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Batch vs. Flow Photochemistry: A Thorough Analysis of Yields and Productivities

Elliott, Luke D and Knowles , Jonathan P and Maskill, Kate G and Ralph, Michael J and Lejeune, Guillaume and Hook, Ben D A and Edwards, Lee and Robinson, Richard and Clemens, Ian and Cox, Brian and Pascoe, David and Koch, Guido and Eberle, Martin and Berry, Malcolm B and Booker-Milburn, Kevin I (2014) Batch vs. Flow Photochemistry: A Thorough Analysis of Yields and Productivities. Chemistry - a European journal, 20 (46). pp. 15226-15232. ISSN 09476539

Abstract

The use of flow photochemistry and its apparent superiority over batch has been reported by a number of groups over recent years. In order to rigorously determine whether flow does indeed have an advantage over batch, a broad range of synthetic photochemical transformations were optimized in both batch and flow and their yields and productivities compared. Although yields were essentially identical in all cases, 3-layer FEP flow reactors showed an average of 20% greater productivity. In most cases single layer flow reactors were marginally less productive than their batch counterparts. The utility of flow chemistry was demonstrated in the scale-up of the ring opening reaction of the potentially explosive bicyclo[1.1.1]pentane 26 with butane-2,3-dione.

Item Type: Article
Date Deposited: 12 Oct 2016 00:45
Last Modified: 12 Oct 2016 00:45
URI: https://oak.novartis.com/id/eprint/22204

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