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2-Amino-7-Substitued Benzoxazole Analogs as Potent RSK2 Inhibitors

Costales, Abran and Mathur, Michelle and Ramurthy, Savithri and Lan, Jiong and Subramanian, Sharadha and Jain, Rama and Atallah, Gordana and Setti, Lina and Lindvall, Mika and Appleton, Brent and Ornelas, Elizabeth and Feucht, Paul and Warne, Robert and Doyle, Laura and Basham, Stephen and Aronchik, Ida and Jefferson, A.B. and Shafer, Cynthia (2014) 2-Amino-7-Substitued Benzoxazole Analogs as Potent RSK2 Inhibitors. Bioorganic and Medicinal Chemistry Letters, 24 (6). pp. 1592-1596. ISSN 0960894X

Abstract

2-Amino-7-substituted benzoxazole analogs were identified by HTS as inhibitors of RSK2. Molecular modeling and medicinal chemistry techniques were employed to explore the SAR for this series with a focus of improving in vitro and target modulation potency and physicochemical properties.

Item Type: Article
Date Deposited: 02 May 2016 23:45
Last Modified: 02 May 2016 23:45
URI: https://oak.novartis.com/id/eprint/20358

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