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Development of a High-Pressure Aerodynamic Lens for Focusing Large Particles (4-10 mu m) into the Aerosol Time-of-Flight Mass Spectrometer

Cahill, JF and Darlington, TK and Wang, X and Mayer, J and Spencer, MT and Holecek, JC and Reed, BE and Prather, KA (2014) Development of a High-Pressure Aerodynamic Lens for Focusing Large Particles (4-10 mu m) into the Aerosol Time-of-Flight Mass Spectrometer. Aerosol Science and Technology. pp. 948-956.

Abstract

A new aerodynamic lens system for an online aerosol time-of-flight mass spectrometer (ATOFMS) has been designed and constructed to transmit and allow the analysis of individual particles in the 4-10-mu m-size range. Modeling was used to help design the lens within the bounds of ATOFMS instrumental constraints. The aerodynamic lens operates at a high inlet pressure, 3066 Pa (23 Torr), with a unique tapered relaxation region to improve large particle transmission. Every stage of the lens was tested empirically using a combination of particle deposition and light scattering experiments. The critical orifice was found to significantly impact large particle transmission, with orifices <200 mu m in diameter completely suppressing large particle transmission. The addition of a virtual impactor allowed for the use of large orifices without any loss of functionality in the ATOFMS. The detection efficiency of the ATOFMS was >10% for particles from 4-10 mu m with a peak efficiency of 74 +/- 9% for 6-mu m particles. With the extended size range provided by this inlet, the ATOFMS can now be extended to investigate single cell metabolomics

Item Type: Article
Additional Information: NIBR author: Spencer, MT institute: NIBR contributor address: Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA ; NanoComposix, San Diego, CA USA ; Univ Nevada, Desert Res Inst, Div Atmospher Sci, Reno, NV 89506 USA ; Novartis Inst Biomed Res, Cambridge, MA USA ; Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA, Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA kprather@ucsd.edu; Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA; Prather, KA; Univ Calif San Diego, Dept Chem & Biochem, M-C 0314 Urey Hall 2108,9500 Gilman Dr, La Jolla, CA 92093 USA
Date Deposited: 13 Oct 2015 13:12
Last Modified: 13 Oct 2015 13:12
URI: https://oak.novartis.com/id/eprint/24247

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