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Asymmetric synthesis of (-)-(S,S)-homaline

Stonehouse, Jeff and Lee, James and Roberts, Paul and Thomson, James and Davies, Stephen (2012) Asymmetric synthesis of (-)-(S,S)-homaline. Tetrahedron letters, 53 (9). pp. 1119-1121. ISSN 0040-4039

Abstract

The asymmetric synthesis of (–)-(S,S)-homaline was achieved in 8 steps and 18% overall yield from commercially available starting materials, using the diastereoselective conjugate addition of lithium (R)-N-(3-chloropropyl)-N-(α-methyl-p-methoxybenzyl)amide to methyl cinnamate as the key step.

Item Type: Article
Additional Information: Generated as part of the EPSRC-CASE collaboration between Novartis and the University of Oxford
Date Deposited: 13 Oct 2015 13:14
Last Modified: 13 Oct 2015 13:14
URI: https://oak.novartis.com/id/eprint/6410

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