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A synthesis of 5-Hydroxysedamine using Hydroformylation

Simon, Oliver and Bates, Roderick W. and Tang, Chi H. (2014) A synthesis of 5-Hydroxysedamine using Hydroformylation. Tetrahedron, 70 (12). pp. 2134-2140. ISSN 00404020

Abstract

A synthesis of 5-hydroxysedamine, a Sedum alkaloid, has been completed using N,O-heterocycle chemistry to establish the aminoalcohol structure, hydroformylation to form the piperidine ring and diastereoselective dihydroxylation to introduce the 5-hydroxy group.

Item Type: Article
Keywords: 5-hydroxysedamine, hydroformylation, dihydroxylation, allylation, stereoselectivity
Date Deposited: 27 Apr 2016 23:45
Last Modified: 27 Apr 2016 23:45
URI: https://oak.novartis.com/id/eprint/20299

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