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Proton Exchange Reactions in Isotope Chemistry (I) Synthesis of Stable Isotope Labeled TKI258 and Its Metabolites

Jian, Zhigang and Ray, Tapan and Wu, Aiyin and Jones, Lawrence (2012) Proton Exchange Reactions in Isotope Chemistry (I) Synthesis of Stable Isotope Labeled TKI258 and Its Metabolites. Journal of Labeled Compounds and Radiopharmaceuticals, 55 (2). pp. 84-87. ISSN 0362-4803

Abstract

Direct H-D exchange reactions were applied to the preparations of stable isotope labeled TKI258 and two TKI258 metabolites. Each compound was made in one single H-D exchange reaction with excellent isotope incorporation. The number of deuterium incorporated and deuterium distribution in the molecules were similar in all three compounds. Stable isotope labeled TKI258 was also prepared from d8-methylpiperazine in a multi-step synthesis.

Item Type: Article
Additional Information: author can archive post-print (ie final draft post-refereeing); On personal web site or secure external website at authors institution; Publisher's version/PDF cannot be used
Keywords: Deuterium, exchange, stable isotope
Date Deposited: 13 Oct 2015 13:15
Last Modified: 13 Oct 2015 13:15
URI: https://oak.novartis.com/id/eprint/4945

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