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Counterion Quantification for Discovery Chemistry and Preformulation Salt Screening

Reilly, John and Wright, Penny and Larrow, Jay and Mann, Thierry and Twomey Iii, Joseph and Grondine, Melissa and Dodd, Stephanie and Capacci-Daniel, Christina and Bilotta, Jennifer and Shah, Lipa and Towler, Christopher (2012) Counterion Quantification for Discovery Chemistry and Preformulation Salt Screening. Journal of Liquid Chromatography and Related Technologies.

Abstract

Abstract
A fast method has been developed to determine the amount of anions and cations present in discovery samples using a reagent free ion chromatography system. The system separates and quantifies counterions present in novel discovery compounds from an accurately weighed sample of 1mg. The advantage of using these methods in the discovery phase and early development to accurately characterize salt identity and stoichiometry has been demonstrated. Likewise, a further advantage is the ability to accurately quantify undesirable counterions that may be present due to process related manipulation of material and to quantify salt equivalents for “mixed” salt samples. The instrumentation described also has the ability to utilise a reagent-free automated eluent generation approach which in addition to saving time, eliminates the variability that can occur with manually prepared eluents. Several examples have been collated to highlight the usefulness of this approach within discovery.

Item Type: Article
Keywords: Keywords: Ion Chromatography; Counterions; Anions; Cations; Gradient; Discovery Chemistry; Pre-Formulation
Date Deposited: 13 Oct 2015 13:15
Last Modified: 13 Oct 2015 13:15
URI: https://oak.novartis.com/id/eprint/4731

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