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Total scattering atomic pair distribution function: The use of the total scattering atomic pair distribution function methods in pharmaceutical analysis

Masadeh, AS and Atassi, F and Shatnawi, MTM (2014) Total scattering atomic pair distribution function: The use of the total scattering atomic pair distribution function methods in pharmaceutical analysis. Pharmazeutische Industrie. pp. 1283-1291.

Abstract

Analyzing powder X-ray diffraction data using the total scattering pair distribution function (PDF) technique is an evolving trend in the field of pharmaceutical material science. The use of high-energy X-ray total scattering PDF analysis introduces a new (PDF-based) methodology for structural analysis of amorphous, mesomorphous and nano-structured phases of pharmaceutical systems. Properties of the solid state are critical in determining the behavior of many pharmaceutical formulations and PDF methods utilized in the analysis of both Bragg as well as diffuse scattering by the sample have been recognized as a powerful tool in atomic structural studies of amorphous and disordered pharmaceutical solids. Recently, PDF methods have been reported as key tool to determine the optimal measurement strategy for fingerprinting condensed phases of pharmaceutical systems and as a unique tool to extract the coherent domain size of amorphous pharmaceutical solids. While PDF is an actively researched topic, its development as a tool in pharmaceutical analysis is largely dependent on advancements in available software. This article is an introduction to the fundamental concept of PDF with the focus on the challenges of using this technique in analyzing disordered organic materials and briefly reviews the current applications of this technique in the pharmaceutical field

Item Type: Article
Additional Information: NIBR author: Atassi, F institute: NIBR contributor address: (Masadeh, Shatnawi) Department of Physics, University of Jordan, Amman 11942, Jordan (Atassi) Novartis Institutes of Biomedical Research, Cambridge, MA, United States
Date Deposited: 13 Oct 2015 13:11
Last Modified: 13 Oct 2015 13:11
URI: https://oak.novartis.com/id/eprint/24249

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