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Structural insights into the recognition of phosphopeptide by the FHA domain of Kanadaptin

Grant, Joanna and Lesley, Scott and Xu, Qingping and Deller, Marc and Elsliger, Marc and Deacon, Ashley and Wilson, Ian and Nielsen, Tine (2014) Structural insights into the recognition of phosphopeptide by the FHA domain of Kanadaptin. PLoS ONE, 9 (9). ISSN 1932-6203

Abstract

Kanadaptin is a nuclear protein of unknown function that is widely expressed in mammalian tissues. The crystal structure of the forkhead-associated (FHA) domain of human kanadaptin was determined to 1.6 A˚resolution. The structure reveals an asymmetric dimer in which one monomer is complexed with a phosphopeptide mimic derived from a peptide segment from the N-terminus of a symmetry-related molecule as well as a sulfate bound to the structurally conserved phosphothreonine recognition cleft. This structure provides insights into the molecular recognition features utilized by this family of proteins and represents the first evidence that kanadaptin is likely involved in a phosphorylation-mediated signaling pathway. These results will be of use for designing experiments to further probe the function of kanadaptin.

Item Type: Article
Date Deposited: 25 Nov 2017 00:45
Last Modified: 25 Jan 2019 00:46
URI: https://oak.novartis.com/id/eprint/20581

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