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Bodenlenz, Manfred, Höfferer, Christian, Magnes, Christoph, Schaller, R., Schaupp, L., Feichtner, F., Ratzer, Maria, Pickl, Karin, Sinner, Frank, Wutte, A., Korsatko, S., Köhler, G., Legat, F.J., Benfeldt, E., Wright, Andrew, Neddermann, Daniel, Jung, Thomas and Pieber, Thomas R. (2012) Dermal PK/PD of a lipophilic topical drug in psoriatic patients by continuous intradermal membrane-free sampling. European Journal of Pharmaceutics and Biopharmaceutics, 81 (3). pp. 635-641. ISSN 0939-6411

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Boos, Julien, Kirk, David William, Dattler, Andre, Piccolotto, Mari-Luz, Zuercher, Werner, Gfeller, Sandro, Neuner, Philippe, Christensen, Jesper, Wishart, William L., Beverly, Michael, Von Arx, Fabian, Litherland, Karine, Van De Kerkhof, Esther, Swart, Pieter Jacob, Faller, Thomas, Beyerbach, Armin, Morrissey, David, Hunziker, Juerg and Beuvink, Iwan (2012) Whole-body scanning PCR; a sensitive method to study the biodistribution of mRNAs, noncoding RNAs and therapeutic oligonucleotides. Nucleic Acids Research, Nuclei. ISSN 0305-1048

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Britschgi, Adrian, Andraos-Rey, Rita, Brinkhaus, Heike, Klebba, Ina, Romanet, Vincent, Mueller, Urs, Murakami, Masato, Radimerski, Thomas and Bentires-Alj, Mohamed (2012) JAK2/STAT5 Inhibition Circumvents Resistance to PI3K/mTOR Blockade: A Rationale for Cotargeting These Pathways in Metastatic Breast Cancer. Cancer Cell, 22 (6). pp. 796-811. ISSN 1535-6108

Brockhoff, Marielle, Hau, Jean-Christophe, Fontana, Patrizia, Zimmermann, Catherine, De Pover, Alain, Erdmann, Dirk and Chene, Patrick (2012) Factors influencing the inhibition of protein kinases. Journal of Enzyme Inhibition and Medicinal Chemistry, 27 (2). pp. 194-200. ISSN 1475-6366

Broome, Michelle and Villarreal, Beth (2012) Differential Staining of Mast Cells with Toluidine Blue. Journal of Histotechnology, 35 (1). pp. 27-30. ISSN 0147-8885

Browne, Brigid / C, Eustace, Alex / J, Kennedy, Susan, O'Brien, Neil / A, Pedersen, Kasper, Larkin, Annemarie, Ballot, Jo, Mahgoub, Thamir, Sclafani, Francesco, Madden, Stephen, Kennedy, John, Duffy, Michael / J, Crown, John and O'Donovan, Norma (2012) Evaluation of IGF1R and phosphorylated IGF1R as targets in HER2-positive breast cancer cell lines and tumours. Breast Cancer Res Treat, 136 (3). pp. 717-727. ISSN 0167-6806

Bruce, Ian, Akhlaq, Mohammed, Bloomfield, Graham, Budd, Emma, Cox, Brian, Finan, Peter, Gedeck, Peter, Hayler, Judy, Head, Denise, Kirman, Louise, Leblanc, Catherine, Le Grand, Darren, Owen, Charles, Oza, Mrinalini, Sviridenko, Lilya, Whitehead, Lewis, Keller, Thomas, McCarthy, Clive, O'Connor, Desmond, Pilgrim, Gaynor, Press, Nicola and Cuenoud, Bernard (2012) Development of isoform selective PI 3-Kinase inhibitors as pharmacological tools for elucidating the PI3K pathway. Bioorganic & Medicinal Chemistry Letters, 22 (17). pp. 5445-5450. ISSN 0960-894X

Busch, Steven, Hoffmann, Peter, Foley, James, Sahota, Pritam, Johnson, Robert, Kothny, Wolfgang and Meyer, Franck (2012) Studies in rodents with the DPP-4 inhibitor vildagliptin to evaluate possible drug-induced pancreatic histological changes that are predictive of pancreatitis and cancer development in man. Diabetes, Obesity and Metabolism.

Butler, Matt, Sanmugalingam, Devika, Burton, Victoria, Wilson, Tammy, Pearson, Ruth, Watson, Robert, Smith, Philip and Parkinson, Scott James (2012) IMPAIRMENT OF ADENOSINE A3 RECEPTOR ACTIVITY DISRUPTS NEUTROPHIL MIGRATORY CAPACITY AND IMPACTS INNATE IMMUNE FUNCTION IN VIVO. European Journal of Immunology. ISSN 0014-2980

Caffery, Barbary, Joyce, Elizabeth, Miriam, Heynen, Ritter Iii, Robert, Lyndon, Jones and Michelle, Senchyna (2012) Quantification of Conjunctival TNFα mRNA Expression in Sub Populations of Human Aqueous Deficient Dry Eye. Molecular Vision.

Camenisch, Gian P. and Umehara, Ken-Ichi (2012) Predicting human hepatic clearance from in vitro drug metabolism and transport data: A scientific and pharmaceutical perspective for assessing drug-drug interactions. Biopharmaceutics and Drug Disposition. ISSN 0142-2782

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Chakraborty, Abhijit, Tannenbaum, Stacey, Rordorf, Christiane, Lowe, Phil, Floch, David, Gram, Hermann and Roy, Sandip (2012) Overview of the Pharmacokinetic and Pharmacodynamic Properties of Canakinumab, a Human anti-IL-1β Monoclonal Antibody. Clinical Pharmacokinetics, 51 (6). e1-e18. ISSN 0312-5963

Chapelat, Julien, Berst, Frederic, Marzinzik, Andreas, Moebitz, Henrik, Drueckes, Peter, Trappe, Joerg, Fabbro, Doriano and Seebach, Dieter (2012) The Substrate-Activity-Screening methodology applied to receptor tyrosine kinases: A proof-of-concept study. European Journal of Medicinal Chemistry. ISSN 0223-5234

Chatterjee, Arnab and Yeung, Bryan (2012) Back to the future: Lessons learned in modern target-based and whole-cell lead optimization of antimalarials. Current topics in Medicinal Chemistry.

Chioato, Andrea, Noseda, Emanuele, Stevens, Michael, Gaitatzis, Nikolaos, Kleinschmidt, Annett and Picaud, Henri (2012) Treatment with the IL-17 blocking antibody secukinumab (AIN457) does not interfere with the efficacy of Influenza and Meningococcal vaccination in healthy subjects. Results of an open-label, parallel group, randomized, single-center study. Clinical and Vaccine Immunology (CVI), 19 (10). pp. 1597-1602. ISSN 1556-6811

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Damiano, Jason, Rendahl, Katherine, Karim, Christopher, Embry, Millicent, Ghoddusi, Majid, Holash, Jocelyn, Fanidi, Abdallah, Abrams, Tinya and Abraham, Judith (2012) Neutralization of Prolactin Receptor Function by Monoclonal Antibody LFA102, A Novel Potential Therapeutic for the Treatment of Breast Cancer. Molecular Cancer Therapeutics, 12 (3). pp. 295-305. ISSN 1535-7163

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Davies, Nicholas G. M., Browne, Helen, Davis, Ben, Foloppe, Nicolas, Geoffrey, Stephanie, Gibbons, Ben, Hart, Terry, Drysdale, Martin J., Mansell, Howard, Massey, Andrew, Matassova, Natalia, Moore, Jonathan D, Murray, James, Pratt, Robert, Ray, Stuart, Roughley, Stephen D., Jensen, Michael Rugaard, Schoepfer, Joseph, Scriven, Kirsten, Simmonite, Heather, Stokes, Stephen, Surgenor, Alan, Webb, Paul, Wright, Lisa and Brough, Paul (2012) Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization. Bioorganic & Medicinal Chemistry, 20 (22). pp. 67770-67789. ISSN 0968-0896

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Devine, Patrick, Perreault, Sally and Luderer, Ulrike (2012) Roles of reactive oxygen species and antioxidants in ovarian toxicity. Biology of Reproduction, 86 (2). p. 27. ISSN 0006-3363

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Dobi, Alice, Sartori, Simone, Busti, Daniela, Flor, Peter, Van Der Putten, P. Herman, Singewald, Nicolas, Shigemoto, Ryuichi and Ferraguti, Francesco (2012) Neural substrates for the opposing effects of distinct presynaptic group III metabotropic glutamate receptors on extinction of contextual fear conditioning in mice. Neuropharmacology. pp. 1-16. ISSN 0028-3908

Dobo, Krista, Green, Nigel, et al, et al and Glowienke, Susanne (2012) In Silico Methods Combined with Expert Knowledge Rule out Mutagenic Potential of Pharmaceutical Impurities: An Industry Survey. Regulatory Toxicology and Pharmacology.

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Dunne, Christine, Bushee, Jennifer and Argikar, Upendra (2012) Metabolism of bromopride in mouse, rat, rabbit, dog, monkey, and human hepatocytes. Drug Metabolism and Pharmacokinetics.

Ebersbach, Hilmar, Zhang, Chonghui and Proetzel, Gabriele (2012) Antigen Presentation for the Generation of Binding Molecules. In: Methods in Molecular Biology: Antibody Protocols and Methods. Humana Press. ISBN 978-1-58829-092-2

Ebersbach, Hilmar and Geisse, Sabine (2012) Antigen generation and display in therapeutic antibody drug discovery – a neglected but critical player. Biotechnology Journal. ISSN 1860-6768

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Elnakat Thomas, Hala, Mercer, Carol A., Carnevalli, Larissa S., Park, Jongsun, Andersen, Jesper B., Conner, Elizabeth A., Tanaka, Kazuhiro, Matsutani, Tomoo, Iwanami, Akio, Aronow, Bruce J., Liu, Manway, Thorgeisson, Snorri S., Mischel, Paul S., Thomas, George and Kozma, Sara C. (2012) Dual Inhibition of mTOR in hepatocellular carcinoma induces tumor regression, return to normal liver gene expression and autophagy. Science Translational Medicine, 4 (139). ra84. ISSN 1946-6234

Emotte, Corinne, Deglave, Fanny, Picard, Franck, Chaturvedi, Animesh, Majumdar, Tapan, Agarwal, Ashish and Kretz, Olivier (2012) Validation of on-line solid- phase extraction coupled with high-performance liquid chromatography–mass spectrometry assays for the determination of indacaterol, a potent β-adrenoceptor agonist in human serum. Journal of chromatography B, 895/89. pp. 1-9. ISSN 1570-0232

Endacott, John and Poolman, Robert (2012) Looking for Insights – Quality Control Initiatives for Enhancing Patent Searches. World Patent Information, 35 (1). pp. 3-7.

Erdemli, Gul, Kim, Albert, Ju, Haisong, Springer, Clayton, Penland, Robert and Hoffmann, Peter (2012) Cardiac Safety Implications of hNav1.5 Blockade and a Framework for Pre-Clinical Evaluation. Frontiers in Pharmaceutical Medicine and Outcomes Research.

Erdemli, Gul, Priest, Birgit and Wickenden, Alan (2012) Ion Channel Drug Discovery: Challenges and Future Directions. Future Medicinal Chemistry.

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Ertl, Peter and Lewis, Richard (2012) IADE - A System for Intelligent Automatic Design of Bioisosteric Analogs. Journal of Computer-Aided Molecular Design, 26 (11). pp. 1207-1215. ISSN 0920-654X

Ertl, Peter and Rohde, Bernhard (2012) The Molecule Cloud - compact visualization of large collections of molecules. Journal of Cheminformatics, 4 (1). p. 12. ISSN 1758-2946

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Farmer, I, Pancholi, S, Thornhill, AM, Ghazoui, Z, Evans, Dean Brent, Lane, Heidi A, Johnston, SR, Dowsett, Mitch, Martin, Lesley-Ann and Imark, Esther (2012) Effectiveness and molecular interactions of the clinically active mTORC1 inhibitor everolimus in combination with tamoxifen or letrozole in vitro and in vivo. Breast Cancer Research, 14 (5). ISSN 1465-5411

Feuerbach, Dominik, Arias, Hugo R, Targowska-Duda, Katarzyna M, Aggarwal, Shaili, Lapinsky, Daniel J and Jozwiak, Krzysztof (2012) Structural and functional interaction of (+)-2-(N-tert-butylamino)-3’-iodo-4’-azidopropiophenone, a photoactivatable bupropion derivative, with nicotinic acetylcholine receptors. Biochemistry.

Fiez-Vandal, Cedric, Leder, Lukas, Freuler, Felix, Sykes, David, Charlton, Steven, Siehler Wagner, Sandra, Schopfer, Ulrich and Duckely, Myriam (2012) HDL-like discs for assaying membrane proteins in drug discovery. Biophysical Chemistry, 165/16. pp. 56-61. ISSN 0301-4622

Fischer, Simon, Charara, Nadine, Gerber, Andrea, Woelfel, Jens, Schiedner, Gudrun, Voedisch, Bernd and Geisse, Sabine (2012) Transient recombinant protein expression in a human amniocyte cell line: the CAP-T cell system. Biotechnology & Bioengineering, 109 (9). pp. 2250-2261. ISSN 0006-3592

Flarakos, Jimmy, Ting, Lillian, Du, Yancy, Stein, Daniel, Reynolds, Christine, Patel, Manish, Roy, Sandip and Mangold, James (2012) Disposition and metabolism of [14C]PTZ601 in healthy volunteers. Xenobiotica. ISSN 0049-8254

Fredenhagen, Andreas, Kittelmann, Matthias, Oberer, Lukas, Kuhn, Anton, Kuehnoel, Juergen, Delemonte, Thierry, Aichholz, Reiner, Wang, Ping, Atadja, Peter and Shultz, Michael (2012) Biocatalytic synthesis and structure elucidation of cyclized metabolites of the deacetylase inhibitor Panobinostat (LBH589). Drug Metabolism and Disposition, 40 (5). pp. 1041-1050. ISSN 0090-9556

Frieauff, Wilfried, Martus, Hans-Joerg, Suter, Willi and Elhajouji, Azeddine (2012) Automatic Analysis of the Micronucleus Test in Primary Human Lymphocytes Using Image Analysis. Mutagenesis.

Fu, Shijun, Fei, Qi, Jiang, Hua, Chuai, Shannon, Song, Shi, Xiong, Wen, Jiang, Lei, Lu, Chris, Atadja, Peter, Li, En and Shou, Jianyong (2012) Involvement of histone acetylation of Sox17 and Foxa2 promoters during mouse definitive endoderm differentiation revealed by microRNA profiling. PLOS One.

Furet, Pascal, Chene, Patrick, De Pover, Alain, Valat, Therese-Marie, Hergovich Lisztwan, Joanna, Kallen, Joerg and Masuya, Keiichi (2012) The Central Valine Concept Provides an Entry in a New Class of Non Peptide Inhibitors of the P53-MDM2 Interaction. Bioorganic & Medicinal Chemistry Letters.

Gamsjaeger, Sonja, Hofstetter, B, Zwettler, Elisabeth, Recker, Robert, Gasser, Juerg Andreas, Eriksen, Erik Fink, Klaushofer, Klaus and Paschalis, Eleftherios P (2012) Effects of Three Years Treatment With Once-Yearly Zoledronic Acid on the Kinetics of Bone Matrix Maturation in Osteoporotic Patients. Osteoporosis International.

Gao, Zhenhai, Menezes, Daniel, Machajewski, Timothy, Abrams, Tinya, Jensen, Michael Rugaard, Yu, Guoying, Stuart, Darrin, Duhl, David, Pryer, Nancy and Sellers, William (2012) THE NOVEL ORAL HSP90 INHIBITOR NVP-HSP990 EXHIBITS POTENT AND BROAD-SPECTRUM ANTI-TUMOR ACTIVITIES IN VITRO AND IN VIVO. Molecular Cancer Therapeutics. ISSN 1535-7163

Garofalo, Cecilia, Mancarella, Caterina, Grilli, Andrea, Manara, Maria Cristina, Astolfi, Annalisa, Marino, Maria Teresa, Conte, Alexia, Sigismund, Sara, Carè, Alessandra, Belfiore, Antonino, Picci, Piero and Scotlandi, Katia (2012) Identification of both common and distinctive mechanisms of resistance to different anti-IGF-1R agents in Ewing’s sarcoma. Molecular Endocrinology, 26 (9). pp. 1603-1616. ISSN 0888-8809

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Villarreal, Beth (2012) Ki-67 immunohistochemical staining in rat tibia and femur growth plates. Journal of Histotechnology, 35 (4). pp. 171-174. ISSN 0147-8885

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Westling, Lucas and Evans, Kate (2012) Purity and Mass Determination by LC/MS Using Solid Core HPLC Columns: a Column Lifetime Study. Thermo Scientific Application Note 20571.

Widler, Leo and Green, Jonathan (2012) The Chemistry of Bisphosphonates: From anti-scaling agents to potent therapeutics. Anti-cancer Agents in Medicinal Chemistry, 12 (2). pp. 95-101. ISSN PMID:21864230

Wiesmann, Christian, Leder, Lukas, Bernardi, Anna, Melkko, Samu, D'Arcy, Allan, Villard, Frederic, Erbel, Paulus, Hughes, Nicola, Freuler, Felix, Nikolay, Rainer, Bornancin, Frederic, Blank, Jutta, Alves, Juliano, Meyerhofer, Marco, Stettler, Thomas and Renatus, Martin (2012) Structural determinants of MALT1 protease activity. J Mol Biol, 419 (1-2). pp. 4-21. ISSN 0022-2836

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Wnuk, Monika, Hlushchuk, Ruslan, Tuffin, Gerald, Martiny-Baron, Georg, Holzer, Philipp, Imbach, Patricia, Djonov, Valentin and Huynh-Do, Uyen (2012) EphB4 forward signalling maintains podocyte homeostasis during Thy1.1 nephritis. Journal of American Society of Nephrology, 81 (12). pp. 1212-1225. ISSN 00852538

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Xie, Yang, Avello, Monika, Schirle, Markus, Whinnie, Elizabeth Mc, Feng, Yan, Bric-Furlong, Eva, Wilson, Christopher, Nathans, Robin, Zhang, Jing, Kirschner, Marc W, Huang, Shih-Min A and Cong, Feng (2012) Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 and protects it from ligase activity-dependent self-degradation. The Journal of biological chemistry. ISSN 1083-351X

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Yi, Tangsheng, Wang, Xiaoming, Kelly, Lisa M., An, Jinping, Xu, Ying, Sailer, Andreas, Gustafsson, Jan-Ake, Russell, David W. and Cyster, Jason G. (2012) Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses. Immunity, 37 (3). pp. 535-548. ISSN 1074-7613

Yusuff, Naeem, Dore, Michael, Joud, Carol, Visser, Michael, Springer, Clayton, Xie, Xiaoling, Herlihy, Kara, Porter, Dale and Toure, Bakary-Barry (2012) Lipophilic Isosteres of a pi-pi Stacking Interaction: Design of New Inhibitors of the Bcl-2-Bak Protein-Protein Interaction. ACS medicinal chemistry letters, 3 (7). pp. 579-583. ISSN 1948-5875

Zeng, Fanning, Wind, Nicholas, Mcclengahan, Conor, Verkuijl, Martin, Watson, Robert and Nash, Mark (2012) GPR39 is coupled to TMEM16a in intestinal fibroblast-like cells. PLoS ONE, 7 (10). e47686.

Zhang, Lin, Orban, Martin, Lorenz, Michael, Barocke, Verena, Braun, Daniel, Urtz, Nicole, Schulz, Christian, Proia, Richard L., von Bruehl, Marie-Luise, Graf, Thomas, Bolz, Steffen-Sebastian, Montanez, Eloi, Prinz, Marco, Müller, Alexandra, Billich, Andreas, Sixt, Michael, von Andrian, Ulrich H., Junt, Tobias, Massberg, Steffen, Tirniceriu, Anca, Gaertner, Florian, von Baumgarten, Louisa and Faessler, Reinhard (2012) A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis. Journal of Experimental Medicine, 209 (12). pp. 2165-2181. ISSN 0022-1007

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Zhang, Weidong, Korstanje, Ron, Thaisz, Jill, Staedtler, Frank, Hartmann, Nicole, Xu, Lingfei, Feng, Minjie, Yanas, Liane, Yang, Hyuna, Valdar, William, Churchill, Gary and Dipetrillo, Keith (2012) Genome-wide Association Mapping of Quantitative Traits in Outbred Mice. G3: Gene/Genomes/Genetics, 2 (2). pp. 167-174. ISSN 2160-1836

Zielen, S, Lieb, A, De La Motte, D, Wagner, F, De Monchy, J, Fuhr, R, Munzu, Clara, Koehne-Voss, Stephan, Riviere, G, Kaiser, Guenther and Erpenbeck, Veit (2012) Omalizumab protects against allergen-induced bronchoconstriction in allergic (IgE-mediated) asthma. International archives of allergy and immunology, 160 (1). pp. 102-110. ISSN 1018-2438

Zou, Bin, Yap, Peiling, Sonntag, Sebastian, Leong, Seh Yong, Yeung, Bryan King Sing and Keller, Thomas (2012) Mechanistic Study of the Spiroindolones: A New Class of Antimalarials. Molecules, 17 (9). pp. 10131-10141. ISSN 1420-3049

Zou, Gang, Kukkaro, Petra, Lok, Shee Mei, Ng, Jowin, Tan, Grace, Alonso, Sylvie, Macary, Paul and Shi, Pei-Yong (2012) Resistance analysis of an antibody that selectively inhibits dengue virus serotype-1. Antiviral Reseaech, 95 (3). pp. 216-223. ISSN 0166-3542

Zumsteg, Adrian, Caviezel, Christoph, Pisarsky, Laura, Strittmatter, Karin, Garcia-Echeverria, Carlos, Hofmann, Francesco and Christofori, Gerhard (2012) Repression of malignant tumor progression upon pharmacologic IGF1R blockade in a mouse model of insulinoma. Molecular Cancer Research, 10 (6). pp. 800-809. ISSN 1557-3125

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infante, Jeffrey R, Dees, E Claire, Olszanski, Anthony J, Dhuria, Shyeilla, Sen, Suman, Cameron, John and Cohen, Roger B (2012) A Phase I dose-escalation study of LCL161, an oral IAP inhibitor, in patients with advanced solid tumors. Journal of Clinical Oncology.