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Linking DNA Damage, NAD(+)/SIRT1, and Aging

Guarente, L (2014) Linking DNA Damage, NAD(+)/SIRT1, and Aging. Cell Metabolism. pp. 706-707.


Diseases due to DNA damage repair machinery defects can resemble premature aging. In this issue of Cell Metabolism, Scheibye-Knudsen et al. (2014) demonstrate that increasing NAD(+) levels may reverse the inactivation of Sirt1 and mitochondrial defects in Cockayne Syndrome B that stem from nuclear NAD(+) depletion by the DNA repair protein PARP. Copyright 2014 Elsevier Inc. All rights reserved

Item Type: Article
Additional Information: NIBR author: Guarente, L institute: NIBR contributor address: Novartis Professor of Biology, Director of the Glenn Labs for the Science of Aging, and Affiliate of the Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA. Electronic address:
Date Deposited: 13 Oct 2015 13:11
Last Modified: 13 Oct 2015 13:11


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