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Microwave Mediated Suzuki-Miyaura Couplings of S- and Ortho-Substituted Methylphenylboronic Acid Esters

Press, Neil and baltus, christine B and Spencer, John (2012) Microwave Mediated Suzuki-Miyaura Couplings of S- and Ortho-Substituted Methylphenylboronic Acid Esters. Synlett, 23 (17). pp. 2477-2480. ISSN 0936-5214

Abstract

Hitherto unsuccessful cross couplings of ortho-substituted or thioether-substituted methylphenylboronates have been achieved, under microwave conditions, enabling the synthesis of a library of novel biaryls. Tetrakis(triphenylphosphine)palladium and various bases e.g. sodium carbonate or cesium fluoride were found to mediate the crucial C-C bond forming cross coupling reaction.

Item Type: Article
Additional Information: Paper from CASE collaboration - no proprietary structures or research
Keywords: Microwave, Suzuki-Miyaura, couplings, methylphenylboronic acid, palladium, catalysis, cross-coupling, biaryls, microwaves
Date Deposited: 13 Oct 2015 13:14
Last Modified: 13 Oct 2015 13:14
URI: https://oak.novartis.com/id/eprint/7372

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