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Drug Discovery Considerations in the Development of Covalent Inhibitors

Mah, Robert and Thomas, Jason and Shafer, Cynthia (2014) Drug Discovery Considerations in the Development of Covalent Inhibitors. Bioorganic and Medicinal Chemistry Letters, 24 (1). pp. 33-39. ISSN 0960894X

Abstract

A resurgence of interest in covalent inhibitors has led to the development of new tools and techniques to characterize these compounds. This review will highlight a number of techniques useful for prosecuting covalent inhibitor drug discovery programs.

Item Type: Article
Additional Information: This article is a review of available technology for prosecuting a covalent inhibitor project. The target audience is medicinal chemists. This article does not discuss any Novartis programs or compounds. The abstract for this review was approved in October 2012 (OAK 8826).
Keywords: covalent inhibitor
Date Deposited: 02 May 2016 23:45
Last Modified: 02 May 2016 23:45
URI: https://oak.novartis.com/id/eprint/10633

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