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The role of BMX in inflammation, cardiovascular disease and cancer

Cenni, Bruno and Gutmann, Sascha and Dodeller, Francis and Gottar-Guillier, Marie (2012) The role of BMX in inflammation, cardiovascular disease and cancer. International Reviews of Immunology, 31 (2). pp. 166-173. ISSN 0883-0185

Abstract

Bone marrow kinase on chromosome X (BMX) is a cytosolic tyrosine kinase and member of the TEC family kinases. BMX is expressed in hematopoietic cells of the myeloid lineage where it participates in the immune response, as well as in the endocardium and the cardiac endothelium where it is involved in the response to ischemia and pressure overload. Moreover, BMX is also expressed in several types of cancers and very recently has been shown to mediate the survival and tumorigenicity of glioblastoma cancer stem cells. In the inflammatory response BMX regulates the secretion of pro-inflammatory cytokines induced by TNF, IL1b and TLR agonists. It is required for the activation of the MAP kinase and NFkB pathways and acts at the level of the common TAK1/TAB complex. Cellular regulation of the IL-8 promoter by BMX is dependent on membrane localization mediated by its PH domain, as well as on BMX kinase activity. In a mouse model of arthritis BMX deficiency was protective. Interestingly, this effect was independent of BMX kinase activity and the consequences for the development of BMX inhibitors are discussed. This review summarizes recent advances in the knowledge of BMX biology and their relevance for translational medicine.

Item Type: Article
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Additional Information: Invited review
Keywords: TEC kinases, inflammation, cancer, angiogenesis, arthritis
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Date Deposited: 13 Oct 2015 13:14
Last Modified: 13 Oct 2015 13:14
URI: https://oak.novartis.com/id/eprint/6610

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