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Effectiveness and molecular interactions of the clinically active mTORC1 inhibitor everolimus in combination with tamoxifen or letrozole in vitro and in vivo

Farmer, I and Pancholi, S and Thornhill, AM and Ghazoui, Z and Evans, Dean Brent and Lane, Heidi A and Johnston, SR and Dowsett, Mitch and Martin, Lesley-Ann and Imark, Esther (2012) Effectiveness and molecular interactions of the clinically active mTORC1 inhibitor everolimus in combination with tamoxifen or letrozole in vitro and in vivo. Breast Cancer Research, 14 (5). ISSN 1465-5411

Abstract

Strategies to improve the efficacy of endocrine agents in breast cancer (BC) therapy and to delay the onset of resistance include concomitant targeting of the estrogen receptor alpha (ER) and the mammalian target of rapamycin complex 1 (mTORC1), which regulate cell-cycle progression and are supported by recent clinical results.

Item Type: Article
Date Deposited: 04 May 2016 23:45
Last Modified: 04 May 2016 23:45
URI: https://oak.novartis.com/id/eprint/1991

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