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Discovery of 1H-pyrrolo[2,3-c]pyridine-7-carboxamides as novel, allosteric mGluR5 antagonists

Koller, Manuel and Carcache, David and Orain, David and Ertl, Peter and Behnke, Dirk and Desrayaud, Sandrine and Laue, Grit and Vranesic, Ivan-Toma (2012) Discovery of 1H-pyrrolo[2,3-c]pyridine-7-carboxamides as novel, allosteric mGluR5 antagonists. Bioorganic Medicinal Chemistry Letters, 22. pp. 6454-6459.

Official URL: http://www.elsevier.com

Abstract

1H-pyrrolo[2,3-c]pyridine-7-carboxamides constitute a new series of allosteric mGluR5 antagonists. Variation of the substituents attached to the heterocyclic scaffold allowed improving the physico-chemical parameters for optimization of the aqueous solubility while retaining high in vitro potency.

Item Type: Article
Keywords: Excitatory amino acids; metabotropic glutamate receptor; mGluR5; negative allosteric modulator; 1H-pyrrolo[2,3-c]pyridine-7-carboxamides
Date Deposited: 03 May 2016 23:45
Last Modified: 03 May 2016 23:45
URI: https://oak.novartis.com/id/eprint/8018

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