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Dynamic expression of the D6 chemokine scavenging receptor contributes to the pathogenesis of psoriasis

Singh, Mark D and King, Vicky and Baldwin, Helen and Jamieson, Thomas and Carballido, Jose and Rot, Antal and Graham, Gerard J (2012) Dynamic expression of the D6 chemokine scavenging receptor contributes to the pathogenesis of psoriasis. The American Journal of Pathology, 158 (4). pp. 1158-1164. ISSN 0002-9440

Abstract

Chemokines are key regulators of the development of inflammatory pathologies including psoriasis. However, the overall regulation of chemokine function in the pathogenesis of psoriasis has not yet been elucidated. Here we show that the D6 chemokine-scavenging is differentially expressed within psoriatic skin to impair the development of psoriatic lesions. Our data highlight D6 as a novel contributor to the pathogenesis of psoriasis and highlight it as a potential therapeutic target.

Item Type: Article
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Keywords: D6, Chemokines, Psoriasis,
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Date Deposited: 13 Oct 2015 13:15
Last Modified: 13 Oct 2015 13:15
URI: https://oak.novartis.com/id/eprint/5138

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