Baertschi, Stefan, Baur, Nina, Lueders-Lefevre, Valerie, Voshol, Johannes and Keller, Hansjoerg (2014) Class I and IIa Histone Deacetylases Have Opposite Effects on Sclerostin Gene Regulation. Journal of Biological Chemistry.

Abstract

Background: Gene regulation of the bone repressor sclerostin (SOST) is only poorly understood.
Results: SOST gene suppression by PTH is partially mediated by HDAC5 inhibiting MEF2 and SOST gene expression requires class I HDAC activity.
Conclusions: SOST gene expression is negatively regulated by HDAC5 and positively by class I HDACs.
Significance: Class I HDAC inhibitors represent a novel approach for bone forming osteoporosis therapies.

Item Type:	Article
Keywords:	Sclerostin, histone deacetylase, transcription, gene
Date Deposited:	13 Oct 2015 13:14
Last Modified:	13 Oct 2015 13:14
URI:	https://oak.novartis.com/id/eprint/7350