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HMGA2-IGF2BP2 Axis Regulates Muscle Stem Cell Activation and Myogenesis

Li, Zhizhong and Glass, David and Gilbert, Jason and Zhang, Yunyu and Eash, John (2014) HMGA2-IGF2BP2 Axis Regulates Muscle Stem Cell Activation and Myogenesis. Dev Cell, 23 (6). pp. 1176-1188.

Abstract

A group of genes were identified that are highly and specifically expressed in proliferating skeletal myoblasts during myogenesis. Temporal regulation of one of these, HMGA2, is required for satellite cell activation and expansion. Endogenous HMGA2 expression increases coincident with satellite cell activation, and later its expression significantly declines correlating with fusion of myoblasts into myotubes. Hmga2 knockout mice exhibit impaired muscle development and reduced myoblast proliferation, while overexpression of HMGA2 promotes myoblast growth. This perturbation in proliferation can be explained by the finding that HMGA2 directly regulates RNA-binding protein IGF2BP2. IGF2BP2 in turn binds to and controls the translation of a set of mRNAs, which encode for proteins involved in regulating cell growth, including c-Myc, IGF1R and Sp1. These data demonstrate that HMGA2-IGF2BP2 axis functions as a key regulator of satellite cell proliferation and therefore skeletal muscle development.

Item Type: Article
Date Deposited: 26 Apr 2016 23:46
Last Modified: 26 Apr 2016 23:46
URI: https://oak.novartis.com/id/eprint/7977

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