Browse views: by Year, by Function, by GLF, by Subfunction, by Conference, by Journal

ROLE OF SPHINGOSINE 1-PHOSPHATE AND LYSOPHOSPHATIDIC ACID IN FIBROSIS

Pyne, Nigel J. and Dubois, Gerald and Pyne, Susan (2012) ROLE OF SPHINGOSINE 1-PHOSPHATE AND LYSOPHOSPHATIDIC ACID IN FIBROSIS. Biochimica et Biophysica Acta. ISSN 0006-3002

Abstract

This review highlights a significant role for sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) in many different types of fibrosis and their therapeutic potential. Indeed, the development of effective LPA receptor 1 (LPA1) antagonists and a neutralising anti-S1P antibody that is currently in Phase 1 clinical trials for treatment of age related macular degeneration indicate that translational progress to the clinic is well advanced. However, both LPA and S1P are involved in the multi-process pathogenesis of fibrosis, being implicated in promoting differentiation of fibroblasts to myofibroblasts, epithelial-mesenchymal transition and fibrocyte homing to fibrotic lesions. These processes provide new opportunities for drug intervention targeted at S1P and LPA biology.

Item Type: Article
Related URLs:
Additional Information: T his is a review with no proprietary data included.
Keywords: sphingosine 1-phosphate, lysophosphatidic acid, fibrosis, TGFβ, signaling, connective tissue growth factor
Related URLs:
Date Deposited: 13 Oct 2015 13:14
Last Modified: 13 Oct 2015 13:14
URI: https://oak.novartis.com/id/eprint/7497

Search

Email Alerts

Register with OAK to receive email alerts for saved searches.