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Design and synthesis of orally bioavailable benzimidazole reverse amides as pan RAF kinase inhibitors

Subramanian, Sharadha and Costales, Abran and Poon, Daniel and Shafer, Cynthia and Stuart, Darrin (2014) Design and synthesis of orally bioavailable benzimidazole reverse amides as pan RAF kinase inhibitors. ACS Medicinal Chemistry Letters, 5 (9). pp. 989-992. ISSN 1948-5875

Abstract

Benzimidazole reverse amides were designed and synthesized as Pan RAF kinase inhibitors. Investigation of the structure-activity relationship of the compounds revealed that they were potent in vitro and exhibited desirable in vivo properties.

Item Type: Article
Keywords: colony stimulating factor-1 receptor CSF1R MAP ras-mitogen activated protein kinase receptor tyrosine kinases RTKs serine threonine kinases STKs TKs tyrosine kinases vascular endothelial growth factor receptor VEGF
Date Deposited: 13 Mar 2018 00:45
Last Modified: 25 Jan 2019 00:46
URI: https://oak.novartis.com/id/eprint/20560

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