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Anti-tumor effect of a novel FAK inhibitor TAE226 against human oral squamous cell carcinoma

Kurio, Naito and Shimo, Tsuyoshi and Fukazawa, Takuya and Okui, Tatsuo and Hassan, Nur Mohammad Monsur and Honami, Tatsuki and Horikiri, Yuu and Hatakeyama, Shinji and Takaoka, Munenori and Naomoto, Yoshio and Sasaki, Akira (2012) Anti-tumor effect of a novel FAK inhibitor TAE226 against human oral squamous cell carcinoma. Oral Oncology, 48 (11). pp. 1159-1170. ISSN 1368-8375

Abstract

Focal adhesion kinase (FAK) overexpression is frequently found in invasive and metastatic cancers, but its role in oral squamous cell carcinoma is not yet well understood. In order to seek therapies targeting oral squamous cell carcinoma we developed a novel FAK Tyr397 inhibitor, TAE226, and investigated its anti-tumor effects and mechanisms. We found that phosphorylated FAK was highly expressed in human tongue oral squamous cell carcinoma in patients. Importantly, TAE226 greatly suppressed the proliferation, migration and invasion of human oral squamous cell carcinoma SAS cells with an apparent structural change of actin fiber and a loss of cell adhesion. In addition, TAE226 inhibited the expression of phospho-FAK Tyr397 and phospho AKT Ser473, resulting in caspase-mediated apoptosis. Furthermore, oral administration of TAE226 in mice suppressed the growth and angiogenesis of oral squamous cell carcinoma xenografts in vivo. Our results provide compelling evidence that FAK is critically involved in oral squamous cell carcinoma and that the FAK inhibitor TAE226 can potentially be effectively used for the treatment of oral squamous cell carcinoma.

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Date Deposited: 13 Oct 2015 13:14
Last Modified: 13 Oct 2015 13:14
URI: https://oak.novartis.com/id/eprint/6953

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