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Improving the plausibility of success with inefficient metrics

Shultz, Michael (2014) Improving the plausibility of success with inefficient metrics. ACS Medicinal Chemistry Letters, 5 (1). pp. 2-5. ISSN 1948-5875


To increase the probability of success in drug discovery, the concept of drug-like properties was introduced. Efficiency metrics that normalize potency against these properties could help reach drug-like space more efficiently. Potential reasons for the inefficient use of metrics and suboptimal decision making are discussed. © 2013 American Chemical Society.

Item Type: Article
Keywords: decision making drug-likeness efficiency metrics fragment-based drug design Ligand efficiency (LE) lipophilic efficiency (LipE)
Date Deposited: 30 Nov 2017 00:45
Last Modified: 25 Jan 2019 00:46


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