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Items where Year is 2012

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Number of items: 286.

Article

Akkus, Funda, Ametamey, Simon, Treyer, Valerie, Burger, Cyrill, Johayem, Annas, Umbricht, Daniel, Gomez-Mancilla, Baltazar, Sovago, Judit, Buck, Alfred and Hasler, Gregor (2012) Marked Global Reduction in mGluR5 Binding in Smokers and Ex-smokers Determined by [11C]ABP688 Positron Emission Tomography. Proceedings of the National Academy of Sciences, 110 (2). pp. 737-742. ISSN 0027-8424

Allegrini, Peter Roland (2012) MRI in drug discovery. Eropean pharmaceutical review, 2012 (1).

Angst, Daniela, Bollbuck, Birgit, Janser, Philipp, Quancard, Jean, Buehlmayer, Peter, Berst, Frederic, Oberer, Lukas, Beerli, Christian, Pally, Charles, Streiff, Markus and Bassilana, Frederic (2012) An oral S1P1 antagonist prodrug with efficacy in vivo: discovery, synthesis and evaluation. Journal of Medicinal Chemistry, 55 (22). pp. 9722-9734. ISSN 0022-2623

Argikar, Upendra (2012) Unusual Glucuronides. Drug Metabolism and Disposition.

Arias, HR, Feuerbach, Dominik and Ortello, M (2012) Bupropion and its photoreactive analog (±)-SADU-3-72 interact with luminal and non-luminal sites at human α4β2 nicotinic acetylcholine receptors. Biomembranes.

Baba, Nobuyasu, Rubio, Manuel, Kenins, Linda, Regairaz, Camille, Woisetchlager, Maximilian, Carballido, Jose and Sarfati, Marika (2012) Aryl hydrocarbon receptor (AhR) ligation by VAF347 promotes Th22 and inhibits Th1 polarization. Human Immunology, 73. pp. 795-800. ISSN 0198-8859

Babin, Anna Louise, Cannet, Catherine, Ble, Francois-Xavier, Gerard Sachot, Christelle, Takeichi, Masatoshi, Page, Clive, Sparrer, Helmut, Matsuguchi, Tetsuya and Beckmann, Nicolau (2012) BLEOMYCIN-INDUCED LUNG INJURY ASSESSED NON-INVASIVELY AND IN SPONTANEOUSLY BREATHING MICE BY PROTON MRI: MODEL ASSESSMENT AND TARGET VALIDATION. Magnetic Resonance in Medicine, 67 (2). pp. 499-509. ISSN 0740-3194

Bahe, Amine, Toth, Iulia, Fendt, Markus, Neumann, Inga D, Flor, Peter J and Slattery, David A (2012) Pharmacological interference with metabotropic glutamate receptor subtype 7 but not subtype 5 differentially affects within- and between-session extinction of Pavlovian conditioned fear. Neuropsychopharmacology, 62 (4). pp. 1619-1626. ISSN 0028-3908

Baltus, Christine, Press, Neil, Antonijevic, Milan, Tizzard, Graham, Coles, Simon and Spencer, John (2012) Synthesis of a biphenyl library for studies of hydrogen bonding in the solid state. Tetrahedron, 68 (45). pp. 9272-9277. ISSN 0040-4020

Barretina, Jordi, Caponigro, Giordano, Stransky, Nicolas, Venkatesan, Kavitha, Schlegel, Robert, Sellers, William and Garraway, Levi (2012) The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature, 483 (7391). pp. 603-607. ISSN 0028-0836

Beattie, David, Beer, David, Bradley, Michelle, Bruce, Ian, Charlton, Steven, Cuenoud, Bernard, Fairhurst, Robin, Farr, David Colin, Fozard, John R., Janus, Diana, Rosethorne, Elizabeth, Sandham, David, Sykes, David, Trifilieff, Alexandre, Turner, Katharine and Wissler, Elke (2012) An Investigation into the Structure Activity Relationships Associated with the Systematic Modification of the beta2-Adrenoceptor Agonist Indacaterol. Bioorganic & medicinal chemistry letters, 22 (19). pp. 6280-6285. ISSN 0960-894X

Beckett, Martin (2012) Book review: The Algebra of Organic Synthesis by John Andraos, CRC Press 2011. Chemistry and Industry, Sept 2. pp. 48-49.

Bedrosian, Andrea S, Nguyen, Andrew H, Mushlin, Harry M, Hackman, Muchael, Ochi, Atsuo, Connolly, Michael K, Ibrahim, Junaid, Rehman, Adeel, Henning, Justin R, Barilla, Rocky, Pylayeva-Gupta, Yuliya, Mallen-St. Clair, John, Hajdu, Cristina, Frey, Alan B, Bar-Sagi, Dafna and Miller, George (2012) MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells. Journal Experimental Medicine, 209 (9). pp. 1671-1687. ISSN 0022-1007, 1540-9538

Bell, Leslie and Wang, Jianling (2012) Probe ADME and Test Hypotheses: A PATH beyond clearance in vitro-in vivo correlations in early drug discovery. Expert Opintion on Drug Metabolism and Toxicology. ISSN 1742-5255

Benned-Jensen, Tau, Norm, Christoffer, Laurent, Stephane, Medom Madsen, Christian, Niss Arfelt, Kristine, Wolf, Romain, Frimurer, Thomas, Sailer, Andreas and Rosenkilde, Mette (2012) Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced receptor 2 (GPR183). Journal of Biological Chemistry, 287 (42). pp. 35470-35483. ISSN 0021-9258

Biason-Lauber, Anna, Böni-Schnetzler, Marianne, Hubbard, Basil P, Bouzakri, Karim, Brunner, Andrea, Cavelti-Weder, Claudia, Keller, Cornelia, Meyer-Böni, Monika, Meier, Daniel T, Brorsson, Caroline, Timper, Katharina, Leibowitz, Gil, Patrignani, Andrea, Bruggmann, Remy, Boily, Gino, Zulewski, Henryk, Geier, Andreas, Cermak, Jennifer M, Elliott, Peter, Ellis, James L, Westphal, Christoph, Knobel, Urs, Eloranta, Jyrki J, Kerr-Conte, Julie, Pattou, François, Konrad, Daniel, Matter, Christian M, Fontana, Adriano, Rogler, Gerhard, Schlapbach, Ralph, Regairaz, Camille, Carballido, Jose, Glaser, Benjamin, McBurney, Michael W, Pociot, Flemming, Sinclair, David A and Donath, Marc Y (2012) Identification of a SIRT1 mutation in a family with Type 1 Diabetes. Cell Metabolism, 17 (3). pp. 448-455. ISSN 1550-4131

Bidinosti, Michael, Shimshek, Derya, Mollenhauer, Brit, Marcellin, David, Schweizer, Tatjana, Lotz, Gregor, Schlossmacher, Michael and Weiss, Andreas (2012) Novel One-step Immunoassays to Quantify α-Synuclein: APPLICATIONS FOR BIOMARKER DEVELOPMENT AND HIGH-THROUGHPUT SCREENING. The Journal of Biological Chemistry, 287 (40). pp. 33691-33705. ISSN 0021-9258

Bielen, Aleksandra, Box, Gary, Perryman, Lara, Bjerke, Lynn, Popov, Sergey, Jamin, Yann, Jury, Alexa, Valenti, Melanie, de Haven Brandon, Alexis, Martins, Vanessa, Romanet, Vincent, Jeay, Sebastien, Raynaud, Florence, Hofmann, Francesco, Robinson, Simon, Eccles, Suzanne and Jones, Chris (2012) Dependence of Wilms tumour cells on signalling through IGF1R in an orthotopic xenograft model targetable by specific receptor inhibition. PNAS. ISSN 0027-8424

Bigaud, Marc, Wieczorek, Grazyna, Menninger, Klaus, Barbet, Irène, Jean, Christian, Beerli, Christian, Audet, Maxime, Blancher, Antoine, Heusser, Christoph, Morris, Randall and Wagner, Juergen (2012) SOTRASTAURIN, (AEB071), PROLONGS KIDNEY ALLOGRAFT SURVIVAL ALONE OR IN COMBINATION WITH CYCLOSPORINE IN NON-HUMAN PRIMATES. Transplantation, 93 (2). pp. 156-164. ISSN 0041-1337

Bill, Anke, Lilley, Sarah, Renaud, Nicole, Groot Kormelink, Paul and Gaither, Larry (2012) The putative reentrant loop domain of ANO1 facilitates channel activation. Nature Structural and Molecular Biology.

Billy, Christine, Koch, Guido, Widmer, Hans, von Krogh, Georg, Erden, Zeynep and Schneider, Andreas (2012) Rethinking Leadership in Drug Discovery. Drug Discovery Today, 17 (23/24). pp. 1258-1262. ISSN 1359-6446

Bodenlenz, Manfred, Höfferer, Christian, Magnes, Christoph, Schaller, R., Schaupp, L., Feichtner, F., Ratzer, Maria, Pickl, Karin, Sinner, Frank, Wutte, A., Korsatko, S., Köhler, G., Legat, F.J., Benfeldt, E., Wright, Andrew, Neddermann, Daniel, Jung, Thomas and Pieber, Thomas R. (2012) Dermal PK/PD of a lipophilic topical drug in psoriatic patients by continuous intradermal membrane-free sampling. European Journal of Pharmaceutics and Biopharmaceutics, 81 (3). pp. 635-641. ISSN 0939-6411

Bolognani, Federico, Gallani, Anne-Isabelle, Sokol, Lena, Baskin, David and Meisner Kober, Nicole-Claudia (2012) mRNA stability alterations mediated by HuR are necessary to sustain the fast growth of glioma cells. Journal of Neuro-Oncology, 106 (3). pp. 531-542. ISSN 0167-594X

Bonapace, Laura, Wyckoff, Jeffery, Oertner, Thomas, van Rheenen, Jacco, Junt, Tobias and Bentires-Alj, Mohamed (2012) If we don’t look we won’t see: Intravital Multiphoton Imaging of Breast Cancer Metastasis. Journal of Mammary gland Biology and Neoplasia, 17 (1). ISSN 1083-3021

Boos, Julien, Kirk, David William, Dattler, Andre, Piccolotto, Mari-Luz, Zuercher, Werner, Gfeller, Sandro, Neuner, Philippe, Christensen, Jesper, Wishart, William L., Beverly, Michael, Von Arx, Fabian, Litherland, Karine, Van De Kerkhof, Esther, Swart, Pieter Jacob, Faller, Thomas, Beyerbach, Armin, Morrissey, David, Hunziker, Juerg and Beuvink, Iwan (2012) Whole-body scanning PCR; a sensitive method to study the biodistribution of mRNAs, noncoding RNAs and therapeutic oligonucleotides. Nucleic Acids Research, Nuclei. ISSN 0305-1048

Bowes, Joanne, Brown, Andrew J, Hamon, Jacques, Jarolimek, Wolfgang, Sridhar, Arun, Waldron, Gareth and Whitebread, Steven (2012) Reducing safety-related drug attrition: The use of in vitro pharmacological profiling. Nature Reviews Drug discovery, 11 (12). pp. 909-922. ISSN 1474-1776

Britschgi, Adrian, Andraos-Rey, Rita, Brinkhaus, Heike, Klebba, Ina, Romanet, Vincent, Mueller, Urs, Murakami, Masato, Radimerski, Thomas and Bentires-Alj, Mohamed (2012) JAK2/STAT5 Inhibition Circumvents Resistance to PI3K/mTOR Blockade: A Rationale for Cotargeting These Pathways in Metastatic Breast Cancer. Cancer Cell, 22 (6). pp. 796-811. ISSN 1535-6108

Brockhoff, Marielle, Hau, Jean-Christophe, Fontana, Patrizia, Zimmermann, Catherine, De Pover, Alain, Erdmann, Dirk and Chene, Patrick (2012) Factors influencing the inhibition of protein kinases. Journal of Enzyme Inhibition and Medicinal Chemistry, 27 (2). pp. 194-200. ISSN 1475-6366

Broome, Michelle and Villarreal, Beth (2012) Differential Staining of Mast Cells with Toluidine Blue. Journal of Histotechnology, 35 (1). pp. 27-30. ISSN 0147-8885

Browne, Brigid / C, Eustace, Alex / J, Kennedy, Susan, O'Brien, Neil / A, Pedersen, Kasper, Larkin, Annemarie, Ballot, Jo, Mahgoub, Thamir, Sclafani, Francesco, Madden, Stephen, Kennedy, John, Duffy, Michael / J, Crown, John and O'Donovan, Norma (2012) Evaluation of IGF1R and phosphorylated IGF1R as targets in HER2-positive breast cancer cell lines and tumours. Breast Cancer Res Treat, 136 (3). pp. 717-727. ISSN 0167-6806

Bruce, Ian, Akhlaq, Mohammed, Bloomfield, Graham, Budd, Emma, Cox, Brian, Finan, Peter, Gedeck, Peter, Hayler, Judy, Head, Denise, Kirman, Louise, Leblanc, Catherine, Le Grand, Darren, Owen, Charles, Oza, Mrinalini, Sviridenko, Lilya, Whitehead, Lewis, Keller, Thomas, McCarthy, Clive, O'Connor, Desmond, Pilgrim, Gaynor, Press, Nicola and Cuenoud, Bernard (2012) Development of isoform selective PI 3-Kinase inhibitors as pharmacological tools for elucidating the PI3K pathway. Bioorganic & Medicinal Chemistry Letters, 22 (17). pp. 5445-5450. ISSN 0960-894X

Busch, Steven, Hoffmann, Peter, Foley, James, Sahota, Pritam, Johnson, Robert, Kothny, Wolfgang and Meyer, Franck (2012) Studies in rodents with the DPP-4 inhibitor vildagliptin to evaluate possible drug-induced pancreatic histological changes that are predictive of pancreatitis and cancer development in man. Diabetes, Obesity and Metabolism.

Butler, Matt, Sanmugalingam, Devika, Burton, Victoria, Wilson, Tammy, Pearson, Ruth, Watson, Robert, Smith, Philip and Parkinson, Scott James (2012) IMPAIRMENT OF ADENOSINE A3 RECEPTOR ACTIVITY DISRUPTS NEUTROPHIL MIGRATORY CAPACITY AND IMPACTS INNATE IMMUNE FUNCTION IN VIVO. European Journal of Immunology. ISSN 0014-2980

Caffery, Barbary, Joyce, Elizabeth, Miriam, Heynen, Ritter Iii, Robert, Lyndon, Jones and Michelle, Senchyna (2012) Quantification of Conjunctival TNFα mRNA Expression in Sub Populations of Human Aqueous Deficient Dry Eye. Molecular Vision.

Camenisch, Gian P. and Umehara, Ken-Ichi (2012) Predicting human hepatic clearance from in vitro drug metabolism and transport data: A scientific and pharmaceutical perspective for assessing drug-drug interactions. Biopharmaceutics and Drug Disposition. ISSN 0142-2782

Cenni, Bruno, Gutmann, Sascha, Dodeller, Francis and Gottar-Guillier, Marie (2012) The role of BMX in inflammation, cardiovascular disease and cancer. International Reviews of Immunology, 31 (2). pp. 166-173. ISSN 0883-0185

Chakraborty, Abhijit, Tannenbaum, Stacey, Rordorf, Christiane, Lowe, Phil, Floch, David, Gram, Hermann and Roy, Sandip (2012) Overview of the Pharmacokinetic and Pharmacodynamic Properties of Canakinumab, a Human anti-IL-1β Monoclonal Antibody. Clinical Pharmacokinetics, 51 (6). e1-e18. ISSN 0312-5963

Chapelat, Julien, Berst, Frederic, Marzinzik, Andreas, Moebitz, Henrik, Drueckes, Peter, Trappe, Joerg, Fabbro, Doriano and Seebach, Dieter (2012) The Substrate-Activity-Screening methodology applied to receptor tyrosine kinases: A proof-of-concept study. European Journal of Medicinal Chemistry. ISSN 0223-5234

Chatterjee, Arnab and Yeung, Bryan (2012) Back to the future: Lessons learned in modern target-based and whole-cell lead optimization of antimalarials. Current topics in Medicinal Chemistry.

Chioato, Andrea, Noseda, Emanuele, Stevens, Michael, Gaitatzis, Nikolaos, Kleinschmidt, Annett and Picaud, Henri (2012) Treatment with the IL-17 blocking antibody secukinumab (AIN457) does not interfere with the efficacy of Influenza and Meningococcal vaccination in healthy subjects. Results of an open-label, parallel group, randomized, single-center study. Clinical and Vaccine Immunology (CVI), 19 (10). pp. 1597-1602. ISSN 1556-6811

Cho, Young, Brain, Christopher, Chen, Christine, Cheng, Hong, Chopra, Rajiv, Giraldes, John, Kovats, Steven, Lagu, Bharat, Luzzio, Michael, Shen, Junqing, Yang, Fan, Wrona, Wojciech, O'Reilly, Marc, Howard, Steven, Loo, Alice, Haas, Kristy, Kim, Sunkyu, Lu, Yipin, Maniara, Wieslawa, Smith, Troy, Xu, Mei, Angove, Hayley, Cheng, Robert, Congreve, Miles, Dagostin, Claudio, J.Davis, Deborah, Feltell, Ruth, D.Hiscock, Steven, Lewry, Kim, McMenamin, Rachel, N.Mortenson, Paul, Benning, Rajdeep, C.Rees, David, Williams, Glyn and Woolford, Alison (2012) Fragment-Based Discovery and Structure-Guided Optimization of 2-Benzoyl-7-azabenzimidazoles as Potent, Highly Selective and Orally Active CDK4/6 Inhibitors. ACS Medicinal Chemistry Letters, 3 (6). pp. 445-449. ISSN 1948-5875

Christensen, Jesper, Natt, Francois, Hunziker, Juerg, Krauser, Joel, Andres, Hendrik and Swart, Pieter Jacob (2012) Tritium labeling of full length small interfering RNA’s. Journal of Labelled Compounds and Radiopharmaceuticals, 55 (6). pp. 189-196. ISSN 0362-4803

Coan, Kristin Emily, Swann, Marcus and Ottl, Johannes (2012) Measurement and differentiation of ligand-induced calmodulin conformations by dual polarization interferometry. Analytical Chemistry, 84 (3). pp. 1586-1591. ISSN 0003-2700

Costa, R.O., Lacor, P.N., Ferreira, I.L., Auberson, Yves, Klein, W.L., Oliveira, C.R., Rego, A.C. and Pereira, C.M.F. (2012) Endoplasmic reticulum stress occurs downstream of NR2B subunit of N-methyl-D-aspartate receptor in mature hippocampal cultures treated with amyloid-β oligomers. Aging Cell.

Cunliffe, Jennifer (2012) Fast Chromatography in the Regulated Bioanalytical Environment: Sub-2 um vs. Fused-core Particles. Bioanalysis, 4 (8). pp. 861-863. ISSN 1757-6180

Damiano, Jason, Rendahl, Katherine, Karim, Christopher, Embry, Millicent, Ghoddusi, Majid, Holash, Jocelyn, Fanidi, Abdallah, Abrams, Tinya and Abraham, Judith (2012) Neutralization of Prolactin Receptor Function by Monoclonal Antibody LFA102, A Novel Potential Therapeutic for the Treatment of Breast Cancer. Molecular Cancer Therapeutics, 12 (3). pp. 295-305. ISSN 1535-7163

David, Olivier J, Kovarik, John M and Schmouder, Robert L (2012) Clinical pharmacokinetics of fingolimod. Clinical pharmacokinetics, 51 (1). pp. 15-28. ISSN 0312-5963

Davies, Nicholas G. M., Browne, Helen, Davis, Ben, Foloppe, Nicolas, Geoffrey, Stephanie, Gibbons, Ben, Hart, Terry, Drysdale, Martin J., Mansell, Howard, Massey, Andrew, Matassova, Natalia, Moore, Jonathan D, Murray, James, Pratt, Robert, Ray, Stuart, Roughley, Stephen D., Jensen, Michael Rugaard, Schoepfer, Joseph, Scriven, Kirsten, Simmonite, Heather, Stokes, Stephen, Surgenor, Alan, Webb, Paul, Wright, Lisa and Brough, Paul (2012) Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization. Bioorganic & Medicinal Chemistry, 20 (22). pp. 67770-67789. ISSN 0968-0896

Defontis, Myriam, Cote, Serge, Stirn, Martina and Ledieu, David (2012) Optimization of Multiplate® whole blood platelet aggregometry in the Beagle dog and Wistar rat for ex vivo drug toxicity testing. Experimental and Toxicologic Pathology. ISSN 0940-2993

Denes, A, Drake, C, Stordy, J, Chamberlain, J, Gram, Hermann, Crossman, D, Francis, S and Rothwell, N (2012) Interleukin-1 mediates neuroinflammatory changes associated with diet-induced atherosclerosis. Journal of the American Heart Association, 1 (3). e002006. ISSN 2047-9980

Devine, Patrick, Perreault, Sally and Luderer, Ulrike (2012) Roles of reactive oxygen species and antioxidants in ovarian toxicity. Biology of Reproduction, 86 (2). p. 27. ISSN 0006-3363

Di Padova, Franco E., Gomery, Kathryn and Evans, Stephen V (2012) Antibody WN1 222-5 Mimics Toll-like Receptor 4 Binding in the Recognition of LPS. Proocedings national academy sciences, 109 (51). pp. 20877-20882.

Diagana, Thierry, Yeung, Bryan and Sauerwein, Robert (2012) The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to Anopheles mosquito vector. Antimicrobial Agents and Chemotherapy. ISSN 0066-4804

Dobi, Alice, Sartori, Simone, Busti, Daniela, Flor, Peter, Van Der Putten, P. Herman, Singewald, Nicolas, Shigemoto, Ryuichi and Ferraguti, Francesco (2012) Neural substrates for the opposing effects of distinct presynaptic group III metabotropic glutamate receptors on extinction of contextual fear conditioning in mice. Neuropharmacology. pp. 1-16. ISSN 0028-3908

Dobo, Krista, Green, Nigel, et al, et al and Glowienke, Susanne (2012) In Silico Methods Combined with Expert Knowledge Rule out Mutagenic Potential of Pharmaceutical Impurities: An Industry Survey. Regulatory Toxicology and Pharmacology.

Duca, Jose and Karki, Rajeshri (2012) Noticing The Unnoticed: Bridging Structural Data And Drug Design. Future Medicinal Chemistry, 4 (15). pp. 1869-1871. ISSN 1756-8919

Dudek, Timothy E, No, Daniel C, Seung, Edward, Vrbanac, Vladimir D, Fadda, Lena, Bhoumik, Priyasma, Boutwell, Christian L, Power, Karen A, Gladden, Adrianne D, Battis, Laura, Mellors, Elizabeth F, Tivey, Trevor R, Gao, Xiaojiang, Altfeld, Marcus, Luster, Andrew D, Tager, Andrew M and Allen, Todd M (2012) Rapid evolution of HIV-1 to functional CD8⁺ T cell responses in humanized BLT mice. Science translational medicine, 4 (143). 143ra98. ISSN 1946-6242

Dunne, Christine, Bushee, Jennifer and Argikar, Upendra (2012) Metabolism of bromopride in mouse, rat, rabbit, dog, monkey, and human hepatocytes. Drug Metabolism and Pharmacokinetics.

Ebersbach, Hilmar and Geisse, Sabine (2012) Antigen generation and display in therapeutic antibody drug discovery – a neglected but critical player. Biotechnology Journal. ISSN 1860-6768

Ekyalongo, Roudy / C, Mukohara, Toru, Kataoka, Yu, Kiyota, Naomi, Fujiwara, Yutaka and Minami, Hironobu (2012) Mechanisms of acquired resistance to insulin-like growth factor 1 receptor inhibitor in MCF-7 breast cancer cell line. Investigational New Drugs. ISSN 0167-6997

Elnakat Thomas, Hala, Mercer, Carol A., Carnevalli, Larissa S., Park, Jongsun, Andersen, Jesper B., Conner, Elizabeth A., Tanaka, Kazuhiro, Matsutani, Tomoo, Iwanami, Akio, Aronow, Bruce J., Liu, Manway, Thorgeisson, Snorri S., Mischel, Paul S., Thomas, George and Kozma, Sara C. (2012) Dual Inhibition of mTOR in hepatocellular carcinoma induces tumor regression, return to normal liver gene expression and autophagy. Science Translational Medicine, 4 (139). ra84. ISSN 1946-6234

Emotte, Corinne, Deglave, Fanny, Picard, Franck, Chaturvedi, Animesh, Majumdar, Tapan, Agarwal, Ashish and Kretz, Olivier (2012) Validation of on-line solid- phase extraction coupled with high-performance liquid chromatography–mass spectrometry assays for the determination of indacaterol, a potent β-adrenoceptor agonist in human serum. Journal of chromatography B, 895/89. pp. 1-9. ISSN 1570-0232

Endacott, John and Poolman, Robert (2012) Looking for Insights – Quality Control Initiatives for Enhancing Patent Searches. World Patent Information, 35 (1). pp. 3-7.

Erdemli, Gul, Kim, Albert, Ju, Haisong, Springer, Clayton, Penland, Robert and Hoffmann, Peter (2012) Cardiac Safety Implications of hNav1.5 Blockade and a Framework for Pre-Clinical Evaluation. Frontiers in Pharmaceutical Medicine and Outcomes Research.

Erdemli, Gul, Priest, Birgit and Wickenden, Alan (2012) Ion Channel Drug Discovery: Challenges and Future Directions. Future Medicinal Chemistry.

Ertl, Peter (2012) Database of bioactive ring systems with calculated properties and its use in bioisosteric design and scaffold hopping. Bioorganic and Medicinal Chemistry, 20 (18). pp. 5436-5442. ISSN 0968-0896

Ertl, Peter and Lewis, Richard (2012) IADE - A System for Intelligent Automatic Design of Bioisosteric Analogs. Journal of Computer-Aided Molecular Design, 26 (11). pp. 1207-1215. ISSN 0920-654X

Ertl, Peter and Rohde, Bernhard (2012) The Molecule Cloud - compact visualization of large collections of molecules. Journal of Cheminformatics, 4 (1). p. 12. ISSN 1758-2946

Ertl, Peter, Steinbeck, Christoph, Jayaseelan, Kalai Vanii, Moreno, Pablo and Truszkowski, Andreas (2012) Natural product-likeness score revisited: an open-source, open-data implementation. BMC Bioinformatics, 13 (106).

Farmer, I, Pancholi, S, Thornhill, AM, Ghazoui, Z, Evans, Dean Brent, Lane, Heidi A, Johnston, SR, Dowsett, Mitch, Martin, Lesley-Ann and Imark, Esther (2012) Effectiveness and molecular interactions of the clinically active mTORC1 inhibitor everolimus in combination with tamoxifen or letrozole in vitro and in vivo. Breast Cancer Research, 14 (5). ISSN 1465-5411

Feuerbach, Dominik, Arias, Hugo R, Targowska-Duda, Katarzyna M, Aggarwal, Shaili, Lapinsky, Daniel J and Jozwiak, Krzysztof (2012) Structural and functional interaction of (+)-2-(N-tert-butylamino)-3’-iodo-4’-azidopropiophenone, a photoactivatable bupropion derivative, with nicotinic acetylcholine receptors. Biochemistry.

Fiez-Vandal, Cedric, Leder, Lukas, Freuler, Felix, Sykes, David, Charlton, Steven, Siehler Wagner, Sandra, Schopfer, Ulrich and Duckely, Myriam (2012) HDL-like discs for assaying membrane proteins in drug discovery. Biophysical Chemistry, 165/16. pp. 56-61. ISSN 0301-4622

Fischer, Simon, Charara, Nadine, Gerber, Andrea, Woelfel, Jens, Schiedner, Gudrun, Voedisch, Bernd and Geisse, Sabine (2012) Transient recombinant protein expression in a human amniocyte cell line: the CAP-T cell system. Biotechnology & Bioengineering, 109 (9). pp. 2250-2261. ISSN 0006-3592

Flarakos, Jimmy, Ting, Lillian, Du, Yancy, Stein, Daniel, Reynolds, Christine, Patel, Manish, Roy, Sandip and Mangold, James (2012) Disposition and metabolism of [14C]PTZ601 in healthy volunteers. Xenobiotica. ISSN 0049-8254

Fredenhagen, Andreas, Kittelmann, Matthias, Oberer, Lukas, Kuhn, Anton, Kuehnoel, Juergen, Delemonte, Thierry, Aichholz, Reiner, Wang, Ping, Atadja, Peter and Shultz, Michael (2012) Biocatalytic synthesis and structure elucidation of cyclized metabolites of the deacetylase inhibitor Panobinostat (LBH589). Drug Metabolism and Disposition, 40 (5). pp. 1041-1050. ISSN 0090-9556

Frieauff, Wilfried, Martus, Hans-Joerg, Suter, Willi and Elhajouji, Azeddine (2012) Automatic Analysis of the Micronucleus Test in Primary Human Lymphocytes Using Image Analysis. Mutagenesis.

Fu, Shijun, Fei, Qi, Jiang, Hua, Chuai, Shannon, Song, Shi, Xiong, Wen, Jiang, Lei, Lu, Chris, Atadja, Peter, Li, En and Shou, Jianyong (2012) Involvement of histone acetylation of Sox17 and Foxa2 promoters during mouse definitive endoderm differentiation revealed by microRNA profiling. PLOS One.

Furet, Pascal, Chene, Patrick, De Pover, Alain, Valat, Therese-Marie, Hergovich Lisztwan, Joanna, Kallen, Joerg and Masuya, Keiichi (2012) The Central Valine Concept Provides an Entry in a New Class of Non Peptide Inhibitors of the P53-MDM2 Interaction. Bioorganic & Medicinal Chemistry Letters.

Gamsjaeger, Sonja, Hofstetter, B, Zwettler, Elisabeth, Recker, Robert, Gasser, Juerg Andreas, Eriksen, Erik Fink, Klaushofer, Klaus and Paschalis, Eleftherios P (2012) Effects of Three Years Treatment With Once-Yearly Zoledronic Acid on the Kinetics of Bone Matrix Maturation in Osteoporotic Patients. Osteoporosis International.

Gao, Zhenhai, Menezes, Daniel, Machajewski, Timothy, Abrams, Tinya, Jensen, Michael Rugaard, Yu, Guoying, Stuart, Darrin, Duhl, David, Pryer, Nancy and Sellers, William (2012) THE NOVEL ORAL HSP90 INHIBITOR NVP-HSP990 EXHIBITS POTENT AND BROAD-SPECTRUM ANTI-TUMOR ACTIVITIES IN VITRO AND IN VIVO. Molecular Cancer Therapeutics. ISSN 1535-7163

Garofalo, Cecilia, Mancarella, Caterina, Grilli, Andrea, Manara, Maria Cristina, Astolfi, Annalisa, Marino, Maria Teresa, Conte, Alexia, Sigismund, Sara, Carè, Alessandra, Belfiore, Antonino, Picci, Piero and Scotlandi, Katia (2012) Identification of both common and distinctive mechanisms of resistance to different anti-IGF-1R agents in Ewing’s sarcoma. Molecular Endocrinology, 26 (9). pp. 1603-1616. ISSN 0888-8809

Gaz, Claudio, Cremona, George, Panunzi, Simona, Patterson, Beverley and De Gaetano, Andrea (2012) A geometrical approach to the PKPD modelling of inhaled bronchodilators. Journal of pharmacokinetics and pharmacodynamics, 39 (5). pp. 415-428. ISSN 1567-567X

Geall, Andrew, Verma, Ayush, Otten, Gillis, Shaw, Christine, Hekele, Armin, Banerjee, Kaustuv, Beard, Clayton, Cu, Yen, Brito, Luis, Krucker, Thomas, O'Hagan, Derek, Singh, Manmohan, Mason, Peter, Valiante, Nicholas, Dormitzer, Philip, Barnett, Susan, Rappuoli, Rino, Ulmer, Jeffrey and Mandl, Christian (2012) Non-viral delivery of self-amplifying RNA. PNAS (Proceedings of the National Academy of Sciences), 109 (36). pp. 14604-14609. ISSN 1091-6490

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Terranova, Remi and Pond, Leslie (2012) Postdoctoral position to study genomic markers of carcinogenesis. Nature jobs.

Thaisz, Jill, Tsaih, Shirng Wern, Feng, Minjie, Philip, Vivek, Yanas, Liane, Sheehan, Susan, Xu, Lingfei, Paigen, Beverly, Chesler, Elissa, Churchill, Gary and Dipetrillo, Keith (2012) Genetic analysis of albuminuria in Collaborative Cross and multiple mouse intercross populations. American Journal of Physiology:Renal Physiology, 303 (7). F972-F981. ISSN 1931-857X

Thampi, Prajitha, Vittal Rao, Haripriya, Mitter, Sayak K, Cai, Jun, Mao, Haoyu, Li, Hong, Seo, Soojung S, Qi, Xiaoping, Lewin, Alfred S., Boulton, Michael E. and Romano, Carmelo (2012) The 5HT1a Receptor Agonist 8-OH DPAT Induces Protection from Lipofuscin Accumulation and Oxidative Stress in the Retinal Pigment Epithelium. PLoS One, 7 (4). e34468. ISSN 1932-6203

Thomson, John P, Lempiaeinen, Harri, Hackett, Jamie, Nestor, Colm E, Mueller, Arne, Bolognani, Federico, Oakeley, Edward James, Schuebeler, Dirk, Terranova, Remi, Rheinhardt, Diana, Moggs, Jonathan and Meehan, Richard R (2012) Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome. Genome Biology, 13 (10). R93. ISSN 1465-6906

Tichý, Michal, Pohl, Radek, Hocek, Michal, Shi, Pei-Yong, Yokokawa, Fumiaki, Xu, Haoying and Chen, Yen Liang (2012) Synthesis of 4,6-Disubstituted Pyrimido[4,5-b]indole Ribonucleosides through Regioselective Cross-coupling Reactions. Bioorganic & Medicinal Chemistry, 20 (20). pp. 6123-6133. ISSN 0968-0896

Ting, Lillian, Praestgaard, Jens, Grunenberg, Nicole, Komjathy, Steven, Leeds, Jennifer and Pertel, Peter (2012) A first-in-human, randomized, double-blind, placebo-controlled, time-lagged, single- and multiple-ascending oral dose study to assess the safety and tolerability of LFF571 in healthy volunteers. Antimicrobial Agents and Chemotherapy, 56 (11). p. 5946. ISSN 0066-4804

Tran, Que Tien, Williams, Sarah, Farid, Ramy, Erdemli, Gul and Pearlstein, Robert (2012) The Translocation Kinetics of Antibiotics Through Porin OmpC: Insights from Structure-Based Solvation Mapping using WaterMap. Proteins: Structure, Function, and Bioinformatics, 81 (2). pp. 291-299. ISSN 0887-3585

Trendelenburg, Anne-Ulrike, Meyer, Angelika, Jacobi, Carsten, Feige, Jerome and Glass, David (2012) TAK-1/p38/NFkappaB Signaling Inhibits Myoblast Differentiation By Increasing Levels of Activin A. Skeletal Muscle, 2 (1). p. 3. ISSN 2044-5040

Trifilieff, Alexandre and Fozard, John R. (2012) Sphingosine-1-phosphate induced airway hyperreactivity in rodents is mediated by the S1P3 receptor. Journal of Pharmacoloy and Experimenal Therapeutics. ISSN 0022-3565

Tse, Francis, White, Ronald, Evans, David, Hop, Cornelis, Moore, David, Prakash, Chandra and Surapaneni, Sekhar (2012) Radiolabelled mass-balance excretion and metabolism studies in laboratory animals: a commentary on why they are still necessary. Xenobiotica, 43 (2). pp. 219-225. ISSN 0049-8254]

Unterreiner, Vincent and Gabriel, Daniela (2012) When High Content Screening meets High Throughput. Drug Discovery World, Winter (4). pp. 19-25.

Vacchi-Suzzi, Caterina, Moggs, Jonathan, Pognan, Francois, Grenet, Olivier, Bauer, Yasmina, Gerrish, Kevin, Hamadeh, Hisham K., Letzkus, Martin, Paules, Richard, Lyon, Jonathan, Vidgeon-Hart, Martin, Berridge, Brian and Couttet, Philippe (2012) Perturbation of microRNAs in rat heart during chronic doxorubicin treatment. PLoS ONE, 7 (7). e40395. ISSN 1932-6203

Venable, John, Okach, Linda, Agarwalla, Sanjay and Brock, Ansgar (2012) Sub-Zero Temperature Chromatography for Reduced Back-Exchange and Improved Dynamic Range in Amide Hydrogen Deuterium Exchange Mass Spectrometry. Analytical Chemistry, 84 (21). pp. 9601-9608. ISSN 0003-2700

Villarreal, Beth (2012) Ki-67 immunohistochemical staining in rat tibia and femur growth plates. Journal of Histotechnology, 35 (4). pp. 171-174. ISSN 0147-8885

Vincent, Karen and Zurini, Mauro (2012) Current strategies in antibody engineering: Fc engineering and pH-dependent antigen binding, bispecific antibodies and antibody drug conjugates. Biotechnology Journal. ISSN 1860-6768

Vitry, Véronique, Del Rio Espinola, Alberto, Grenet, Olivier and Moggs, Jonathan (2012) Identification et conséquences des polymorphismes chez différentes populations de cynomolgus (“Macaca fascicularis”) Implication pour les études de Toxicologie. Master Thesis.

Vulpetti, Anna, Kalliokoski, Tuomo and Milletti, Francesca (2012) Chemogenomics in Drug Discovery: Methods Based on the Comparison of Binding Sites. Future Medicinal Chemistry, 4 (15). pp. 1971-1979. ISSN 1756-8919

Wallett, Jane, Baeschlin, Daniel, Hoehn, Frank and Engeloch, Caroline (2012) Speeding up drug discovery. Tecan Journal.

Warncke, Max, Calzascia, Thomas, Coulot, Michele, Balke, Nicole, Touil, Ratiba, Kolbinger, Frank and Heusser, Christoph (2012) Different adaptations of IgG effector function in human and non-human primates and implications for therapeutic antibody treatment. Journal of Immunology. ISSN 0022-1767

Weigert, Oliver, Bird, Liat, Kopp, Nadja, Lane A, Andrew, Chapuy, Bjoern, van Bodegom, Diederik, Toms, Angela, Marubayashi, Sachie, McKeown, Michael, Bradner E., James, Yoda, Akinori, Gaul, Christoph, Vangrevelinghe, Eric, Romanet, Vincent, Murakami, Masato, Ebel, Nicolas, De Pover, Alain, Regnier, Catherine, Hofmann, Francesco, eck, Michael, Ross L, Levine, Kung, Andrew, Baffert, Fabienne, Radimerski, Thomas and Weinstock M, David (2012) Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition. Journal of experimental medicine, 209 (2). pp. 259-273. ISSN 0022-1007

Westling, Lucas and Evans, Kate (2012) Purity and Mass Determination by LC/MS Using Solid Core HPLC Columns: a Column Lifetime Study. Thermo Scientific Application Note 20571.

Widler, Leo and Green, Jonathan (2012) The Chemistry of Bisphosphonates: From anti-scaling agents to potent therapeutics. Anti-cancer Agents in Medicinal Chemistry, 12 (2). pp. 95-101. ISSN PMID:21864230

Wiesmann, Christian, Leder, Lukas, Bernardi, Anna, Melkko, Samu, D'Arcy, Allan, Villard, Frederic, Erbel, Paulus, Hughes, Nicola, Freuler, Felix, Nikolay, Rainer, Bornancin, Frederic, Blank, Jutta, Alves, Juliano, Meyerhofer, Marco, Stettler, Thomas and Renatus, Martin (2012) Structural determinants of MALT1 protease activity. J Mol Biol, 419 (1-2). pp. 4-21. ISSN 0022-2836

Winblad, Bengt, Andreasen, Niels, Minthon, Lennart, Floesser, Annette, Imbert, Georges, Dumortier, Thomas, Maguire, Paul, blennow, Kaj, lundmark, joens, Staufenbiel, Matthias, orgogozo, jean-marc and Graf, Ana (2012) Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study. Lancet Neurology.

Wnuk, Monika, Hlushchuk, Ruslan, Tuffin, Gerald, Martiny-Baron, Georg, Holzer, Philipp, Imbach, Patricia, Djonov, Valentin and Huynh-Do, Uyen (2012) EphB4 forward signalling maintains podocyte homeostasis during Thy1.1 nephritis. Journal of American Society of Nephrology, 81 (12). pp. 1212-1225. ISSN 00852538

Wolf, Babette, Morgan, Hannah, Gani, Zaahira, Milicov, Adriana, Warncke, Max, Jones, Stewart, Krieg, Jennifer, Sims, Jennifer, Kiessling, Andrea and Brennan, Frank (2012) A whole blood in vitro cytokine release assay with aqueous monoclonal antibody presentation for the prediction of therapeutic protein induced cytokine release syndrome in humans. Cytokine. ISSN 1063-4666

Xie, Yang, Avello, Monika, Schirle, Markus, Whinnie, Elizabeth Mc, Feng, Yan, Bric-Furlong, Eva, Wilson, Christopher, Nathans, Robin, Zhang, Jing, Kirschner, Marc W, Huang, Shih-Min A and Cong, Feng (2012) Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 and protects it from ligase activity-dependent self-degradation. The Journal of biological chemistry. ISSN 1083-351X

Yeo, Wee Kiang, Nilar, Shahul Hameed and Go, Mei Lin (2012) Extraction and validation of substructure profiles for enriching compound libraries. Journal of Computer-Aided Molecular Design, 26 (10). pp. 1127-1141. ISSN 0920-654X

Yeo, Wee Kiang, Tan, Kheng Lin, Koh, Siang Boon, Khan, Matiullah, Nilar, Shahul and Go, Mei Lin (2012) Exploration and optimization of structure-activity relationships in drug design using the Taguchi Method. ChemMedChem.

Yi, Tangsheng, Wang, Xiaoming, Kelly, Lisa M., An, Jinping, Xu, Ying, Sailer, Andreas, Gustafsson, Jan-Ake, Russell, David W. and Cyster, Jason G. (2012) Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses. Immunity, 37 (3). pp. 535-548. ISSN 1074-7613

Yusuff, Naeem, Dore, Michael, Joud, Carol, Visser, Michael, Springer, Clayton, Xie, Xiaoling, Herlihy, Kara, Porter, Dale and Toure, Bakary-Barry (2012) Lipophilic Isosteres of a pi-pi Stacking Interaction: Design of New Inhibitors of the Bcl-2-Bak Protein-Protein Interaction. ACS medicinal chemistry letters, 3 (7). pp. 579-583. ISSN 1948-5875

Zeng, Fanning, Wind, Nicholas, Mcclengahan, Conor, Verkuijl, Martin, Watson, Robert and Nash, Mark (2012) GPR39 is coupled to TMEM16a in intestinal fibroblast-like cells. PLoS ONE, 7 (10). e47686.

Zhang, Lin, Orban, Martin, Lorenz, Michael, Barocke, Verena, Braun, Daniel, Urtz, Nicole, Schulz, Christian, Proia, Richard L., von Bruehl, Marie-Luise, Graf, Thomas, Bolz, Steffen-Sebastian, Montanez, Eloi, Prinz, Marco, Müller, Alexandra, Billich, Andreas, Sixt, Michael, von Andrian, Ulrich H., Junt, Tobias, Massberg, Steffen, Tirniceriu, Anca, Gaertner, Florian, von Baumgarten, Louisa and Faessler, Reinhard (2012) A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis. Journal of Experimental Medicine, 209 (12). pp. 2165-2181. ISSN 0022-1007

Zhang, Long, Zhou, Fangfang, Mickanin, Craig, Sheppard, Kelly-Ann, Porter, Jeffrey, Lu, Chris and ten Dijke, Peter (2012) USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGFbeta type I receptor. Nature Cell Biology, 14 (7). pp. 717-726. ISSN 1465-7392

Zhang, Weidong, Korstanje, Ron, Thaisz, Jill, Staedtler, Frank, Hartmann, Nicole, Xu, Lingfei, Feng, Minjie, Yanas, Liane, Yang, Hyuna, Valdar, William, Churchill, Gary and Dipetrillo, Keith (2012) Genome-wide Association Mapping of Quantitative Traits in Outbred Mice. G3: Gene/Genomes/Genetics, 2 (2). pp. 167-174. ISSN 2160-1836

Zielen, S, Lieb, A, De La Motte, D, Wagner, F, De Monchy, J, Fuhr, R, Munzu, Clara, Koehne-Voss, Stephan, Riviere, G, Kaiser, Guenther and Erpenbeck, Veit (2012) Omalizumab protects against allergen-induced bronchoconstriction in allergic (IgE-mediated) asthma. International archives of allergy and immunology, 160 (1). pp. 102-110. ISSN 1018-2438

Zou, Bin, Yap, Peiling, Sonntag, Sebastian, Leong, Seh Yong, Yeung, Bryan King Sing and Keller, Thomas (2012) Mechanistic Study of the Spiroindolones: A New Class of Antimalarials. Molecules, 17 (9). pp. 10131-10141. ISSN 1420-3049

Zou, Gang, Kukkaro, Petra, Lok, Shee Mei, Ng, Jowin, Tan, Grace, Alonso, Sylvie, Macary, Paul and Shi, Pei-Yong (2012) Resistance analysis of an antibody that selectively inhibits dengue virus serotype-1. Antiviral Reseaech, 95 (3). pp. 216-223. ISSN 0166-3542

Zumsteg, Adrian, Caviezel, Christoph, Pisarsky, Laura, Strittmatter, Karin, Garcia-Echeverria, Carlos, Hofmann, Francesco and Christofori, Gerhard (2012) Repression of malignant tumor progression upon pharmacologic IGF1R blockade in a mouse model of insulinoma. Molecular Cancer Research, 10 (6). pp. 800-809. ISSN 1557-3125

Zumsteg, Adrian, Strittmatter, Karin, Caviezel, Christoph, Garcia-Echeverria, Carlos, Hofmann, Francesco and Christofori, Gerhard (2012) Repression of malignant tumor progression upon pharmacological IGF-1R blockade in a mouse model of insulinoma. Molecular Cancer Research, 10 (6). pp. 800-809. ISSN 1541-7786

infante, Jeffrey R, Dees, E Claire, Olszanski, Anthony J, Dhuria, Shyeilla, Sen, Suman, Cameron, John and Cohen, Roger B (2012) A Phase I dose-escalation study of LCL161, an oral IAP inhibitor, in patients with advanced solid tumors. Journal of Clinical Oncology.

Book Section

Ebersbach, Hilmar, Zhang, Chonghui and Proetzel, Gabriele (2012) Antigen Presentation for the Generation of Binding Molecules. In: Methods in Molecular Biology: Antibody Protocols and Methods. Humana Press. ISBN 978-1-58829-092-2

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