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If we don’t look we won’t see: Intravital Multiphoton Imaging of Breast Cancer Metastasis

Bonapace, Laura and Wyckoff, Jeffery and Oertner, Thomas and van Rheenen, Jacco and Junt, Tobias and Bentires-Alj, Mohamed (2012) If we don’t look we won’t see: Intravital Multiphoton Imaging of Breast Cancer Metastasis. Journal of Mammary gland Biology and Neoplasia, 17 (1). ISSN 1083-3021

Abstract

A fundamental hallmark of cancer is its progression to metastases. Breast cancer metastatic growth in the lungs, bones, liver and/or brain causes fatal complications. Unfortunately, the cellular and biochemical mechanisms governing this multi-step process remain ill-defined. The recent application of intravital multiphoton microscopy (IV-MPM) to image fluorescently labeled cells in mouse models of cancer allowed a dynamic observation of the metastatic process at the subcellular level. In this article, we discuss the use of IV-MPM for studying breast cancer metastasis and describe a versatile multiphoton microscope for imaging tumor-stroma interactions.

Item Type: Article
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Date Deposited: 13 Oct 2015 13:14
Last Modified: 13 Oct 2015 13:14
URI: https://oak.novartis.com/id/eprint/7131

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