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Liquid microjunction surface sampling of acetaminophen, terfenadine and their metabolites in thin tissue sections

Paranthaman, Nithya and Kertesz, Vilmos and Moench, Paul and Catoire, Alexandre and Flarakos, Jimmy and Van Berkel, Gary J. (2014) Liquid microjunction surface sampling of acetaminophen, terfenadine and their metabolites in thin tissue sections. Bioanalysis, 6 (19). pp. 2599-2606. ISSN 1757-6180

Abstract

Background: The aim of this work was to evaluate the analytical performance of a fully automated droplet-based surface-sampling system for determining the distribution of the drugs acetaminophen and terfenadine, and their metabolites, in rat thin tissue sections. Results: The rank order of acetaminophen concentration observed in tissues was stomach > small intestine > liver, while the concentrations of its glucuronide and sulfate metabolites were greatest in the liver and small intestine. Terfenadine was most concentrated in the liver and kidney, while its major metabolite, fexofenadine, was found in the liver and small intestine. Conclusion: The spatial distributions of both drugs and their respective metabolites observed in this work were consistent
with previous studies using radiolabeled drugs.

Item Type: Article
Additional Information: Dr. Jimmy Flarakos, Paul Moench, Adam Bentley and Alexandre Catoire (Novartis Pharmaceuticals Corporation, East Hanover, NJ) are thanked for providing the whole-body rat thin tissue sections through Work for Others project with Novartis Pharmaceuticals Corporation.
Date Deposited: 26 Apr 2016 23:46
Last Modified: 26 Apr 2016 23:46
URI: https://oak.novartis.com/id/eprint/9226

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