Browse views: by Year, by Function, by GLF, by Subfunction, by Conference, by Journal

A combined approach of ion chromatography and quantitative NMR to accurately determine counterion stoichiometry

Grondine, Melissa and Gunderson, Karl and Reilly, John and Twomey Iii, Joseph and Vandenberg, Jennifer and Wang, Bing (2014) A combined approach of ion chromatography and quantitative NMR to accurately determine counterion stoichiometry. Journal of Liquid Chromatography and Related Technologies, 37 (10). pp. 1453-1464. ISSN 1082-6076

Abstract

Early phase pharmaceutical research compounds must be fully characterized in order to have confidence in any testing results. Traditional methods such as HPLC/MS do not give any indication of counterion presence or identity for many common counterions such as trifluoroacetate, acetate, or succinate. Herein, we describe a combined approach of ion chromatography and quantitative nuclear magnetic resonance spectroscopy in order to identify and quantify counterions in research samples of limited quantity. Forty-two research samples were analyzed and compared for trifluoroacetate, acetate, and succinate salts. Copyright © Taylor & Francis Group, LLC.

Item Type: Article
Keywords: Anions Cations Counterions Drug discovery Ion chromatography Nuclear magnetic resonance
Date Deposited: 18 Oct 2017 00:45
Last Modified: 25 Jan 2019 00:46
URI: https://oak.novartis.com/id/eprint/8502

Search

Email Alerts

Register with OAK to receive email alerts for saved searches.