Article

Akkus, Funda, Ametamey, Simon, Treyer, Valerie, Burger, Cyrill, Johayem, Annas, Umbricht, Daniel, Gomez-Mancilla, Baltazar, Sovago, Judit, Buck, Alfred and Hasler, Gregor (2012) Marked Global Reduction in mGluR5 Binding in Smokers and Ex-smokers Determined by [11C]ABP688 Positron Emission Tomography. Proceedings of the National Academy of Sciences, 110 (2). pp. 737-742. ISSN 0027-8424

Allegrini, Peter Roland (2012) MRI in drug discovery. Eropean pharmaceutical review, 2012 (1).

Angst, Daniela, Bollbuck, Birgit, Janser, Philipp, Quancard, Jean, Buehlmayer, Peter, Berst, Frederic, Oberer, Lukas, Beerli, Christian, Pally, Charles, Streiff, Markus and Bassilana, Frederic (2012) An oral S1P1 antagonist prodrug with efficacy in vivo: discovery, synthesis and evaluation. Journal of Medicinal Chemistry, 55 (22). pp. 9722-9734. ISSN 0022-2623

Argikar, Upendra (2012) Unusual Glucuronides. Drug Metabolism and Disposition.

Arias, HR, Feuerbach, Dominik and Ortello, M (2012) Bupropion and its photoreactive analog (±)-SADU-3-72 interact with luminal and non-luminal sites at human α4β2 nicotinic acetylcholine receptors. Biomembranes.

Baba, Nobuyasu, Rubio, Manuel, Kenins, Linda, Regairaz, Camille, Woisetchlager, Maximilian, Carballido, Jose and Sarfati, Marika (2012) Aryl hydrocarbon receptor (AhR) ligation by VAF347 promotes Th22 and inhibits Th1 polarization. Human Immunology, 73. pp. 795-800. ISSN 0198-8859

Babin, Anna Louise, Cannet, Catherine, Ble, Francois-Xavier, Gerard Sachot, Christelle, Takeichi, Masatoshi, Page, Clive, Sparrer, Helmut, Matsuguchi, Tetsuya and Beckmann, Nicolau (2012) BLEOMYCIN-INDUCED LUNG INJURY ASSESSED NON-INVASIVELY AND IN SPONTANEOUSLY BREATHING MICE BY PROTON MRI: MODEL ASSESSMENT AND TARGET VALIDATION. Magnetic Resonance in Medicine, 67 (2). pp. 499-509. ISSN 0740-3194

Bahe, Amine, Toth, Iulia, Fendt, Markus, Neumann, Inga D, Flor, Peter J and Slattery, David A (2012) Pharmacological interference with metabotropic glutamate receptor subtype 7 but not subtype 5 differentially affects within- and between-session extinction of Pavlovian conditioned fear. Neuropsychopharmacology, 62 (4). pp. 1619-1626. ISSN 0028-3908

Baltus, Christine, Press, Neil, Antonijevic, Milan, Tizzard, Graham, Coles, Simon and Spencer, John (2012) Synthesis of a biphenyl library for studies of hydrogen bonding in the solid state. Tetrahedron, 68 (45). pp. 9272-9277. ISSN 0040-4020

Barretina, Jordi, Caponigro, Giordano, Stransky, Nicolas, Venkatesan, Kavitha, Schlegel, Robert, Sellers, William and Garraway, Levi (2012) The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature, 483 (7391). pp. 603-607. ISSN 0028-0836

Beattie, David, Beer, David, Bradley, Michelle, Bruce, Ian, Charlton, Steven, Cuenoud, Bernard, Fairhurst, Robin, Farr, David Colin, Fozard, John R., Janus, Diana, Rosethorne, Elizabeth, Sandham, David, Sykes, David, Trifilieff, Alexandre, Turner, Katharine and Wissler, Elke (2012) An Investigation into the Structure Activity Relationships Associated with the Systematic Modification of the beta2-Adrenoceptor Agonist Indacaterol. Bioorganic & medicinal chemistry letters, 22 (19). pp. 6280-6285. ISSN 0960-894X

Beckett, Martin (2012) Book review: The Algebra of Organic Synthesis by John Andraos, CRC Press 2011. Chemistry and Industry, Sept 2. pp. 48-49.

Bedrosian, Andrea S, Nguyen, Andrew H, Mushlin, Harry M, Hackman, Muchael, Ochi, Atsuo, Connolly, Michael K, Ibrahim, Junaid, Rehman, Adeel, Henning, Justin R, Barilla, Rocky, Pylayeva-Gupta, Yuliya, Mallen-St. Clair, John, Hajdu, Cristina, Frey, Alan B, Bar-Sagi, Dafna and Miller, George (2012) MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells. Journal Experimental Medicine, 209 (9). pp. 1671-1687. ISSN 0022-1007, 1540-9538

Bell, Leslie and Wang, Jianling (2012) Probe ADME and Test Hypotheses: A PATH beyond clearance in vitro-in vivo correlations in early drug discovery. Expert Opintion on Drug Metabolism and Toxicology. ISSN 1742-5255

Benned-Jensen, Tau, Norm, Christoffer, Laurent, Stephane, Medom Madsen, Christian, Niss Arfelt, Kristine, Wolf, Romain, Frimurer, Thomas, Sailer, Andreas and Rosenkilde, Mette (2012) Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced receptor 2 (GPR183). Journal of Biological Chemistry, 287 (42). pp. 35470-35483. ISSN 0021-9258

Biason-Lauber, Anna, Böni-Schnetzler, Marianne, Hubbard, Basil P, Bouzakri, Karim, Brunner, Andrea, Cavelti-Weder, Claudia, Keller, Cornelia, Meyer-Böni, Monika, Meier, Daniel T, Brorsson, Caroline, Timper, Katharina, Leibowitz, Gil, Patrignani, Andrea, Bruggmann, Remy, Boily, Gino, Zulewski, Henryk, Geier, Andreas, Cermak, Jennifer M, Elliott, Peter, Ellis, James L, Westphal, Christoph, Knobel, Urs, Eloranta, Jyrki J, Kerr-Conte, Julie, Pattou, François, Konrad, Daniel, Matter, Christian M, Fontana, Adriano, Rogler, Gerhard, Schlapbach, Ralph, Regairaz, Camille, Carballido, Jose, Glaser, Benjamin, McBurney, Michael W, Pociot, Flemming, Sinclair, David A and Donath, Marc Y (2012) Identification of a SIRT1 mutation in a family with Type 1 Diabetes. Cell Metabolism, 17 (3). pp. 448-455. ISSN 1550-4131

Bidinosti, Michael, Shimshek, Derya, Mollenhauer, Brit, Marcellin, David, Schweizer, Tatjana, Lotz, Gregor, Schlossmacher, Michael and Weiss, Andreas (2012) Novel One-step Immunoassays to Quantify α-Synuclein: APPLICATIONS FOR BIOMARKER DEVELOPMENT AND HIGH-THROUGHPUT SCREENING. The Journal of Biological Chemistry, 287 (40). pp. 33691-33705. ISSN 0021-9258

Bielen, Aleksandra, Box, Gary, Perryman, Lara, Bjerke, Lynn, Popov, Sergey, Jamin, Yann, Jury, Alexa, Valenti, Melanie, de Haven Brandon, Alexis, Martins, Vanessa, Romanet, Vincent, Jeay, Sebastien, Raynaud, Florence, Hofmann, Francesco, Robinson, Simon, Eccles, Suzanne and Jones, Chris (2012) Dependence of Wilms tumour cells on signalling through IGF1R in an orthotopic xenograft model targetable by specific receptor inhibition. PNAS. ISSN 0027-8424

Bigaud, Marc, Wieczorek, Grazyna, Menninger, Klaus, Barbet, Irène, Jean, Christian, Beerli, Christian, Audet, Maxime, Blancher, Antoine, Heusser, Christoph, Morris, Randall and Wagner, Juergen (2012) SOTRASTAURIN, (AEB071), PROLONGS KIDNEY ALLOGRAFT SURVIVAL ALONE OR IN COMBINATION WITH CYCLOSPORINE IN NON-HUMAN PRIMATES. Transplantation, 93 (2). pp. 156-164. ISSN 0041-1337

Bill, Anke, Lilley, Sarah, Renaud, Nicole, Groot Kormelink, Paul and Gaither, Larry (2012) The putative reentrant loop domain of ANO1 facilitates channel activation. Nature Structural and Molecular Biology.

Billy, Christine, Koch, Guido, Widmer, Hans, von Krogh, Georg, Erden, Zeynep and Schneider, Andreas (2012) Rethinking Leadership in Drug Discovery. Drug Discovery Today, 17 (23/24). pp. 1258-1262. ISSN 1359-6446

Bodenlenz, Manfred, Höfferer, Christian, Magnes, Christoph, Schaller, R., Schaupp, L., Feichtner, F., Ratzer, Maria, Pickl, Karin, Sinner, Frank, Wutte, A., Korsatko, S., Köhler, G., Legat, F.J., Benfeldt, E., Wright, Andrew, Neddermann, Daniel, Jung, Thomas and Pieber, Thomas R. (2012) Dermal PK/PD of a lipophilic topical drug in psoriatic patients by continuous intradermal membrane-free sampling. European Journal of Pharmaceutics and Biopharmaceutics, 81 (3). pp. 635-641. ISSN 0939-6411

Bolognani, Federico, Gallani, Anne-Isabelle, Sokol, Lena, Baskin, David and Meisner Kober, Nicole-Claudia (2012) mRNA stability alterations mediated by HuR are necessary to sustain the fast growth of glioma cells. Journal of Neuro-Oncology, 106 (3). pp. 531-542. ISSN 0167-594X

Bonapace, Laura, Wyckoff, Jeffery, Oertner, Thomas, van Rheenen, Jacco, Junt, Tobias and Bentires-Alj, Mohamed (2012) If we don’t look we won’t see: Intravital Multiphoton Imaging of Breast Cancer Metastasis. Journal of Mammary gland Biology and Neoplasia, 17 (1). ISSN 1083-3021

Boos, Julien, Kirk, David William, Dattler, Andre, Piccolotto, Mari-Luz, Zuercher, Werner, Gfeller, Sandro, Neuner, Philippe, Christensen, Jesper, Wishart, William L., Beverly, Michael, Von Arx, Fabian, Litherland, Karine, Van De Kerkhof, Esther, Swart, Pieter Jacob, Faller, Thomas, Beyerbach, Armin, Morrissey, David, Hunziker, Juerg and Beuvink, Iwan (2012) Whole-body scanning PCR; a sensitive method to study the biodistribution of mRNAs, noncoding RNAs and therapeutic oligonucleotides. Nucleic Acids Research, Nuclei. ISSN 0305-1048

Bowes, Joanne, Brown, Andrew J, Hamon, Jacques, Jarolimek, Wolfgang, Sridhar, Arun, Waldron, Gareth and Whitebread, Steven (2012) Reducing safety-related drug attrition: The use of in vitro pharmacological profiling. Nature Reviews Drug discovery, 11 (12). pp. 909-922. ISSN 1474-1776

Britschgi, Adrian, Andraos-Rey, Rita, Brinkhaus, Heike, Klebba, Ina, Romanet, Vincent, Mueller, Urs, Murakami, Masato, Radimerski, Thomas and Bentires-Alj, Mohamed (2012) JAK2/STAT5 Inhibition Circumvents Resistance to PI3K/mTOR Blockade: A Rationale for Cotargeting These Pathways in Metastatic Breast Cancer. Cancer Cell, 22 (6). pp. 796-811. ISSN 1535-6108

Brockhoff, Marielle, Hau, Jean-Christophe, Fontana, Patrizia, Zimmermann, Catherine, De Pover, Alain, Erdmann, Dirk and Chene, Patrick (2012) Factors influencing the inhibition of protein kinases. Journal of Enzyme Inhibition and Medicinal Chemistry, 27 (2). pp. 194-200. ISSN 1475-6366

Broome, Michelle and Villarreal, Beth (2012) Differential Staining of Mast Cells with Toluidine Blue. Journal of Histotechnology, 35 (1). pp. 27-30. ISSN 0147-8885

Browne, Brigid / C, Eustace, Alex / J, Kennedy, Susan, O'Brien, Neil / A, Pedersen, Kasper, Larkin, Annemarie, Ballot, Jo, Mahgoub, Thamir, Sclafani, Francesco, Madden, Stephen, Kennedy, John, Duffy, Michael / J, Crown, John and O'Donovan, Norma (2012) Evaluation of IGF1R and phosphorylated IGF1R as targets in HER2-positive breast cancer cell lines and tumours. Breast Cancer Res Treat, 136 (3). pp. 717-727. ISSN 0167-6806

Bruce, Ian, Akhlaq, Mohammed, Bloomfield, Graham, Budd, Emma, Cox, Brian, Finan, Peter, Gedeck, Peter, Hayler, Judy, Head, Denise, Kirman, Louise, Leblanc, Catherine, Le Grand, Darren, Owen, Charles, Oza, Mrinalini, Sviridenko, Lilya, Whitehead, Lewis, Keller, Thomas, McCarthy, Clive, O'Connor, Desmond, Pilgrim, Gaynor, Press, Nicola and Cuenoud, Bernard (2012) Development of isoform selective PI 3-Kinase inhibitors as pharmacological tools for elucidating the PI3K pathway. Bioorganic & Medicinal Chemistry Letters, 22 (17). pp. 5445-5450. ISSN 0960-894X

Busch, Steven, Hoffmann, Peter, Foley, James, Sahota, Pritam, Johnson, Robert, Kothny, Wolfgang and Meyer, Franck (2012) Studies in rodents with the DPP-4 inhibitor vildagliptin to evaluate possible drug-induced pancreatic histological changes that are predictive of pancreatitis and cancer development in man. Diabetes, Obesity and Metabolism.

Butler, Matt, Sanmugalingam, Devika, Burton, Victoria, Wilson, Tammy, Pearson, Ruth, Watson, Robert, Smith, Philip and Parkinson, Scott James (2012) IMPAIRMENT OF ADENOSINE A3 RECEPTOR ACTIVITY DISRUPTS NEUTROPHIL MIGRATORY CAPACITY AND IMPACTS INNATE IMMUNE FUNCTION IN VIVO. European Journal of Immunology. ISSN 0014-2980

Caffery, Barbary, Joyce, Elizabeth, Miriam, Heynen, Ritter Iii, Robert, Lyndon, Jones and Michelle, Senchyna (2012) Quantification of Conjunctival TNFα mRNA Expression in Sub Populations of Human Aqueous Deficient Dry Eye. Molecular Vision.

Camenisch, Gian P. and Umehara, Ken-Ichi (2012) Predicting human hepatic clearance from in vitro drug metabolism and transport data: A scientific and pharmaceutical perspective for assessing drug-drug interactions. Biopharmaceutics and Drug Disposition. ISSN 0142-2782

Cenni, Bruno, Gutmann, Sascha, Dodeller, Francis and Gottar-Guillier, Marie (2012) The role of BMX in inflammation, cardiovascular disease and cancer. International Reviews of Immunology, 31 (2). pp. 166-173. ISSN 0883-0185

Chakraborty, Abhijit, Tannenbaum, Stacey, Rordorf, Christiane, Lowe, Phil, Floch, David, Gram, Hermann and Roy, Sandip (2012) Overview of the Pharmacokinetic and Pharmacodynamic Properties of Canakinumab, a Human anti-IL-1β Monoclonal Antibody. Clinical Pharmacokinetics, 51 (6). e1-e18. ISSN 0312-5963

Chapelat, Julien, Berst, Frederic, Marzinzik, Andreas, Moebitz, Henrik, Drueckes, Peter, Trappe, Joerg, Fabbro, Doriano and Seebach, Dieter (2012) The Substrate-Activity-Screening methodology applied to receptor tyrosine kinases: A proof-of-concept study. European Journal of Medicinal Chemistry. ISSN 0223-5234

Chatterjee, Arnab and Yeung, Bryan (2012) Back to the future: Lessons learned in modern target-based and whole-cell lead optimization of antimalarials. Current topics in Medicinal Chemistry.

Chioato, Andrea, Noseda, Emanuele, Stevens, Michael, Gaitatzis, Nikolaos, Kleinschmidt, Annett and Picaud, Henri (2012) Treatment with the IL-17 blocking antibody secukinumab (AIN457) does not interfere with the efficacy of Influenza and Meningococcal vaccination in healthy subjects. Results of an open-label, parallel group, randomized, single-center study. Clinical and Vaccine Immunology (CVI), 19 (10). pp. 1597-1602. ISSN 1556-6811

Cho, Young, Brain, Christopher, Chen, Christine, Cheng, Hong, Chopra, Rajiv, Giraldes, John, Kovats, Steven, Lagu, Bharat, Luzzio, Michael, Shen, Junqing, Yang, Fan, Wrona, Wojciech, O'Reilly, Marc, Howard, Steven, Loo, Alice, Haas, Kristy, Kim, Sunkyu, Lu, Yipin, Maniara, Wieslawa, Smith, Troy, Xu, Mei, Angove, Hayley, Cheng, Robert, Congreve, Miles, Dagostin, Claudio, J.Davis, Deborah, Feltell, Ruth, D.Hiscock, Steven, Lewry, Kim, McMenamin, Rachel, N.Mortenson, Paul, Benning, Rajdeep, C.Rees, David, Williams, Glyn and Woolford, Alison (2012) Fragment-Based Discovery and Structure-Guided Optimization of 2-Benzoyl-7-azabenzimidazoles as Potent, Highly Selective and Orally Active CDK4/6 Inhibitors. ACS Medicinal Chemistry Letters, 3 (6). pp. 445-449. ISSN 1948-5875

Christensen, Jesper, Natt, Francois, Hunziker, Juerg, Krauser, Joel, Andres, Hendrik and Swart, Pieter Jacob (2012) Tritium labeling of full length small interfering RNA’s. Journal of Labelled Compounds and Radiopharmaceuticals, 55 (6). pp. 189-196. ISSN 0362-4803

Coan, Kristin Emily, Swann, Marcus and Ottl, Johannes (2012) Measurement and differentiation of ligand-induced calmodulin conformations by dual polarization interferometry. Analytical Chemistry, 84 (3). pp. 1586-1591. ISSN 0003-2700

Costa, R.O., Lacor, P.N., Ferreira, I.L., Auberson, Yves, Klein, W.L., Oliveira, C.R., Rego, A.C. and Pereira, C.M.F. (2012) Endoplasmic reticulum stress occurs downstream of NR2B subunit of N-methyl-D-aspartate receptor in mature hippocampal cultures treated with amyloid-β oligomers. Aging Cell.

Cunliffe, Jennifer (2012) Fast Chromatography in the Regulated Bioanalytical Environment: Sub-2 um vs. Fused-core Particles. Bioanalysis, 4 (8). pp. 861-863. ISSN 1757-6180

Damiano, Jason, Rendahl, Katherine, Karim, Christopher, Embry, Millicent, Ghoddusi, Majid, Holash, Jocelyn, Fanidi, Abdallah, Abrams, Tinya and Abraham, Judith (2012) Neutralization of Prolactin Receptor Function by Monoclonal Antibody LFA102, A Novel Potential Therapeutic for the Treatment of Breast Cancer. Molecular Cancer Therapeutics, 12 (3). pp. 295-305. ISSN 1535-7163

David, Olivier J, Kovarik, John M and Schmouder, Robert L (2012) Clinical pharmacokinetics of fingolimod. Clinical pharmacokinetics, 51 (1). pp. 15-28. ISSN 0312-5963

Davies, Nicholas G. M., Browne, Helen, Davis, Ben, Foloppe, Nicolas, Geoffrey, Stephanie, Gibbons, Ben, Hart, Terry, Drysdale, Martin J., Mansell, Howard, Massey, Andrew, Matassova, Natalia, Moore, Jonathan D, Murray, James, Pratt, Robert, Ray, Stuart, Roughley, Stephen D., Jensen, Michael Rugaard, Schoepfer, Joseph, Scriven, Kirsten, Simmonite, Heather, Stokes, Stephen, Surgenor, Alan, Webb, Paul, Wright, Lisa and Brough, Paul (2012) Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization. Bioorganic & Medicinal Chemistry, 20 (22). pp. 67770-67789. ISSN 0968-0896

Defontis, Myriam, Cote, Serge, Stirn, Martina and Ledieu, David (2012) Optimization of Multiplate® whole blood platelet aggregometry in the Beagle dog and Wistar rat for ex vivo drug toxicity testing. Experimental and Toxicologic Pathology. ISSN 0940-2993

Denes, A, Drake, C, Stordy, J, Chamberlain, J, Gram, Hermann, Crossman, D, Francis, S and Rothwell, N (2012) Interleukin-1 mediates neuroinflammatory changes associated with diet-induced atherosclerosis. Journal of the American Heart Association, 1 (3). e002006. ISSN 2047-9980

Devine, Patrick, Perreault, Sally and Luderer, Ulrike (2012) Roles of reactive oxygen species and antioxidants in ovarian toxicity. Biology of Reproduction, 86 (2). p. 27. ISSN 0006-3363

Di Padova, Franco E., Gomery, Kathryn and Evans, Stephen V (2012) Antibody WN1 222-5 Mimics Toll-like Receptor 4 Binding in the Recognition of LPS. Proocedings national academy sciences, 109 (51). pp. 20877-20882.

Diagana, Thierry, Yeung, Bryan and Sauerwein, Robert (2012) The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to Anopheles mosquito vector. Antimicrobial Agents and Chemotherapy. ISSN 0066-4804

Dobi, Alice, Sartori, Simone, Busti, Daniela, Flor, Peter, Van Der Putten, P. Herman, Singewald, Nicolas, Shigemoto, Ryuichi and Ferraguti, Francesco (2012) Neural substrates for the opposing effects of distinct presynaptic group III metabotropic glutamate receptors on extinction of contextual fear conditioning in mice. Neuropharmacology. pp. 1-16. ISSN 0028-3908

Dobo, Krista, Green, Nigel, et al, et al and Glowienke, Susanne (2012) In Silico Methods Combined with Expert Knowledge Rule out Mutagenic Potential of Pharmaceutical Impurities: An Industry Survey. Regulatory Toxicology and Pharmacology.

Duca, Jose and Karki, Rajeshri (2012) Noticing The Unnoticed: Bridging Structural Data And Drug Design. Future Medicinal Chemistry, 4 (15). pp. 1869-1871. ISSN 1756-8919

Dudek, Timothy E, No, Daniel C, Seung, Edward, Vrbanac, Vladimir D, Fadda, Lena, Bhoumik, Priyasma, Boutwell, Christian L, Power, Karen A, Gladden, Adrianne D, Battis, Laura, Mellors, Elizabeth F, Tivey, Trevor R, Gao, Xiaojiang, Altfeld, Marcus, Luster, Andrew D, Tager, Andrew M and Allen, Todd M (2012) Rapid evolution of HIV-1 to functional CD8⁺ T cell responses in humanized BLT mice. Science translational medicine, 4 (143). 143ra98. ISSN 1946-6242

Dunne, Christine, Bushee, Jennifer and Argikar, Upendra (2012) Metabolism of bromopride in mouse, rat, rabbit, dog, monkey, and human hepatocytes. Drug Metabolism and Pharmacokinetics.

Ebersbach, Hilmar and Geisse, Sabine (2012) Antigen generation and display in therapeutic antibody drug discovery – a neglected but critical player. Biotechnology Journal. ISSN 1860-6768

Ekyalongo, Roudy / C, Mukohara, Toru, Kataoka, Yu, Kiyota, Naomi, Fujiwara, Yutaka and Minami, Hironobu (2012) Mechanisms of acquired resistance to insulin-like growth factor 1 receptor inhibitor in MCF-7 breast cancer cell line. Investigational New Drugs. ISSN 0167-6997

Elnakat Thomas, Hala, Mercer, Carol A., Carnevalli, Larissa S., Park, Jongsun, Andersen, Jesper B., Conner, Elizabeth A., Tanaka, Kazuhiro, Matsutani, Tomoo, Iwanami, Akio, Aronow, Bruce J., Liu, Manway, Thorgeisson, Snorri S., Mischel, Paul S., Thomas, George and Kozma, Sara C. (2012) Dual Inhibition of mTOR in hepatocellular carcinoma induces tumor regression, return to normal liver gene expression and autophagy. Science Translational Medicine, 4 (139). ra84. ISSN 1946-6234

Emotte, Corinne, Deglave, Fanny, Picard, Franck, Chaturvedi, Animesh, Majumdar, Tapan, Agarwal, Ashish and Kretz, Olivier (2012) Validation of on-line solid- phase extraction coupled with high-performance liquid chromatography–mass spectrometry assays for the determination of indacaterol, a potent β-adrenoceptor agonist in human serum. Journal of chromatography B, 895/89. pp. 1-9. ISSN 1570-0232

Endacott, John and Poolman, Robert (2012) Looking for Insights – Quality Control Initiatives for Enhancing Patent Searches. World Patent Information, 35 (1). pp. 3-7.

Erdemli, Gul, Kim, Albert, Ju, Haisong, Springer, Clayton, Penland, Robert and Hoffmann, Peter (2012) Cardiac Safety Implications of hNav1.5 Blockade and a Framework for Pre-Clinical Evaluation. Frontiers in Pharmaceutical Medicine and Outcomes Research.

Erdemli, Gul, Priest, Birgit and Wickenden, Alan (2012) Ion Channel Drug Discovery: Challenges and Future Directions. Future Medicinal Chemistry.

Ertl, Peter (2012) Database of bioactive ring systems with calculated properties and its use in bioisosteric design and scaffold hopping. Bioorganic and Medicinal Chemistry, 20 (18). pp. 5436-5442. ISSN 0968-0896

Ertl, Peter and Lewis, Richard (2012) IADE - A System for Intelligent Automatic Design of Bioisosteric Analogs. Journal of Computer-Aided Molecular Design, 26 (11). pp. 1207-1215. ISSN 0920-654X

Ertl, Peter and Rohde, Bernhard (2012) The Molecule Cloud - compact visualization of large collections of molecules. Journal of Cheminformatics, 4 (1). p. 12. ISSN 1758-2946

Ertl, Peter, Steinbeck, Christoph, Jayaseelan, Kalai Vanii, Moreno, Pablo and Truszkowski, Andreas (2012) Natural product-likeness score revisited: an open-source, open-data implementation. BMC Bioinformatics, 13 (106).

Farmer, I, Pancholi, S, Thornhill, AM, Ghazoui, Z, Evans, Dean Brent, Lane, Heidi A, Johnston, SR, Dowsett, Mitch, Martin, Lesley-Ann and Imark, Esther (2012) Effectiveness and molecular interactions of the clinically active mTORC1 inhibitor everolimus in combination with tamoxifen or letrozole in vitro and in vivo. Breast Cancer Research, 14 (5). ISSN 1465-5411

Feuerbach, Dominik, Arias, Hugo R, Targowska-Duda, Katarzyna M, Aggarwal, Shaili, Lapinsky, Daniel J and Jozwiak, Krzysztof (2012) Structural and functional interaction of (+)-2-(N-tert-butylamino)-3’-iodo-4’-azidopropiophenone, a photoactivatable bupropion derivative, with nicotinic acetylcholine receptors. Biochemistry.

Fiez-Vandal, Cedric, Leder, Lukas, Freuler, Felix, Sykes, David, Charlton, Steven, Siehler Wagner, Sandra, Schopfer, Ulrich and Duckely, Myriam (2012) HDL-like discs for assaying membrane proteins in drug discovery. Biophysical Chemistry, 165/16. pp. 56-61. ISSN 0301-4622

Fischer, Simon, Charara, Nadine, Gerber, Andrea, Woelfel, Jens, Schiedner, Gudrun, Voedisch, Bernd and Geisse, Sabine (2012) Transient recombinant protein expression in a human amniocyte cell line: the CAP-T cell system. Biotechnology & Bioengineering, 109 (9). pp. 2250-2261. ISSN 0006-3592

Flarakos, Jimmy, Ting, Lillian, Du, Yancy, Stein, Daniel, Reynolds, Christine, Patel, Manish, Roy, Sandip and Mangold, James (2012) Disposition and metabolism of [14C]PTZ601 in healthy volunteers. Xenobiotica. ISSN 0049-8254

Fredenhagen, Andreas, Kittelmann, Matthias, Oberer, Lukas, Kuhn, Anton, Kuehnoel, Juergen, Delemonte, Thierry, Aichholz, Reiner, Wang, Ping, Atadja, Peter and Shultz, Michael (2012) Biocatalytic synthesis and structure elucidation of cyclized metabolites of the deacetylase inhibitor Panobinostat (LBH589). Drug Metabolism and Disposition, 40 (5). pp. 1041-1050. ISSN 0090-9556

Frieauff, Wilfried, Martus, Hans-Joerg, Suter, Willi and Elhajouji, Azeddine (2012) Automatic Analysis of the Micronucleus Test in Primary Human Lymphocytes Using Image Analysis. Mutagenesis.

Fu, Shijun, Fei, Qi, Jiang, Hua, Chuai, Shannon, Song, Shi, Xiong, Wen, Jiang, Lei, Lu, Chris, Atadja, Peter, Li, En and Shou, Jianyong (2012) Involvement of histone acetylation of Sox17 and Foxa2 promoters during mouse definitive endoderm differentiation revealed by microRNA profiling. PLOS One.

Furet, Pascal, Chene, Patrick, De Pover, Alain, Valat, Therese-Marie, Hergovich Lisztwan, Joanna, Kallen, Joerg and Masuya, Keiichi (2012) The Central Valine Concept Provides an Entry in a New Class of Non Peptide Inhibitors of the P53-MDM2 Interaction. Bioorganic & Medicinal Chemistry Letters.

Gamsjaeger, Sonja, Hofstetter, B, Zwettler, Elisabeth, Recker, Robert, Gasser, Juerg Andreas, Eriksen, Erik Fink, Klaushofer, Klaus and Paschalis, Eleftherios P (2012) Effects of Three Years Treatment With Once-Yearly Zoledronic Acid on the Kinetics of Bone Matrix Maturation in Osteoporotic Patients. Osteoporosis International.

Gao, Zhenhai, Menezes, Daniel, Machajewski, Timothy, Abrams, Tinya, Jensen, Michael Rugaard, Yu, Guoying, Stuart, Darrin, Duhl, David, Pryer, Nancy and Sellers, William (2012) THE NOVEL ORAL HSP90 INHIBITOR NVP-HSP990 EXHIBITS POTENT AND BROAD-SPECTRUM ANTI-TUMOR ACTIVITIES IN VITRO AND IN VIVO. Molecular Cancer Therapeutics. ISSN 1535-7163

Garofalo, Cecilia, Mancarella, Caterina, Grilli, Andrea, Manara, Maria Cristina, Astolfi, Annalisa, Marino, Maria Teresa, Conte, Alexia, Sigismund, Sara, Carè, Alessandra, Belfiore, Antonino, Picci, Piero and Scotlandi, Katia (2012) Identification of both common and distinctive mechanisms of resistance to different anti-IGF-1R agents in Ewing’s sarcoma. Molecular Endocrinology, 26 (9). pp. 1603-1616. ISSN 0888-8809

Gaz, Claudio, Cremona, George, Panunzi, Simona, Patterson, Beverley and De Gaetano, Andrea (2012) A geometrical approach to the PKPD modelling of inhaled bronchodilators. Journal of pharmacokinetics and pharmacodynamics, 39 (5). pp. 415-428. ISSN 1567-567X

Geall, Andrew, Verma, Ayush, Otten, Gillis, Shaw, Christine, Hekele, Armin, Banerjee, Kaustuv, Beard, Clayton, Cu, Yen, Brito, Luis, Krucker, Thomas, O'Hagan, Derek, Singh, Manmohan, Mason, Peter, Valiante, Nicholas, Dormitzer, Philip, Barnett, Susan, Rappuoli, Rino, Ulmer, Jeffrey and Mandl, Christian (2012) Non-viral delivery of self-amplifying RNA. PNAS (Proceedings of the National Academy of Sciences), 109 (36). pp. 14604-14609. ISSN 1091-6490

Genovino, Julien, Lagu, Bharat, Toure, Bakary-Barry and Wang, Kate (2012) Synthesis of sterically hindered enamides via a Ti-mediated condensation of amides with aldehydes and ketones. Chemical Communications, 48 (53). pp. 6735-6737. ISSN 1359-7345

Glowienke, Susanne, Martus, Hans-Joerg and Suter, Willi (2012) Bacterial Mutagenicity Screening in the pharmaceutical industry. Mutation Research - Reviews in Mutation Research. ISSN 0027-5107

Gomez-Mancilla, Baltazar (2012) Autism-Tweaking the social network. Science translational medicine, 4 (131). 131fs9. ISSN 1946-6234

Grant, James (2012) "Chemistry and the Law". Pharmaceutical Patent Analyst, 1 (3). pp. 241-243. ISSN 2046-8954

Grassian, Alexandra, Lin, Fallon, Barrett, Rosemary, Liu, Yue, Jiang, Wei, Korpal, Manav, Levell, Julian, Korn, Joshua and Pagliarini, Raymond (2012) Isocitrate Dehydrogenase Mutations Promote a ZEB1/mir-200-dependent Epithelial Mesenchymal Transition. Journal of Biological Chemistry, 287 (50). pp. 42180-42194. ISSN 0021-9258

Greenidge, Paulette, Wolf, Romain, Kramer, Christian and Mozziconacci, Jean-Christophe (2012) MM/GBSA Binding Energy Prediction on the PDBbind Data Set: Successes, Failures, and Directions for Further Improvement. Journal of Chemical Information and Modeling. ISSN 1549-9596

Gregori-Puigjané, Elisabet, Setola, Vincent, Hert, Jérôme, Evans, Jon, Crews, Brenda C, Lounkine, Eugen, Marnett, Larry, Shoichet, Brian K and Roth, Bryan L (2012) Identifying Targets for Drugs and Probes with Unknown Mechanisms of Action. PNAS, 109 (28). pp. 11178-11183. ISSN 1091-6490

Groot-Kormelink, Paulus, Fawcett, Lindsay, Wright, Paul, Gosling, Martin and Kent, Toby (2012) Quantitative GPCR and ion channel transcriptomics in primary alveolar macrophages and macrophage surrogates. BMC Immunology, 13 (1). p. 57. ISSN 1471-2172

Grueninger, Stephan (2012) Mutant huntingtin fragmentation in immune cells tracks Huntington’s disease progression. Journal of Clinical Investigation.

Gschwind, Hans-Peter, Glaenzel, Ulrike, Waldmeier, Felix, Wirz, Bernard, Sabia, Helene, Picard, Franck, Weiss, Markus, Choi, Les, Swart, Pieter Jacob, Vasudevan, Ajithkumar and Azria, Moise (2012) Metabolism and disposition of the oral absorption enhancer 14C-radiolabeled 8-(N-2-hydroxy-5-chlorobenzoyl)-amino-caprylic acid (5-CNAC) in healthy postmenopausal women and supplementary investigations in vitro. European Journal of Pharmaceutical Sciences. ISSN 0928-0987

Guadalupe, Rivero, Llorente, Javier, McPherson, Jamie, Cooke, Alex, Mundell, Stuart J, McArdle, Craig A, Rosethorne, Elizabeth, Charlton, Steven, Cornelius, Krasel, Dewey, William L, Bailey, Christopher P, Henderson, Graeme and Kelly, Eamonn (2012) Endomorphin-2: a biased agonist at the µ-opioid receptor. Molecular Pharmacology, 82 (2). pp. 178-188. ISSN 0026-895X

Guagnano, Vito, Kauffmann, Audrey, Stamm, Christelle, Yao, Yao, Li, Fang, Zhang, Yun, Chen, Zhi, Ito, Moriko, Wilson, Christopher, Woehrle, Simon, Bordas, Vincent, Le Douget, Mickael, Gaither, Larry, Borawski, Jason, Monahan, John, Venkatesan, Kavitha, Bruemmendorf, Thomas, Garcia-Echeverria, Carlos, Hofmann, Francesco, Sellers, William and Graus Porta, Diana (2012) FGFR genetic alterations predict for response to NVP-BGJ398, a selective pan-FGFR inhibitor in Phase I clinical trials. Cancer Discovery, 2 (12). pp. 1118-1133. ISSN 23002168

Gutmann, Heike, Camenisch, Gian P., Kunze, Annett and Huwyler, Joerg (2012) Interaction of the antiviral drug telaprevir with renal and hepatic drug transporters. Biochemical Pharmacology. ISSN 0006-2952

Hanlon, Steven, Camattari, Andrea, Abad, Sandra, Glieder, Anton, Kittelmann, Matthias, Luetz, Stephan, Wirz, Beat and Winkler, Margit (2012) Expression of Recombinant Human Flavin Monooxygenase and application for N-oxidation of Moclobemide. Chemical communications. ISSN 1359-7349

Harbinski, Fred, Craig, Vanessa, Sanghavi, Sneha, Jeffery, Douglas, Liu, Lijuan, Sheppard, Kelly-Ann, Wagner, Sabrina, Stamm, Christelle, Buness, Andreas, Chatenay-Rivauday, Christian, Metz, Thomas, Finan, Peter, Hofmann, Francesco, Sellers, William, Porter, Jeffrey, Myer, Vic, Yao, Yao, Graus Porta, Diana, Wilson, Christopher, Buckler, Alan and Tiedt, Ralph (2012) Rescue screens with secreted proteins reveal compensatory potential of receptor tyrosine kinases in driving cancer growth. Cancer Discovery. ISSN 2159-8274

Harbut, Michael B., Patel, Bhumit A., Yeung, Bryan King Sing, Mcnamara, Case, Golde, Todd E., Winzeler, Elizabeth, Diagana, Thierry Tidiane and Greenbaum, Doron C. (2012) Targeting the ERAD Pathway via Inhibition of Signal Peptide Peptidase for Antiparasitic Therapeutic Design. Proceedings of the National Academy of Sciences USA, 109 (52). pp. 21486-21491. ISSN 0027-8424

Harleman, JH, Hargreaves, A, Andersson, H and Kirk, S (2012) A review of the incidence and coincidence of uterine and mammary tumours in Wistar and Sprague Dawley rats based on the RITA database and the role of prolactin Evaluation of carcinogenicity results needs an awareness of tumour interdependency in pathogenesis. Toxicologic Pathology, 40 (6). pp. 926-930. ISSN 0192-6233

Hartenfeller, Markus, Eberle, Martin, Meier, Peter, Nieto-Oberhuber, Cristina, Altmann, Karl-Heinz, Schneider, Gisbert, Jacoby, Edgar and Renner, Steffen (2012) Probing the bioactivity-relevant chemical space of robust reactions and common molecular building blocks. Journal of Chemical Information and Modeling. ISSN 1549-9596

Hashimoto, Kohei, Masumori, Naoya, Tanaka, Toshiaki, Maeda, Toshihiro, Kobayashi, Ko, Kitamura, Hiroshi, Hirata, Koichi and Tsukamoto, Taiji (2012) Zoledronic acid but not somatostatin analogs exerts anti-tumor effects in a model of murine prostatic neuroendocrine carcinoma of the development of castration-resistant prostate cancer. The Prostate. ISSN 0270-4137

Hefti, Katharina, Holst, Sebastian, Wehrle, Renate, Sovago, Judit, Bachmann, Valerie, Buck, Alfred, Ametamey, Simon/M, Scheidegger, Milan, Berthold, Thomas, Treyer, Valerie, Burger, Cyrill, Gomez-Mancilla, Baltazar, Seifritz, Erich and Landolt, Hans-Peter (2012) Increased Metabotropic Glutamate Receptor Subtype5 Availability in Human Brain After One Night Without Sleep. Biological Psychiatry. ISSN 0006-3223

Herzig, Martin, Bidinosti, Michael, Schweizer, Tatjana, Hafner, Thomas, Stemmelen, Christine, Danner, Simone, Vidotto, Nella, Stauffer, Daniela, Barske, Carmen, Mayer, Franziska, Schmid, Peter, Rovelli, Giorgio, Van Der Putten, P. Herman and Shimshek, Derya (2012) High LRRK2 Levels Fail to Induce or Exacerbate Neuronal Alpha-Synucleinopathy in Mouse Brain. Plos ONE. e36581.

Hoepfner, Dominic, McNamara, Case, Lim, Chek Shik, Studer, Christian, Riedl, Ralph, Aust, Thomas, McCormack, Susan L, Plouffe, David M, Schuierer, Sven, Plikat, Uwe, Hartmann, Nicole, Staedtler, Frank, Cotesta, Simona, Schmitt, Esther, Petersen, Frank, Supek, Frantisek, Glynne, Richard J, Tallarico, John, Porter, Jeffrey, Fishman, Mark, Bodenreider, Christophe, Diagana, Thierry Tidiane, Movva, Rao and Winzeler, Elizabeth A (2012) Cladosporin, a fungal metabolite with potent blood and hepatic stage antimalarial activity targets lysyl-tRNA synthetase. Cell Host & Microbe, 11 (6). pp. 654-663. ISSN 1931-3128

Hoffmaster, Keith, Zamek-Gliszczynski, Maciej, Tweedie, Donald, Giacomini, Kathleen and Hillgren, Kathleen (2012) Highlights from the International Transporter Consortium (ITC) 2nd Workshop. Clinical Pharmacology and Experimental Therapeutics, 92 (5). pp. 553-556. ISSN 0009-92361532-6535

Horn, Angelika, Trayana, Kireva, Palumbo-Zerr, Katrin, Dees, Clara, Tomcik, Michal, Cordazzo, Cinzia, Zerr, Pawel, Akhmetshina, Alfiya, Ruat, Martial, Distler, Oliver, Beyer, Christian, Schett, Georg and Distler, Jörg HW (2012) Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis. Annals of the Rheumatic Diseases, 71 (5). pp. 785-789. ISSN 0003-4967

Horvath, Christopher, Maclachlan, Timothy and Milton, Mark (2012) Letter to the Editor - Response to Hunig Commentary in Nat Rev Immunol. Nature Reviews Immunology.

Hunt, Thomas, Howsham, Catherine, Danahay, Henry, Atherton, Hazel, Coote, Kevin, Czarnecki, Sarah, Hunt, Peter and Paisley, Derek (2012) Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 2: α-Branched quaternary amines. Bioorganic and Medicinal Chemistry Letters, 22 (8). pp. 2877-2879. ISSN 0960-894X

Hutter, Caroline, Kauer, Max, Simonitsch-Klupp, Ingrid, Jug, Gunhild, Schwentner, Raphaela, Leitner, Judith, Bock, Peter, Steinberger, Peter, Bauer, Wolfgang, Carlesso, Nadia, Minkov, Milen, Gadner, Helmut, Stingl, Georg, Kovar, Heinrich and Kriehuber, Ernst (2012) Notch is active in Langerhans Cell Histiocytosis and confers pathognomonic features on dendritic cells. Blood. ISSN 0006-4971

Irwin, David / A and Van der Kraak, Glen (2012) Hormonal and cellular regulation and actions of IGF-III in the ovary of zebrafish (Danio rerio). General and Comparative Endocrinology, 177 (1). pp. 187-194. ISSN 0016-6480

Jakab, Annamaria, Winter, Serge, Guy, Bertrand, Raccuglia, Marc, Picard, Franck, Kovarik, John M., Chudasama, Jayraj, Guttikar, Swati, Singhal, Puran and Kretz, Olivier (2012) Validation of a liquid chromatography/tandem mass spectrometry method for the simultaneous quantification of Sotrastaurin and its metabolite N-desmethyl-sotrastaurin in human blood. Journal of Chromatography B, 897. pp. 10-16. ISSN 1570-0232

Jenkins, Jeremy (2012) QSAR in Phenotypic HTS. Molecular Informatics, 31 (6-7). pp. 508-514. ISSN 1868-1743

Jian, Zhigang, Ray, Tapan, Wu, Aiyin and Jones, Lawrence (2012) Proton Exchange Reactions in Isotope Chemistry (I) Synthesis of Stable Isotope Labeled TKI258 and Its Metabolites. Journal of Labeled Compounds and Radiopharmaceuticals, 55 (2). pp. 84-87. ISSN 0362-4803

Jiang, Liewen, Bondell, Howard and Wang, Judy (2012) Interquantile Shrinkage in Regression Models. Journal of Computational and Graphical Statistics. ISSN 1061-8600

Jiang, Wei and Erve, John (2012) Spectral Accuracy of Molecular Ions in a New Hybrid Quadrupole Time-of-Flight Mass Spectrometer: Application to Ranking Small Molecule Elemental Compositions. Rapid communications in Mass Spectrometry, 26 (9). pp. 1014-1022. ISSN 0951-4198

Johnson, Leland, Powers, James, Ma, Fupeng, Jendza, Keith, Wang, Bing, Meredith, Erik and Mainolfi, Nello (2012) A Reliable Synthesis of 3-Amino-5-Alkyl and 5-Amino-3-Alkyl Isoxazoles. Synthesis, 45. A-C. ISSN 0039-7881

Kaddis, John S, Bowers, Jessica, Wai, Daniel H, Hartmann, Nicole, Baeriswyl, Lukas, Bajaj, Sheetal, Anderson, Michael J, Getts, Robert C and Triche, Timothy J (2012) Influence of RNA Labeling on High-Throughput Expression Profiling of MicroRNAs. The Journal of Molecular Diagnostics, 14 (1). pp. 12-21. ISSN 1525-1578

Kagan, Mark, Reynolds, Christine, Dain, Jeremy and Peng, Lana (2012) Metabolism, pharmacokinetics, and excretion of indacaterol in humans. Drug metabolism and disposition : the biological fate of chemicals, 40 (9). pp. 1712-1722. ISSN 0090-9556

Karkare, Shantanu, Hoepfner, Dominic, Pfeifer, Martin, Trunzer, Markus, De Bonnechose, Sophie, Zimmerlin, Alfred Gilbert, Tao, Jianshi, Richie, Daryl, Hofmann, Andreas, Reinker, Stefan, Frederiksen, Mathias, Movva, Rao, Porter, Jeffrey, Ryder, Neil and Parker, Christian (2012) An integrated approach for the identification and target validation of anti-fungal compounds Active against Erg11p. Antimicrobial Agents and Chemotherapy, 58 (8). pp. 4233-4240. ISSN 0066-4804

Katsuyama, Yohei, Harmrolfs, Kirsten, Pistorius, Dominik, Li , Yanyan and Müller, Rolf (2012) A semipinacol rearrangement directed by an enzymatic system featuring dual-function FAD-dependent monooxygenase. Angewandte Chemie International Edition, 51 (37). pp. 9437-9440.

Kent, Toby, Akhlaq, Mohammed, Rosethorne, Elizabeth and Sattikar, Afrah (2012) The Use of Cold Plasma Technology to Reduce Carry-Over in Screening Assays. Journal of Laboratory Automation. ISSN 2211-0682

Kirby, Christina, Cheung, Atwood, Fazal, Aleem, Shultz, Michael and Stams, Travis (2012) Structure of Human Tankyrase-1 in Complex with Small Molecule Inhibitors, PJ34 and XAV939. Acta Crystallographica Section F, F68 (2). pp. 115-118. ISSN 1744-3091

Klionsky, Dan, Nyfeler, Beat and Murphy, Leon (2012) Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy in Higher Eukaryotes. Autophagy, 8 (4). pp. 445-544. ISSN 1554-8635

Kochlamazashvili, Gaga, Bukalo, Olena, Senkov, Oleg, Salmen, Benedikt, Gerardy-SChahn, Rita, Engel, Andreas, Schachner, Melitta and Dityatev, Alexander (2012) Restoration of synaptic plasticity and learning in young and aged NCAM-deficient mice via elevation of neurotransmission mediated by the GluN2A-containing NMDA receptors. J Neuroscience.

Kocsis, Bernat (2012) Differential role of NR2A and NR2B subunits in NMDA receptor antagonist-induced cortical gamma oscillations. Biological Psychiatry, 1 (17). pp. 987-995. ISSN 0006-3223

Koller, Manuel, Carcache, David, Orain, David, Ertl, Peter, Behnke, Dirk, Desrayaud, Sandrine, Laue, Grit and Vranesic, Ivan-Toma (2012) Discovery of 1H-pyrrolo[2,3-c]pyridine-7-carboxamides as novel, allosteric mGluR5 antagonists. Bioorganic Medicinal Chemistry Letters, 22. pp. 6454-6459.

Kramer, Christian, Gedeck, Peter and Meuwly, Markus (2012) Atomic Multipoles: Electrostatic Potential Fit, Local Reference Axis Systems and Conformational Dependence. Journal of Computational Chemistry. ISSN 0192-8651

Kramer, Christian, Kalliokoski, Tuomo, Gedeck, Peter and Vulpetti, Anna (2012) The experimental uncertainty of heterogeneous public Ki data. Journal of Medicinal Chemistry, 55 (11). pp. 5165-5173. ISSN 0022-2623

Krauser, Joel, Walles, Markus, Wolf, Thierry, Graf, Daniel and Swart, Pieter Jacob (2012) An Innovative Automation Platform for Metabolite Identification Studies. Plos One , 7 (6).

Krauser, Joel, Walles, Markus, Wolf, Thierry, Graf, Daniel and Swart, Pieter Jacob (2012) A Unique Automation Platform for Metabolite Identification Studies. PloS One, 7 (6). e39070. ISSN 1932-6203

Kubovcakova, Lucia, Lundberg, Pontus, Grisouard, Jean, Hao-Shen, Hui, Dirnhofer, Stephan, Wagner, Kay-Uwe, Skoda, Radek, Romanet, Vincent, Andraos-Rey, Rita, Murakami, Masato and Radimerski, Thomas (2012) Differential effects of hydroxyurea and INC424 on mutant allele burden and myeloproliferative phenotype in a JAK2-V617F polycythemia vera mouse model. Blood. ISSN 0006-4971

Kurio, Naito, Shimo, Tsuyoshi, Fukazawa, Takuya, Okui, Tatsuo, Hassan, Nur Mohammad Monsur, Honami, Tatsuki, Horikiri, Yuu, Hatakeyama, Shinji, Takaoka, Munenori, Naomoto, Yoshio and Sasaki, Akira (2012) Anti-tumor effect of a novel FAK inhibitor TAE226 against human oral squamous cell carcinoma. Oral Oncology, 48 (11). pp. 1159-1170. ISSN 1368-8375

Lamarche, Matthew, Borawski, Jason, Bose, Avirup, Capacci-Daniel, Christina, Colvin, Richard, Dennehy, Michelle, Ding, Jian, Drumm Iii, Joseph, Gaither, Larry, Gao, Jiaping, Jiang, Xiaoqun, Lin, Kai, Mckeever, Una, Puyang, Xiaoling, Raman, Prakash, Thohan, Sanjeev, Tommasi, Ruben, Wagner, Kathrin, Xiong, Xiaowei, Zabawa, Thomas, Zhu, Shejin and Wiedmann, Brigitte (2012) Anti-HCV activity and toxicity of PI4KIIIβ inhibitors. Antimicrobial Agents and Chemotherapy. ISSN 0066-4804

Lamarche, Matthew, Leeds, Jennifer, Amaral, Adam, Brewer, Jason, Bushell, Simon, Ding, Jian, Dzink-Fox, Joann, Gamber, Gabriel, Jain, Akash, Lee, Kwangho, Lister, Troy, Mckenney, David, Mullin, Steve, Osborne, Colin, Palestrant, Deborah, Patane, Michael, Rann, Elin, Sachdeva, Meena, Shao, Jian, Tiamfook, Stacey, Williams, Anna, Whitehead, Lewis, Yifru, Aregahegn, Yu, Donghui, Yan, Wanlin and Zhu, Qingming (2012) DISCOVERY OF LFF571 AS AN INVESTIGATIONAL AGENT FOR Clostridium difficile INFECTION. Journal of Medicinal Chemistry, 55 (5). pp. 2376-2387. ISSN 0022-2623

Lamarche, Matthew, Rann, Elin, Leeds, Jennifer, Krastel, Philipp, Gangl, Eric, Palestrant, Deborah, Patane, Michael, Neckermann, Georg and Yu, Donghui (2012) Antibiotic Optimization and Chemical Structure Stabilization of Thiomuracin A. Journal of Medicinal Chemistry, 55 (15). pp. 6934-6941. ISSN 0022-2623

Landrum, Gregory and Stiefl, Nikolaus (2012) Is that a scientific publication or an advertisement? Future Medicinal Chemistry, 4 (15). p. 1887. ISSN 1756-8919

Lee, David and Boilard, Eric (2012) Microparticle-associated immune complexes predominate in rheumatoid arthritis synovial fluid. EMBO molecular medicine, 4. pp. 1-15. ISSN 1757-4676

Lee, David and Nigrovic, Peter (2012) Hypogalactosylation of IgG fails to predict clinical response to methotrexate and TNF inhibition in rheumatoid arthritis. Arthritis Research and Therapy, 14 (2). R43. ISSN 1478-6354

Lee, David and Oyoshi, Michiko (2012) LTB4 driven neutrophil recruitment to the skin is essential for allergic skin inflammation. Immunity, 37 (4). pp. 747-758. ISSN 1074-7613

Lee, Seung-Joo, Liang, Li, Nantona, Minelva R., Gondwe, Ester N., Msefula, Chisomo L., Kayala, Matthew A., Necchi, Francesca, Heath, Jennifer N., Hart, Peter, Tsolis, Renée M., Heyderman, Robert S., Maclennan, Calman Alexander, Felgner, Philip L., Davies, D. Huw and McSorley, Stephen J. (2012) Identification of a common immune signature in murine and human systemic Salmonellosis. Proceedings of the National Academy of Sciences, USA. ISSN 0027-8424

Leeds, Jennifer, Sachdeva, Meena, Mullin, Steve, Dzink-Fox, Joann and Lamarche, Matthew (2012) Mechanism of action of, and mechanism of reduced susceptibility to the novel anti-Clostridium difficile compound LFF571. Antimicrobial Agents and Chemotherapy, 56 (8). pp. 4463-4465. ISSN 0066-4804

Legangneux, Eric, Gardin, Anne and Johns, Donald (2012) Dose titration of BAF312 attenuates the initial heart rate reducing effect in healthy subjects. British Journal of Clinical Pharmacology, 10 (1111). pp. 1365-2125. ISSN 0306-5251

Lempiaeinen, Harri, Couttet, Philippe, Bolognani, Federico, Mueller, Arne, Dubost, Valerie, Luisier, Raphaelle, Hahne, Florian, Zollinger, Tulipan, Brasa, Sarah, Kalteis, Magdalena, Marcellin, Magali, Morawiec, Laurent, Zamurovic Ribrioux, Natasa, Laengle, Ulrich, Schuebeler, Dirk, Chibout, Salah-Dine, Marlowe, Jennifer, Theil, Diethilde, Heard, David, Grenet, Olivier, Moulin, Pierre, Terranova, Remi, Moggs, Jonathan, Unterberger, Elif, Thomson, John, Treindl, Fridolin, Metzger, Ute, Wrzodek, Clemens, Giudicelli, Fanny Bernadette, Braeuning, Albert, Scheer, Nico, Goodman, Jay, Zell, Andreas, Templin, Markus, Meehan, Richard, Wolf, C. Roland, Elcombe, Clifford and Schwarz, Michael (2012) Identification of Dlk1-Dio3 imprinted gene cluster non-coding RNAs as novel candidate biomarkers for liver tumor promotion. Toxicological Sciences. ISSN 1096-6080

Lewis, Richard and Kramer, Christian (2012) QSARs, data and error in the modern age of drug discovery. Current Topics in Medicinal Chemistry, 12 (17). pp. 1896-1902. ISSN 1268-0266

Li, Shu, Hao, Qin, Gounarides, John and Wang, Yingqi (2012) Full Utilization of the Mass Spectrometer by On-Demand sharing with Multiple LC Units. Journal of Mass Spectrometry, 47 (8). pp. 1074-1082. ISSN 1076-5174

Li, Wenkui, Doherty, John, Kulmatycki, Kenneth, Smith, Harold and Tse, Francis (2012) Simultaneous LC-MS/MS quantitation of acetaminophen and its glucuronide and sulfate metabolites from human dried blood spot samples collected by subjects. Bioanalysis, 4 (12). pp. 1429-1443. ISSN 1757-6180

Lin, Ying, Fan, Hong, Frederiksen, Mathias, Zhao, Kehao, Jiang, Lei, Wang, Zhaofu, Zhou, Shaolian, Guo, Weihui, Li, Shu, Harrington, Edmund, Meier, Peter, Scheufler, Clemens, Xu, Yao-Chang, Atadja, Peter, Lu, Chris, Li, En and Gu, Justin (2012) Detecting SAM-induced conformational change of a histone methyltransferase using a homogenous time-resolved fluorescence-based binding assay. Analytical Biochemistry, 423. pp. 171-177.

Lito, Piro, Pratilas, Christine, Joseph, Eric, Tadi, Madhavi, Halilovic, Ensar, Zubrowski, Matt, Huang, Alan, Wong, Wai Lin, Callahan, Margaret, Merghoub, Taha, Wolchok, Jedd, DeStanchina, Elisa, Chandarlapaty, Sarat, Poulikakos, Poulikos, Fagin, James and Rosen, Neal (2012) RELIEF OF PROFOUND FEEDBACK INHIBITION OF MITOGENIC SIGNALING BY RAF INHIBITORS ATTENUATES THEIR ACTIVITY IN BRAFV600E MELANOMAS. Cancer Cell, 22 (5). pp. 668-682. ISSN 1535-6108

London, Anne, Kerins, Brendan, Tschantz, William and Mackay, Kasey (2012) Endotoxin Removal and Prevention for Pre-Clinical Biologics Production. Biotechnology Journal. ISSN 1860-6768

Long, Zhang, HuiZhe, Huang, Fang Fang, Zhou, Sheppard, Kelly-Ann, Mickanin, Craig, Porter, Jeffrey, Hans, van Dam, Gribnau, Joost, Lu, Chris and Peter, ten Dijke (2012) RNF12 Controls Embryonic Stem Cell Fate and Morphogenesis in Zebrafish Embryos by Targeting Smad7 for Degradation. Molecular Cell, 46 (5). pp. 650-661. ISSN 1097-2765

Lounkine, Eugen, Keiser, Michael J, Whitebread, Steven, Mikhailov, Dmitri, Hamon, Jacques, Jenkins, Jeremy, Lavan, Paul, Weber, Eckhard, Doak, Allison K, Cote, Serge, Shoichet, Brian K and Urban, Laszlo (2012) Large Scale Prediction and Testing of Drug Activity on Side-Effect Targets. Nature, 486 (7403). pp. 361-367. ISSN 0028-0836

Lounkine, Eugen, Kutchukian, Peter, Petrone, Paula, Davies, John and Glick, Meir (2012) Chemotography for multi-target SAR analysis in the context of biological pathways. Bioorganic and Medicinal Chemistry. ISSN 0968-0896

Lu, Zhijian, Deng, Sujun, Huang, Dagang, He, Yun, Lei, Ming, Zhou, Li and Jin, Pei (2012) Frontier of Therapeutic Antibody Discovery: the Challenges and How to Deal with Them. World Journal of Biological Chemistry, 3 (12). pp. 187-196. ISSN 1949-8454

Maclennan, Calman Alexander (2012) Host defense against malaria favors Salmonella. Nature Medicine, 18 (1). pp. 21-22. ISSN 1078-8956

Madrid, Alexis and Ganem, Donald (2012) A ligand for the orphan NK activating receptor NKp44 is targeted for downregulation by the Kaposi’s Sarcoma-Associated Herpesvirus protein ORF54/dUTPase. Journal of Virology, 86 (6). pp. 8693-8704. ISSN 0022-538X

Mainolfi, Nello, Zhang, Yun and Patel, Sejal (2012) Copper-Catalyzed Decarboxylative C—N Cross-Coupling for N-Arylation. Chemical Science, on lin. ISSN 2041-6520

Mang, Geraldine, Duerst, Thomas, Imobersteg, Stefan, Buerki, Hugo, Abramowski, Dorothee, Schuepbach, Edi, Hoyer, Daniel, Fendt, Markus and Gee, Christine (2012) The dual orexin receptor antagonist almorexant induces sleep and decreases orexin-induced locomotion by blocking orexin 2 receptors. Sleep, 35 (12). pp. 1625-1635. ISSN 0161-8105

Marcellin, David, Abramowski, Dorothee, Douglas, Young, Richter, Jens, Weiss, Andreas, Marcel, Audrey, Maassen, Julia, Kauffmann, Muriel, Bibel, Miriam, Shimshek, Derya, Richard, Faull, Bates, Gillian, Kuhn, Rainer R, Van Der Putten, P. Herman, Schmid, Peter and Lotz, Gregor (2012) Fragments of HdhQ150 Mutant Huntingtin Form a Soluble Oligomer Pool That Declines with Aggregate Deposition upon Aging. PloS One.

Marshall, Stephen, Reilly, Dorothy, Sansone, Susanna-Assunta, Rocca-Serra, Philippe, Field, Dawn, Maguire, Eamonn, Taylor, Chris, Hide, Winston, Hofmann, Oliver, Fang, Hong, Neumann, Steffan, Tong, Weida, Amaral-Zettler, Linda, Begley, Kimberly, Booth, Tim, Bougueleret, Lydie, Burns, Gully, Chapman, Brad, Clark, Tim, Coleman, Lee-Ann, Das, Sudeshna, de Daruvar, Antoine, de Matos, Paula, Dix, Ian, Edmunds, Scott, Evelo, Chris, Forster, Mark, Gaudet, Pascale, Gilbert, Jack, Goble, Carole, Griffin, Julian L, Jacob, Daniel, Kleinjans, Jos, Harland, Lee, Haug, Kenneth, Hermjakob, Henning, Ho Sui, Shannon, Laederach, Alain, Liang, Shaoguang, Merrill, Emily M, Roux, Magali, Saito, Jahn-Takeshi, Scheuerman, Richard H, Steinbeck, Christoph, Trefethen, Anne, Williams-Jones, Bryn, Wolstencroft, Katherine, Xenarios, Ioannis, Shamu, Caroline, McGrath, Annette, Shang, Catherine and Copeland, Jay (2012) Towards interoperable bioscience data. Nature Genetics, 44 (2). pp. 121-126. ISSN 1061-4036

Martin, Laura B (2012) Vaccines for typhoid fever and other salmonelloses. Current opinion in infectious diseases, 25 (5). pp. 489-499. ISSN 0951-7375

Matsuno, Yosuke, Coelho, Ana, Jarai, Gabor, Westwick, John and Hogaboam, Cory (2012) Notch signaling mediates TGF-β1-induced EMT through the induction of Snai1. The International Journal of Biochemistry and Cell Biology, 44 (5). pp. 776-789. ISSN 1357-2725

Matsushima, Soichiro, Matthews, Ivan, Woessner, Ralph, Pinault, Gregory, Hara, Hisanori, Wilkins, Justin and Sekiguchi, Kaneo (2012) Systemic pharmacokinetics of indacaterol, an inhaled once-daily long-acting β2-agonist, in different ethnic populations. International journal of clinical pharmacology and therapeutics, 50. pp. 545-556. ISSN 0946-1965

Mattsson, Niklas, Rajendran, Lawrence, Zetterberg, Henrik, Gustavsson, Mikael, Andreasson, Ulf, Olsson, Maria, Brinkmalm, Gunnar, Lundkvist, Johan, Jacobson, Laura, Perrot, Ludovic, Neumann, Ulf, Borghys, Herman, Mercken, Marc, Dhuyvetter, Deborah, Jeppsson, Fredrik, Blennow, Kaj and Portelius, Erik (2012) BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous system. PLosOne, 7 (2). e31084-e31084. ISSN 1932-6203

McDonnell, Liam A., Heeren, Ron M.A., Andrén, Per E., Stoeckli, Markus and Corthals, Garry (2012) Going forward: Increasing the accessibility of imaging mass spectrometry. Journal of Proteomics. ISSN 1874-3919

Mccarren, Patrick, Whitehead, Lewis and Hall, Michelle (2012) The Chemical Tuning of a Weak Zinc Binding Motif for Histone Deacetylase Using Electronic Effects. Chemical Biology & Drug Design. ISSN 1747-0277

Meyer, Hans-Peter, Eichhorn, Eric, Hanlon, Steven, Luetz, Stephan, Schürmann, Martin, Wohlgemuth, Roland and Coppolecchia, Raffaella (2012) The use of enzymes in industrial organic synthesis. Catalysis Science & Technology.

Micoli, F, Rondini, S, Pisoni, I, Giannelli, C, Di Cioccio, V, Costantino, P, Saul, A and Martin, L B (2012) Production of a conjugate vaccine for Salmonella enterica serovar Typhi from Citrobacter Vi. Vaccine, 30 (5). pp. 853-861. ISSN 1873-2518

Micoli, Francesca, Rondini, Simona, Gavini, Massimiliano, Lanzilao, Luisa, Pisoni, Ivan, Colucci, Anna Maria, Sollai, Luigi, Giannelli, Carlo, Pippi, Federico, Maclennan, Calman Alexander, Pinto, Vittoria, Berti, Francesco, Saul, Allan James and Laura, Martin (2012) A scalable method for O-antigen purification applied to different Salmonella serovars. Analytical Biochemistry.

Micoli, Francesca, Rondini, Simona, Gavini, Massimiliano, Lanzilao, Luisa, Saul, Allan James and Martin, Laura Bartle (2012) O:2-CRM197 conjugates against Salmonella Paratyphi A. Plos One.

Millar, John, Wang, Wan-Heng, Pang, Iok-Hou, Silverman, Sean, Mao, Weiming, Clark, Abbot F, Wordinger, Robert J and Liu, Yang (2012) Existence of the canonical Wnt signaling pathway in the human trabecular meshwork. Investigative ophthalmology & visual science, 53 (11). pp. 7043-7051. ISSN 0146-0404

Miller, Kimberly and Poolman, Robert (2012) Chemical Structure Searching: The Next Steps. Pharmaceutical Patent Analyst, 1 (3). pp. 269-274.

Moggs, Jonathan (2012) Correspondence with Hepatology Journal - Response to letter from Qi et al regarding the use of endogenous normalizers for serum microRNAs. Hepatology, 55 (5). pp. 1642-1643. ISSN 0270-9139

Moggs, Jonathan, Merz, Michael, Couttet, Philippe, Grenet, Olivier, Park, Kevin, Dear, James, Starkey-Lewis, Philip, Goldring, Chris and Antoine, Daniel (2012) Serum microRNA biomarkers for human drug-induced liver injury. Clinical Pharmacology and Therapeutics, 92 (3). pp. 291-293. ISSN 0009-9236

Moggs, Jonathan, Moulin, Pierre, Pognan, Francois, Brees, Dominique, Bouisset-Leonard, Michele, Busch, Steven, Cordier, Andre, Heard, David, Kammueller, Michael, Merz, Michael, Bouchard, Page and Chibout, Salah-Dine (2012) Investigative safety science as a competitive advantage for Pharma. Expert Opinion on Drug Metabolism and Toxicology, 8 (9). pp. 1071-1082. ISSN 1742-5255

Moggs, Jonathan, Terranova, Remi, Kammueller, Michael and Chibout, Salah-Dine (2012) Regulation of Allergic Responses to Chemicals: Possible Roles of Epigenetic Mechanisms. Toxicological Sciences, 130 (1). pp. 60-69. ISSN 1096-6080

Morawska, Marta Magdalena and Fendt, Markus (2012) The effects of muscimol and AMN082 injections into the medial prefrontal cortex on the expression and extinction of conditioned fear in mice. Journal of Experimental Biology. ISSN 0022-0949

Moser, Christian, lang, Sven A and Stoeltzing, Oliver (2012) Targeting HSP90 by the novel inhibitor NVP-AUY922 reduces growth and angiogenesis of pancreatic cancer. Anticancer research, 32 (7). pp. 2551-2561. ISSN 1791-7530

Mukherjee, Prasenjit and Martin, Eric (2012) Profile-QSAR and Surrogate AutoShim Protein-Family Modeling of Proteases. Journal of Chemical Information and Modeling. ISSN 1549-9596

Murdoch, Jenna and Junt, Tobias (2012) Peer across the barrier – new live transmissions from the intestinal mucosa. Journal of Leukocyte Biology. ISSN 0741-5400

Nagao, Kohjiro, Maeda, Minami, Manucat, Noyalyn B. and Ueda, Kazumitsu (2012) Cyclosporine A and PSC833 inhibits ABCA1 function via direct binding. Biochimica et Biophysica Acta, 1831 (2). pp. 398-406. ISSN 0006-3002

Namoto, Kenji (2012) Changing the practice of medicine – Strategy and Approach of Novartis’ Biomedical R&D. MEDCHEM NEWS, 22 (2). pp. 15-18.

Nigsch, Florian, Hutz, Janna, Cornett, Allen, Selinger, Douglas, Mcallister, Gregory, Bandyopadhyay, Somnath, Loureiro, Joseph and Jenkins, Jeremy (2012) Determination of minimal transcriptional signatures of compounds for target prediction. EURASIP Journal on Bioinformatics and Systems Biology, 1 (2). p. 2.

Nindl, Veronika, Ludewig, Burkhard and Di Padova, Franco E. (2012) Cooperation of Th1 and Th17 cells determines transition from autoimmune myocarditis to dilated cardiomyopathy. European Journal of Immunology.

Noble, Christian Guy and Shi, Pei-Yong (2012) Structural biology of dengue virus enzymes towards therapeutics. Antiviral Therapy, 96 (2). pp. 115-126. ISSN 0166-3542

Nyfeler, Beat, Chen, Yan, Li, Xiaoyan, Pinzon-Ortiz, Maria, Wang, Zuncai, Reddy, Anupama, Pradhan, Elina, Das, Rita, Lehar, Joseph, Schlegel, Robert, Finan, Peter, Cao, Alex, Murphy, Leon and Huang, Alan (2012) RAD001 enhances the potency of BEZ235 to inhibit mTOR signaling and tumor growth. PLOS ONE, 7 (11). e48548-e48548. ISSN 1932-6203

Nyfeler, Beat, Hoepfner, Dominic, Palestrant, Deborah, Kirby, Christina, Whitehead, Lewis, Yu, Robert, Deng, Gejing, Caughlan, Ruth, Woods, Angela, Jones, Adriana, Barnes, Whitney, Walker, John, Gaulis, Swann, Hauy, Ervan, Brachmann, Saskia, Krastel, Philipp, Studer, Christian, Riedl, Ralph, Estoppey, David, Aust, Thomas, Movva, Rao, Wang, Zuncai, Salcius, Michael, Michaud, Gregory, Mcallister, Gregory, Murphy, Leon, Tallarico, John, Wilson, Christopher, Myer, Vic and Dean, Charles (2012) The natural product argyrin B inhibits bacteria and eukaryotic cell growth by inhibition of elongation factor G1. PLoS ONE, 7 (9). pp. 1-12. ISSN 1932-6203

Orain, David, Carcache, David, Froestl, Wolfgang, Allgeier, Hans, Rasetti, Vittorio, Nozulak, Joachim, Mattes, Henri, Koller, Manuel, Soldermann, Nicolas, Floersheim, Philipp, Desrayaud, Sandrine, Kallen, Joerg, Ofner, Silvio, Lingenhoehl, Kurt and Urwyler, Stephan (2012) 6-Amino quinazolinedione sulfonamides as orally active competitive AMPA receptor antagonists. Bioorganic & Medicinal Chemistry Letters, 22 (2). pp. 996-999. ISSN 1464-3405

Orru, Alessandro, Fujani, Daniele, Cassina, Chiara and Cervo, Luigi (2012) Operant, oral alcoholic-beer self-administration in C57BL/6J mice: modulation by BHF177, a positive allosteric modulator of GABAB receptors. Psychopharmacology, 222 (4). pp. 685-700. ISSN 1432-2072

Pan, Guoyu, Boiselle, Carri and Wang, Jianling (2012) Assessment of biliary clearance in early drug discovery using sandwich-cultured hepatocytes model (SCH). Journal of Pharmaceutical Sciences. ISSN 0022-3549

Patel, Dhavalkumar, Kolbinger, Frank, Lee, David and Antoni, Christian (2012) Effect of IL-17A blockade with secukinumab in autoimmune diseases. Annals of the rheumatic diseases. ISSN 0003-4967

Perera, Natascha C., Kittel, Heike, Walter, Back, Kremmer, Elisabeth and Jenne, Dieter E. (2012) NSP4, a novel elastase-related protease with unique specificity is produced by human neutrophils. Proceedings of the National Academy of Sciences of the United States of America, 109 (16). pp. 6229-6234. ISSN 0027-8424

Peters, Haley L, Wang, Xiaojiang, Liu, Cuiling, Pan, Zenggang, Oulette, Micheal M, Hollingworth, Michael A, McDonald, Richard G and Solheim, Joyce C (2012) Relevance of Amyloid Precursor-like Protein e C-terminal Fragments in Pancreatic Cancer Cells. International Journnal of Oncology, 41 (4). pp. 1464-1474.

Pluess-Li, Ying, Bongiovanni, Sandrine, Oakeley, Edward J, Johnson, Keith J and Staedtler, Frank (2012) The virtuous technology cycle concept and its application in next-generation sequencing. Drug discovery today. ISSN 1878-5832

Pluess-Li, Ying, Bongiovanni, Sandrine, Oakeley, Edward James, Johnson, Keith and Staedtler, Frank (2012) The Virtuous Technology Cycle Concept and its Application to Next Generation Sequencing. Drug Discovery Today, 17 (17-18). pp. 1016-1022. ISSN 1359-6446

Porter, David, Shipman, Michael and Iacobini, Greg (2012) Chemo- and Enantioselective Rh-Catalyzed Hydrogenation of Methylene-1,2-diazetidines for the Synthesis of Vicinal Diamines. Chemical Communications, 48. pp. 9852-9854.

Press, Neil, Bond, Andrew, Holmes, Andrew, Roughley, Stephen, Smith, Catherine, Adams, Joseph, Hodges, Alastair, Turnbull, Michael, Saubern, Simon, Ryan, John and Newton, Annabella (2012) The total syntheses of the alkaloids (-)-histrionicotoxin 259A, 285C and 285E. Organic and Biomolecular Chemistry, 10 (45). pp. 8963-8974. ISSN 1477-0520

Press, Neil, Taylor, Roger, Fullerton, Joe, Tranter, Pamela, Mccarthy, Clive, Keller, Thomas, Arnold, Nicola, Brown, Lyndon, Cheung, Robert, Christie, Julie, Denholm, Alastair, Haberthuer, Sandra, Keenan, Mark, Hatto, Julia, Mercer, Mark, Oakman, Helen, Sahri, Helene, Trifilieff, Alexandre, Tuffnell, Andrew, Tweed, Morris, Wagner, Beatrix, Beer, David, Tyler, John and Fozard, John R. (2012) Solubility-Driven Optimisation of Phosphodiesterase-4 Inhibitors Leading to a Clinical Candidate. Journal of medicinal chemistry, 55 (17). pp. 7472-7479. ISSN 0022-2623

Press, Neil, baltus, christine B and Spencer, John (2012) Microwave Mediated Suzuki-Miyaura Couplings of S- and Ortho-Substituted Methylphenylboronic Acid Esters. Synlett, 23 (17). pp. 2477-2480. ISSN 0936-5214

Priya, Raghunathan, Biuković, Goran, Manimekalai, Malathy Sony Subramanian, Lim, Jack Wee, Rao, Srinivasa P.S. and Gruber, Gerhard (2012) Solution structure of subunit γ (γ1-204) of the Mycobacterium tuberculosis F-ATP synthase and the unique loop of γ165-178, representing a novel TB drug target. Journal of Bioenergetics and Bioengineering. ISSN 0145-479X

Pyne, Nigel J., Dubois, Gerald and Pyne, Susan (2012) ROLE OF SPHINGOSINE 1-PHOSPHATE AND LYSOPHOSPHATIDIC ACID IN FIBROSIS. Biochimica et Biophysica Acta. ISSN 0006-3002

Qi, Vicky, Chan, Ho Man, Atadja, Peter, Li, Ling, Chuai, Shannon, Lin, Ying, Gu, Justin, Zhang, Ji, Mi, Yuan, Zhang, Maya, Zhao, Kehao, Li, En, Teng, Lin, Zeng, Jue, Li, Min, Fan, Hong, Lin, Ying, Yan, Xiaoxia, Fang, Jialuo, Zhou, Tao, Feng, Grace, Yang, Teddy, Liu, Xianghui, Zhang, Regene, Li, Coben and Chen, Jason (2012) Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation. Proceedings of National Academy of Sciences of the United States of America, 109 (52). pp. 21360-21365. ISSN 1091-6490

Quancard, Jean, Bollbuck, Birgit, Janser, Philipp, Angst, Daniela, Berst, Frederic, Buehlmayer, Peter, Streiff, Markus, Beerli, Christian, Brinkmann, Volker, Guerini, Danilo, Smith, Paul, Seabrook, Tim, Traebert, Martin, Seuwen, Klaus, Hersperger, Rene, Bruns, Christian, Bassilana, Frederic and Bigaud, Marc (2012) A potent and selective S1P1 antagonist with efficacy in Experimental Autoimmune Encephalomyelitis. Chemistry & Biology, 19 (9). pp. 1142-1151. ISSN 1074-5521

Radimerski, Thomas, Andraos-Rey, Rita, Qian, Zhiyan, Bonenfant, Debora, Rubert, Joelle, Vangrevelinghe, Eric, Scheufler, Clemens, Marque, Fanny, Regnier, Catherine, De Pover, Alain, Ryckelynck, Hugues, Bhagwat, Neha, Koppikar, Priya, Goel, Aviva, Wyder, Lorenza, Tavares, Gisele, Baffert, Fabienne, Pissot Soldermann, Carole, Manley, Paul W., Gaul, Christoph, Voshol, Johannes, Levine, Ross L., Sellers, William and Hofmann, Francesco (2012) Modulation of activation-loop phosphorylation by JAK inhibitors is mode of action dependent. Cancer Discovery, 2 (6). pp. 512-523. ISSN 2159-8274

Rebello, Sam, Albrecht, Diego and Streefkerk, Hendrik (2012) Pharmacokinetics of Aliskiren in Patients with End-Stage Renal Disease undergoing Hemodialysis. Clinincal Pharmacokinetics, 51 (10). pp. 661-669. ISSN 0312-5963

Reilly, John, Wright, Penny, Larrow, Jay, Mann, Thierry, Twomey Iii, Joseph, Grondine, Melissa, Dodd, Stephanie, Capacci-Daniel, Christina, Bilotta, Jennifer, Shah, Lipa and Towler, Christopher (2012) Counterion Quantification for Discovery Chemistry and Preformulation Salt Screening. Journal of Liquid Chromatography and Related Technologies.

Renn, Oliver, Archer, Michael, Burkhardt, Carmen, Ginestet, Jeannette, Nielsen, Henning P. and Woodward, Joanna (2012) P-D-R Blueprint for an Ideal Corporate Information Center. Nature Drugs Reviews Drug Discovery.

Richie, Daryl, Thompson, Katherine, Ghannoum, Mahmoud and Ryder, Neil (2012) The Non-Specific effect of Efungumab on Amphotericin B Minimum Inhibitory Concentration. Antimicrobial Agents and Chemotherapy, 56 (7). pp. 3963-3964. ISSN 0066-4804

Richter, Wolfgang F, Bhansali, Suraj G and Morris, Marilyn E (2012) Mechanistic determinants of biotherapeutics absorption following SC administration. The AAPS journal, 14 (3). pp. 559-570. ISSN 1550-7416

Riddy, Darren, Stamp, Craig, Sykes, David, Charlton, Steven and Dowling, Mark (2012) Pharmacology of S1P3 ligands using the DiscoverRx PathHunterTM and Ca2+ release functional assays: Re-assessment of the pharmacology of VPC24191 and VPC23019. British Journal of Pharmacology.

Rohrer Bley, Carla, Furmanova, Polina, Orlowski, Katrin, Grosse, Nicole, Broggini-Tenzer, Angela, Pruschy, Martin and Mcsheehy, Paul M.J. (2012) Microtubule Stabilizing Agents and Ionizing Radiation: Multiple Exploitable Mechanisms for Combined Treatment. European Journal of Cancer. ISSN 0959-8049

Rondini, Simona, Micoli, Francesca, Lanzilao, Luisa, Pisoni, Ivan, Di Cioccio, Vito, Saul, Allan James and Martin, Laura Bartle (2012) Characterization of Citrobacter sp. line 328 as a source of Vi for a Vi-CRM197 glycoconjugate vaccine against Salmonella Typhi. The Journal of Infection in Developing Countries, 6 (11). pp. 763-773. ISSN 2036-6590

Roubenoff, Ronenn (2012) A roadmap for the development of effective pharmacotherapy targeted at the skeletal muscles in Chronic Obstructive Pulmonary Disease. Thorax.

Rueeger, Heinrich, Lueoend, Rainer Martin, Rogel, Olivier, Rondeau, Jean-Michel, Moebitz, Henrik, Machauer, Rainer, Jacobson, Laura, Staufenbiel, Matthias, Desrayaud, Sandrine and Neumann, Ulf (2012) Discovery of Cyclic Sulfone Hydroxyethylamines as Potent and Selective β-Site APP-Cleaving Enzyme 1 (BACE1) Inhibitors: Structure Based Design and In Vivo Reduction of Amyloid β-Peptides. Journal of Medicinal Chemistry, 55 (7). pp. 3364-3386. ISSN 0022-2623

Ruffner, Heinz, Sprunger, Joelle, Kheifets, Olga, Leighton-Davies, Juliet, Grosshans, Bianka, Salathe, Adrian, Zietzling, Svenja, Beck, Valerie, Therier, Maxime, Hao, Huaixiang, Shi, Xiaoying, Liu, Dong, Song, Qinhui, Xie, Yang, Clay, Ieuan, Hintzen, Gabriele, Tchorz, Jan, Bouchez, Laure, Michaud, Gregory, Finan, Peter, Myer, Vic, Bouwmeester, Antonius, Porter, Jeffrey, Hild, Marc, Bassilana, Frederic, Parker, Christian and Cong, Feng (2012) R-Spondin Potentiates Wnt/b-Catenin Signaling Through Orphan Receptors LGR4 and LGR5. PLoS One, 7 (7). e40976-e40976. ISSN 1932-6203

Ruiz, Pedro and Jarai, Gabor (2012) Discoidin domain receptor (DDR)2 mediates constitutive and collagen I-induced migration of primary human lung fibroblasts through collagen IV. Fibrogenesis and Tissue Repair, 5 (3). ISSN 1755-1536

Ruiz-Heiland, Gisela, Horn, Angelika, Zerr, Pawel, Hofstetter, Willy, Baum, Wolfgang, Stock, Michael, Distler, Jörg H, Nimmerjahn, Falk, Schett, Georg and Zwerina, Jochen (2012) Blockade of the Hedgehog Pathway inhibits Osteophyte Formation in Arthritis. Annals of Rheumatic Diseases, 71 (2). pp. 400-407. ISSN 0003-4967

Ruperto, Nicolino, Quartier, Pierre, Wulffraat, Nico, Woo, Patricia, Ravelli, Angelo, Mouy, Richard, Bader-Meunier, Brigitte, Vastert, Sebastiaan J, Noseda, Emanuele, D'Ambrosio, Daniele, Lecot, Jean, Chakraborty, Abhijit, Martini, Alberto and Chioato, Andrea (2012) A Phase II Study to Evaluate Dosing and Preliminary Safety and Efficacy of Canakinumab in Systemic Juvenile Idiopathic Arthritis With Active Systemic Features. Arthritis & Rheumatism, 64 (2). pp. 557-567. ISSN 0004-3591

Sasseville, Vito, Markovits, Judit, Mansfield, Keith, Mankowski, Joe, Tremblay, Claudia, Terio, Karen, Matz-Rensing, Kerstin, Gruber-Dujardin, Eva, Delaney, Martha, Schmidt, Lisa, Liu, David, Owston, Michael, Harbison, Carole, Shanmukhappa, Shiva, Miller, Andrew, Kaliyaperumal, Saravanan, Assaf, Basel, Kattenhorn, Lisa, Cummings-Macri, Sheila, Simmons, Heather, Baldessari, Audrey, Sharma, Prachi, Courtney, Cynthia, Bradley, Alys, Cline, Mark, Reindel, James and Hutto, David (2012) Meeting report: Spontaneous Lesions and Diseases in Wild, Captive-Bred, and Zoo-Housed Nonhuman Primates and in Nonhuman Primate Species Used for Drug Safety Studies. Veterinary Pathology, 49 (6). pp. 1057-1069. ISSN 0300-9858

Schaefer, Thorsten, Lorentz, Pascal, Zajonz, Alexandra, Bohnacker, Thomas, Wymann, Matthias and Schweighoffer, Tamas (2012) Luminal decoration of blood vessels by activated perivasal mast cells in allergic rhinitis. Allergy. ISSN 0105-4538

Schirle, Markus, Bantscheff, Marcus and Kuster, Bernhard (2012) Mass Spectrometry-based Proteomics in Pre-clinical Drug Discovery. Chemistry & Biology, 19 (1). pp. 72-84. ISSN 1074-5521

Schmid, Herbert, Giraldi Pecori, F, Pagliardini, L, Cassarino, F, Martucci, F, Castelli, L, Montanari, E and Cavagnini, F (2012) STIMULATORY EFFECT OF SOM230 ON HUMAN AND RAT ADRENAL CORTICOSTEROID SECRETION IN VITRO. General Comp Endocrinology.

Schuffenhauer, Ansgar (2012) Computational methods for scaffold hopping. Wiley Interdisciplinary Reviews: Computational Molecular Sciences, 2 (6). pp. 842-867. ISSN 1759-0884

Scudieri, Paolo, Caci, Emanuela, Bruno, Silvia, Ferrara, Loretta, Schiavon, Marco, Sondo, Elvira, Tomati, Valeria, Gianotti, Ambra, Zegarra-Moran, Olga, Pedemonte, Nicoletta, Rea, Federico and Galietta, Luis J V (2012) Association of TMEM16A protein expression with mucous cell metaplasia of human bronchial epithelial cells. Journal of Physiology.

Sechaud, Romain, Renard, Didier, Zhang Auberson, Lixin, De la Motte, Stephan, Drollmann, Anton Franz and Kaiser, Guenther (2012) The pharmacokinetics of multiple inhaled NVA237 doses in patients with chronic obstructive pulmonary disease (COPD). International Journal of Clinical Pharmacology and Therapeutics, 50 (2). pp. 118-128. ISSN 0946-1965

Sedhom, Mamdouh A.K., Pichery, Melanie, Murdoch, Jenna, Foligne, Benoit, Ortega, Nathalie, Normand, Sylvain, Mertz, Kirsten, Butler, Matt, Brault, Lea, Lefrancais, Emma, Fallon, Padraic G., Quesniaux, Valerie, Cathomas, Gieri, Junt, Tobias, Chamaillard, Mathias, Girard, Jean-Philippe and Ryffel, Bernhard (2012) Neutralization of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice. Gut. ISSN 0017-5749

Seljeset, Sandra and Siehler Wagner, Sandra (2012) Receptor-specific regulation of ERK1/2 activation by members of the ‘Free Fatty Acid Receptor’ family. Journal of Receptors & Signal Transduction, 32 (4). pp. 196-201. ISSN 1079-9893

Sessa, Cristiana, Shapiro, Geoffrey, Bhalla, Kapil, Britten, Carolyn, Jacks, Karen M, Mita, Monica, Papadimitrakopoulou, Vali, Pluard, Tim, Samuel, Thomas A., Akimov, Mikhail, Quadt, Cornelia, Fernandez-Ibarra, Cristina, Lu, Hong, Bailey, Stuart, Chica, Sandra and Banerji, Udai (2012) First-in-Human Phase I Dose-Escalation Study of the HSP90 Inhibitor AUY922 in Patients with Advanced Solid Tumors. Journal of Clinical Oncology.

Shepard, Allan, Pang, Iok-Hou, Conrow, Raymond, Rezwan, Mandana, Rutschmann, Katrin, Auerbach, Daniel, SriRamaratnam, Rohitha and Cornish, Virginia (2012) Identification of PDE6D as a molecular target of anecortave acetate by transcriptome-wide yeast three-hybrid analysis. ACS chemical biology. ISSN 1554-8929

Shimshek, Derya, Schweizer, Tatjana, Schmid, Peter and Van Der Putten, P. Herman (2012) Excess α-synuclein worsens disease in mice lacking ubiquitin carboxy-terminal hydrolase L1. Scientific Reports, 262 (2). ISSN 2045-2322

Shultz, Michael, Kirby, Christina, Stams, Travis, Chin, Donovan, Blank, Jutta, Charlat, Olga, Cheng, Hong, Cheung, Atwood, Feng, Yun, Fortin, Pascal, Hood, Tami, Tyagi, Viraj, Xu, Ming, Zhang, Bailin and Shao, Wenlin (2012) Discovery and SAR of [1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: Antagonists of the Wnt pathway that inhibit tankyrase 1&2. Journal of Medicinal Chemistry, 55 (3). pp. 1127-1136. ISSN 0022-2623

Singh, Mark D, King, Vicky, Baldwin, Helen, Jamieson, Thomas, Carballido, Jose, Rot, Antal and Graham, Gerard J (2012) Dynamic expression of the D6 chemokine scavenging receptor contributes to the pathogenesis of psoriasis. The American Journal of Pathology, 158 (4). pp. 1158-1164. ISSN 0002-9440

Smith, Philip, Siddharth, Jay, Pearson, Ruth, Holway, Nicholas, Shaxted, Mark, Butler, Matt, Clark, Natalie, Jamontt, Joanna, Watson, Robert, Sanmugalingam, Devika and Parkinson, Scott (2012) Host genetics and environmental factors regulate ecological succession of the colon tissue-associated microbiota. Plos One, 7 (1). e30273-e30273. ISSN 1932-6203

Smith, Thomas, Ho, Pei-I, Yue, Qing, Itkin, Zina, Macdougall, Damien, Paolucci, Michael, Hill, William and Auld, Douglas (2012) Comparison of Compound Administration Methods in Biochemical Assays: Effects on Apparent Compound Potency Using Either Assay Ready Compound Plates or Pin tool Delivered Compounds. Journal of Biomolecular Screening. ISSN 1087-0571

Stadlinger, Bernd, Korn, Paula, Tödtmann, Ninette, Eckelt, Uwe, Range, Ursula, Bürki, Alexander, Ferguson, Stephen, Kramer, Ina, Schnabelrauch, Matthias, Kneissel, Michaela and Schlottig, Falko (2012) Osseointegration of biochemically modified implants in an osteoporosis rodent model. European Cells and Materials, 25. pp. 326-340. ISSN 1473-2262

Stafa, Klodjan, Trancikova, Alzbeta, Webber, Philip, Glauser, Liliane, West, Andrew and Moore, Darren (2012) GTPase Activity and Neuronal Toxicity of Parkinson’s Disease–Associated LRRK2 Is Regulated by ArfGAP1. PLoS genetics, 8 (2). ISSN 1553-7404

Staniszewska, Magdalena, Gu, Xiaolin, Romano, Carmelo and Kazlauskas, Andrius (2012) A phage display-based approach to investigate abnormal neovessels of the retina. Investigative Ophthalmalogy & Visual Sciences, 53 (8). pp. 4371-4379. ISSN 0146-0404

Stauffer, Frederic, Furet, Pascal, Floersheimer, Andreas and Lang, Marc (2012) New aromatase inhibitors from the 3-pyridyl arylether and 1-aryl pyrrolo[2,3-c]pyridine series. Bioorganic & Medicinal Chemistry Letters, 22 (5). pp. 1860-1863. ISSN 0960-894X

Stonehouse, Jeff, Davies, Stephen, Lee, James, Roberts, Paul and Thomson, James (2012) Asymmetric synthesis of the homalium alkaloids (–)-(S,S)-homaline and (–)-(R,R)-hopromine. Journal of Organic Chemistry, 77 (16). pp. 7028-7045. ISSN 0022-3263

Stonehouse, Jeff, Lee, James, Roberts, Paul, Thomson, James and Davies, Stephen (2012) Asymmetric synthesis of (-)-(S,S)-homaline. Tetrahedron letters, 53 (9). pp. 1119-1121. ISSN 0040-4039

Stumm, Michael, Walker, Maja Ruth, Stork-Fux, Caroline, Hanoteau, Noelle, O'Reilly, Terence and Wagner, Urs (2012) Validation of a post-fixation tissue storage and transport medium preserving histopathology and molecular pathology analyses (total and phospho-activated proteins, and FISH). American Journal of Clinical Pathology, 137 (3). pp. 429-436. ISSN 0002-9173

Sverdlov, Oleksandr and Rosenberger, William F. (2012) Randomization in Clinical Trials: Can We Eliminate Bias? Clinical Investigation, 3 (1). pp. 37-47. ISSN 2041-6792

Tchorz, Jan, Suply, Thomas, Ksiazek, Iwona, Giachino, Claudio, Cloetta, Dimitri, Doll, Thierry, Danzer, Claus-Peter, Isken, Andrea, Lemaistre, Marianne, Taylor, Verdon, Bettler, Bernhard, Kinzel, Bernd and Mueller, Matthias (2012) A modified RMCE-compatible Rosa26 locus for the expression of transgenes from exogenous promoters. PLOS, 7 (1). E30011-E30011. ISSN 1932-6203

Tengxian, Liu, Traebert, Martin, Ju, Haisong, Suter, Willi, Donglin, Guo, Hoffmann, Peter, Peter R., Kowey and Gan-Xin, Yan (2012) Differentiating Electrophysiological Effects and Cardiac Safety of Drugs Based on the Electrocardiogram: A Blinded Validation. Circulation: Arrhythmia and Electrophysiology.

Terranova, Remi and Pond, Leslie (2012) Postdoctoral position to study genomic markers of carcinogenesis. Nature jobs.

Thaisz, Jill, Tsaih, Shirng Wern, Feng, Minjie, Philip, Vivek, Yanas, Liane, Sheehan, Susan, Xu, Lingfei, Paigen, Beverly, Chesler, Elissa, Churchill, Gary and Dipetrillo, Keith (2012) Genetic analysis of albuminuria in Collaborative Cross and multiple mouse intercross populations. American Journal of Physiology:Renal Physiology, 303 (7). F972-F981. ISSN 1931-857X

Thampi, Prajitha, Vittal Rao, Haripriya, Mitter, Sayak K, Cai, Jun, Mao, Haoyu, Li, Hong, Seo, Soojung S, Qi, Xiaoping, Lewin, Alfred S., Boulton, Michael E. and Romano, Carmelo (2012) The 5HT1a Receptor Agonist 8-OH DPAT Induces Protection from Lipofuscin Accumulation and Oxidative Stress in the Retinal Pigment Epithelium. PLoS One, 7 (4). e34468. ISSN 1932-6203

Thomson, John P, Lempiaeinen, Harri, Hackett, Jamie, Nestor, Colm E, Mueller, Arne, Bolognani, Federico, Oakeley, Edward James, Schuebeler, Dirk, Terranova, Remi, Rheinhardt, Diana, Moggs, Jonathan and Meehan, Richard R (2012) Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome. Genome Biology, 13 (10). R93. ISSN 1465-6906

Tichý, Michal, Pohl, Radek, Hocek, Michal, Shi, Pei-Yong, Yokokawa, Fumiaki, Xu, Haoying and Chen, Yen Liang (2012) Synthesis of 4,6-Disubstituted Pyrimido[4,5-b]indole Ribonucleosides through Regioselective Cross-coupling Reactions. Bioorganic & Medicinal Chemistry, 20 (20). pp. 6123-6133. ISSN 0968-0896

Ting, Lillian, Praestgaard, Jens, Grunenberg, Nicole, Komjathy, Steven, Leeds, Jennifer and Pertel, Peter (2012) A first-in-human, randomized, double-blind, placebo-controlled, time-lagged, single- and multiple-ascending oral dose study to assess the safety and tolerability of LFF571 in healthy volunteers. Antimicrobial Agents and Chemotherapy, 56 (11). p. 5946. ISSN 0066-4804

Tran, Que Tien, Williams, Sarah, Farid, Ramy, Erdemli, Gul and Pearlstein, Robert (2012) The Translocation Kinetics of Antibiotics Through Porin OmpC: Insights from Structure-Based Solvation Mapping using WaterMap. Proteins: Structure, Function, and Bioinformatics, 81 (2). pp. 291-299. ISSN 0887-3585

Trendelenburg, Anne-Ulrike, Meyer, Angelika, Jacobi, Carsten, Feige, Jerome and Glass, David (2012) TAK-1/p38/NFkappaB Signaling Inhibits Myoblast Differentiation By Increasing Levels of Activin A. Skeletal Muscle, 2 (1). p. 3. ISSN 2044-5040

Trifilieff, Alexandre and Fozard, John R. (2012) Sphingosine-1-phosphate induced airway hyperreactivity in rodents is mediated by the S1P3 receptor. Journal of Pharmacoloy and Experimenal Therapeutics. ISSN 0022-3565

Tse, Francis, White, Ronald, Evans, David, Hop, Cornelis, Moore, David, Prakash, Chandra and Surapaneni, Sekhar (2012) Radiolabelled mass-balance excretion and metabolism studies in laboratory animals: a commentary on why they are still necessary. Xenobiotica, 43 (2). pp. 219-225. ISSN 0049-8254]

Unterreiner, Vincent and Gabriel, Daniela (2012) When High Content Screening meets High Throughput. Drug Discovery World, Winter (4). pp. 19-25.

Vacchi-Suzzi, Caterina, Moggs, Jonathan, Pognan, Francois, Grenet, Olivier, Bauer, Yasmina, Gerrish, Kevin, Hamadeh, Hisham K., Letzkus, Martin, Paules, Richard, Lyon, Jonathan, Vidgeon-Hart, Martin, Berridge, Brian and Couttet, Philippe (2012) Perturbation of microRNAs in rat heart during chronic doxorubicin treatment. PLoS ONE, 7 (7). e40395. ISSN 1932-6203

Venable, John, Okach, Linda, Agarwalla, Sanjay and Brock, Ansgar (2012) Sub-Zero Temperature Chromatography for Reduced Back-Exchange and Improved Dynamic Range in Amide Hydrogen Deuterium Exchange Mass Spectrometry. Analytical Chemistry, 84 (21). pp. 9601-9608. ISSN 0003-2700

Villarreal, Beth (2012) Ki-67 immunohistochemical staining in rat tibia and femur growth plates. Journal of Histotechnology, 35 (4). pp. 171-174. ISSN 0147-8885

Vincent, Karen and Zurini, Mauro (2012) Current strategies in antibody engineering: Fc engineering and pH-dependent antigen binding, bispecific antibodies and antibody drug conjugates. Biotechnology Journal. ISSN 1860-6768

Vitry, Véronique, Del Rio Espinola, Alberto, Grenet, Olivier and Moggs, Jonathan (2012) Identification et conséquences des polymorphismes chez différentes populations de cynomolgus (“Macaca fascicularis”) Implication pour les études de Toxicologie. Master Thesis.

Vulpetti, Anna, Kalliokoski, Tuomo and Milletti, Francesca (2012) Chemogenomics in Drug Discovery: Methods Based on the Comparison of Binding Sites. Future Medicinal Chemistry, 4 (15). pp. 1971-1979. ISSN 1756-8919

Wallett, Jane, Baeschlin, Daniel, Hoehn, Frank and Engeloch, Caroline (2012) Speeding up drug discovery. Tecan Journal.

Warncke, Max, Calzascia, Thomas, Coulot, Michele, Balke, Nicole, Touil, Ratiba, Kolbinger, Frank and Heusser, Christoph (2012) Different adaptations of IgG effector function in human and non-human primates and implications for therapeutic antibody treatment. Journal of Immunology. ISSN 0022-1767

Weigert, Oliver, Bird, Liat, Kopp, Nadja, Lane A, Andrew, Chapuy, Bjoern, van Bodegom, Diederik, Toms, Angela, Marubayashi, Sachie, McKeown, Michael, Bradner E., James, Yoda, Akinori, Gaul, Christoph, Vangrevelinghe, Eric, Romanet, Vincent, Murakami, Masato, Ebel, Nicolas, De Pover, Alain, Regnier, Catherine, Hofmann, Francesco, eck, Michael, Ross L, Levine, Kung, Andrew, Baffert, Fabienne, Radimerski, Thomas and Weinstock M, David (2012) Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition. Journal of experimental medicine, 209 (2). pp. 259-273. ISSN 0022-1007

Westling, Lucas and Evans, Kate (2012) Purity and Mass Determination by LC/MS Using Solid Core HPLC Columns: a Column Lifetime Study. Thermo Scientific Application Note 20571.

Widler, Leo and Green, Jonathan (2012) The Chemistry of Bisphosphonates: From anti-scaling agents to potent therapeutics. Anti-cancer Agents in Medicinal Chemistry, 12 (2). pp. 95-101. ISSN PMID:21864230

Wiesmann, Christian, Leder, Lukas, Bernardi, Anna, Melkko, Samu, D'Arcy, Allan, Villard, Frederic, Erbel, Paulus, Hughes, Nicola, Freuler, Felix, Nikolay, Rainer, Bornancin, Frederic, Blank, Jutta, Alves, Juliano, Meyerhofer, Marco, Stettler, Thomas and Renatus, Martin (2012) Structural determinants of MALT1 protease activity. J Mol Biol, 419 (1-2). pp. 4-21. ISSN 0022-2836

Winblad, Bengt, Andreasen, Niels, Minthon, Lennart, Floesser, Annette, Imbert, Georges, Dumortier, Thomas, Maguire, Paul, blennow, Kaj, lundmark, joens, Staufenbiel, Matthias, orgogozo, jean-marc and Graf, Ana (2012) Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study. Lancet Neurology.

Wnuk, Monika, Hlushchuk, Ruslan, Tuffin, Gerald, Martiny-Baron, Georg, Holzer, Philipp, Imbach, Patricia, Djonov, Valentin and Huynh-Do, Uyen (2012) EphB4 forward signalling maintains podocyte homeostasis during Thy1.1 nephritis. Journal of American Society of Nephrology, 81 (12). pp. 1212-1225. ISSN 00852538

Wolf, Babette, Morgan, Hannah, Gani, Zaahira, Milicov, Adriana, Warncke, Max, Jones, Stewart, Krieg, Jennifer, Sims, Jennifer, Kiessling, Andrea and Brennan, Frank (2012) A whole blood in vitro cytokine release assay with aqueous monoclonal antibody presentation for the prediction of therapeutic protein induced cytokine release syndrome in humans. Cytokine. ISSN 1063-4666

Xie, Yang, Avello, Monika, Schirle, Markus, Whinnie, Elizabeth Mc, Feng, Yan, Bric-Furlong, Eva, Wilson, Christopher, Nathans, Robin, Zhang, Jing, Kirschner, Marc W, Huang, Shih-Min A and Cong, Feng (2012) Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 and protects it from ligase activity-dependent self-degradation. The Journal of biological chemistry. ISSN 1083-351X

Yeo, Wee Kiang, Nilar, Shahul Hameed and Go, Mei Lin (2012) Extraction and validation of substructure profiles for enriching compound libraries. Journal of Computer-Aided Molecular Design, 26 (10). pp. 1127-1141. ISSN 0920-654X

Yeo, Wee Kiang, Tan, Kheng Lin, Koh, Siang Boon, Khan, Matiullah, Nilar, Shahul and Go, Mei Lin (2012) Exploration and optimization of structure-activity relationships in drug design using the Taguchi Method. ChemMedChem.

Yi, Tangsheng, Wang, Xiaoming, Kelly, Lisa M., An, Jinping, Xu, Ying, Sailer, Andreas, Gustafsson, Jan-Ake, Russell, David W. and Cyster, Jason G. (2012) Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses. Immunity, 37 (3). pp. 535-548. ISSN 1074-7613

Yusuff, Naeem, Dore, Michael, Joud, Carol, Visser, Michael, Springer, Clayton, Xie, Xiaoling, Herlihy, Kara, Porter, Dale and Toure, Bakary-Barry (2012) Lipophilic Isosteres of a pi-pi Stacking Interaction: Design of New Inhibitors of the Bcl-2-Bak Protein-Protein Interaction. ACS medicinal chemistry letters, 3 (7). pp. 579-583. ISSN 1948-5875

Zeng, Fanning, Wind, Nicholas, Mcclengahan, Conor, Verkuijl, Martin, Watson, Robert and Nash, Mark (2012) GPR39 is coupled to TMEM16a in intestinal fibroblast-like cells. PLoS ONE, 7 (10). e47686.

Zhang, Lin, Orban, Martin, Lorenz, Michael, Barocke, Verena, Braun, Daniel, Urtz, Nicole, Schulz, Christian, Proia, Richard L., von Bruehl, Marie-Luise, Graf, Thomas, Bolz, Steffen-Sebastian, Montanez, Eloi, Prinz, Marco, Müller, Alexandra, Billich, Andreas, Sixt, Michael, von Andrian, Ulrich H., Junt, Tobias, Massberg, Steffen, Tirniceriu, Anca, Gaertner, Florian, von Baumgarten, Louisa and Faessler, Reinhard (2012) A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis. Journal of Experimental Medicine, 209 (12). pp. 2165-2181. ISSN 0022-1007

Zhang, Long, Zhou, Fangfang, Mickanin, Craig, Sheppard, Kelly-Ann, Porter, Jeffrey, Lu, Chris and ten Dijke, Peter (2012) USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGFbeta type I receptor. Nature Cell Biology, 14 (7). pp. 717-726. ISSN 1465-7392

Zhang, Weidong, Korstanje, Ron, Thaisz, Jill, Staedtler, Frank, Hartmann, Nicole, Xu, Lingfei, Feng, Minjie, Yanas, Liane, Yang, Hyuna, Valdar, William, Churchill, Gary and Dipetrillo, Keith (2012) Genome-wide Association Mapping of Quantitative Traits in Outbred Mice. G3: Gene/Genomes/Genetics, 2 (2). pp. 167-174. ISSN 2160-1836

Zielen, S, Lieb, A, De La Motte, D, Wagner, F, De Monchy, J, Fuhr, R, Munzu, Clara, Koehne-Voss, Stephan, Riviere, G, Kaiser, Guenther and Erpenbeck, Veit (2012) Omalizumab protects against allergen-induced bronchoconstriction in allergic (IgE-mediated) asthma. International archives of allergy and immunology, 160 (1). pp. 102-110. ISSN 1018-2438

Zou, Bin, Yap, Peiling, Sonntag, Sebastian, Leong, Seh Yong, Yeung, Bryan King Sing and Keller, Thomas (2012) Mechanistic Study of the Spiroindolones: A New Class of Antimalarials. Molecules, 17 (9). pp. 10131-10141. ISSN 1420-3049

Zou, Gang, Kukkaro, Petra, Lok, Shee Mei, Ng, Jowin, Tan, Grace, Alonso, Sylvie, Macary, Paul and Shi, Pei-Yong (2012) Resistance analysis of an antibody that selectively inhibits dengue virus serotype-1. Antiviral Reseaech, 95 (3). pp. 216-223. ISSN 0166-3542

Zumsteg, Adrian, Caviezel, Christoph, Pisarsky, Laura, Strittmatter, Karin, Garcia-Echeverria, Carlos, Hofmann, Francesco and Christofori, Gerhard (2012) Repression of malignant tumor progression upon pharmacologic IGF1R blockade in a mouse model of insulinoma. Molecular Cancer Research, 10 (6). pp. 800-809. ISSN 1557-3125

Zumsteg, Adrian, Strittmatter, Karin, Caviezel, Christoph, Garcia-Echeverria, Carlos, Hofmann, Francesco and Christofori, Gerhard (2012) Repression of malignant tumor progression upon pharmacological IGF-1R blockade in a mouse model of insulinoma. Molecular Cancer Research, 10 (6). pp. 800-809. ISSN 1541-7786

infante, Jeffrey R, Dees, E Claire, Olszanski, Anthony J, Dhuria, Shyeilla, Sen, Suman, Cameron, John and Cohen, Roger B (2012) A Phase I dose-escalation study of LCL161, an oral IAP inhibitor, in patients with advanced solid tumors. Journal of Clinical Oncology.

Book Section

Ebersbach, Hilmar, Zhang, Chonghui and Proetzel, Gabriele (2012) Antigen Presentation for the Generation of Binding Molecules. In: Methods in Molecular Biology: Antibody Protocols and Methods. Humana Press. ISBN 978-1-58829-092-2