lazic, SE and Fuss, J and Gass, P (2014) Quantifying the behavioural relevance of hippocampal neurogenesis. PLoS One. e113855-.

Abstract

Few studies that examine the neurogenesis-behaviour relationship formally establish covariation between neurogenesis and behaviour or rule out competing explanations. The behavioural relevance of neurogenesis might therefore be overestimated if other mechanisms account for some, or even all, of the experimental effects. A systematic review of the literature was conducted and the data reanalysed using causal mediation analysis, which can estimate the behavioural contribution of new hippocampal neurons separately from other mechanisms that might be operating. Results from eleven eligible individual studies were then combined in a meta-analysis to increase precision (representing data from 215 animals) and showed that neurogenesis made a negligible contribution to behaviour (standarised effect = 0.15; 95% CI = -0.04 to 0.34; p = 0.128); other mechanisms accounted for the majority of experimental effects (standardised effect = 1.06; 95% CI = 0.74 to 1.38; p = 1.7x10-11)

Item Type: Article
Additional Information: NIBR author: Lazic, SE institute: NIBR contributor address: In Silico Lead Discovery, Novartis Institutes for Biomedical Research, Basel, SwitzerlandDepartment of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, GermanyDepartment of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany
Date Deposited: 13 Oct 2015 13:11
Last Modified: 13 Oct 2015 13:11
URI: https://oak.novartis.com/id/eprint/24944

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