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Serum microRNA biomarkers for human drug-induced liver injury

Moggs, Jonathan, Merz, Michael, Couttet, Philippe, Grenet, Olivier, Park, Kevin, Dear, James, Starkey-Lewis, Philip, Goldring, Chris and Antoine, Daniel (2012) Serum microRNA biomarkers for human drug-induced liver injury. Clinical Pharmacology and Therapeutics, 92 (3). pp. 291-293. ISSN 0009-9236


New biomarkers of liver injury are required in the clinic and in preclinical pharmaceutical evaluation. Liver-enriched microRNAs are promising serum biomarkers of acetaminophen-induced acute liver injury in mice. The utility of circulating microRNAs as potential markers of human acute drug-induced liver injury (DILI) is discussed in the context of correlation with existing biomarkers of liver injury and patient outcomes, mechanisms of cellular microRNA release and their potential role in functional adaption to injury.

Item Type: Article
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Additional Information: No Novartis compounds or projects are discussed. All primary data have been previously OAK approved and disseminated in the public domain.
Keywords: DILI safety biomarker microRNA miR-122
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Date Deposited: 13 Oct 2015 13:14
Last Modified: 13 Oct 2015 13:14


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