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A review of the incidence and coincidence of uterine and mammary tumours in Wistar and Sprague Dawley rats based on the RITA database and the role of prolactin Evaluation of carcinogenicity results needs an awareness of tumour interdependency in pathogenesis

Harleman, JH and Hargreaves, A and Andersson, H and Kirk, S (2012) A review of the incidence and coincidence of uterine and mammary tumours in Wistar and Sprague Dawley rats based on the RITA database and the role of prolactin Evaluation of carcinogenicity results needs an awareness of tumour interdependency in pathogenesis. Toxicologic Pathology, 40 (6). pp. 926-930. ISSN 0192-6233

Abstract

Wistar rats are frequently selected for use in carcinogenicity studies due to their advantageous survival rate, which is more favourable than other strains such as the Sprague Dawley (SD) strain. Uterine and mammary tumurs are relatively common spontaneous neoplasms of both strains. We examined the incidence and co-incidence of uterine tumours and mammary tumours in control animals of both strains within the RITA database. There was a strong inverse relationship between these tumour types in Wistar rats (p< 0.001). A less strong relationship was present in SD rats (p = 0.057). This association is likely to be related to prolactin. A short review of the role of prolactin in rats is given. These results are also discussed in the background of non-specific toxicity at high dose levels in carcinogenicity studies above MTD levels resulting in reduction in bodyweights of >10%.

Item Type: Article
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Keywords: Mammary tumours Uterine tumours interdependency Sprague-Dawley Wistar rats prolactin Interdependency Sprague-Dawley Wistar Rats Prolactin
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Date Deposited: 13 Oct 2015 13:15
Last Modified: 13 Oct 2015 13:15
URI: https://oak.novartis.com/id/eprint/5855

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