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The Non-Specific effect of Efungumab on Amphotericin B Minimum Inhibitory Concentration

Richie, Daryl and Thompson, Katherine and Ghannoum, Mahmoud and Ryder, Neil (2012) The Non-Specific effect of Efungumab on Amphotericin B Minimum Inhibitory Concentration. Antimicrobial Agents and Chemotherapy, 56 (7). pp. 3963-3964. ISSN 0066-4804

Abstract

Background: Mycograb C28Y is a recombinant human antibody fragment thought to target HSP-90. Absence of in vivo efficacy led us to reevaluate its in vitro activity. Methods: Interaction between amphotericin B (AMB) and Mycograb C28Y were characterized following CLSI guidelines. Results: Addition of Mycograb C28Y and non-specific proteins resulted in a four fold decrease in MIC as compared to AMB alone. Conclusion: Potentiation of AMB by Mycograb C28Y appears to be a non-specific protein effect.

Item Type: Article
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Date Deposited: 13 Oct 2015 13:14
Last Modified: 13 Oct 2015 13:14
URI: https://oak.novartis.com/id/eprint/6882

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