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Class I and IIa Histone Deacetylases Have Opposite Effects on Sclerostin Gene Regulation

Baertschi, Stefan and Baur, Nina and Lueders-Lefevre, Valerie and Voshol, Johannes and Keller, Hansjoerg (2014) Class I and IIa Histone Deacetylases Have Opposite Effects on Sclerostin Gene Regulation. Journal of Biological Chemistry.

Official URL: http://www.jbc.org/

Abstract

Background: Gene regulation of the bone repressor sclerostin (SOST) is only poorly understood.
Results: SOST gene suppression by PTH is partially mediated by HDAC5 inhibiting MEF2 and SOST gene expression requires class I HDAC activity.
Conclusions: SOST gene expression is negatively regulated by HDAC5 and positively by class I HDACs.
Significance: Class I HDAC inhibitors represent a novel approach for bone forming osteoporosis therapies.

Item Type: Article
Keywords: Sclerostin, histone deacetylase, transcription, gene
Date Deposited: 13 Oct 2015 13:14
Last Modified: 13 Oct 2015 13:14
URI: https://oak.novartis.com/id/eprint/7350

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