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Number of items: 286.

A

Akkus, Funda and Ametamey, Simon and Treyer, Valerie and Burger, Cyrill and Johayem, Annas and Umbricht, Daniel and Gomez-Mancilla, Baltazar and Sovago, Judit and Buck, Alfred and Hasler, Gregor (2012) Marked Global Reduction in mGluR5 Binding in Smokers and Ex-smokers Determined by [11C]ABP688 Positron Emission Tomography. Proceedings of the National Academy of Sciences, 110 (2). pp. 737-742. ISSN 0027-8424

Allegrini, Peter Roland (2012) MRI in drug discovery. Eropean pharmaceutical review, 2012 (1).

Angst, Daniela and Bollbuck, Birgit and Janser, Philipp and Quancard, Jean and Buehlmayer, Peter and Berst, Frederic and Oberer, Lukas and Beerli, Christian and Pally, Charles and Streiff, Markus and Bassilana, Frederic (2012) An oral S1P1 antagonist prodrug with efficacy in vivo: discovery, synthesis and evaluation. Journal of Medicinal Chemistry, 55 (22). pp. 9722-9734. ISSN 0022-2623

Argikar, Upendra (2012) Unusual Glucuronides. Drug Metabolism and Disposition.

Arias, HR and Feuerbach, Dominik and Ortello, M (2012) Bupropion and its photoreactive analog (±)-SADU-3-72 interact with luminal and non-luminal sites at human α4β2 nicotinic acetylcholine receptors. Biomembranes.

B

Baba, Nobuyasu and Rubio, Manuel and Kenins, Linda and Regairaz, Camille and Woisetchlager, Maximilian and Carballido, Jose and Sarfati, Marika (2012) Aryl hydrocarbon receptor (AhR) ligation by VAF347 promotes Th22 and inhibits Th1 polarization. Human Immunology, 73. pp. 795-800. ISSN 0198-8859

Babin, Anna Louise and Cannet, Catherine and Ble, Francois-Xavier and Gerard Sachot, Christelle and Takeichi, Masatoshi and Page, Clive and Sparrer, Helmut and Matsuguchi, Tetsuya and Beckmann, Nicolau (2012) BLEOMYCIN-INDUCED LUNG INJURY ASSESSED NON-INVASIVELY AND IN SPONTANEOUSLY BREATHING MICE BY PROTON MRI: MODEL ASSESSMENT AND TARGET VALIDATION. Magnetic Resonance in Medicine, 67 (2). pp. 499-509. ISSN 0740-3194

Bahe, Amine and Toth, Iulia and Fendt, Markus and Neumann, Inga D and Flor, Peter J and Slattery, David A (2012) Pharmacological interference with metabotropic glutamate receptor subtype 7 but not subtype 5 differentially affects within- and between-session extinction of Pavlovian conditioned fear. Neuropsychopharmacology, 62 (4). pp. 1619-1626. ISSN 0028-3908

Baltus, Christine and Press, Neil and Antonijevic, Milan and Tizzard, Graham and Coles, Simon and Spencer, John (2012) Synthesis of a biphenyl library for studies of hydrogen bonding in the solid state. Tetrahedron, 68 (45). pp. 9272-9277. ISSN 0040-4020

Barretina, Jordi and Caponigro, Giordano and Stransky, Nicolas and Venkatesan, Kavitha and Schlegel, Robert and Sellers, William and Garraway, Levi (2012) The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature, 483 (7391). pp. 603-607. ISSN 0028-0836

Beattie, David and Beer, David and Bradley, Michelle and Bruce, Ian and Charlton, Steven and Cuenoud, Bernard and Fairhurst, Robin and Farr, David Colin and Fozard, John R. and Janus, Diana and Rosethorne, Elizabeth and Sandham, David and Sykes, David and Trifilieff, Alexandre and Turner, Katharine and Wissler, Elke (2012) An Investigation into the Structure Activity Relationships Associated with the Systematic Modification of the beta2-Adrenoceptor Agonist Indacaterol. Bioorganic & medicinal chemistry letters, 22 (19). pp. 6280-6285. ISSN 0960-894X

Beckett, Martin (2012) Book review: The Algebra of Organic Synthesis by John Andraos, CRC Press 2011. Chemistry and Industry, Sept 2. pp. 48-49.

Bedrosian, Andrea S and Nguyen, Andrew H and Mushlin, Harry M and Hackman, Muchael and Ochi, Atsuo and Connolly, Michael K and Ibrahim, Junaid and Rehman, Adeel and Henning, Justin R and Barilla, Rocky and Pylayeva-Gupta, Yuliya and Mallen-St. Clair, John and Hajdu, Cristina and Frey, Alan B and Bar-Sagi, Dafna and Miller, George (2012) MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells. Journal Experimental Medicine, 209 (9). pp. 1671-1687. ISSN 0022-1007, 1540-9538

Bell, Leslie and Wang, Jianling (2012) Probe ADME and Test Hypotheses: A PATH beyond clearance in vitro-in vivo correlations in early drug discovery. Expert Opintion on Drug Metabolism and Toxicology. ISSN 1742-5255

Benned-Jensen, Tau and Norm, Christoffer and Laurent, Stephane and Medom Madsen, Christian and Niss Arfelt, Kristine and Wolf, Romain and Frimurer, Thomas and Sailer, Andreas and Rosenkilde, Mette (2012) Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced receptor 2 (GPR183). Journal of Biological Chemistry, 287 (42). pp. 35470-35483. ISSN 0021-9258

Biason-Lauber, Anna and Böni-Schnetzler, Marianne and Hubbard, Basil P and Bouzakri, Karim and Brunner, Andrea and Cavelti-Weder, Claudia and Keller, Cornelia and Meyer-Böni, Monika and Meier, Daniel T and Brorsson, Caroline and Timper, Katharina and Leibowitz, Gil and Patrignani, Andrea and Bruggmann, Remy and Boily, Gino and Zulewski, Henryk and Geier, Andreas and Cermak, Jennifer M and Elliott, Peter and Ellis, James L and Westphal, Christoph and Knobel, Urs and Eloranta, Jyrki J and Kerr-Conte, Julie and Pattou, François and Konrad, Daniel and Matter, Christian M and Fontana, Adriano and Rogler, Gerhard and Schlapbach, Ralph and Regairaz, Camille and Carballido, Jose and Glaser, Benjamin and McBurney, Michael W and Pociot, Flemming and Sinclair, David A and Donath, Marc Y (2012) Identification of a SIRT1 mutation in a family with Type 1 Diabetes. Cell Metabolism, 17 (3). pp. 448-455. ISSN 1550-4131

Bidinosti, Michael and Shimshek, Derya and Mollenhauer, Brit and Marcellin, David and Schweizer, Tatjana and Lotz, Gregor and Schlossmacher, Michael and Weiss, Andreas (2012) Novel One-step Immunoassays to Quantify α-Synuclein: APPLICATIONS FOR BIOMARKER DEVELOPMENT AND HIGH-THROUGHPUT SCREENING. The Journal of Biological Chemistry, 287 (40). pp. 33691-33705. ISSN 0021-9258

Bielen, Aleksandra and Box, Gary and Perryman, Lara and Bjerke, Lynn and Popov, Sergey and Jamin, Yann and Jury, Alexa and Valenti, Melanie and de Haven Brandon, Alexis and Martins, Vanessa and Romanet, Vincent and Jeay, Sebastien and Raynaud, Florence and Hofmann, Francesco and Robinson, Simon and Eccles, Suzanne and Jones, Chris (2012) Dependence of Wilms tumour cells on signalling through IGF1R in an orthotopic xenograft model targetable by specific receptor inhibition. PNAS. ISSN 0027-8424

Bigaud, Marc and Wieczorek, Grazyna and Menninger, Klaus and Barbet, Irène and Jean, Christian and Beerli, Christian and Audet, Maxime and Blancher, Antoine and Heusser, Christoph and Morris, Randall and Wagner, Juergen (2012) SOTRASTAURIN, (AEB071), PROLONGS KIDNEY ALLOGRAFT SURVIVAL ALONE OR IN COMBINATION WITH CYCLOSPORINE IN NON-HUMAN PRIMATES. Transplantation, 93 (2). pp. 156-164. ISSN 0041-1337

Bill, Anke and Lilley, Sarah and Renaud, Nicole and Groot Kormelink, Paul and Gaither, Larry (2012) The putative reentrant loop domain of ANO1 facilitates channel activation. Nature Structural and Molecular Biology.

Billy, Christine and Koch, Guido and Widmer, Hans and von Krogh, Georg and Erden, Zeynep and Schneider, Andreas (2012) Rethinking Leadership in Drug Discovery. Drug Discovery Today, 17 (23/24). pp. 1258-1262. ISSN 1359-6446

Bodenlenz, Manfred and Höfferer, Christian and Magnes, Christoph and Schaller, R. and Schaupp, L. and Feichtner, F. and Ratzer, Maria and Pickl, Karin and Sinner, Frank and Wutte, A. and Korsatko, S. and Köhler, G. and Legat, F.J. and Benfeldt, E. and Wright, Andrew and Neddermann, Daniel and Jung, Thomas and Pieber, Thomas R. (2012) Dermal PK/PD of a lipophilic topical drug in psoriatic patients by continuous intradermal membrane-free sampling. European Journal of Pharmaceutics and Biopharmaceutics, 81 (3). pp. 635-641. ISSN 0939-6411

Bolognani, Federico and Gallani, Anne-Isabelle and Sokol, Lena and Baskin, David and Meisner Kober, Nicole-Claudia (2012) mRNA stability alterations mediated by HuR are necessary to sustain the fast growth of glioma cells. Journal of Neuro-Oncology, 106 (3). pp. 531-542. ISSN 0167-594X

Bonapace, Laura and Wyckoff, Jeffery and Oertner, Thomas and van Rheenen, Jacco and Junt, Tobias and Bentires-Alj, Mohamed (2012) If we don’t look we won’t see: Intravital Multiphoton Imaging of Breast Cancer Metastasis. Journal of Mammary gland Biology and Neoplasia, 17 (1). ISSN 1083-3021

Boos, Julien and Kirk, David William and Dattler, Andre and Piccolotto, Mari-Luz and Zuercher, Werner and Gfeller, Sandro and Neuner, Philippe and Christensen, Jesper and Wishart, William L. and Beverly, Michael and Von Arx, Fabian and Litherland, Karine and Van De Kerkhof, Esther and Swart, Pieter Jacob and Faller, Thomas and Beyerbach, Armin and Morrissey, David and Hunziker, Juerg and Beuvink, Iwan (2012) Whole-body scanning PCR; a sensitive method to study the biodistribution of mRNAs, noncoding RNAs and therapeutic oligonucleotides. Nucleic Acids Research, Nuclei. ISSN 0305-1048

Bowes, Joanne and Brown, Andrew J and Hamon, Jacques and Jarolimek, Wolfgang and Sridhar, Arun and Waldron, Gareth and Whitebread, Steven (2012) Reducing safety-related drug attrition: The use of in vitro pharmacological profiling. Nature Reviews Drug discovery, 11 (12). pp. 909-922. ISSN 1474-1776

Britschgi, Adrian and Andraos-Rey, Rita and Brinkhaus, Heike and Klebba, Ina and Romanet, Vincent and Mueller, Urs and Murakami, Masato and Radimerski, Thomas and Bentires-Alj, Mohamed (2012) JAK2/STAT5 Inhibition Circumvents Resistance to PI3K/mTOR Blockade: A Rationale for Cotargeting These Pathways in Metastatic Breast Cancer. Cancer Cell, 22 (6). pp. 796-811. ISSN 1535-6108

Brockhoff, Marielle and Hau, Jean-Christophe and Fontana, Patrizia and Zimmermann, Catherine and De Pover, Alain and Erdmann, Dirk and Chene, Patrick (2012) Factors influencing the inhibition of protein kinases. Journal of Enzyme Inhibition and Medicinal Chemistry, 27 (2). pp. 194-200. ISSN 1475-6366

Broome, Michelle and Villarreal, Beth (2012) Differential Staining of Mast Cells with Toluidine Blue. Journal of Histotechnology, 35 (1). pp. 27-30. ISSN 0147-8885

Browne, Brigid / C and Eustace, Alex / J and Kennedy, Susan and O'Brien, Neil / A and Pedersen, Kasper and Larkin, Annemarie and Ballot, Jo and Mahgoub, Thamir and Sclafani, Francesco and Madden, Stephen and Kennedy, John and Duffy, Michael / J and Crown, John and O'Donovan, Norma (2012) Evaluation of IGF1R and phosphorylated IGF1R as targets in HER2-positive breast cancer cell lines and tumours. Breast Cancer Res Treat, 136 (3). pp. 717-727. ISSN 0167-6806

Bruce, Ian and Akhlaq, Mohammed and Bloomfield, Graham and Budd, Emma and Cox, Brian and Finan, Peter and Gedeck, Peter and Hayler, Judy and Head, Denise and Kirman, Louise and Leblanc, Catherine and Le Grand, Darren and Owen, Charles and Oza, Mrinalini and Sviridenko, Lilya and Whitehead, Lewis and Keller, Thomas and McCarthy, Clive and O'Connor, Desmond and Pilgrim, Gaynor and Press, Nicola and Cuenoud, Bernard (2012) Development of isoform selective PI 3-Kinase inhibitors as pharmacological tools for elucidating the PI3K pathway. Bioorganic & Medicinal Chemistry Letters, 22 (17). pp. 5445-5450. ISSN 0960-894X

Busch, Steven and Hoffmann, Peter and Foley, James and Sahota, Pritam and Johnson, Robert and Kothny, Wolfgang and Meyer, Franck (2012) Studies in rodents with the DPP-4 inhibitor vildagliptin to evaluate possible drug-induced pancreatic histological changes that are predictive of pancreatitis and cancer development in man. Diabetes, Obesity and Metabolism.

Butler, Matt and Sanmugalingam, Devika and Burton, Victoria and Wilson, Tammy and Pearson, Ruth and Watson, Robert and Smith, Philip and Parkinson, Scott James (2012) IMPAIRMENT OF ADENOSINE A3 RECEPTOR ACTIVITY DISRUPTS NEUTROPHIL MIGRATORY CAPACITY AND IMPACTS INNATE IMMUNE FUNCTION IN VIVO. European Journal of Immunology. ISSN 0014-2980

C

Caffery, Barbary and Joyce, Elizabeth and Miriam, Heynen and Ritter Iii, Robert and Lyndon, Jones and Michelle, Senchyna (2012) Quantification of Conjunctival TNFα mRNA Expression in Sub Populations of Human Aqueous Deficient Dry Eye. Molecular Vision.

Camenisch, Gian P. and Umehara, Ken-Ichi (2012) Predicting human hepatic clearance from in vitro drug metabolism and transport data: A scientific and pharmaceutical perspective for assessing drug-drug interactions. Biopharmaceutics and Drug Disposition. ISSN 0142-2782

Cenni, Bruno and Gutmann, Sascha and Dodeller, Francis and Gottar-Guillier, Marie (2012) The role of BMX in inflammation, cardiovascular disease and cancer. International Reviews of Immunology, 31 (2). pp. 166-173. ISSN 0883-0185

Chakraborty, Abhijit and Tannenbaum, Stacey and Rordorf, Christiane and Lowe, Phil and Floch, David and Gram, Hermann and Roy, Sandip (2012) Overview of the Pharmacokinetic and Pharmacodynamic Properties of Canakinumab, a Human anti-IL-1β Monoclonal Antibody. Clinical Pharmacokinetics, 51 (6). e1-e18. ISSN 0312-5963

Chapelat, Julien and Berst, Frederic and Marzinzik, Andreas and Moebitz, Henrik and Drueckes, Peter and Trappe, Joerg and Fabbro, Doriano and Seebach, Dieter (2012) The Substrate-Activity-Screening methodology applied to receptor tyrosine kinases: A proof-of-concept study. European Journal of Medicinal Chemistry. ISSN 0223-5234

Chatterjee, Arnab and Yeung, Bryan (2012) Back to the future: Lessons learned in modern target-based and whole-cell lead optimization of antimalarials. Current topics in Medicinal Chemistry.

Chioato, Andrea and Noseda, Emanuele and Stevens, Michael and Gaitatzis, Nikolaos and Kleinschmidt, Annett and Picaud, Henri (2012) Treatment with the IL-17 blocking antibody secukinumab (AIN457) does not interfere with the efficacy of Influenza and Meningococcal vaccination in healthy subjects. Results of an open-label, parallel group, randomized, single-center study. Clinical and Vaccine Immunology (CVI), 19 (10). pp. 1597-1602. ISSN 1556-6811

Cho, Young and Brain, Christopher and Chen, Christine and Cheng, Hong and Chopra, Rajiv and Giraldes, John and Kovats, Steven and Lagu, Bharat and Luzzio, Michael and Shen, Junqing and Yang, Fan and Wrona, Wojciech and O'Reilly, Marc and Howard, Steven and Loo, Alice and Haas, Kristy and Kim, Sunkyu and Lu, Yipin and Maniara, Wieslawa and Smith, Troy and Xu, Mei and Angove, Hayley and Cheng, Robert and Congreve, Miles and Dagostin, Claudio and J.Davis, Deborah and Feltell, Ruth and D.Hiscock, Steven and Lewry, Kim and McMenamin, Rachel and N.Mortenson, Paul and Benning, Rajdeep and C.Rees, David and Williams, Glyn and Woolford, Alison (2012) Fragment-Based Discovery and Structure-Guided Optimization of 2-Benzoyl-7-azabenzimidazoles as Potent, Highly Selective and Orally Active CDK4/6 Inhibitors. ACS Medicinal Chemistry Letters, 3 (6). pp. 445-449. ISSN 1948-5875

Christensen, Jesper and Natt, Francois and Hunziker, Juerg and Krauser, Joel and Andres, Hendrik and Swart, Pieter Jacob (2012) Tritium labeling of full length small interfering RNA’s. Journal of Labelled Compounds and Radiopharmaceuticals, 55 (6). pp. 189-196. ISSN 0362-4803

Coan, Kristin Emily and Swann, Marcus and Ottl, Johannes (2012) Measurement and differentiation of ligand-induced calmodulin conformations by dual polarization interferometry. Analytical Chemistry, 84 (3). pp. 1586-1591. ISSN 0003-2700

Costa, R.O. and Lacor, P.N. and Ferreira, I.L. and Auberson, Yves and Klein, W.L. and Oliveira, C.R. and Rego, A.C. and Pereira, C.M.F. (2012) Endoplasmic reticulum stress occurs downstream of NR2B subunit of N-methyl-D-aspartate receptor in mature hippocampal cultures treated with amyloid-β oligomers. Aging Cell.

Cunliffe, Jennifer (2012) Fast Chromatography in the Regulated Bioanalytical Environment: Sub-2 um vs. Fused-core Particles. Bioanalysis, 4 (8). pp. 861-863. ISSN 1757-6180

D

Damiano, Jason and Rendahl, Katherine and Karim, Christopher and Embry, Millicent and Ghoddusi, Majid and Holash, Jocelyn and Fanidi, Abdallah and Abrams, Tinya and Abraham, Judith (2012) Neutralization of Prolactin Receptor Function by Monoclonal Antibody LFA102, A Novel Potential Therapeutic for the Treatment of Breast Cancer. Molecular Cancer Therapeutics, 12 (3). pp. 295-305. ISSN 1535-7163

David, Olivier J and Kovarik, John M and Schmouder, Robert L (2012) Clinical pharmacokinetics of fingolimod. Clinical pharmacokinetics, 51 (1). pp. 15-28. ISSN 0312-5963

Davies, Nicholas G. M. and Browne, Helen and Davis, Ben and Foloppe, Nicolas and Geoffrey, Stephanie and Gibbons, Ben and Hart, Terry and Drysdale, Martin J. and Mansell, Howard and Massey, Andrew and Matassova, Natalia and Moore, Jonathan D and Murray, James and Pratt, Robert and Ray, Stuart and Roughley, Stephen D. and Jensen, Michael Rugaard and Schoepfer, Joseph and Scriven, Kirsten and Simmonite, Heather and Stokes, Stephen and Surgenor, Alan and Webb, Paul and Wright, Lisa and Brough, Paul (2012) Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization. Bioorganic & Medicinal Chemistry, 20 (22). pp. 67770-67789. ISSN 0968-0896

Defontis, Myriam and Cote, Serge and Stirn, Martina and Ledieu, David (2012) Optimization of Multiplate® whole blood platelet aggregometry in the Beagle dog and Wistar rat for ex vivo drug toxicity testing. Experimental and Toxicologic Pathology. ISSN 0940-2993

Denes, A and Drake, C and Stordy, J and Chamberlain, J and Gram, Hermann and Crossman, D and Francis, S and Rothwell, N (2012) Interleukin-1 mediates neuroinflammatory changes associated with diet-induced atherosclerosis. Journal of the American Heart Association, 1 (3). e002006. ISSN 2047-9980

Devine, Patrick and Perreault, Sally and Luderer, Ulrike (2012) Roles of reactive oxygen species and antioxidants in ovarian toxicity. Biology of Reproduction, 86 (2). p. 27. ISSN 0006-3363

Di Padova, Franco E. and Gomery, Kathryn and Evans, Stephen V (2012) Antibody WN1 222-5 Mimics Toll-like Receptor 4 Binding in the Recognition of LPS. Proocedings national academy sciences, 109 (51). pp. 20877-20882.

Diagana, Thierry and Yeung, Bryan and Sauerwein, Robert (2012) The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to Anopheles mosquito vector. Antimicrobial Agents and Chemotherapy. ISSN 0066-4804

Dobi, Alice and Sartori, Simone and Busti, Daniela and Flor, Peter and Van Der Putten, P. Herman and Singewald, Nicolas and Shigemoto, Ryuichi and Ferraguti, Francesco (2012) Neural substrates for the opposing effects of distinct presynaptic group III metabotropic glutamate receptors on extinction of contextual fear conditioning in mice. Neuropharmacology. pp. 1-16. ISSN 0028-3908

Dobo, Krista and Green, Nigel and et al, et al and Glowienke, Susanne (2012) In Silico Methods Combined with Expert Knowledge Rule out Mutagenic Potential of Pharmaceutical Impurities: An Industry Survey. Regulatory Toxicology and Pharmacology.

Duca, Jose and Karki, Rajeshri (2012) Noticing The Unnoticed: Bridging Structural Data And Drug Design. Future Medicinal Chemistry, 4 (15). pp. 1869-1871. ISSN 1756-8919

Dudek, Timothy E and No, Daniel C and Seung, Edward and Vrbanac, Vladimir D and Fadda, Lena and Bhoumik, Priyasma and Boutwell, Christian L and Power, Karen A and Gladden, Adrianne D and Battis, Laura and Mellors, Elizabeth F and Tivey, Trevor R and Gao, Xiaojiang and Altfeld, Marcus and Luster, Andrew D and Tager, Andrew M and Allen, Todd M (2012) Rapid evolution of HIV-1 to functional CD8⁺ T cell responses in humanized BLT mice. Science translational medicine, 4 (143). 143ra98. ISSN 1946-6242

Dunne, Christine and Bushee, Jennifer and Argikar, Upendra (2012) Metabolism of bromopride in mouse, rat, rabbit, dog, monkey, and human hepatocytes. Drug Metabolism and Pharmacokinetics.

E

Ebersbach, Hilmar and Zhang, Chonghui and Proetzel, Gabriele (2012) Antigen Presentation for the Generation of Binding Molecules. In: Methods in Molecular Biology: Antibody Protocols and Methods. Humana Press. ISBN 978-1-58829-092-2

Ebersbach, Hilmar and Geisse, Sabine (2012) Antigen generation and display in therapeutic antibody drug discovery – a neglected but critical player. Biotechnology Journal. ISSN 1860-6768

Ekyalongo, Roudy / C and Mukohara, Toru and Kataoka, Yu and Kiyota, Naomi and Fujiwara, Yutaka and Minami, Hironobu (2012) Mechanisms of acquired resistance to insulin-like growth factor 1 receptor inhibitor in MCF-7 breast cancer cell line. Investigational New Drugs. ISSN 0167-6997

Elnakat Thomas, Hala and Mercer, Carol A. and Carnevalli, Larissa S. and Park, Jongsun and Andersen, Jesper B. and Conner, Elizabeth A. and Tanaka, Kazuhiro and Matsutani, Tomoo and Iwanami, Akio and Aronow, Bruce J. and Liu, Manway and Thorgeisson, Snorri S. and Mischel, Paul S. and Thomas, George and Kozma, Sara C. (2012) Dual Inhibition of mTOR in hepatocellular carcinoma induces tumor regression, return to normal liver gene expression and autophagy. Science Translational Medicine, 4 (139). ra84. ISSN 1946-6234

Emotte, Corinne and Deglave, Fanny and Picard, Franck and Chaturvedi, Animesh and Majumdar, Tapan and Agarwal, Ashish and Kretz, Olivier (2012) Validation of on-line solid- phase extraction coupled with high-performance liquid chromatography–mass spectrometry assays for the determination of indacaterol, a potent β-adrenoceptor agonist in human serum. Journal of chromatography B, 895/89. pp. 1-9. ISSN 1570-0232

Endacott, John and Poolman, Robert (2012) Looking for Insights – Quality Control Initiatives for Enhancing Patent Searches. World Patent Information, 35 (1). pp. 3-7.

Erdemli, Gul and Kim, Albert and Ju, Haisong and Springer, Clayton and Penland, Robert and Hoffmann, Peter (2012) Cardiac Safety Implications of hNav1.5 Blockade and a Framework for Pre-Clinical Evaluation. Frontiers in Pharmaceutical Medicine and Outcomes Research.

Erdemli, Gul and Priest, Birgit and Wickenden, Alan (2012) Ion Channel Drug Discovery: Challenges and Future Directions. Future Medicinal Chemistry.

Ertl, Peter (2012) Database of bioactive ring systems with calculated properties and its use in bioisosteric design and scaffold hopping. Bioorganic and Medicinal Chemistry, 20 (18). pp. 5436-5442. ISSN 0968-0896

Ertl, Peter and Lewis, Richard (2012) IADE - A System for Intelligent Automatic Design of Bioisosteric Analogs. Journal of Computer-Aided Molecular Design, 26 (11). pp. 1207-1215. ISSN 0920-654X

Ertl, Peter and Rohde, Bernhard (2012) The Molecule Cloud - compact visualization of large collections of molecules. Journal of Cheminformatics, 4 (1). p. 12. ISSN 1758-2946

Ertl, Peter and Steinbeck, Christoph and Jayaseelan, Kalai Vanii and Moreno, Pablo and Truszkowski, Andreas (2012) Natural product-likeness score revisited: an open-source, open-data implementation. BMC Bioinformatics, 13 (106).

F

Farmer, I and Pancholi, S and Thornhill, AM and Ghazoui, Z and Evans, Dean Brent and Lane, Heidi A and Johnston, SR and Dowsett, Mitch and Martin, Lesley-Ann and Imark, Esther (2012) Effectiveness and molecular interactions of the clinically active mTORC1 inhibitor everolimus in combination with tamoxifen or letrozole in vitro and in vivo. Breast Cancer Research, 14 (5). ISSN 1465-5411

Feuerbach, Dominik and Arias, Hugo R and Targowska-Duda, Katarzyna M and Aggarwal, Shaili and Lapinsky, Daniel J and Jozwiak, Krzysztof (2012) Structural and functional interaction of (+)-2-(N-tert-butylamino)-3’-iodo-4’-azidopropiophenone, a photoactivatable bupropion derivative, with nicotinic acetylcholine receptors. Biochemistry.

Fiez-Vandal, Cedric and Leder, Lukas and Freuler, Felix and Sykes, David and Charlton, Steven and Siehler Wagner, Sandra and Schopfer, Ulrich and Duckely, Myriam (2012) HDL-like discs for assaying membrane proteins in drug discovery. Biophysical Chemistry, 165/16. pp. 56-61. ISSN 0301-4622

Fischer, Simon and Charara, Nadine and Gerber, Andrea and Woelfel, Jens and Schiedner, Gudrun and Voedisch, Bernd and Geisse, Sabine (2012) Transient recombinant protein expression in a human amniocyte cell line: the CAP-T cell system. Biotechnology & Bioengineering, 109 (9). pp. 2250-2261. ISSN 0006-3592

Flarakos, Jimmy and Ting, Lillian and Du, Yancy and Stein, Daniel and Reynolds, Christine and Patel, Manish and Roy, Sandip and Mangold, James (2012) Disposition and metabolism of [14C]PTZ601 in healthy volunteers. Xenobiotica. ISSN 0049-8254

Fredenhagen, Andreas and Kittelmann, Matthias and Oberer, Lukas and Kuhn, Anton and Kuehnoel, Juergen and Delemonte, Thierry and Aichholz, Reiner and Wang, Ping and Atadja, Peter and Shultz, Michael (2012) Biocatalytic synthesis and structure elucidation of cyclized metabolites of the deacetylase inhibitor Panobinostat (LBH589). Drug Metabolism and Disposition, 40 (5). pp. 1041-1050. ISSN 0090-9556

Frieauff, Wilfried and Martus, Hans-Joerg and Suter, Willi and Elhajouji, Azeddine (2012) Automatic Analysis of the Micronucleus Test in Primary Human Lymphocytes Using Image Analysis. Mutagenesis.

Fu, Shijun and Fei, Qi and Jiang, Hua and Chuai, Shannon and Song, Shi and Xiong, Wen and Jiang, Lei and Lu, Chris and Atadja, Peter and Li, En and Shou, Jianyong (2012) Involvement of histone acetylation of Sox17 and Foxa2 promoters during mouse definitive endoderm differentiation revealed by microRNA profiling. PLOS One.

Furet, Pascal and Chene, Patrick and De Pover, Alain and Valat, Therese-Marie and Hergovich Lisztwan, Joanna and Kallen, Joerg and Masuya, Keiichi (2012) The Central Valine Concept Provides an Entry in a New Class of Non Peptide Inhibitors of the P53-MDM2 Interaction. Bioorganic & Medicinal Chemistry Letters.

G

Gamsjaeger, Sonja and Hofstetter, B and Zwettler, Elisabeth and Recker, Robert and Gasser, Juerg Andreas and Eriksen, Erik Fink and Klaushofer, Klaus and Paschalis, Eleftherios P (2012) Effects of Three Years Treatment With Once-Yearly Zoledronic Acid on the Kinetics of Bone Matrix Maturation in Osteoporotic Patients. Osteoporosis International.

Gao, Zhenhai and Menezes, Daniel and Machajewski, Timothy and Abrams, Tinya and Jensen, Michael Rugaard and Yu, Guoying and Stuart, Darrin and Duhl, David and Pryer, Nancy and Sellers, William (2012) THE NOVEL ORAL HSP90 INHIBITOR NVP-HSP990 EXHIBITS POTENT AND BROAD-SPECTRUM ANTI-TUMOR ACTIVITIES IN VITRO AND IN VIVO. Molecular Cancer Therapeutics. ISSN 1535-7163

Garofalo, Cecilia and Mancarella, Caterina and Grilli, Andrea and Manara, Maria Cristina and Astolfi, Annalisa and Marino, Maria Teresa and Conte, Alexia and Sigismund, Sara and Carè, Alessandra and Belfiore, Antonino and Picci, Piero and Scotlandi, Katia (2012) Identification of both common and distinctive mechanisms of resistance to different anti-IGF-1R agents in Ewing’s sarcoma. Molecular Endocrinology, 26 (9). pp. 1603-1616. ISSN 0888-8809

Gaz, Claudio and Cremona, George and Panunzi, Simona and Patterson, Beverley and De Gaetano, Andrea (2012) A geometrical approach to the PKPD modelling of inhaled bronchodilators. Journal of pharmacokinetics and pharmacodynamics, 39 (5). pp. 415-428. ISSN 1567-567X

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Ting, Lillian and Praestgaard, Jens and Grunenberg, Nicole and Komjathy, Steven and Leeds, Jennifer and Pertel, Peter (2012) A first-in-human, randomized, double-blind, placebo-controlled, time-lagged, single- and multiple-ascending oral dose study to assess the safety and tolerability of LFF571 in healthy volunteers. Antimicrobial Agents and Chemotherapy, 56 (11). p. 5946. ISSN 0066-4804

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Yi, Tangsheng and Wang, Xiaoming and Kelly, Lisa M. and An, Jinping and Xu, Ying and Sailer, Andreas and Gustafsson, Jan-Ake and Russell, David W. and Cyster, Jason G. (2012) Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses. Immunity, 37 (3). pp. 535-548. ISSN 1074-7613

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Zhang, Lin and Orban, Martin and Lorenz, Michael and Barocke, Verena and Braun, Daniel and Urtz, Nicole and Schulz, Christian and Proia, Richard L. and von Bruehl, Marie-Luise and Graf, Thomas and Bolz, Steffen-Sebastian and Montanez, Eloi and Prinz, Marco and Müller, Alexandra and Billich, Andreas and Sixt, Michael and von Andrian, Ulrich H. and Junt, Tobias and Massberg, Steffen and Tirniceriu, Anca and Gaertner, Florian and von Baumgarten, Louisa and Faessler, Reinhard (2012) A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis. Journal of Experimental Medicine, 209 (12). pp. 2165-2181. ISSN 0022-1007

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Zhang, Weidong and Korstanje, Ron and Thaisz, Jill and Staedtler, Frank and Hartmann, Nicole and Xu, Lingfei and Feng, Minjie and Yanas, Liane and Yang, Hyuna and Valdar, William and Churchill, Gary and Dipetrillo, Keith (2012) Genome-wide Association Mapping of Quantitative Traits in Outbred Mice. G3: Gene/Genomes/Genetics, 2 (2). pp. 167-174. ISSN 2160-1836

Zielen, S and Lieb, A and De La Motte, D and Wagner, F and De Monchy, J and Fuhr, R and Munzu, Clara and Koehne-Voss, Stephan and Riviere, G and Kaiser, Guenther and Erpenbeck, Veit (2012) Omalizumab protects against allergen-induced bronchoconstriction in allergic (IgE-mediated) asthma. International archives of allergy and immunology, 160 (1). pp. 102-110. ISSN 1018-2438

Zou, Bin and Yap, Peiling and Sonntag, Sebastian and Leong, Seh Yong and Yeung, Bryan King Sing and Keller, Thomas (2012) Mechanistic Study of the Spiroindolones: A New Class of Antimalarials. Molecules, 17 (9). pp. 10131-10141. ISSN 1420-3049

Zou, Gang and Kukkaro, Petra and Lok, Shee Mei and Ng, Jowin and Tan, Grace and Alonso, Sylvie and Macary, Paul and Shi, Pei-Yong (2012) Resistance analysis of an antibody that selectively inhibits dengue virus serotype-1. Antiviral Reseaech, 95 (3). pp. 216-223. ISSN 0166-3542

Zumsteg, Adrian and Caviezel, Christoph and Pisarsky, Laura and Strittmatter, Karin and Garcia-Echeverria, Carlos and Hofmann, Francesco and Christofori, Gerhard (2012) Repression of malignant tumor progression upon pharmacologic IGF1R blockade in a mouse model of insulinoma. Molecular Cancer Research, 10 (6). pp. 800-809. ISSN 1557-3125

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