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Identification of a common immune signature in murine and human systemic Salmonellosis.

Lee, Seung-Joo and Liang, Li and Nantona, Minelva R. and Gondwe, Ester N. and Msefula, Chisomo L. and Kayala, Matthew A. and Necchi, Francesca and Heath, Jennifer N. and Hart, Peter and Tsolis, Renée M. and Heyderman, Robert S. and Maclennan, Calman Alexander and Felgner, Philip L. and Davies, D. Huw and McSorley, Stephen J. (2012) Identification of a common immune signature in murine and human systemic Salmonellosis. Proceedings of the National Academy of Sciences, USA. ISSN 0027-8424

Abstract

Despite the importance of Salmonella infections in human and
animal health, the target antigens of Salmonella-specific immunity remain poorly defined. We have previously shown evidence for antibody-mediating protection against invasive Salmonellosis in mice and African children. To generate an overview of antibody targeting in systemic Salmonellosis, a Salmonella proteomic array containing over 2,700 proteins was constructed and probed with immune sera from Salmonella-infected mice and humans. Analysis
of multiple inbred mouse strains identified 117 antigens recognized by systemic antibody responses in murine Salmonellosis. Importantly, many of these antigens were independently identified as target antigens using sera from Malawian children with Salmonella bacteremia, validating the study of the murine model. Furthermore, vaccination with SseB, the most prominent antigenic target in Malawian
children, provided mice with significant protection against
Salmonella infection. Together, these data uncover an overlapping immune signature of disseminated Salmonellosis in mice and humans and provide a foundation for the generation of a protective subunit vaccine.

Item Type: Article
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Date Deposited: 13 Oct 2015 13:14
Last Modified: 13 Oct 2015 13:14
URI: https://oak.novartis.com/id/eprint/7198

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