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Bayesian gamma frailty models for survival data with semi-competing risks and treatment switching

Zhang, Y and Chen, MH and Ibrahim, JG and Zeng, D and Chen, Q and Pan, Z and Xue, X (2014) Bayesian gamma frailty models for survival data with semi-competing risks and treatment switching. Lifetime Data Analysis. pp. 76-105.

Abstract

Motivated from a colorectal cancer study, we propose a class of frailty semi-competing risks survival models to account for the dependence between disease progression time, survival time, and treatment switching. Properties of the proposed models are examined and an efficient Gibbs sampling algorithm using the collapsed Gibbs technique is developed. A Bayesian procedure for assessing the treatment effect is also proposed. The deviance information criterion (DIC) with an appropriate deviance function and Logarithm of the pseudomarginal likelihood (LPML) are constructed for model comparison. A simulation study is conducted to examine the empirical performance of DIC and LPML and as well as the posterior estimates. The proposed method is further applied to analyze data from a colorectal cancer study

Item Type: Article
Additional Information: NIBR author: Zhang, Y institute: NIBR contributor address: Novartis Institutes for BioMedical Research, Inc., 220 Massachusetts Avenue, Cambridge, MA, 02139, USA.
Date Deposited: 13 Oct 2015 13:12
Last Modified: 13 Oct 2015 13:12
URI: https://oak.novartis.com/id/eprint/22612

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