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2-Alkyloxazoles as potent and selective PI4KIIIβ inhibitors for the treatment of HCV

Keaney, Erin and Connolly, Michael and Dobler, Markus and Karki, Rajeshri and Honda, Ayako and Sokup, Samantha and Karur, Subramanian and Britt, Shawn and Patnaik, Anup and Raman, Prakash and Hamann, Lawrence and Wiedmann, Brigitte and Lamarche, Matthew (2014) 2-Alkyloxazoles as potent and selective PI4KIIIβ inhibitors for the treatment of HCV. Bioorganic and Medicinal Chemistry Letters.

Abstract

Synthesis and SAR of 2-alkyloxazoles as class III phosphatidylinositol-4-kinase beta (PI4KIIIβ inhibitors is described. These compounds demonstrate that inhibition of PI4KIIIβleads to potent inhibition of HCV replication as observed in genotype (GT) 1a and 1b replicon and GT2a JFH1 virus assays in vitro.

Item Type: Article
Date Deposited: 13 Oct 2015 13:13
Last Modified: 13 Oct 2015 13:13
URI: https://oak.novartis.com/id/eprint/11353

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