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Copper-Catalyzed Decarboxylative C—N Cross-Coupling for N-Arylation

Mainolfi, Nello, Zhang, Yun and Patel, Sejal (2012) Copper-Catalyzed Decarboxylative C—N Cross-Coupling for N-Arylation. Chemical Science, on lin. ISSN 2041-6520


A novel approach for N-arylation utilizing aryl carboxylic acids as stable, inexpensive and widely available arylating reagents was developed. Employing a simple copper(II)-phenanthroline catalyst system, several benzoic acids bearing suitable ortho-substitutions undergo decarboxylative C—N cross-coupling effectively with various N-nucleophiles.

Item Type: Article
Additional Information: author can archive post-print (ie final draft post-refereeing); Author's version in web repository after 12 months or immediately with fee
Date Deposited: 13 Oct 2015 13:14
Last Modified: 13 Oct 2015 13:14