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Metabotropic Glutamate Receptor 5 Binding in Patients with Obsessive-Compulsive Disorder

Akkus, Funda and Terbeck, Sylvia and Ametamey, Simon/M and Rufer, Michael and Treyer, Valerie and Burger, Cyrill and Johayem, Annas and Gomez-Mancilla, Baltazar and Sovago, Judit and Buck, Alfred and Hasler, Gregor (2014) Metabotropic Glutamate Receptor 5 Binding in Patients with Obsessive-Compulsive Disorder. International Journal of Neuropsychopharmacology.

Abstract

BACKGROUND Obsessive-compulsive disorder (OCD) is a disabling, mostly chronic, psychiatric condition with significant social, and economic impairments and is a major public health issue. However, numerous patients are resistant to currently available pharmacological and psychological interventions. Given that recent animal studies and magnetic resonance spectroscopy research points to glutamate dysfunction in OCD, we investigated the metabotropic glutamate receptor 5 (mGluR5) in patients with OCD and healthy controls.
METHODS We determined mGluR5 distribution volume ratio (DVR) in the brain of 10 patients with OCD and 10 healthy controls by using [11C]ABP688 positron-emission tomography. As a clinical measure of OCD severity, the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) was employed.
RESULTS We found no significant global difference in mGluR5 DVR between patients with OCD and healthy controls. We did, however, observe significant positive correlations between the Y-BOCS obsession subscore and mGluR5 DVR in the cortico-striatal-thalamo-cortical brain circuit, including regions of the amygdala, anterior cingulate cortex, and medial orbitofrontal cortex.
CONCLUSIONS These results suggest that obsessions in particular might have an underlying glutamatergic pathology related to mGluR5. The research indicates that the development of metabotropic glutamate agents would be useful as a new treatment for OCD.

Item Type: Article
Date Deposited: 13 Oct 2015 13:13
Last Modified: 13 Oct 2015 13:13
URI: https://oak.novartis.com/id/eprint/10544

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