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Regulation of Allergic Responses to Chemicals: Possible Roles of Epigenetic Mechanisms

Moggs, Jonathan, Terranova, Remi, Kammueller, Michael and Chibout, Salah-Dine (2012) Regulation of Allergic Responses to Chemicals: Possible Roles of Epigenetic Mechanisms. Toxicological Sciences, 130 (1). pp. 60-69. ISSN 1096-6080


There is increasing evidence that epigenetic regulation of gene expression plays a pivotal role in the orchestration of immune and allergic responses. Such regulatory mechanisms have potentially important implications for the acquisition of sensitization to chemical and drug allergens, and in determining the vigor, characteristics and longevity of allergic responses. Importantly, the discovery of long-lasting epigenetic alterations in specific immunoregulatory genes provides a mechanistic basis for immune cell memory, and thereby the potential of chemical allergens to influence the subsequent orientation of the adaptive immune system. In this article we consider the implications of epigenetic mechanisms for the development of sensitization to chemical allergens and the form that allergic reactions will take.

Item Type: Article
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Additional Information: No Novartis projects are discussed. This invited review article sets the scene for a Novartis-sponsored PhD studentship (affiliated to UK Centre for Drug Safety Sciences) that will explore the relevance of epigenetic mechanisms for xenobiotic-induced perturbations of the immune system leading to allergy
Keywords: allergy epigenetics immunology
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Date Deposited: 13 Oct 2015 13:14
Last Modified: 13 Oct 2015 13:14