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Full Utilization of the Mass Spectrometer by On-Demand sharing with Multiple LC Units

Li, Shu, Hao, Qin, Gounarides, John and Wang, Yingqi (2012) Full Utilization of the Mass Spectrometer by On-Demand sharing with Multiple LC Units. Journal of Mass Spectrometry, 47 (8). pp. 1074-1082. ISSN 1076-5174


The concept and implementation of full utilization of mass spectrometer by on-demand sharing with many LC units is reported. Sharing mass spectrometer with multiple LC’s is not new; however, to fully utilize the MS duty cycle, the number of LC units that a MS will need to recruit is application dependent and could be significantly larger than the current commercial or published implementations. For the example of a single analyte the number can be close to the peak capacity at a first degree of approximation. It remains to be seen whether a MS can be configured to have such a flexibility and scalability. Here we construct a prototypical system using commercially available software and hardware and demonstrate its performance with real applications. The ultimate goal is to have a system that allows the ‘plug & play’ of LC modules on-demand to fully utilize the mass spectrometer for any applications.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); On personal web site or secure external website at authors institution; Publisher's version/PDF cannot be used
Keywords: LC/MS, staggered, multiplex, high throughput, screen, scalable, parallel, enzymatic assay, quantification
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Date Deposited: 13 Oct 2015 13:14
Last Modified: 13 Oct 2015 13:14