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The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to Anopheles mosquito vector

Diagana, Thierry and Yeung, Bryan and Sauerwein, Robert (2012) The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to Anopheles mosquito vector. Antimicrobial Agents and Chemotherapy. ISSN 0066-4804

Abstract

The global malaria agenda has undergone a reorientation from control of clinical cases to entirely eradicating malaria. For that purpose, a key objective is blocking transmission of malaria parasites from humans to mosquito vectors. The new antimalarial drug candidate NITD609 was evaluated for its transmission reducing potential using a suite off in vitro assays. Using a microscopic readout NITD609 was found to inhibit in a dose dependent-fashion the induction and maturation of Plasmodium falciparum gametocytes in vitro. In addition, using the standard membrane feeding assay, NITD609 was also found to be a very effective drug in reducing transmission to Anopheles stephensi mosquito vector. Collectively our data suggest that NITD609 may have potential as a transmission blocking drug in addition to its therapeutic activity against asexual P. falciparum malaria parasites.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); but on personal or university-hosted websites only
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Date Deposited: 13 Oct 2015 13:14
Last Modified: 13 Oct 2015 13:14
URI: https://oak.novartis.com/id/eprint/6462

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