Browse views: by Year, by Function, by GLF, by Subfunction, by Conference, by Journal

The common marmoset genome provides insight into primate biology and evolution

Worley, KC and Warren, WC and Rogers, J and Locke, D and Muzny, DM and Mardis, ER and Weinstock, GM and Tardif, SD and Aagaard, KM and Archidiacono, N and Arul, RN and Batzer, MA and Beal, K and Brejova, B and Capozzi, O and Capuano, SB and Casola, C and Chandrabose, MM and Cree, A and Diep, DM and De Jong, PJ and Cruz-Herrera del, RR and Delehaunty, KD and Dinh, HH and Eichler, EE and Fitzgerald, S and Flicek, P and Fontenot, CC and Fowler, RG and Fronick, C and Fulton, LA and Fulton, RS and Gabisi, RA and Gerlach, D and Graves, TA and Gunaratne, PH and Hahn, MW and Haig, D and Han, Y and Harris, RA and Herrero, J and Hillier, LW and Hubley, R and Hughes, JF and Hume, J and Jhangiani, SN and Jorde, LB and Joshi, V and Karakor, E and Konkel, MK and Kosiol, C and LKovar, C and Kriventseva, EV and Lee, SL and Lewis, LR and Liu, Y and Lopez, J and Lopez-Otin, C and Lorente-Galdos, B and Mansfield, KG and Marques-Bonet, T and Minx, P and Misceo, D and Moncrieff, JS and Morgan, MB and Nazareth, LV and Newsham, I and Nguyen, NB and Okwuonu, GO and Prabhakar, S and Perales, L and Pu, L and Puente, XS and Quesada, V and Ranck, MC and Raney, BJ and Raveendran, M and Deiros, DR and Rocchi, M and Rodriguez, D and Ross, C and Ruffier, M and Ruiz, SJ and Sajjadian, S and Santibanez, J and Schrider, DR and Searle, S and Skaletsky, H and Soibam, B and Smit, AFA and Tennakoon, JB and Tomaska, L and Ullmer, B and Vejnar, CE and Ventura, M and Vilella, AJ and Vinar, T and Vogel, J and Walker, JA and Wang, Q and Warner, CM and Wildman, DE and Witherspoon, DJ and Wright, RA and Wu, Y and Xiao, W and Xing, J and Zdobnov, EM and Zhu, B and Gibbs, RA and Wilson, RK (2014) The common marmoset genome provides insight into primate biology and evolution. Nature Genetics. pp. 850-857.

Abstract

We report the whole-genome sequence of the common marmoset (Callithrix jacchus). The 2.26-Gb genome of a female marmoset was assembled using Sanger read data (6x) and a whole-genome shotgun strategy. A first analysis has permitted comparison with the genomes of apes and Old World monkeys and the identification of specific features that might contribute to the unique biology of this diminutive primate, including genetic changes that may influence body size, frequent twinning and chimerism. We observed positive selection in growth hormone/insulin-like growth factor genes (growth pathways), respiratory complex I genes (metabolic pathways), and genes encoding immunobiological factors and proteases (reproductive and immunity pathways). In addition, both protein-coding and microRNA genes related to reproduction exhibited evidence of rapid sequence evolution. This genome sequence for a New World monkey enables increased power for comparative analyses among available primate genomes and facilitates biomedical research application. 2014 Nature America, Inc

Item Type: Article
Additional Information: NIBR author: Mansfield KG institute: NIBR- address only contributor address: (Worley, Rogers, Muzny, Weinstock, Chandrabose, Cree, Diep Dao, Dinh, Fowler, Gabisi, Gunaratne, Han, Harris, Hume, Jhangiani, Joshi, LKovar, Lee, Lewis, Liu, Lopez, Morgan, Nazareth, Newsham, Nguyen, Okwuonu, Perales, Pu, Raveendran, Deiros, Ruiz, Santibanez, Warner, Wright, Wu, Gibbs) Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, United States (Worley, Rogers, Muzny, Weinstock, Chandrabose, Cree, Diep Dao, Dinh, Fowler, Gabisi, Gunaratne, Han, Harris, Hume, Jhangiani, Joshi, LKovar, Lee, Lewis, Liu, Lopez, Morgan, Nazareth, Newsham, Nguyen, Okwuonu, Perales, Pu, Raveendran, Deiros, Ruiz, Santibanez, Warner, Wright, Wu, Gibbs) Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, United States (Warren, Locke, Mardis, Weinstock, Delehaunty, Fronick, Fulton, Fulton, Graves, Hillier, Minx, Wilson) Genome Institute, Washington University St. Louis, St. Louis, MI, United States (Tardif, Ross) Barshop Institute for Longevity and Aging Studies, University of Texas, Health Science Center at San Antonio, San Antonio, TX, United States (Aagaard, Harris) Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, United States (Archidiacono, Capozzi, Misceo, Rocchi) Department of Biology, Bari University, Bari, Italy (Arul Rayan, Cruz-Herrera del Rosario, Prabhakar) Genome Institute of Singapore, Singapore, Singapore (Batzer, Fontenot, Konkel, Ranck, Walker, Wang) Department of Biological Sciences, Louisiana State University, Baton Rouge, LA, United States (Beal, Fitzgerald, Flicek, Herrero, Ruffier, Vilella) European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom (Brejova, Vinar) Faculty of Mathematics, Physics and Informatics, Comenius University in Bratislava, Bratislava, Slovakia (Capuano) Wisconsin National Primate Research Center, Madison, WI, United States (Casola, Hahn, Schrider) Department of Biology, Indiana University, Bloomington, IN, United States (Casola, Hahn, Schrider) School of Informatics and Computing, Indiana University, Bloomington, IN, United States (De Jong, Misceo, Zhu) Children's Hospital Oakland Research Institute, Oakland, CA, United States (Eichler, Karakor, Sajjadian, Ventura) Department of Genome Sciences, University of Washington, Seattle, WA, United States (Flicek, Kriventseva, Ruffier, Searle, Vogel) Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom (Gerlach, Moncrieff, Vejnar, Zdobnov) Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland (Gunaratne, Soibam, Tennakoon, Xiao) Department of Biology and Biochemistry, University of Houston, Houston, TX, United States (Gunaratne) Department of Pathology, Baylor College of Medicine, Houston, TX, United States (Haig) Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, United States (Hubley, Smit) Institute for Systems Biology, Seattle, WA, United States (Hughes, Skaletsky) Whitehead Institute, Cambridge, MA, United States (Jorde, Witherspoon, Xing) Department of Human Genetics, University of Utah, School of Medicine, Salt Lake City, UT, United States (Kosiol) Institut fur Populationsgenetik, Vetmeduni Vienna, Vienna, Austria (Lopez-Otin, Puente, Quesada, Rodriguez) Departamento de Bioquimica y Biologia Molecular, Instituto Universitario de Oncologia, Universidad de Oviedo, Oviedo, Spain (Lorente-Galdos) Spanish National Bioinformatics Institute (INB), Barcelona, Spain (Lorente-Galdos, Marques-Bonet) Institucio Catalana de Recerca i Estudis Avancats, Institut de Biologia Evolutiva Consejo Superior de Investigaciones Cientificas, Universitat Pompeu Fabra, Barcelona, Spain (Mansfield) Division of Comparative Pathology, New England Primate Research Center, Harvard University Medical School, Southborough, MA, United States (Marques-Bonet) CNAG (Centro Nacional de Analisis Genomico), Barcelona, Spain (Raney) Center for Biomolecular Science and Engineering, School of Engineering, University of California, Santa Cruz, Santa Cruz, CA, United States (Skaletsky) Howard Hughes Medical Institute, Whitehead Institute, Cambridge, MA, United States (Tomaska) Department of Genetics, Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia (Ullmer) Center for Computation and Technology, Louisiana State University, Baton Rouge, LA, United States (Ullmer) Department of Computer Sciences, Louisiana State University, Baton Rouge, LA, United States (Wildman) Center for Molecular Medicine and Genetics, Wayne State University, School of Medicine, Detroit, MI, United States (Zdobnov) Swiss Institute of Bioinformatics, Geneva, Switzerland (Zdobnov) Division of Molecular Biosciences, Imperial College London, London, United Kingdom (Weinstock) Jackson Laboratory for Genomic Medicine, Farmington, CT, United States (Casola) Department of Biology, Saint Louis University, St. Louis, MI, United States (De Jong) Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States (Gerlach) Boehringer Ingelheim, Vienna, Austria (Herrero) Bill Lyons Informatics Centre, University College London Cancer Institute, University College London, London, United Kingdom (Mansfield) Translational Sciences, Novartis Institutes for Biomedical Research, Cambridge, MA, United States (Xing) Department of Genetics, Human Genetics Institute of New Jersey, Rutgers, State University of New Jersey, Piscataway, NJ, United States (Zhu) Chinese Academy of Sciences, Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Beijing, China
Date Deposited: 13 Oct 2015 13:12
Last Modified: 13 Oct 2015 13:12
URI: https://oak.novartis.com/id/eprint/23440

Search

Email Alerts

Register with OAK to receive email alerts for saved searches.