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LTB4 driven neutrophil recruitment to the skin is essential for allergic skin inflammation

Lee, David and Oyoshi, Michiko (2012) LTB4 driven neutrophil recruitment to the skin is essential for allergic skin inflammation. Immunity, 37 (4). pp. 747-758. ISSN 1074-7613


Scratching triggers skin flares in atopic dermatitis (AD), a disease marked by itching
and allergic skin inflammation. Scratching of human skin, and tape stripping of mouse skin,
caused neutrophil influx. This influx in mice was largely dependent on the generation of
leukotriene B4 (LTB4) by neutrophils and their expression of LTB4 receptor BLT1. Allergic skin
inflammation in response to epicutaneous (EC) application of ovalbumin to tape-stripped skin
was severely impaired in BLT1-/- mice, and required the expression of BLT1 on both T cells
and non-T cells. Co-transfer of WT neutrophils, but not neutrophils deficient in BLT1 or the
LTB4 synthesizing enzyme LTA4H, restored the ability of WT CD4+ effector T cells to transfer
allergic skin inflammation to BLT1-/- recipients. Pharmacologic blockade of LTB4 synthesis
inhibited allergic skin inflammation elicited by cutaneous antigen challenge in previously ECsensitized
mice. Blockade of the LTB4-BLT1 axis might provide a potential therapy for AD

Item Type: Article
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Additional Information: Note--this work was performed exclusively at my previous lab at Harvard/BWH **I have asked they update my affiliation to include Novartis Can archive post-print (ie final draft post-refereeing) or publisher's version/PDF
Keywords: atopic dermatitis neutrophils LTB4
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Date Deposited: 13 Oct 2015 13:14
Last Modified: 13 Oct 2015 13:14


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